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Items: 7

1.

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM.

Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19.

PMID:
20725069
2.
3.

In vitro methods to study intestinal drug metabolism.

van de Kerkhof EG, de Graaf IA, Groothuis GM.

Curr Drug Metab. 2007 Oct;8(7):658-75. Review.

PMID:
17979654
4.

Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.

van de Kerkhof EG, de Graaf IA, de Jager MH, Groothuis GM.

Drug Metab Dispos. 2007 Jun;35(6):898-907. Epub 2007 Mar 7.

5.

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM.

Drug Metab Dispos. 2006 Nov;34(11):1893-902. Epub 2006 Aug 16.

6.

Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.

de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM.

Drug Metab Dispos. 2006 Apr;34(4):591-9. Epub 2006 Jan 13.

7.

Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.

van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM.

Drug Metab Dispos. 2005 Nov;33(11):1613-20. Epub 2005 Jul 28.

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