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Items: 1 to 50 of 152

1.

High LDL levels lessen bone destruction during antigen-induced arthritis by inhibiting osteoclast formation and function.

Ascone G, Di Ceglie I, Walgreen B, Sloetjes AW, Lindhout E, Bot I, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van den Bosch MHJ, van Lent PLEM.

Bone. 2019 Nov 9;130:115140. doi: 10.1016/j.bone.2019.115140. [Epub ahead of print]

PMID:
31712132
2.

Osteoporosis and osteoarthritis are two sides of the same coin paid for obesity.

Oliveira MC, Vullings J, van de Loo FAJ.

Nutrition. 2019 Apr 10;70:110486. doi: 10.1016/j.nut.2019.04.001. [Epub ahead of print] Review.

PMID:
31655472
3.

The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.

Kumrungsee T, Kariya T, Hashimoto K, Koyano T, Yazawa N, Hashimoto T, Sanada Y, Matsuyama M, Sotomaru Y, Sakurai H, van de Loo FAJ, Yanaka N.

Sci Rep. 2019 Oct 1;9(1):14101. doi: 10.1038/s41598-019-50685-0.

4.

Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis.

Pieters BCH, Cappariello A, van den Bosch MHJ, van Lent PLEM, Teti A, van de Loo FAJ.

Front Immunol. 2019 Aug 8;10:1901. doi: 10.3389/fimmu.2019.01901. eCollection 2019. Review.

5.

Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice.

Rogier R, Ederveen THA, Wopereis H, Hartog A, Boekhorst J, van Hijum SAFT, Knol J, Garssen J, Walgreen B, Helsen MM, van der Kraan PM, van Lent PLEM, van de Loo FAJ, Abdollahi-Roodsaz S, Koenders MI.

PLoS One. 2019 Jul 8;14(7):e0219366. doi: 10.1371/journal.pone.0219366. eCollection 2019.

6.

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology.

van Dalen SCM, Blom AB, Walgreen B, Slöetjes AW, Helsen MMA, Geven EJW, Ter Huurne M, Vogl T, Roth J, van de Loo FAJ, Koenders MI, Casteilla L, van der Kraan PM, van den Bosch MHJ, van Lent PLEM.

Front Immunol. 2019 May 27;10:1075. doi: 10.3389/fimmu.2019.01075. eCollection 2019.

7.

High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Ascone G, Di Ceglie I, van den Bosch MHJ, Kruisbergen NNL, Walgreen B, Sloetjes AW, Lindhout E, Joosten LAB, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van Lent PLEM.

Clin Exp Rheumatol. 2019 May 7. [Epub ahead of print]

PMID:
31074720
8.

Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment.

van Geffen EW, van Caam APM, Vitters EL, van Beuningen HM, van de Loo FA, van Lent PLEM, Koenders MI, van der Kraan PM.

Tissue Eng Part A. 2019 Aug;25(15-16):1155-1166. doi: 10.1089/ten.TEA.2018.0267. Epub 2019 Mar 28.

PMID:
30526407
9.

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Waterborg CEJ, Broeren MGA, Blaney Davidson EN, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ.

Rheumatology (Oxford). 2019 Mar 1;58(3):536-546. doi: 10.1093/rheumatology/key337.

PMID:
30508140
10.

Rheumatoid Arthritis Patients With Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity.

Arntz OJ, Pieters BCH, Thurlings RM, Wenink MH, van Lent PLEM, Koenders MI, van den Hoogen FHJ, van der Kraan PM, van de Loo FAJ.

Front Immunol. 2018 Oct 29;9:2388. doi: 10.3389/fimmu.2018.02388. eCollection 2018.

11.

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.

Waterborg CEJ, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ.

PLoS One. 2018 Oct 18;13(10):e0205902. doi: 10.1371/journal.pone.0205902. eCollection 2018.

12.

A three-dimensional model to study human synovial pathology.

Broeren MGA, Waterborg CEJ, Wiegertjes R, Thurlings RM, Koenders MI, Van Lent PLEM, Van der Kraan PM, Van de Loo FAJ.

ALTEX. 2019;36(1):18-28. doi: 10.14573/altex.1804161. Epub 2018 Oct 9.

13.

IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3.

van Geffen EW, van Caam APM, Schreurs W, van de Loo FA, van Lent PLEM, Koenders MI, Thudium CS, Bay-Jensen AC, Blaney Davidson EN, van der Kraan PM.

