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Items: 1 to 50 of 315

1.

Beyond the randomized clinical trial: innovative data science to close the pediatric evidence gap.

Goulooze SC, Zwep LB, Vogt JE, Krekels EHJ, Hankemeier T, van den Anker JN, Knibbe CAJ.

Clin Pharmacol Ther. 2019 Dec 20. doi: 10.1002/cpt.1744. [Epub ahead of print] Review.

PMID:
31863465
2.

Pediatric Ontogeny: Moving From Translational Science to Drug Development.

Burckart GJ, van den Anker JN.

J Clin Pharmacol. 2019 Sep;59 Suppl 1:S7-S8. doi: 10.1002/jcph.1481. No abstract available.

PMID:
31502690
3.

Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir.

Liu XI, Momper JD, Rakhmanina N, van den Anker JN, Green DJ, Burckart GJ, Best BM, Mirochnick M, Capparelli EV, Dallmann A.

J Clin Pharmacol. 2020 Feb;60(2):240-255. doi: 10.1002/jcph.1515. Epub 2019 Sep 6.

PMID:
31489678
4.

Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.

Hathout Y, Liang C, Ogundele M, Xu G, Tawalbeh SM, Dang UJ, Hoffman EP, Gordish-Dressman H, Conklin LS, van den Anker JN, Clemens PR, Mah JK, Henricson E, McDonald C.

Sci Rep. 2019 Aug 21;9(1):12167. doi: 10.1038/s41598-019-48548-9.

5.

Dose evaluation of intravenous metamizole (dipyrone) in infants and children: a prospective population pharmacokinetic study.

Ziesenitz VC, Rodieux F, Atkinson A, Borter C, Bielicki JA, Haschke M, Duthaler U, Bachmann F, Erb TO, Gürtler N, Holland-Cunz S, van den Anker JN, Gotta V, Pfister M.

Eur J Clin Pharmacol. 2019 Nov;75(11):1491-1502. doi: 10.1007/s00228-019-02720-2. Epub 2019 Aug 7.

PMID:
31388703
6.

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women.

Mian P, van den Anker JN, van Calsteren K, Annaert P, Tibboel D, Pfister M, Allegaert K, Dallmann A.

Clin Pharmacokinet. 2019 Jul 25. doi: 10.1007/s40262-019-00799-5. [Epub ahead of print]

PMID:
31347013
7.

Perinatal Clinical Pharmacology: Optimizing Pharmacotherapy for Pregnant Women, Their Fetuses and Infants.

Allegaert K, van den Anker JN.

Curr Pharm Des. 2019;25(5):467-468. doi: 10.2174/138161282504190516090723.

PMID:
31215371
8.

Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief.

Mian P, Dallmann A, van den Anker JN, Tibboel D, Allegaert K.

Pain Med. 2019 Jun 18. pii: pnz136. doi: 10.1093/pm/pnz136. [Epub ahead of print] No abstract available.

PMID:
31211382
9.

Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?

Allegaert K, Smits A, van den Anker JN.

Neonatology. 2019;116(2):188-190. doi: 10.1159/000499742. Epub 2019 Jun 11. No abstract available.

PMID:
31185480
10.

Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates.

Krzyzanski W, Cook SF, Wilbaux M, Sherwin CMT, Allegaert K, Vermeulen A, van den Anker JN.

AAPS J. 2019 May 28;21(4):68. doi: 10.1208/s12248-019-0331-0.

11.

Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model.

Völler S, Flint RB, Beggah F, Reiss I, Andriessen P, Zimmermann LJI, van den Anker JN, Liem KD, Koch BCP, de Wildt S, Knibbe CAJ, Simons SHP.

J Clin Pharmacol. 2019 Oct;59(10):1300-1308. doi: 10.1002/jcph.1429. Epub 2019 May 15.

12.

Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.

Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W.

J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138. doi: 10.1093/jac/dkz158.

PMID:
31049551
13.

Author response.

Welzel T, Ziesenitz VC, Seitz S, Donner B, van den Anker JN.

Ann Allergy Asthma Immunol. 2019 Apr;122(4):434-435. doi: 10.1016/j.anai.2019.01.020. No abstract available.

PMID:
30954127
14.

Next Generation Medical Management of Postpartum Hemorrhage.

Phillips JM, van den Anker JN, Ahmadzia HK.

