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Items: 1 to 50 of 85

1.

A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals.

Rugen MD, Vernet MMJL, Hantouti L, Soenens A, Andriotis VME, Rejzek M, Brett P, van den Berg RJBHN, Aerts JMFG, Overkleeft HS, Field RA.

Sci Rep. 2018 Nov 6;8(1):16421. doi: 10.1038/s41598-018-34749-1.

2.

Two-step activity-based protein profiling of diacylglycerol lipase.

van Rooden EJ, Kreekel R, Hansen T, Janssen APA, van Esbroeck ACM, den Dulk H, van den Berg RJBHN, Codée JDC, van der Stelt M.

Org Biomol Chem. 2018 Jul 25;16(29):5250-5253. doi: 10.1039/c8ob01499j.

PMID:
30004552
3.

Development of a Cannabinoid-Based Photoaffinity Probe to Determine the Δ8/9-Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells.

Soethoudt M, Alachouzos G, van Rooden EJ, Moya-Garzón MD, van den Berg RJBHN, Heitman LH, van der Stelt M.

Cannabis Cannabinoid Res. 2018 Jul 1;3(1):136-151. doi: 10.1089/can.2018.0003. eCollection 2018.

4.

Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and α,β-Hydrolase Domain Containing Protein 6.

van Rooden EJ, Kohsiek M, Kreekel R, van Esbroeck ACM, van den Nieuwendijk AMCH, Janssen APA, van den Berg RJBHN, Overkleeft HS, van der Stelt M.

Chem Asian J. 2018 Nov 16;13(22):3491-3500. doi: 10.1002/asia.201800452. Epub 2018 Jun 14.

PMID:
29901868
5.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.

6.

Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors.

Deng H, van der Wel T, van den Berg RJBHN, van den Nieuwendijk AMCH, Janssen FJ, Baggelaar MP, Overkleeft HS, van der Stelt M.

Medchemcomm. 2017 Mar 10;8(5):982-988. doi: 10.1039/c7md00029d. eCollection 2017 May 1.

7.

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M.

J Med Chem. 2017 Jan 12;60(1):428-440. doi: 10.1021/acs.jmedchem.6b01482. Epub 2016 Dec 19.

PMID:
27992221
8.

Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors.

van den Berg RJ, van Rijssel ER, Ferraz MJ, Houben J, Strijland A, Donker-Koopman WE, Wennekes T, Bonger KM, Ghisaidoobe AB, Hoogendoorn S, van der Marel GA, Codée JD, Overkleeft HS, Aerts JM.

ChemMedChem. 2015 Dec;10(12):2042-62. doi: 10.1002/cmdc.201500407. Epub 2015 Oct 23.

PMID:
26492941
9.

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.

Wisse P, de Geus MA, Cross G, van den Nieuwendijk AM, van Rooden EJ, van den Berg RJ, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS.

J Org Chem. 2015 Jul 17;80(14):7258-65. doi: 10.1021/acs.joc.5b00823. Epub 2015 Jun 25.

PMID:
26061009
10.

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

Ghisaidoobe AT, van den Berg RJ, Butt SS, Strijland A, Donker-Koopman WE, Scheij S, van den Nieuwendijk AM, Koomen GJ, van Loevezijn A, Leemhuis M, Wennekes T, van der Stelt M, van der Marel GA, van Boeckel CA, Aerts JM, Overkleeft HS.

J Med Chem. 2014 Nov 13;57(21):9096-104. doi: 10.1021/jm501181z. Epub 2014 Oct 17.

PMID:
25250725
11.

Diagnosis of Clostridium difficile infection using real-time PCR.

van den Berg RJ, Bakker D, Kuijper EJ.

Methods Mol Biol. 2013;943:247-56. doi: 10.1007/978-1-60327-353-4_16.

PMID:
23104294
12.

Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels.

Janssen KG, Li J, Hoang HT, Vulto P, van den Berg RJ, Overkleeft HS, Eijkel JC, Tas NR, van der Linden HJ, Hankemeier T.