Osteoarthritis Cartilage. 2019 Jan;27(1):148-157. doi: 10.1016/j.joca.2018.08.016. Epub 2018 Sep 7.

PMID:
30201492
14.

The role of NOX2-derived reactive oxygen species in collagenase-induced osteoarthritis.

van Dalen SCM, Kruisbergen NNL, Walgreen B, Helsen MMA, Slöetjes AW, Cremers NAJ, Koenders MI, van de Loo FAJ, Roth J, Vogl T, Blom AB, van der Kraan PM, van Lent PLEM, van den Bosch MHJ.

Osteoarthritis Cartilage. 2018 Dec;26(12):1722-1732. doi: 10.1016/j.joca.2018.08.014. Epub 2018 Sep 5.

PMID:
30195046
15.

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation.

Broeren MGA, Di Ceglie I, Bennink MB, van Lent PLEM, van den Berg WB, Koenders MI, Blaney Davidson EN, van der Kraan PM, van de Loo FAJ.

PeerJ. 2018 May 30;6:e4771. doi: 10.7717/peerj.4771. eCollection 2018.

16.

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis.

Di Ceglie I, Ascone G, Cremers NAJ, Sloetjes AW, Walgreen B, Vogl T, Roth J, Verbeek JS, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van den Bosch MHJ, van Lent PLEM.

Arthritis Res Ther. 2018 May 2;20(1):80. doi: 10.1186/s13075-018-1584-1.

17.

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models.

Waterborg CEJ, Beermann S, Broeren MGA, Bennink MB, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ.

Front Immunol. 2018 Apr 13;9:742. doi: 10.3389/fimmu.2018.00742. eCollection 2018.

18.

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis.

Rogier R, Evans-Marin H, Manasson J, van der Kraan PM, Walgreen B, Helsen MM, van den Bersselaar LA, van de Loo FA, van Lent PL, Abramson SB, van den Berg WB, Koenders MI, Scher JU, Abdollahi-Roodsaz S.

Sci Rep. 2017 Nov 15;7(1):15613. doi: 10.1038/s41598-017-15802-x.

19.

Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells.

van den Akker GG, van Beuningen HM, Vitters EL, Koenders MI, van de Loo FA, van Lent PL, Blaney Davidson EN, van der Kraan PM.

Cell Signal. 2017 Dec;40:190-199. doi: 10.1016/j.cellsig.2017.09.010. Epub 2017 Sep 21.

PMID:
28943409
20.

Corrigendum: Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles.

Fafián-Labora J, Lesende-Rodriguez I, Fernández-Pernas P, Sangiao-Alvarellos S, Monserrat L, Arntz OJ, van de Loo FAJ, Mateos J, Arufe MC.

Sci Rep. 2017 Jun 15;7:46850. doi: 10.1038/srep46850.

21.

Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis.

van den Bosch MH, Blom AB, van de Loo FA, Koenders MI, Lafeber FP, van den Berg WB, van der Kraan PM, van Lent PL.

Arthritis Rheumatol. 2017 Oct;69(10):1978-1983. doi: 10.1002/art.40206. Epub 2017 Aug 29.

22.

Transcriptional profiling distinguishes inner and outer annulus fibrosus from nucleus pulposus in the bovine intervertebral disc.

van den Akker GGH, Koenders MI, van de Loo FAJ, van Lent PLEM, Blaney Davidson E, van der Kraan PM.

Eur Spine J. 2017 Aug;26(8):2053-2062. doi: 10.1007/s00586-017-5150-3. Epub 2017 May 31.

PMID:
28567592
23.

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis.

Roeleveld DM, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar L, van de Loo FA, van Lent PL, van der Kraan PM, van den Berg WB, Koenders MI.

PLoS One. 2017 Feb 3;12(2):e0171757. doi: 10.1371/journal.pone.0171757. eCollection 2017.

24.

IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes.

van Geffen EW, van Caam AP, van Beuningen HM, Vitters EL, Schreurs W, van de Loo FA, van Lent PL, Koenders MI, Blaney Davidson EN, van der Kraan PM.

Rheumatology (Oxford). 2017 Mar 1;56(3):351-361. doi: 10.1093/rheumatology/kew411.

PMID:
27940589
25.

Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages.

