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Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.

Avalos M, Garbeva P, Raaijmakers JM, van Wezel GP.

ISME J. 2019 Nov 7. doi: 10.1038/s41396-019-0537-2. [Epub ahead of print]


Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome.

Carrión VJ, Perez-Jaramillo J, Cordovez V, Tracanna V, de Hollander M, Ruiz-Buck D, Mendes LW, van Ijcken WFJ, Gomez-Exposito R, Elsayed SS, Mohanraju P, Arifah A, van der Oost J, Paulson JN, Mendes R, van Wezel GP, Medema MH, Raaijmakers JM.

Science. 2019 Nov 1;366(6465):606-612. doi: 10.1126/science.aaw9285.


A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli.

Petrus MLC, Kiefer LA, Puri P, Heemskerk E, Seaman MS, Barouch DH, Arias S, van Wezel GP, Havenga M.

Appl Microbiol Biotechnol. 2019 Nov;103(21-22):8875-8888. doi: 10.1007/s00253-019-10145-1. Epub 2019 Oct 22.


A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators.

Martinet L, Naômé A, Deflandre B, Maciejewska M, Tellatin D, Tenconi E, Smargiasso N, de Pauw E, van Wezel GP, Rigali S.

MBio. 2019 Aug 13;10(4). pii: e01230-19. doi: 10.1128/mBio.01230-19.


Spatial structure increases the benefits of antibiotic production in Streptomyces.

Westhoff S, Otto SB, Swinkels A, Bode B, van Wezel GP, Rozen DE.

Evolution. 2019 Aug 8. doi: 10.1111/evo.13817. [Epub ahead of print]


Phylogenomic analyses and distribution of terpene synthases among Streptomyces.

Martín-Sánchez L, Singh KS, Avalos M, van Wezel GP, Dickschat JS, Garbeva P.

Beilstein J Org Chem. 2019 May 29;15:1181-1193. doi: 10.3762/bjoc.15.115. eCollection 2019.


Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes.

Schröder SP, de Boer C, McGregor NGS, Rowland RJ, Moroz O, Blagova E, Reijngoud J, Arentshorst M, Osborn D, Morant MD, Abbate E, Stringer MA, Krogh KBRM, Raich L, Rovira C, Berrin JG, van Wezel GP, Ram AFJ, Florea BI, van der Marel GA, Codée JDC, Wilson KS, Wu L, Davies GJ, Overkleeft HS.

ACS Cent Sci. 2019 Jun 26;5(6):1067-1078. doi: 10.1021/acscentsci.9b00221. Epub 2019 May 24.


Structural and Proteomic Changes in Viable but Non-culturable Vibrio cholerae.

Brenzinger S, van der Aart LT, van Wezel GP, Lacroix JM, Glatter T, Briegel A.

Front Microbiol. 2019 Apr 17;10:793. doi: 10.3389/fmicb.2019.00793. eCollection 2019.


Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

Machushynets NV, Wu C, Elsayed SS, Hankemeier T, van Wezel GP.

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):483-492. doi: 10.1007/s10295-019-02140-2. Epub 2019 Feb 7.


Lugdunomycin, an Angucycline-Derived Molecule with Unprecedented Chemical Architecture.

Wu C, van der Heul HU, Melnik AV, Lübben J, Dorrestein PC, Minnaard AJ, Choi YH, van Wezel GP.

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2809-2814. doi: 10.1002/anie.201814581. Epub 2019 Jan 29.


Polyphasic classification of the gifted natural product producer Streptomyces roseifaciens sp. nov.

van der Aart LT, Nouioui I, Kloosterman A, Igual JM, Willemse J, Goodfellow M, van Wezel GP.

Int J Syst Evol Microbiol. 2019 Apr;69(4):899-908. doi: 10.1099/ijsem.0.003215. Epub 2019 Jan 21.


Streptomyces coelicolor.

Hoskisson PA, van Wezel GP.

Trends Microbiol. 2019 May;27(5):468-469. doi: 10.1016/j.tim.2018.12.008. Epub 2019 Jan 6.


Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes.

Ramijan K, Ultee E, Willemse J, Zhang Z, Wondergem JAJ, van der Meij A, Heinrich D, Briegel A, van Wezel GP, Claessen D.

Nat Commun. 2018 Dec 4;9(1):5164. doi: 10.1038/s41467-018-07560-9.


Editorial overview: Antimicrobials.

van Wezel GP, Wright GD.

Curr Opin Microbiol. 2018 Oct;45:iii-v. doi: 10.1016/j.mib.2018.08.001. Epub 2018 Aug 31. No abstract available.


Detection and identification of antibacterial proteins in snake venoms using at-line nanofractionation coupled to LC-MS.

Mladic M, Slagboom J, Kool J, Vonk FJ, van Wezel GP, Richardson MK.

Toxicon. 2018 Dec 1;155:66-74. doi: 10.1016/j.toxicon.2018.08.009. Epub 2018 Aug 31.


Production of Prodiginines Is Part of a Programmed Cell Death Process in Streptomyces coelicolor.

Tenconi E, Traxler MF, Hoebreck C, van Wezel GP, Rigali S.

