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Items: 39

1.

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study.

Schouten LR, van Kaam AH, Kohse F, Veltkamp F, Bos LD, de Beer FM, van Hooijdonk RT, Horn J, Straat M, Witteveen E, Glas GJ, Wieske L, van Vught LA, Wiewel MA, Ingelse SA, Cortjens B, van Woensel JB, Bos AP, Walther T, Schultz MJ, Wösten-van Asperen RM; MARS consortium.

Ann Intensive Care. 2019 May 14;9(1):55. doi: 10.1186/s13613-019-0529-4.

2.

Kinase activity is impaired in neutrophils of sepsis patients.

Hoogendijk AJ, van Vught LA, Wiewel MA, Fuhler GM, Belkasim-Bohoudi H, Horn J, Schultz MJ, Scicluna BP, Peppelenbosch MP, van 't Veer C, de Vos AF, van der Poll T.

Haematologica. 2019 Jun;104(6):e233-e235. doi: 10.3324/haematol.2018.201913. Epub 2018 Dec 4. No abstract available.

3.

Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single-Blind, Parallel Group, Placebo Controlled Trial.

Perlee D, van Vught LA, Scicluna BP, Maag A, Lutter R, Kemper EM, van 't Veer C, Punchard MA, González J, Richard MP, Dalemans W, Lombardo E, de Vos AF, van der Poll T.

Stem Cells. 2018 Nov;36(11):1778-1788. doi: 10.1002/stem.2891. Epub 2018 Aug 20.

PMID:
30063804
4.

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae-Induced Pneumonia-Derived Sepsis.

Claushuis TAM, van der Donk LEH, Luitse AL, van Veen HA, van der Wel NN, van Vught LA, Roelofs JJTH, de Boer OJ, Lankelma JM, Boon L, de Vos AF, van 't Veer C, van der Poll T.

J Immunol. 2018 Aug 15;201(4):1241-1252. doi: 10.4049/jimmunol.1800314. Epub 2018 Jul 9.

PMID:
29987161
5.

Blood pressure-lowering interventions to prevent dementia: a systematic review and meta-analysis.

van Middelaar T, van Vught LA, van Gool WA, Simons EMF, van den Born BH, Moll van Charante EP, Richard E.

J Hypertens. 2018 Sep;36(9):1780-1787. doi: 10.1097/HJH.0000000000001829.

PMID:
29927845
6.

Visit-To-Visit Blood Pressure Variability and the Risk of Dementia in Older People.

van Middelaar T, van Dalen JW, van Gool WA, van den Born BH, van Vught LA, Moll van Charante EP, Richard E.

J Alzheimers Dis. 2018;62(2):727-735. doi: 10.3233/JAD-170757.

PMID:
29480175
7.

The host response in critically ill sepsis patients on statin therapy: a prospective observational study.

Wiewel MA, Scicluna BP, van Vught LA, Hoogendijk AJ, Zwinderman AH, Lutter R, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T.

Ann Intensive Care. 2018 Jan 18;8(1):9. doi: 10.1186/s13613-017-0349-3.

8.

Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis upon ICU Admission.

Scicluna BP, Wiewel MA, van Vught LA, Hoogendijk AJ, Klarenbeek AM, Franitza M, Toliat MR, Nürnberg P, Horn J, Bonten MJ, Schultz MJ, Cremer OL, van der Poll T.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1070-1073. doi: 10.1164/rccm.201707-1339LE. No abstract available.

PMID:
28972859
9.

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T; MARS consortium.

Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.

PMID:
28864056
10.

Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.

van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PMC, Ong DSY, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Bonten MMJ, Schultz MJ, van der Poll T; MARS Consortium.

Crit Care Med. 2017 Nov;45(11):1854-1862. doi: 10.1097/CCM.0000000000002649.

PMID:
28806220
11.

Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis.

van Vught LA, Holman R, de Jonge E, de Keizer NF, van der Poll T.

Crit Care Med. 2017 Oct;45(10):e1026-e1035. doi: 10.1097/CCM.0000000000002590.

PMID:
28737575
12.

Lower dementia risk with different classes of antihypertensive medication in older patients.

van Middelaar T, van Vught LA, Moll van Charante EP, Eurelings LSM, Ligthart SA, van Dalen JW, van den Born BJH, Richard E, van Gool WA.

J Hypertens. 2017 Oct;35(10):2095-2101. doi: 10.1097/HJH.0000000000001411.

PMID:
28509727
13.

Selective decontamination of the digestive tract halves the prevalence of ventilator-associated pneumonia compared to selective oral decontamination.

Bos LD, Stips C, Schouten LR, van Vught LA, Wiewel MA, Wieske L, van Hooijdonk RT, Straat M, de Beer FM, Glas GJ, Visser CE, de Jonge E, Juffermans NP, Horn J, Schultz MJ.