Lab Chip. 2012 Aug 21;12(16):2888-93. doi: 10.1039/c2lc21011h. Epub 2012 Jun 12.

PMID:
22691967
13.

Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.

van den Berg RJ, Wennekes T, Ghisaidoobe A, Donker-Koopman WE, Strijland A, Boot RG, van der Marel GA, Aerts JM, Overkleeft HS.

ACS Med Chem Lett. 2011 Apr 7;2(7):519-22. doi: 10.1021/ml200050s. eCollection 2011 Jul 14.

14.

Three distinct modes of exocytosis revealed by amperometry in neuroendocrine cells.

van Kempen GT, vanderLeest HT, van den Berg RJ, Eilers P, Westerink RH.

Biophys J. 2011 Feb 16;100(4):968-77. doi: 10.1016/j.bpj.2011.01.010.

15.

Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.

Ghisaidoobe A, Bikker P, de Bruijn AC, Godschalk FD, Rogaar E, Guijt MC, Hagens P, Halma JM, Van't Hart SM, Luitjens SB, van Rixel VH, Wijzenbroek M, Zweegers T, Donker-Koopman WE, Strijland A, Boot R, van der Marel G, Overkleeft HS, Aerts JM, van den Berg RJ.

ACS Med Chem Lett. 2010 Dec 2;2(2):119-23. doi: 10.1021/ml100192b. eCollection 2011 Feb 10.

16.

Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.

van den Nieuwendijk AM, Ruben M, Engelsma SE, Risseeuw MD, van den Berg RJ, Boot RG, Aerts JM, Brussee J, van der Marel GA, Overkleeft HS.

Org Lett. 2010 Sep 3;12(17):3957-9. doi: 10.1021/ol101556k.

PMID:
20690611
17.

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.

Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM.

J Med Chem. 2010 Jan 28;53(2):689-98. doi: 10.1021/jm901281m.

PMID:
20000679
18.

Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.

van Scherpenzeel M, van den Berg RJ, Donker-Koopman WE, Liskamp RM, Aerts JM, Overkleeft HS, Pieters RJ.

Bioorg Med Chem. 2010 Jan 1;18(1):267-73. doi: 10.1016/j.bmc.2009.10.060. Epub 2009 Oct 31.

PMID:
19931460
19.

Glycosphingolipids--nature, function, and pharmacological modulation.

Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM.

Angew Chem Int Ed Engl. 2009;48(47):8848-69. doi: 10.1002/anie.200902620. Review.

PMID:
19862781
20.

Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, Overkleeft HS.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. doi: 10.1016/j.bmcl.2009.10.022. Epub 2009 Oct 8.

PMID:
19853441
21.

Complementary chemoenzymatic routes to both enantiomers of febrifugine.

Wijdeven MA, van den Berg RJ, Wijtmans R, Botman PN, Blaauw RH, Schoemaker HE, van Delft FL, Rutjes FP.

Org Biomol Chem. 2009 Jul 21;7(14):2976-80. doi: 10.1039/b901670h. Epub 2009 Jun 4.

PMID:
19582308
22.

Comparison of molecular typing methods applied to Clostridium difficile.

Kuijper EJ, van den Berg RJ, Brazier JS.

Methods Mol Biol. 2009;551:159-71. doi: 10.1007/978-1-60327-999-4_13. Review.

PMID:
19521874
23.

Discovery of selective luteinizing hormone receptor agonists using the bivalent ligand method.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, van Koppen CJ, Timmers CM, Overkleeft HS, van der Marel GA.

ChemMedChem. 2009 Jul;4(7):1189-95. doi: 10.1002/cmdc.200900058.

PMID:
19475639
24.

Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina.

Goorhuis A, Legaria MC, van den Berg RJ, Harmanus C, Klaassen CH, Brazier JS, Lumelsky G, Kuijper EJ.

Clin Microbiol Infect. 2009 Dec;15(12):1080-6. doi: 10.1111/j.1469-0691.2009.02759.x. Epub 2009 May 11.

25.

Successful combat of an outbreak due to Clostridium difficile PCR ribotype 027 and recognition of specific risk factors.