Front Microbiol. 2018 Aug 6;9:1742. doi: 10.3389/fmicb.2018.01742. eCollection 2018.


NgcESco Acts as a Lower-Affinity Binding Protein of an ABC Transporter for the Uptake of N,N'-Diacetylchitobiose in Streptomyces coelicolor A3(2).

Iinuma C, Saito A, Ohnuma T, Tenconi E, Rosu A, Colson S, Mizutani Y, Liu F, Świątek-Połatyńska M, van Wezel GP, Rigali S, Fujii T, Miyashita K.

Microbes Environ. 2018 Sep 29;33(3):272-281. doi: 10.1264/jsme2.ME17172. Epub 2018 Aug 7.


High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

van der Aart LT, Spijksma GK, Harms A, Vollmer W, Hankemeier T, van Wezel GP.

J Bacteriol. 2018 Sep 24;200(20). pii: e00290-18. doi: 10.1128/JB.00290-18. Print 2018 Oct 15.


Production of poly-β-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces.

van Dissel D, Willemse J, Zacchetti B, Claessen D, Pier GB, van Wezel GP.

Microb Cell. 2018 Feb 12;5(6):269-279. doi: 10.15698/mic2018.06.635.


Complete Genome Sequence of Streptomyces lunaelactis MM109T, Isolated from Cave Moonmilk Deposits.

Naômé A, Maciejewska M, Calusinska M, Martinet L, Anderssen S, Adam D, Tenconi E, Deflandre B, Coppieters W, Karim L, Hanikenne M, Baurain D, Delfosse P, van Wezel GP, Rigali S.

Genome Announc. 2018 May 24;6(21). pii: e00435-18. doi: 10.1128/genomeA.00435-18.


Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD.

Zhang L, Willemse J, Hoskisson PA, van Wezel GP.

Sci Rep. 2018 May 9;8(1):7328. doi: 10.1038/s41598-018-25782-1.


Complete Genome Sequence of Escherichia coli AS19, an Antibiotic-Sensitive Variant of E. coli Strain B REL606.

Avalos M, Boetzer M, Pirovano W, Arenas NE, Douthwaite S, van Wezel GP.

Genome Announc. 2018 May 3;6(18). pii: e00385-18. doi: 10.1128/genomeA.00385-18.


Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era.

van der Heul HU, Bilyk BL, McDowall KJ, Seipke RF, van Wezel GP.

Nat Prod Rep. 2018 Jun 20;35(6):575-604. doi: 10.1039/c8np00012c. Review.


Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.

Du C, van Wezel GP.

Proteomics. 2018 Sep;18(18):e1700332. doi: 10.1002/pmic.201700332. Epub 2018 Jun 10. Review.


Dispatches from the land of the morning calm: special issue papers from the 18th International Symposium on the Biology of Actinomycetes.

Hoskisson PA, van Wezel GP.

Antonie Van Leeuwenhoek. 2018 May;111(5):639. doi: 10.1007/s10482-018-1077-x. No abstract available.


Healthy scents: microbial volatiles as new frontier in antibiotic research?

Avalos M, van Wezel GP, Raaijmakers JM, Garbeva P.

Curr Opin Microbiol. 2018 Oct;45:84-91. doi: 10.1016/j.mib.2018.02.011. Epub 2018 Mar 12. Review.


Microencapsulation extends mycelial viability of Streptomyces lividans 66 and increases enzyme production.

Zacchetti B, Andrianos A, van Dissel D, de Ruiter E, van Wezel GP, Claessen D.

BMC Biotechnol. 2018 Mar 12;18(1):13. doi: 10.1186/s12896-018-0425-2.


Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity.

van der Meij A, Willemse J, Schneijderberg MA, Geurts R, Raaijmakers JM, van Wezel GP.

Antonie Van Leeuwenhoek. 2018 May;111(5):679-690. doi: 10.1007/s10482-018-1014-z. Epub 2018 Jan 15.


Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery.

Rigali S, Anderssen S, Naômé A, van Wezel GP.

Biochem Pharmacol. 2018 Jul;153:24-34. doi: 10.1016/j.bcp.2018.01.007. Epub 2018 Jan 5. Review.


Morphology-driven downscaling of Streptomyces lividans to micro-cultivation.

van Dissel D, van Wezel GP.

Antonie Van Leeuwenhoek. 2018 Mar;111(3):457-469. doi: 10.1007/s10482-017-0967-7. Epub 2017 Nov 1.


Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.

Gubbens J, Wu C, Zhu H, Filippov DV, Florea BI, Rigali S, Overkleeft HS, van Wezel GP.

ACS Chem Biol. 2017 Nov 17;12(11):2756-2766. doi: 10.1021/acschembio.7b00597. Epub 2017 Oct 2.


SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures.

Willemse J, Büke F, van Dissel D, Grevink S, Claessen D, van Wezel GP.

Antonie Van Leeuwenhoek. 2018 Feb;111(2):171-182. doi: 10.1007/s10482-017-0939-y. Epub 2017 Sep 15.


Actinoalloteichus fjordicus sp. nov. isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation.

