Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 42

1.

PXE, a Mysterious Inborn Error Clarified.

Borst P, Váradi A, van de Wetering K.

Trends Biochem Sci. 2019 Feb;44(2):125-140. doi: 10.1016/j.tibs.2018.10.005. Epub 2018 Nov 13. Review.

PMID:
30446375
2.

Pseudoxanthoma Elasticum as a Paradigm of Heritable Ectopic Mineralization Disorders: Pathomechanisms and Treatment Development.

Li Q, van de Wetering K, Uitto J.

Am J Pathol. 2019 Feb;189(2):216-225. doi: 10.1016/j.ajpath.2018.09.014. Epub 2018 Nov 7. Review.

PMID:
30414410
3.

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547.

Kas SM, de Ruiter JR, Schipper K, Schut E, Bombardelli L, Wientjens E, Drenth AP, de Korte-Grimmerink R, Mahakena S, Phillips C, Smith PD, Klarenbeek S, van de Wetering K, Berns A, Wessels LFA, Jonkers J.

Cancer Res. 2018 Oct 1;78(19):5668-5679. doi: 10.1158/0008-5472.CAN-18-0757. Epub 2018 Aug 16.

4.

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora KM, De Lorenzi V, Stijf-Bultsma Y, van den Broek B, Jalink K, Sidenius N, Perrakis A, Moolenaar WH.

Elife. 2017 Aug 29;6. pii: e23649. doi: 10.7554/eLife.23649.

5.

Oral administration of pyrophosphate inhibits connective tissue calcification.

Dedinszki D, Szeri F, Kozák E, Pomozi V, Tőkési N, Mezei TR, Merczel K, Letavernier E, Tang E, Le Saux O, Arányi T, van de Wetering K, Váradi A.

EMBO Mol Med. 2017 Nov;9(11):1463-1470. doi: 10.15252/emmm.201707532.

6.

Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.

Pomozi V, Brampton C, van de Wetering K, Zoll J, Calio B, Pham K, Owens JB, Marh J, Moisyadi S, Váradi A, Martin L, Bauer C, Erdmann J, Aherrahrou Z, Le Saux O.

Am J Pathol. 2017 Jun;187(6):1258-1272. doi: 10.1016/j.ajpath.2017.02.009. Epub 2017 Apr 14.

7.

Insights into Pathomechanisms and Treatment Development in Heritable Ectopic Mineralization Disorders: Summary of the PXE International Biennial Research Symposium-2016.

Uitto J, Li Q, van de Wetering K, Váradi A, Terry SF.

J Invest Dermatol. 2017 Apr;137(4):790-795. doi: 10.1016/j.jid.2016.12.014. Review.

8.

Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum.

Li Q, Kingman J, van de Wetering K, Tannouri S, Sundberg JP, Uitto J.

J Invest Dermatol. 2017 May;137(5):1025-1032. doi: 10.1016/j.jid.2016.11.042. Epub 2017 Jan 19.

9.

Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.

Pomozi V, Brampton C, Szeri F, Dedinszki D, Kozák E, van de Wetering K, Hopkins H, Martin L, Váradi A, Le Saux O.

J Invest Dermatol. 2017 Mar;137(3):595-602. doi: 10.1016/j.jid.2016.10.035. Epub 2016 Nov 5.

10.

Effects of Different Variants in the ENPP1 Gene on the Functional Properties of Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1.

Stella J, Buers I, van de Wetering K, Höhne W, Rutsch F, Nitschke Y.

Hum Mutat. 2016 Nov;37(11):1190-1201. doi: 10.1002/humu.23057. Epub 2016 Aug 23.

PMID:
27467858
11.

MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum.

Rijpma SR, van der Velden M, Bilos A, Jansen RS, Mahakena S, Russel FG, Sauerwein RW, van de Wetering K, Koenderink JB.

FEBS Lett. 2016 Feb;590(4):482-92. doi: 10.1002/1873-3468.12079. Epub 2016 Feb 17.

12.

ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs.

Jansen RS, Mahakena S, de Haas M, Borst P, van de Wetering K.

J Biol Chem. 2015 Dec 18;290(51):30429-40. doi: 10.1074/jbc.M115.692103. Epub 2015 Oct 29.

13.

N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.

Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, Altelaar M, IJlst L, Wanders RJ, Borst P, van de Wetering K.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601-6. doi: 10.1073/pnas.1424638112. Epub 2015 May 11.

14.

ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.

Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Váradi A, Plomp A, Bergen AA, Oude Elferink RP, Borst P, van de Wetering K.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1985-9. doi: 10.1161/ATVBAHA.114.304017. Epub 2014 Jun 26.

15.

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.

Jansen RS, Küçükosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20206-11. doi: 10.1073/pnas.1319582110. Epub 2013 Nov 25.

16.

Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide.

Swartjes M, Mooren RA, Waxman AR, Arout C, van de Wetering K, den Hartigh J, Beijnen JH, Kest B, Dahan A.

Mol Med. 2012 Dec 6;18:1320-6. doi: 10.2119/molmed.2012.00244.

17.

Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol.

Zander SA, Kersbergen A, Sol W, Gonggrijp M, van de Wetering K, Jonkers J, Borst P, Rottenberg S.

Cancer Prev Res (Phila). 2012 Aug;5(8):1053-60. doi: 10.1158/1940-6207.CAPR-12-0050. Epub 2012 Jul 5.

18.

ABCG2 functions as a general phytoestrogen sulfate transporter in vivo.

van de Wetering K, Sapthu S.

FASEB J. 2012 Oct;26(10):4014-24. doi: 10.1096/fj.12-210039. Epub 2012 Jun 15.

PMID:
22707564
19.

Oral availability of cefadroxil depends on ABCC3 and ABCC4.

de Waart DR, van de Wetering K, Kunne C, Duijst S, Paulusma CC, Oude Elferink RP.

Drug Metab Dispos. 2012 Mar;40(3):515-21. doi: 10.1124/dmd.111.041731. Epub 2011 Dec 13.

PMID:
22166395
20.

Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays.

Krumpochova P, Sapthu S, Brouwers JF, de Haas M, de Vos R, Borst P, van de Wetering K.

FASEB J. 2012 Feb;26(2):738-47. doi: 10.1096/fj.11-195743. Epub 2011 Oct 27.

21.

Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.

Vlaming ML, van Esch A, Pala Z, Wagenaar E, van de Wetering K, van Tellingen O, Schinkel AH.

Mol Cancer Ther. 2009 Dec;8(12):3350-9. doi: 10.1158/1535-7163.MCT-09-0668.

22.

Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin.

Beedholm-Ebsen R, van de Wetering K, Hardlei T, Nexø E, Borst P, Moestrup SK.

Blood. 2010 Feb 25;115(8):1632-9. doi: 10.1182/blood-2009-07-232587. Epub 2009 Nov 6.

PMID:
19897579
23.

Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.

van de Wetering K, Feddema W, Helms JB, Brouwers JF, Borst P.

Gastroenterology. 2009 Nov;137(5):1725-35. doi: 10.1053/j.gastro.2009.06.052. Epub 2009 Jul 3.

PMID:
19577570
24.

Unimpaired immune functions in the absence of Mrp4 (Abcc4).

van de Ven R, de Groot J, Reurs AW, Wijnands PG, van de Wetering K, Schuetz JD, de Gruijl TD, Scheper RJ, Scheffer GL.

Immunol Lett. 2009 Jun 4;124(2):81-7. doi: 10.1016/j.imlet.2009.04.007. Epub 2009 May 3.

PMID:
19406153
25.

Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo.

Vlaming ML, Pala Z, van Esch A, Wagenaar E, de Waart DR, van de Wetering K, van der Kruijssen CM, Oude Elferink RP, van Tellingen O, Schinkel AH.

Clin Cancer Res. 2009 May 1;15(9):3084-93. doi: 10.1158/1078-0432.CCR-08-2940. Epub 2009 Apr 21.

26.

Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol.

van de Wetering K, Burkon A, Feddema W, Bot A, de Jonge H, Somoza V, Borst P.

Mol Pharmacol. 2009 Apr;75(4):876-85. doi: 10.1124/mol.108.052019. Epub 2008 Dec 29.

PMID:
19114588
27.

Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.

Vlaming ML, Pala Z, van Esch A, Wagenaar E, van Tellingen O, de Waart DR, Oude Elferink RP, van de Wetering K, Schinkel AH.

