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Items: 14

1.

Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors.

Müskens FM, Ward RJ, Herkt D, van de Langemheen H, Tobin AB, Liskamp RMJ, Milligan G.

Mol Pharmacol. 2019 Feb;95(2):196-209. doi: 10.1124/mol.118.114249. Epub 2018 Dec 4.

2.

Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives.

Longin O, Hezwani M, van de Langemheen H, Liskamp RMJ.

Org Biomol Chem. 2018 Jul 25;16(29):5254-5274. doi: 10.1039/c8ob01104d.

PMID:
29892733
3.

Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides.

Artschwager R, Ward DJ, Gannon S, Brouwer AJ, van de Langemheen H, Kowalski H, Liskamp RMJ.

J Med Chem. 2018 Jun 28;61(12):5395-5411. doi: 10.1021/acs.jmedchem.8b00685. Epub 2018 Jun 13.

PMID:
29782167
4.

Immobilization by Surface Conjugation of Cyclic Peptides for Effective Mimicry of the HCV-Envelope E2 Protein as a Strategy toward Synthetic Vaccines.

Meuleman TJ, Dunlop JI, Owsianka AM, van de Langemheen H, Patel AH, Liskamp RMJ.

Bioconjug Chem. 2018 Apr 18;29(4):1091-1101. doi: 10.1021/acs.bioconjchem.7b00755. Epub 2018 Feb 19.

5.

Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides.

Herrero Alvarez N, van de Langemheen H, Brouwer AJ, Liskamp RMJ.

Bioorg Med Chem. 2017 Oct 1;25(19):5055-5063. doi: 10.1016/j.bmc.2017.07.019. Epub 2017 Jul 12.

PMID:
28734665
6.

An orthogonally protected CycloTriVeratrylene (CTV) as a highly pre-organized molecular scaffold for subsequent ligation of different cyclic peptides towards protein mimics.

Longin O, van de Langemheen H, Liskamp RMJ.

Bioorg Med Chem. 2017 Sep 15;25(18):5008-5015. doi: 10.1016/j.bmc.2017.05.038. Epub 2017 May 18.

PMID:
28583807
7.

Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides.

van de Langemheen H, Korotkovs V, Bijl J, Wilson C, Kale SS, Heinis C, Liskamp RM.

Chembiochem. 2017 Feb 16;18(4):387-395. doi: 10.1002/cbic.201600612. Epub 2017 Jan 16.

PMID:
27982494
8.

Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides.

Brouwer AJ, Herrero Álvarez N, Ciaffoni A, van de Langemheen H, Liskamp RM.

Bioorg Med Chem. 2016 Aug 15;24(16):3429-35. doi: 10.1016/j.bmc.2016.05.042. Epub 2016 May 24.

PMID:
27316540
9.

Synthesis of the TACO scaffold as a new selectively deprotectable conformationally restricted triazacyclophane based scaffold.

Brouwer AJ, van de Langemheen H, Ciaffoni A, Schilder KE, Liskamp RM.

Org Lett. 2014 Jun 6;16(11):3106-9. doi: 10.1021/ol5012218. Epub 2014 May 23.

PMID:
24856258
10.

Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation.

van de Langemheen H, van Hoeke M, Quarles van Ufford HC, Kruijtzer JA, Liskamp RM.

Org Biomol Chem. 2014 Jul 7;12(25):4471-8. doi: 10.1039/c4ob00190g.

PMID:
24849139
11.

Efficient synthesis of protein mimics by sequential native chemical ligation.

van de Langemheen H, Quarles van Ufford HL, Kruijtzer JA, Liskamp RM.

Org Lett. 2014 Apr 18;16(8):2138-41. doi: 10.1021/ol500604h. Epub 2014 Apr 7.

PMID:
24708093
12.

Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold.

Werkhoven PR, van de Langemheen H, van der Wal S, Kruijtzer JA, Liskamp RM.

J Pept Sci. 2014 Apr;20(4):235-9. doi: 10.1002/psc.2624. Epub 2014 Mar 6.

PMID:
24599619
13.

Synthesis of cyclic peptides containing a thioester handle for native chemical ligation.

van de Langemheen H, Brouwer AJ, Kemmink J, Kruijtzer JA, Liskamp RM.

J Org Chem. 2012 Nov 16;77(22):10058-64. doi: 10.1021/jo3015566. Epub 2012 Nov 5.

PMID:
23078179
14.

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.

Gould TA, van de Langemheen H, Muñoz-Elías EJ, McKinney JD, Sacchettini JC.

Mol Microbiol. 2006 Aug;61(4):940-7.

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