Curr Pharm Des. 2019;25(5):549-555. doi: 10.2174/1381612825666190320155337.

PMID:
30894102
15.

Monoclonal Antibodies and Fc-Fusion Proteins for Pediatric Use: Dosing, Immunogenicity, and Modeling and Simulation in Data Submitted to the US Food and Drug Administration.

Liu XI, Dallmann A, Wang YM, Green DJ, Burnham JM, Chiang B, Wu P, Sheng M, Lu K, van den Anker JN, Burckart GJ.

J Clin Pharmacol. 2019 Aug;59(8):1130-1143. doi: 10.1002/jcph.1406. Epub 2019 Mar 13.

16.

Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates.

Leroux S, van den Anker JN, Smits A, Pfister M, Allegaert K.

Br J Clin Pharmacol. 2019 May;85(5):865-867. doi: 10.1111/bcp.13899. Epub 2019 Mar 4. No abstract available.

PMID:
30834552
17.

Prescription Drug Shortages: Pediatric Emergency and Critical Care Medications.

Donnelly KA, Zocchi MS, Katy TA, Fox ER, Pines JM, van den Anker JN, Mazer-Amirshahi ME.

Pediatr Emerg Care. 2019 Feb 25. doi: 10.1097/PEC.0000000000001773. [Epub ahead of print]

PMID:
30829846
18.

Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis.

Hahn A, Fanous H, Jensen C, Chaney H, Sami I, Perez GF, Koumbourlis AC, Louie S, Bost JE, van den Anker JN, Freishtat RJ, Zemanick ET, Crandall KA.

Sci Rep. 2019 Feb 22;9(1):2534. doi: 10.1038/s41598-019-38984-y.

19.

A Comparison of Pediatric and Adult Safety Studies for Antipsychotic and Antidepressant Drugs Submitted to the United States Food and Drug Administration.

Liu XI, Schuette P, Burckart GJ, Green DJ, La J, Burnham JM, Rakhmanina N, Robb A, Huang SM, van den Anker JN.

J Pediatr. 2019 May;208:236-242.e3. doi: 10.1016/j.jpeds.2018.12.033. Epub 2019 Jan 21.

PMID:
30679050
20.

Use of a personalized phenytoin dosing approach to manage difficult to control seizures in an infant with a SCN2A mutation.

Welzel T, Ziesenitz VC, Waldvogel S, Scheidegger S, Weber P, van den Anker JN, Gotta V.

Eur J Clin Pharmacol. 2019 May;75(5):737-739. doi: 10.1007/s00228-019-02629-w. Epub 2019 Jan 15. No abstract available.

PMID:
30643928
21.

Use of inhaled steroids to prevent bronchopulmonary dysplasia: a matter of great debate.

Samiee-Zafarghandy S, van den Anker JN.

Arch Dis Child. 2019 Sep;104(9):924-925. doi: 10.1136/archdischild-2018-316132. Epub 2018 Nov 29. No abstract available.

PMID:
30498060
22.

Longitudinal trends in U.S. shortages of sterile solutions, 2001-17.

Mazer-Amirshahi M, Fox ER, Zocchi MS, Pines JM, van den Anker JN.

Am J Health Syst Pharm. 2018 Dec 1;75(23):1903-1908. doi: 10.2146/ajhp180203.

PMID:
30463866
23.

Relationship of Pulmonary Outcomes, Microbiology, and Serum Antibiotic Concentrations in Cystic Fibrosis Patients.

Hahn A, Jensen C, Fanous H, Chaney H, Sami I, Perez GF, Louie S, Koumbourlis AC, Bost JE, van den Anker JN.

J Pediatr Pharmacol Ther. 2018 Sep-Oct;23(5):379-389. doi: 10.5863/1551-6776-23.5.379.

24.

Prescription Drug Shortages: Impact on Neonatal Intensive Care.

Ziesenitz VC, Fox E, Zocchi M, Samiee-Zafarghandy S, van den Anker JN, Mazer-Amirshahi M.

Neonatology. 2019;115(2):108-115. doi: 10.1159/000493119. Epub 2018 Nov 1.

PMID:
30384374
25.

Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis.

Allegaert K, Mian P, Lapillonne A, van den Anker JN.