Sanada Y, Yamamoto T, Satake R, Yamashita A, Kanai S, Kato N, van de Loo FA, Nishimura F, Scherer PE, Yanaka N.

Sci Rep. 2016 Dec 8;6:38697. doi: 10.1038/srep38697.

26.

Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology.

Di Ceglie I, van den Akker GG, Ascone G, Ten Harkel B, Häcker H, van de Loo FA, Koenders MI, van der Kraan PM, de Vries TJ, Vogl T, Roth J, van Lent PL.

J Leukoc Biol. 2017 Apr;101(4):957-966. doi: 10.1189/jlb.1AB0416-180RR. Epub 2016 Dec 5.

PMID:
27920208
27.

Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium.

Broeren MG, de Vries M, Bennink MB, van Lent PL, van der Kraan PM, Koenders MI, Thurlings RM, van de Loo FA.

PLoS One. 2016 Nov 21;11(11):e0167076. doi: 10.1371/journal.pone.0167076. eCollection 2016.

28.

S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis.

Geven EJ, van den Bosch MH, Di Ceglie I, Ascone G, Abdollahi-Roodsaz S, Sloetjes AW, Hermann S, Schäfers M, van de Loo FA, van der Kraan PM, Koenders MI, Foell D, Roth J, Vogl T, van Lent PL.

Arthritis Res Ther. 2016 Oct 24;18(1):247.

29.

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis.

van Dalen SC, Blom AB, Slöetjes AW, Helsen MM, Roth J, Vogl T, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, van den Bosch MH, van Lent PL.

Osteoarthritis Cartilage. 2017 Mar;25(3):385-396. doi: 10.1016/j.joca.2016.09.009. Epub 2016 Sep 18.

30.

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, van Lent PL, van der Kraan PM, van den Berg WB, van den Hoogen FH, Koenders MI, van de Loo FA.

Arthritis Res Ther. 2016 Aug 12;18:186. doi: 10.1186/s13075-016-1083-1.

31.

Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins.

de Munter W, Geven EJ, Blom AB, Walgreen B, Helsen MM, Joosten LA, Roth J, Vogl T, van de Loo FA, Koenders MI, van den Berg WB, van der Kraan PM, van Lent PL.

Osteoarthritis Cartilage. 2017 Jan;25(1):118-127. doi: 10.1016/j.joca.2016.07.020. Epub 2016 Aug 8.

32.

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.

van den Bosch MH, Blom AB, Schelbergen RF, Koenders MI, van de Loo FA, van den Berg WB, Vogl T, Roth J, van der Kraan PM, van Lent PL.

J Rheumatol. 2016 Oct;43(10):1874-1884. Epub 2016 Aug 1.

PMID:
27481901
33.

Two opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation.

Oliveira MC, Silveira AL, Tavares LP, Rodrigues DF, van de Loo FA, Sousa LP, Teixeira MM, Amaral FA, Ferreira AV.

Nutrition. 2017 Jan;33:132-140. doi: 10.1016/j.nut.2016.05.008. Epub 2016 Jun 5.

PMID:
27427510
34.

Milk-Derived Nanoparticle Fraction Promotes the Formation of Small Osteoclasts But Reduces Bone Resorption.

Oliveira MC, Di Ceglie I, Arntz OJ, van den Berg WB, van den Hoogen FH, Ferreira AV, van Lent PL, van de Loo FA.

J Cell Physiol. 2017 Jan;232(1):225-33. doi: 10.1002/jcp.25414. Epub 2016 Jun 2.

PMID:
27138291
35.

Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation.

Oliveira MC, Arntz OJ, Blaney Davidson EN, van Lent PL, Koenders MI, van der Kraan PM, van den Berg WB, Ferreira AV, van de Loo FA.

J Nutr Biochem. 2016 Apr;30:74-84. doi: 10.1016/j.jnutbio.2015.11.017. Epub 2015 Dec 28.

PMID:
27012623
36.

Tetraspanin CD37 protects against the development of B cell lymphoma.

de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, Jabbar KJ, van den Brand M, van der Schaaf A, Elfrink S, van Houdt IS, Gijbels MJ, van de Loo FA, Bennink MB, Hebeda KM, Groenen PJ, van Krieken JH, Figdor CG, van Spriel AB.

J Clin Invest. 2016 Feb;126(2):653-66. doi: 10.1172/JCI81041. Epub 2016 Jan 19.

37.

Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis.