Nouioui I, Rückert C, Willemse J, van Wezel GP, Klenk HP, Busche T, Kalinowski J, Bredholt H, Zotchev SB.

Antonie Van Leeuwenhoek. 2017 Dec;110(12):1705-1717. doi: 10.1007/s10482-017-0920-9. Epub 2017 Aug 2.


Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics.

Gubbens J, Janus MM, Florea BI, Overkleeft HS, van Wezel GP.

Mol Microbiol. 2017 Jul;105(1):175. doi: 10.1111/mmi.13714. Epub 2017 Jun 2. No abstract available.


Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria.

Barka EA, Vatsa P, Sanchez L, Gaveau-Vaillant N, Jacquard C, Meier-Kolthoff JP, Klenk HP, Clément C, Ouhdouch Y, van Wezel GP.

Microbiol Mol Biol Rev. 2016 Nov 9;80(4):iii. doi: 10.1128/MMBR.00044-16. Print 2016 Dec. No abstract available.


Chemical ecology of antibiotic production by actinomycetes.

van der Meij A, Worsley SF, Hutchings MI, van Wezel GP.

FEMS Microbiol Rev. 2017 May 1;41(3):392-416. doi: 10.1093/femsre/fux005. Review.


Aromatic Polyketide GTRI-02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2).

Wu C, Ichinose K, Choi YH, van Wezel GP.

Chembiochem. 2017 Jul 18;18(14):1428-1434. doi: 10.1002/cbic.201700107. Epub 2017 Jun 7.


Distance-dependent danger responses in bacteria.

Westhoff S, van Wezel GP, Rozen DE.

Curr Opin Microbiol. 2017 Apr;36:95-101. doi: 10.1016/j.mib.2017.02.002. Epub 2017 Mar 1. Review.


Genome Sequence of the Filamentous Actinomycete Kitasatospora viridifaciens.

Ramijan K, van Wezel GP, Claessen D.

Genome Announc. 2017 Feb 9;5(6). pii: e01560-16. doi: 10.1128/genomeA.01560-16.


Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow.

Wu C, Du C, Ichinose K, Choi YH, van Wezel GP.

J Nat Prod. 2017 Feb 24;80(2):269-277. doi: 10.1021/acs.jnatprod.6b00478. Epub 2017 Jan 27.


The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor.

Westhoff S, van Leeuwe TM, Qachach O, Zhang Z, van Wezel GP, Rozen DE.

ISME J. 2017 May;11(5):1168-1178. doi: 10.1038/ismej.2016.194. Epub 2017 Jan 17.


Structural and functional characterization of the alanine racemase from Streptomyces coelicolor A3(2).

Tassoni R, van der Aart LT, Ubbink M, van Wezel GP, Pannu NS.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):122-128. doi: 10.1016/j.bbrc.2016.12.183. Epub 2016 Dec 29.


OsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons.

Urem M, van Rossum T, Bucca G, Moolenaar GF, Laing E, Świątek-Połatyńska MA, Willemse J, Tenconi E, Rigali S, Goosen N, Smith CP, van Wezel GP.

mSystems. 2016 May 3;1(3). pii: e00014-16. eCollection 2016 May-Jun.


Goodbye to brute force in antibiotic discovery?

Kolter R, van Wezel GP.

Nat Microbiol. 2016 Jan 27;1:15020. doi: 10.1038/nmicrobiol.2015.20. No abstract available.


Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae.

Yagüe P, Willemse J, Koning RI, Rioseras B, López-García MT, Gonzalez-Quiñonez N, Lopez-Iglesias C, Shliaha PV, Rogowska-Wrzesinska A, Koster AJ, Jensen ON, van Wezel GP, Manteca Á.

Nat Commun. 2016 Aug 12;7:12467. doi: 10.1038/ncomms12467.


Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces.

Urem M, Świątek-Połatyńska MA, Rigali S, van Wezel GP.

Mol Microbiol. 2016 Oct;102(2):183-195. doi: 10.1111/mmi.13464. Epub 2016 Aug 9. Review.


Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces.

Celler K, Koning RI, Willemse J, Koster AJ, van Wezel GP.

Nat Commun. 2016 Jun 13;7:ncomms11836. doi: 10.1038/ncomms11836.


Substrate Inhibition of VanA by d-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner.

van der Aart LT, Lemmens N, van Wamel WJ, van Wezel GP.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4930-9. doi: 10.1128/AAC.00276-16. Print 2016 Aug.


Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces.

Zacchetti B, Willemse J, Recter B, van Dissel D, van Wezel GP, Wösten HA, Claessen D.

Sci Rep. 2016 May 31;6:27045. doi: 10.1038/srep27045.


Modestobacter caceresii sp. nov., novel actinobacteria with an insight into their adaptive mechanisms for survival in extreme hyper-arid Atacama Desert soils.

Busarakam K, Bull AT, Trujillo ME, Riesco R, Sangal V, van Wezel GP, Goodfellow M.

Syst Appl Microbiol. 2016 Jun;39(4):243-251. doi: 10.1016/j.syapm.2016.03.007. Epub 2016 Mar 24.


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