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Items: 6

1.

Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile.

Barf T, Covey T, Izumi R, van de Kar B, Gulrajani M, van Lith B, van Hoek M, de Zwart E, Mittag D, Demont D, Verkaik S, Krantz F, Pearson PG, Ulrich R, Kaptein A.

J Pharmacol Exp Ther. 2017 Nov;363(2):240-252. doi: 10.1124/jpet.117.242909. Epub 2017 Sep 7.

PMID:
28882879
2.

Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study.

Liu N, Hoogendoorn S, van de Kar B, Kaptein A, Barf T, Driessen C, Filippov DV, van der Marel GA, van der Stelt M, Overkleeft HS.

Org Biomol Chem. 2015 May 14;13(18):5147-57. doi: 10.1039/c5ob00474h.

PMID:
25849561
3.

Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series.

Oubrie A, Kaptein A, de Zwart E, Hoogenboom N, Goorden R, van de Kar B, van Hoek M, de Kimpe V, van der Heijden R, Borsboom J, Kazemier B, de Roos J, Scheffers M, Lommerse J, Schultz-Fademrecht C, Barf T.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):613-8. doi: 10.1016/j.bmcl.2011.10.071. Epub 2011 Nov 3.

PMID:
22119462
4.

Structure-based lead identification of ATP-competitive MK2 inhibitors.

Barf T, Kaptein A, de Wilde S, van der Heijden R, van Someren R, Demont D, Schultz-Fademrecht C, Versteegh J, van Zeeland M, Seegers N, Kazemier B, van de Kar B, van Hoek M, de Roos J, Klop H, Smeets R, Hofstra C, Hornberg J, Oubrie A.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3818-22. doi: 10.1016/j.bmcl.2011.04.018. Epub 2011 Apr 16.

PMID:
21565500
5.

Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors.

Kaptein A, Oubrie A, de Zwart E, Hoogenboom N, de Wit J, van de Kar B, van Hoek M, Vogel G, de Kimpe V, Schultz-Fademrecht C, Borsboom J, van Zeeland M, Versteegh J, Kazemier B, de Roos J, Wijnands F, Dulos J, Jaeger M, Leandro-Garcia P, Barf T.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3823-7. doi: 10.1016/j.bmcl.2011.04.016. Epub 2011 Apr 16.

PMID:
21565498
6.

[Resident psychiatrists in Amsterdam recognize the value of personal therapy].

Piras GM, Van de Kar BW, Oostindiƫr A, Schwarz RV.

Tijdschr Psychiatr. 2006;48(5):361-72. Dutch.

PMID:
16956026

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