Br J Clin Pharmacol. 2019 Jan;85(1):245-251. doi: 10.1111/bcp.13778. Epub 2018 Oct 25.

26.

Comorbidity of Migraine and Epilepsy in Pediatrics: A Review.

Jancic J, Djuric V, Hencic B, van den Anker JN, Samardzic J.

J Child Neurol. 2018 Oct;33(12):801-808. doi: 10.1177/0883073818788942. Epub 2018 Aug 10. Review.

PMID:
30095015
27.

Management of anaphylaxis and allergies in patients with long QT syndrome: A review of the current evidence.

Welzel T, Ziesenitz VC, Seitz S, Donner B, van den Anker JN.

Ann Allergy Asthma Immunol. 2018 Nov;121(5):545-551. doi: 10.1016/j.anai.2018.07.027. Epub 2018 Jul 27. Review.

PMID:
30059791
28.

Author's Reply to Reith: "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults".

van Rongen A, van den Anker JN, Knibbe CAJ.

Clin Pharmacokinet. 2018 Oct;57(10):1357-1358. doi: 10.1007/s40262-018-0692-z. No abstract available.

PMID:
29936679
29.

Psychiatric Disorder or Adverse Drug Reaction? - How CYP2D6 Metabolizing Activity Can Result in Dextromethorphan Intoxication.

Ziesenitz VC, van den Anker JN.

Klin Padiatr. 2019 Jan;231(1):46-48. doi: 10.1055/a-0627-7462. Epub 2018 Jun 6.

PMID:
29874682
30.

Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children.

Fuchs A, Bielicki J, Mathur S, Sharland M, Van Den Anker JN.

Paediatr Int Child Health. 2018 Nov;38(sup1):S3-S15. doi: 10.1080/20469047.2017.1408738.

31.

Prescription Drug Shortages: Implications for Ambulatory Pediatrics.

Donnelly KA, Zocchi MS, Katy TA, Fox ER, van den Anker JN, Mazer-Amirshahi ME.

J Pediatr. 2018 Aug;199:65-70. doi: 10.1016/j.jpeds.2018.04.008. Epub 2018 May 8.

PMID:
29752177
32.

First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Brussee JM, Yu H, Krekels EHJ, de Roos B, Brill MJE, van den Anker JN, Rostami-Hodjegan A, de Wildt SN, Knibbe CAJ.

CPT Pharmacometrics Syst Pharmacol. 2018 Jun;7(6):374-383. doi: 10.1002/psp4.12295. Epub 2018 May 10.

33.

Personalized weight change prediction in the first week of life.

Wilbaux M, Kasser S, Gromann J, Mancino I, Coscia T, Lapaire O, van den Anker JN, Pfister M, Wellmann S.

Clin Nutr. 2019 Apr;38(2):689-696. doi: 10.1016/j.clnu.2018.04.001. Epub 2018 Apr 11.

PMID:
29703559
34.

Evident bias in a paracetamol metabolite population pharmacokinetic model applied to an external dataset.

Roberts JK, Linakis MW, Liu X, Sherwin CMT, van den Anker JN.

Br J Clin Pharmacol. 2018 Jul;84(7):1628-1630. doi: 10.1111/bcp.13588. Epub 2018 Apr 17. No abstract available.

35.

Primary Endpoints in Pediatric Efficacy Trials Submitted to the US FDA.

Green DJ, Burnham JM, Schuette P, Liu XI, Maas BM, Yao L, McCune SK, Chen J, van den Anker JN, Burckart GJ.

J Clin Pharmacol. 2018 Jul;58(7):885-890. doi: 10.1002/jcph.1109. Epub 2018 Apr 17.

36.

Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study.

Linakis MW, Cook SF, Kumar SS, Liu X, Wilkins DG, Gaedigk R, Gaedigk A, Sherwin CMT, van den Anker JN.

Clin Pharmacokinet. 2018 Oct;57(10):1325-1336. doi: 10.1007/s40262-018-0634-9.

37.

Acetaminophen in the Neonatal Intensive Care Unit: Shotgun Approach or Silver Bullet.

van den Anker JN, Allegaert K.

J Pediatr. 2018 Jul;198:10-11. doi: 10.1016/j.jpeds.2018.02.046. Epub 2018 Mar 28. No abstract available.

PMID:
29605390
38.

Drug evaluation studies in neonates: how to overcome the current limitations.