Debast SB, Vaessen N, Choudry A, Wiegers-Ligtvoet EA, van den Berg RJ, Kuijper EJ.

Clin Microbiol Infect. 2009 May;15(5):427-34. doi: 10.1111/j.1469-0691.2009.02713.x. Epub 2009 Mar 23.

26.

Laboratory-acquired clostridium difficile polymerase chain reaction ribotype 027: a new risk for laboratory workers?

Bouza E, Martin A, Van den Berg RJ, Kuijper EJ.

Clin Infect Dis. 2008 Dec 1;47(11):1493-4. doi: 10.1086/593109. No abstract available.

PMID:
18986267
27.

N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide.

Wijdeven MA, Wijtmans R, van den Berg RJ, Noorduin W, Schoemaker HE, Sonke T, van Delft FL, Blaauw RH, Fitch RW, Spande TF, Daly JW, Rutjes FP.

Org Lett. 2008 Sep 18;10(18):4001-3. doi: 10.1021/ol801490m. Epub 2008 Aug 15.

PMID:
18702495
28.

The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells.

Rampaart LJ, Beekwilder JP, van Kempen GT, van den Berg RJ, Ypey DL.

Anesth Analg. 2008 Jun;106(6):1778-83. doi: 10.1213/ane.0b013e318172c3a2.

PMID:
18499609
29.

Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile-associated disease.

Debast SB, van Kregten E, Oskam KM, van den Berg T, Van den Berg RJ, Kuijper EJ.

Clin Microbiol Infect. 2008 Jun;14(6):622-4. doi: 10.1111/j.1469-0691.2008.01999.x. Epub 2008 Apr 3.

30.

Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA.

Bioorg Med Chem. 2008 Apr 1;16(7):3744-58. doi: 10.1016/j.bmc.2008.01.054. Epub 2008 Feb 2.

PMID:
18282756
31.

Use of highly discriminatory fingerprinting to analyze clusters of Clostridium difficile infection cases due to epidemic ribotype 027 strains.

Fawley WN, Freeman J, Smith C, Harmanus C, van den Berg RJ, Kuijper EJ, Wilcox MH.

J Clin Microbiol. 2008 Mar;46(3):954-60. doi: 10.1128/JCM.01764-07. Epub 2008 Jan 23.

32.

Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing.

Killgore G, Thompson A, Johnson S, Brazier J, Kuijper E, Pepin J, Frost EH, Savelkoul P, Nicholson B, van den Berg RJ, Kato H, Sambol SP, Zukowski W, Woods C, Limbago B, Gerding DN, McDonald LC.

J Clin Microbiol. 2008 Feb;46(2):431-7. Epub 2007 Nov 26.

33.

Characteristics and incidence of Clostridium difficile-associated disease in The Netherlands, 2005.

Paltansing S, van den Berg RJ, Guseinova RA, Visser CE, van der Vorm ER, Kuijper EJ.

Clin Microbiol Infect. 2007 Nov;13(11):1058-64.

34.

Enzymatic enantioselective C-C-bond formation in microreactors.

Koch K, van den Berg RJ, Nieuwland PJ, Wijtmans R, Schoemaker HE, van Hest JC, Rutjes FP.

Biotechnol Bioeng. 2008 Mar 1;99(4):1028-33.

PMID:
17879309
35.

Clostridium difficile-associated diarrhoea: bovine anti-Clostridium difficile whey protein to help aid the prevention of relapses.

Numan SC, Veldkamp P, Kuijper EJ, van den Berg RJ, van Dissel JT.

Gut. 2007 Jun;56(6):888-9. No abstract available.

36.

Synthesis and evaluation of homo-bivalent GnRHR ligands.

Bonger KM, van den Berg RJ, Heitman LH, IJzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA.

Bioorg Med Chem. 2007 Jul 15;15(14):4841-56. Epub 2007 May 6.

PMID:
17517510
37.

First isolation of Clostridium difficile 027 in Japan.

Kato H, Ito Y, van den Berg RJ, Kuijper EJ, Arakawa Y.

Euro Surveill. 2007 Jan 11;12(1):E070111.3. No abstract available.