Clin Cancer Res. 2008 Dec 15;14(24):8152-60. doi: 10.1158/1078-0432.CCR-08-1609.

28.

Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone.

Lagas JS, van der Kruijssen CM, van de Wetering K, Beijnen JH, Schinkel AH.

Drug Metab Dispos. 2009 Jan;37(1):129-36. doi: 10.1124/dmd.108.023200. Epub 2008 Oct 9.

PMID:
18845662
29.

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

de Wolf C, Jansen R, Yamaguchi H, de Haas M, van de Wetering K, Wijnholds J, Beijnen J, Borst P.

Mol Cancer Ther. 2008 Sep;7(9):3092-102. doi: 10.1158/1535-7163.MCT-08-0427. Epub 2008 Sep 2.

30.
31.

Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2).

Zimmermann C, van de Wetering K, van de Steeg E, Wagenaar E, Vens C, Schinkel AH.

Drug Metab Dispos. 2008 Apr;36(4):631-40. doi: 10.1124/dmd.107.019620. Epub 2008 Jan 7.

PMID:
18180270
32.

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van Tellingen O, Schouten JP, Jonkers J, Borst P.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12117-22. Epub 2007 Jul 11.

33.

Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides.

van de Wetering K, Zelcer N, Kuil A, Feddema W, Hillebrand M, Vlaming ML, Schinkel AH, Beijnen JH, Borst P.

Mol Pharmacol. 2007 Aug;72(2):387-94. Epub 2007 May 7.

PMID:
17485564
34.

Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.

Ono N, Van der Heijden I, Scheffer GL, Van de Wetering K, Van Deemter E, De Haas M, Boerke A, Gadella BM, De Rooij DG, Neefjes JJ, Groothuis TA, Oomen L, Brocks L, Ishikawa T, Borst P.

Biochem J. 2007 Aug 15;406(1):31-40.

35.

Discussing and documenting (do not attempt) resuscitation orders in a Dutch Hospital: a disappointing reality.

Meilink M, van de Wetering K, Klip H.

Resuscitation. 2006 Dec;71(3):322-6. Epub 2006 Oct 24.

PMID:
17064837
36.

Sepsis due to gestational psittacosis: A multidisciplinary approach within a perinatological center--review of reported cases.

Janssen MJ, van de Wetering K, Arabin B.

Int J Fertil Womens Med. 2006 Jan-Feb;51(1):17-20. Review.

PMID:
16596904
37.

Multidrug resistance-associated proteins 3, 4, and 5.

Borst P, de Wolf C, van de Wetering K.

Pflugers Arch. 2007 Feb;453(5):661-73. Epub 2006 Apr 4. Review.

PMID:
16586096
38.

MRP2 and 3 in health and disease.

Borst P, Zelcer N, van de Wetering K.

Cancer Lett. 2006 Mar 8;234(1):51-61. Epub 2006 Jan 4. Review.

PMID:
16387425
39.

On the putative co-transport of drugs by multidrug resistance proteins.

Borst P, Zelcer N, van de Wetering K, Poolman B.

FEBS Lett. 2006 Feb 13;580(4):1085-93. Epub 2005 Dec 20. Review.

40.

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

Zelcer N, van de Wetering K, de Waart R, Scheffer GL, Marschall HU, Wielinga PR, Kuil A, Kunne C, Smith A, van der Valk M, Wijnholds J, Elferink RO, Borst P.

J Hepatol. 2006 Apr;44(4):768-75. Epub 2005 Aug 9.

PMID:
16225954
41.

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.

Zelcer N, van de Wetering K, Hillebrand M, Sarton E, Kuil A, Wielinga PR, Tephly T, Dahan A, Beijnen JH, Borst P.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7274-9. Epub 2005 May 10.

42.

Synthesis and biological evaluation of modified DNA fragments for the study of nucleotide excision repair in E. coli.

Monaco V, van de Wetering KI, Meeuwenoord NJ, van den Elst HA, Stuivenberg HR, Visse R, van der Kaaden JC, Moolenaar GF, Verhoeven EE, Goosen N, van der Marel GA, van Boom JH.

Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1339-41.

PMID:
10474222

Supplemental Content

Loading ...
Support Center