Intensive Care Med. 2017 Oct;43(10):1535-1537. doi: 10.1007/s00134-017-4838-5. Epub 2017 May 11. No abstract available.

PMID:
28497272
14.

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis.

Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, Artigas A, Martin-Loeches I, Hoogendijk AJ, van der Poll T, Horn J, Juffermans N, Calfee CS, Schultz MJ; MARS consortium.

Thorax. 2017 Oct;72(10):876-883. doi: 10.1136/thoraxjnl-2016-209719. Epub 2017 Apr 27.

15.

Clinical Characteristics and Outcomes of Patients With Cellulitis Requiring Intensive Care.

Cranendonk DR, van Vught LA, Wiewel MA, Cremer OL, Horn J, Bonten MJ, Schultz MJ, van der Poll T, Wiersinga WJ.

JAMA Dermatol. 2017 Jun 1;153(6):578-582. doi: 10.1001/jamadermatol.2017.0159.

16.

An Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study.

Frencken JF, van Vught LA, Peelen LM, Ong DSY, Klein Klouwenberg PMC, Horn J, Bonten MJM, van der Poll T, Cremer OL; MARS Consortium.

Crit Care Med. 2017 May;45(5):e493-e499. doi: 10.1097/CCM.0000000000002292.

PMID:
28257334
17.

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Hoogendijk AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, Belkasim-Bohoudi H, Duitman J, Horn J, Schultz MJ, Scicluna BP, van 't Veer C, de Vos AF, van der Poll T.

Crit Care Med. 2017 May;45(5):e524-e531. doi: 10.1097/CCM.0000000000002294.

PMID:
28240686
18.

The Host Response in Patients with Sepsis Developing Intensive Care Unit-acquired Secondary Infections.

van Vught LA, Wiewel MA, Hoogendijk AJ, Frencken JF, Scicluna BP, Klein Klouwenberg PMC, Zwinderman AH, Lutter R, Horn J, Schultz MJ, Bonten MMJ, Cremer OL, van der Poll T.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):458-470. doi: 10.1164/rccm.201606-1225OC.

PMID:
28107024
19.

Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis: A Prospective Observational Study.

Wiewel MA, van Vught LA, Scicluna BP, Hoogendijk AJ, Frencken JF, Zwinderman AH, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium.

Crit Care Med. 2017 Mar;45(3):454-463. doi: 10.1097/CCM.0000000000002236.

PMID:
28079604
20.

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study.

Lankelma JM, van Vught LA, Belzer C, Schultz MJ, van der Poll T, de Vos WM, Wiersinga WJ.

Intensive Care Med. 2017 Jan;43(1):59-68. doi: 10.1007/s00134-016-4613-z. Epub 2016 Nov 11.

21.

Risk factors, host response and outcome of hypothermic sepsis.

Wiewel MA, Harmon MB, van Vught LA, Scicluna BP, Hoogendijk AJ, Horn J, Zwinderman AH, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T, Juffermans NP, Wiersinga WJ.

Crit Care. 2016 Oct 14;20(1):328.

22.

Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study.

Wiewel MA, Huson MA, van Vught LA, Hoogendijk AJ, Klein Klouwenberg PM, Horn J, Lutter R, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T; MARS Consortium.

Crit Care. 2016 Oct 10;20(1):322.

23.

Secondary Infection in Patients With Sepsis--Reply.

van Vught LA, Klein Klouwenberg PM, van der Poll T.

JAMA. 2016 Aug 16;316(7):772. doi: 10.1001/jama.2016.9279. No abstract available.

PMID:
27533168
24.

Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients.

van Vught LA, Scicluna BP, Hoogendijk AJ, Wiewel MA, Klein Klouwenberg PM, Cremer OL, Horn J, Nürnberg P, Bonten MM, Schultz MJ, van der Poll T.

Crit Care. 2016 Aug 6;20(1):252. doi: 10.1186/s13054-016-1429-8.

25.

Incidence, Predictors, and Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with Sepsis. A Cohort Study.

Klein Klouwenberg PM, Frencken JF, Kuipers S, Ong DS, Peelen LM, van Vught LA, Schultz MJ, van der Poll T, Bonten MJ, Cremer OL; MARS Consortium *.

Am J Respir Crit Care Med. 2017 Jan 15;195(2):205-211. doi: 10.1164/rccm.201603-0618OC.

PMID:
27467907
26.

Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients.

van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PM, Franitza M, Toliat MR, Nürnberg P, Cremer OL, Horn J, Schultz MJ, Bonten MM, van der Poll T.

Am J Respir Crit Care Med. 2016 Dec 1;194(11):1366-1374.

PMID:
27267747
27.