PMID:
17370932
38.

Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, Overkleeft HS.

J Org Chem. 2007 Feb 16;72(4):1088-97. Epub 2007 Jan 23.

PMID:
17243712
39.

Evaluation of real-time PCR and conventional diagnostic methods for the detection of Clostridium difficile-associated diarrhoea in a prospective multicentre study.

van den Berg RJ, Vaessen N, Endtz HP, Schülin T, van der Vorm ER, Kuijper EJ.

J Med Microbiol. 2007 Jan;56(Pt 1):36-42.

PMID:
17172514
40.

Typing and subtyping of Clostridium difficile isolates by using multiple-locus variable-number tandem-repeat analysis.

van den Berg RJ, Schaap I, Templeton KE, Klaassen CH, Kuijper EJ.

J Clin Microbiol. 2007 Mar;45(3):1024-8. Epub 2006 Dec 13.

41.

Pores in synthetic nerve conduits are beneficial to regeneration.

Vleggeert-Lankamp CL, de Ruiter GC, Wolfs JF, Pêgo AP, van den Berg RJ, Feirabend HK, Malessy MJ, Lakke EA.

J Biomed Mater Res A. 2007 Mar 15;80(4):965-82.

PMID:
17106899
42.

Nitrile hydrolysis activity of Rhodococcus erythropolis NCIMB 11540 whole cells.

Vink MK, Wijtmans R, Reisinger C, van den Berg RJ, Schortinghuis CA, Schwab H, Schoemaker HE, Rutjes FP.

Biotechnol J. 2006 May;1(5):569-73.

PMID:
16892293
43.

Clostridium difficile ribotype 027, toxinotype III, the Netherlands.

Kuijper EJ, van den Berg RJ, Debast S, Visser CE, Veenendaal D, Troelstra A, van der Kooi T, van den Hof S, Notermans DW.

Emerg Infect Dis. 2006 May;12(5):827-30.

44.

Rapid diagnosis of toxinogenic Clostridium difficile in faecal samples with internally controlled real-time PCR.

van den Berg RJ, Kuijper EJ, van Coppenraet LE, Claas EC.

Clin Microbiol Infect. 2006 Feb;12(2):184-6.

45.

An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine.

van den Berg RJ, Boltje TJ, Verhagen CP, Litjens RE, van der Marel GA, Overkleeft HS.

J Org Chem. 2006 Jan 20;71(2):836-9.

PMID:
16409007
46.

The local anesthetic butamben inhibits and accelerates low-voltage activated T-type currents in small sensory neurons.

Beekwilder JP, van Kempen GT, van den Berg RJ, Ypey DL.

Anesth Analg. 2006 Jan;102(1):141-5.

PMID:
16368819
47.

Prospective multicenter evaluation of a new immunoassay and real-time PCR for rapid diagnosis of Clostridium difficile-associated diarrhea in hospitalized patients.

van den Berg RJ, Bruijnesteijn van Coppenraet LS, Gerritsen HJ, Endtz HP, van der Vorm ER, Kuijper EJ.

J Clin Microbiol. 2005 Oct;43(10):5338-40.

48.

The block of total and N-type calcium conductance in mouse sensory neurons by the local anesthetic n-butyl-p-aminobenzoate.

Beekwilder JP, Winkelman DL, van Kempen GT, van den Berg RJ, Ypey DL.

Anesth Analg. 2005 Jun;100(6):1674-9.

PMID:
15920194
49.

Preparation of 1-thio uronic acid lactones and their use in oligosaccharide synthesis.

van den Bos LJ, Litjens RE, van den Berg RJ, Overkleeft HS, van der Marel GA.

Org Lett. 2005 May 12;7(10):2007-10.

PMID:
15876041
50.

Coexistence of multiple PCR-ribotype strains of Clostridium difficile in faecal samples limits epidemiological studies.

van den Berg RJ, Ameen HA, Furusawa T, Claas EC, van der Vorm ER, Kuijper EJ.

J Med Microbiol. 2005 Feb;54(Pt 2):173-9.

PMID:
15673513

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