Allegaert K, Smits A, van den Anker JN.

Expert Rev Clin Pharmacol. 2018 Apr;11(4):387-396. doi: 10.1080/17512433.2018.1439378. Epub 2018 Mar 14. Review.

PMID:
29421929
39.

Obesity and Pediatric Drug Development.

Vaughns JD, Conklin LS, Long Y, Zheng P, Faruque F, Green DJ, van den Anker JN, Burckart GJ.

J Clin Pharmacol. 2018 May;58(5):650-661. doi: 10.1002/jcph.1054. Epub 2018 Jan 19.

PMID:
29350758
40.

Safety of dipyrone (metamizole) in children-What's the risk of agranulocytosis?

Ziesenitz VC, Erb TO, Trachsel D, van den Anker JN.

Paediatr Anaesth. 2018 Feb;28(2):186-187. doi: 10.1111/pan.13312. No abstract available.

PMID:
29345086
41.

How reliable are commercially available trackers in detecting daytime sleep.

Lambrechtse P, Ziesenitz VC, Cohen A, van den Anker JN, Bos EJ.

Br J Clin Pharmacol. 2018 Mar;84(3):605-606. doi: 10.1111/bcp.13475. Epub 2018 Jan 17. No abstract available.

42.

Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia.

Bassler D, Shinwell ES, Hallman M, Jarreau PH, Plavka R, Carnielli V, Meisner C, Engel C, Koch A, Kreutzer K, van den Anker JN, Schwab M, Halliday HL, Poets CF; Neonatal European Study of Inhaled Steroids Trial Group.

N Engl J Med. 2018 Jan 11;378(2):148-157. doi: 10.1056/NEJMoa1708831.

43.

Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review.

Fjalstad JW, Esaiassen E, Juvet LK, van den Anker JN, Klingenberg C.

J Antimicrob Chemother. 2018 Mar 1;73(3):569-580. doi: 10.1093/jac/dkx426.

PMID:
29182785
44.

Correction to: Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.

Ziesenitz VC, Vaughns JD, Koch G, Mikus G, van den Anker JN.

Clin Pharmacokinet. 2018 Mar;57(3):393-417. doi: 10.1007/s40262-017-0609-2.

PMID:
29178007
45.

Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

Brussee JM, Vet NJ, Krekels EHJ, Valkenburg AJ, Jacqz-Aigrain E, van Gerven JMA, Swart EL, van den Anker JN, Tibboel D, de Hoog M, de Wildt SN, Knibbe CAJ.

Br J Clin Pharmacol. 2018 Feb;84(2):358-368. doi: 10.1111/bcp.13459. Epub 2017 Nov 29.

46.

No, we are not-we keep forgetting the right ventricle.

Ziesenitz VC, Haefeli WE, van den Anker JN, Gorenflo M.

Eur J Clin Pharmacol. 2018 Jan;74(1):141-143. doi: 10.1007/s00228-017-2349-5. Epub 2017 Oct 13. No abstract available.

PMID:
29030645
47.

Therapeutic Drug Monitoring in Neonates: What Makes them Unique?

Mian P, Flint RB, Tibboel D, van den Anker JN, Allegaert K, Koch BCP.

Curr Pharm Des. 2017;23(38):5790-5800. doi: 10.2174/1381612823666170926143820. Review.

PMID:
28950825
48.

Developmental Pharmacokinetics in Neonates: Maturational Changes and Beyond.

Allegaert K, Mian P, van den Anker JN.

Curr Pharm Des. 2017;23(38):5769-5778. doi: 10.2174/1381612823666170926121124. Review.

PMID:
28950819
49.

Optimising β -lactam Dosing in Neonates: A Review of Pharmacokinetics, Drug Exposure and Pathogens.

Fuchs A, Li G, van den Anker JN, Bielicki J.

Curr Pharm Des. 2017;23(38):5805-5838. doi: 10.2174/1381612823666170925162143. Review.

PMID:
28950814
50.

Augmented Renal Clearance in Critically Ill Pediatric Patients: Does It Impact the Outcome of Pharmacotherapy?

van den Anker JN, Knibbe CAJ, Tibboel D.

Pediatr Crit Care Med. 2017 Sep;18(9):901-902. doi: 10.1097/PCC.0000000000001264. No abstract available.

PMID:
28863094

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