Oliveira MC, Tavares LP, Vago JP, Batista NV, Queiroz-Junior CM, Vieira AT, Menezes GB, Sousa LP, van de Loo FA, Teixeira MM, Amaral FA, Ferreira AV.

PLoS One. 2016 Jan 7;11(1):e0146403. doi: 10.1371/journal.pone.0146403. eCollection 2016.

38.

Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis.

Broeren MG, de Vries M, Bennink MB, Arntz OJ, Blom AB, Koenders MI, van Lent PL, van der Kraan PM, van den Berg WB, van de Loo FA.

Hum Gene Ther. 2016 Mar;27(3):244-54. doi: 10.1089/hum.2015.127. Epub 2016 Feb 16.

PMID:
26711533
39.

High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis.

de Munter W, van den Bosch MH, Slöetjes AW, Croce KJ, Vogl T, Roth J, Koenders MI, van de Loo FA, van den Berg WB, van der Kraan PM, van Lent PL.

Osteoarthritis Cartilage. 2016 May;24(5):844-55. doi: 10.1016/j.joca.2015.11.016. Epub 2015 Dec 12.

40.
41.

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models.

Arntz OJ, Pieters BC, Oliveira MC, Broeren MG, Bennink MB, de Vries M, van Lent PL, Koenders MI, van den Berg WB, van der Kraan PM, van de Loo FA.

Mol Nutr Food Res. 2015 Sep;59(9):1701-12. doi: 10.1002/mnfr.201500222. Epub 2015 Jul 1.

PMID:
26047123
42.

Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage.

van den Bosch MH, Blom AB, Sloetjes AW, Koenders MI, van de Loo FA, van den Berg WB, van Lent PL, van der Kraan PM.

Am J Pathol. 2015 Jul;185(7):1970-80. doi: 10.1016/j.ajpath.2015.03.013. Epub 2015 May 12.

PMID:
25976248
43.

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL.

Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12.

PMID:
25969431
44.

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis.

Vermeij EA, Koenders MI, Bennink MB, Crowe LA, Maurizi L, Vallée JP, Hofmann H, van den Berg WB, van Lent PL, van de Loo FA.

PLoS One. 2015 May 8;10(5):e0126687. doi: 10.1371/journal.pone.0126687. eCollection 2015.

45.

Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β.

Pieters BC, Arntz OJ, Bennink MB, Broeren MG, van Caam AP, Koenders MI, van Lent PL, van den Berg WB, de Vries M, van der Kraan PM, van de Loo FA.

PLoS One. 2015 Mar 30;10(3):e0121123. doi: 10.1371/journal.pone.0121123. eCollection 2015.

46.

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

Blaney Davidson EN, van Caam AP, Vitters EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent PL, van de Loo FA, van der Kraan PM.

Osteoarthritis Cartilage. 2015 Mar;23(3):478-86. doi: 10.1016/j.joca.2014.12.005. Epub 2014 Dec 18.

47.

Serum samples that have been stored long-term (>10 years) can be used as a suitable data source for developing cardiovascular risk prediction models in large observational rheumatoid arthritis cohorts.

Arts EE, Popa CD, Smith JP, Arntz OJ, van de Loo FA, Donders R, Semb AG, Kitas GD, van Riel PL, Fransen J.

Biomed Res Int. 2014;2014:930925. doi: 10.1155/2014/930925. Epub 2014 Sep 11.

48.

How to build an inducible cartilage-specific transgenic mouse.

Blaney Davidson EN, van de Loo FA, van den Berg WB, van der Kraan PM.

Arthritis Res Ther. 2014;16(3):210. Review.

49.

Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis.

Vermeij EA, Broeren MG, Bennink MB, Arntz OJ, Gjertsson I, van Lent PL, van den Berg WB, Koenders MI, van de Loo FA.

Ann Rheum Dis. 2015 Nov;74(11):2084-91. doi: 10.1136/annrheumdis-2014-205223. Epub 2014 Jul 15.

PMID:
25028707
50.

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels.

Schelbergen RF, van Dalen S, ter Huurne M, Roth J, Vogl T, Noël D, Jorgensen C, van den Berg WB, van de Loo FA, Blom AB, van Lent PL.

Osteoarthritis Cartilage. 2014 Aug;22(8):1158-66. doi: 10.1016/j.joca.2014.05.022. Epub 2014 Jun 10.

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