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis.

van Vught LA, Klein Klouwenberg PM, Spitoni C, Scicluna BP, Wiewel MA, Horn J, Schultz MJ, Nürnberg P, Bonten MJ, Cremer OL, van der Poll T; MARS Consortium.

JAMA. 2016 Apr 12;315(14):1469-79. doi: 10.1001/jama.2016.2691.

PMID:
26975785
28.

Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response.

van Vught LA, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Scicluna BP, Ong DS, Cremer OL, Horn J, Bonten MM, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.

Crit Care Med. 2016 Jul;44(7):1338-46. doi: 10.1097/CCM.0000000000001650.

PMID:
26958752
29.

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients.

Claushuis TA, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Ong DS, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Zwinderman AH, Bonten MJ, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.

Blood. 2016 Jun 16;127(24):3062-72. doi: 10.1182/blood-2015-11-680744. Epub 2016 Mar 8.

30.

The Impact of HIV Co-Infection on the Genomic Response to Sepsis.

Huson MA, Scicluna BP, van Vught LA, Wiewel MA, Hoogendijk AJ, Cremer OL, Bonten MJ, Schultz MJ, Franitza M, Toliat MR, Nürnberg P, Grobusch MP, van der Poll T.

PLoS One. 2016 Feb 12;11(2):e0148955. doi: 10.1371/journal.pone.0148955. eCollection 2016.

31.

Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis.

Wiewel MA, de Stoppelaar SF, van Vught LA, Frencken JF, Hoogendijk AJ, Klein Klouwenberg PMC, Horn J, Bonten MJ, Zwinderman AH, Cremer OL, Schultz MJ, van der Poll T; MARS Consortium.

Intensive Care Med. 2016 Mar;42(3):352-360. doi: 10.1007/s00134-015-4171-9. Epub 2016 Jan 14.

32.

Reply: FAIM3:PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired Pneumonia: Comparing Apples to Oranges?

Scicluna BP, van Vught LA, van der Poll T, Klein Klouwenberg PM, Cremer OL.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):102-3. doi: 10.1164/rccm.201509-1752LE. No abstract available.

PMID:
26720792
33.

Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients.

Hoogendijk AJ, Wiewel MA, van Vught LA, Scicluna BP, Belkasim-Bohoudi H, Horn J, Zwinderman AH, Klein Klouwenberg PM, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T; MARS consortium.

Crit Care. 2015 Nov 25;19:412. doi: 10.1186/s13054-015-1125-0.

34.

Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study.

Klein Klouwenberg PM, Cremer OL, van Vught LA, Ong DS, Frencken JF, Schultz MJ, Bonten MJ, van der Poll T.

Crit Care. 2015 Sep 7;19:319. doi: 10.1186/s13054-015-1035-1.

35.

A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission.

Scicluna BP, Klein Klouwenberg PM, van Vught LA, Wiewel MA, Ong DS, Zwinderman AH, Franitza M, Toliat MR, Nürnberg P, Hoogendijk AJ, Horn J, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):826-35. doi: 10.1164/rccm.201502-0355OC.

PMID:
26121490
36.

Reduced Responsiveness of Blood Leukocytes to Lipopolysaccharide Does not Predict Nosocomial Infections in Critically Ill Patients.

van Vught LA, Wiewel MA, Hoogendijk AJ, Scicluna BP, Belkasim-Bohoudi H, Horn J, Schultz MJ, van der Poll T.

Shock. 2015 Aug;44(2):110-4. doi: 10.1097/SHK.0000000000000391.

PMID:
25895151
37.

The effect of age on the systemic inflammatory response in patients with community-acquired pneumonia.

van Vught LA, Endeman H, Meijvis SC, Zwinderman AH, Scicluna BP, Biesma DH, van der Poll T.

Clin Microbiol Infect. 2014 Nov;20(11):1183-8. doi: 10.1111/1469-0691.12717. Epub 2014 Jul 18.

38.

Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients.

Klein Klouwenberg PM, Ong DS, Bos LD, de Beer FM, van Hooijdonk RT, Huson MA, Straat M, van Vught LA, Wieske L, Horn J, Schultz MJ, van der Poll T, Bonten MJ, Cremer OL.

Crit Care Med. 2013 Oct;41(10):2373-8. doi: 10.1097/CCM.0b013e3182923712.

PMID:
23921277
39.

Developing quality indicators for the care of HIV-infected pregnant women in the Dutch Caribbean.

Hermanides HS, van Vught LA, Voigt R, Muskiet FD, Durand A, van Osch G, Koolman-Wever S, Gerstenbluth I, Smit C, Duits AJ.

AIDS Res Ther. 2011 Sep 22;8(1):32. doi: 10.1186/1742-6405-8-32.

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