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Items: 1 to 50 of 108

1.

Energy coupling in ABC exporters.

van Veen HW, Singh H, Agboh K, Fagg LA, Guo D, Swain B, de Kruijf RF, Guffick C.

Res Microbiol. 2019 Aug 20. pii: S0923-2508(19)30087-7. doi: 10.1016/j.resmic.2019.08.003. [Epub ahead of print]

PMID:
31442612
2.

Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force.

Agboh K, Lau CHF, Khoo YSK, Singh H, Raturi S, Nair AV, Howard J, Chiapello M, Feret R, Deery MJ, Murakami S, van Veen HW.

Sci Adv. 2018 Sep 19;4(9):eaas9365. doi: 10.1126/sciadv.aas9365. eCollection 2018 Sep.

3.

Author Correction: Multidrug efflux pumps: structure, function and regulation.

Du D, Wang-Kan X, Neuberger A, van Veen HW, Pos KM, Piddock LJV, Luisi BF.

Nat Rev Microbiol. 2018 Sep;16(9):577. doi: 10.1038/s41579-018-0060-x.

PMID:
30022105
4.

Multidrug efflux pumps: structure, function and regulation.

Du D, Wang-Kan X, Neuberger A, van Veen HW, Pos KM, Piddock LJV, Luisi BF.

Nat Rev Microbiol. 2018 Sep;16(9):523-539. doi: 10.1038/s41579-018-0048-6. Review. Erratum in: Nat Rev Microbiol. 2018 Jul 18;:.

PMID:
30002505
5.

Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii.

Okada U, Yamashita E, Neuberger A, Morimoto M, van Veen HW, Murakami S.

Nat Commun. 2017 Nov 6;8(1):1336. doi: 10.1038/s41467-017-01399-2.

6.

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.

Fitzpatrick AWP, Llabrés S, Neuberger A, Blaza JN, Bai XC, Okada U, Murakami S, van Veen HW, Zachariae U, Scheres SHW, Luisi BF, Du D.

Nat Microbiol. 2017 May 15;2:17070. doi: 10.1038/nmicrobiol.2017.70.

7.

Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions.

Nair AV, Singh H, Raturi S, Neuberger A, Tong Z, Ding N, Agboh K, van Veen HW.

Sci Rep. 2016 Dec 5;6:38052. doi: 10.1038/srep38052.

8.

ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled.

Singh H, Velamakanni S, Deery MJ, Howard J, Wei SL, van Veen HW.

Nat Commun. 2016 Aug 8;7:12387. doi: 10.1038/ncomms12387.

9.

WITHDRAWN: Multidrug Transporter LmrP allows Relocation of Catalytic Carboxylates.

Tong Z, Ding N, Neuberger A, van Veen HW.

J Biol Chem. 2015 Dec 2. pii: jbc.M115.694901. [Epub ahead of print]

10.

Hoechst 33342 Is a Hidden "Janus" amongst Substrates for the Multidrug Efflux Pump LmrP.

Neuberger A, van Veen HW.

PLoS One. 2015 Nov 5;10(11):e0141991. doi: 10.1371/journal.pone.0141991. eCollection 2015.

11.

Structures and functions of mitochondrial ABC transporters.

Schaedler TA, Faust B, Shintre CA, Carpenter EP, Srinivasan V, van Veen HW, Balk J.

Biochem Soc Trans. 2015 Oct;43(5):943-51. doi: 10.1042/BST20150118. Review.

PMID:
26517908
12.

Effects of nucleotide binding to LmrA: A combined MAS-NMR and solution NMR study.

Hellmich UA, Mönkemeyer L, Velamakanni S, van Veen HW, Glaubitz C.

Biochim Biophys Acta. 2015 Dec;1848(12):3158-65. doi: 10.1016/j.bbamem.2015.10.003. Epub 2015 Oct 9.

13.

Structure, mechanism and cooperation of bacterial multidrug transporters.

Du D, van Veen HW, Murakami S, Pos KM, Luisi BF.

Curr Opin Struct Biol. 2015 Aug;33:76-91. doi: 10.1016/j.sbi.2015.07.015. Epub 2015 Aug 15. Review.

14.

Assembly and operation of bacterial tripartite multidrug efflux pumps.

Du D, van Veen HW, Luisi BF.

Trends Microbiol. 2015 May;23(5):311-9. doi: 10.1016/j.tim.2015.01.010. Epub 2015 Feb 24. Review.

PMID:
25728476
15.

A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly.

Schaedler TA, Thornton JD, Kruse I, Schwarzländer M, Meyer AJ, van Veen HW, Balk J.

J Biol Chem. 2014 Aug 22;289(34):23264-74. doi: 10.1074/jbc.M114.553438. Epub 2014 Jul 8.

16.

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state.

Choudhury HG, Tong Z, Mathavan I, Li Y, Iwata S, Zirah S, Rebuffat S, van Veen HW, Beis K.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9145-50. doi: 10.1073/pnas.1320506111. Epub 2014 Jun 11.

17.

Multidrug transport protein norM from vibrio cholerae simultaneously couples to sodium- and proton-motive force.

Jin Y, Nair A, van Veen HW.

J Biol Chem. 2014 May 23;289(21):14624-32. doi: 10.1074/jbc.M113.546770. Epub 2014 Apr 7.

18.

β-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket.

Kobayashi N, Tamura N, van Veen HW, Yamaguchi A, Murakami S.

J Biol Chem. 2014 Apr 11;289(15):10680-90. doi: 10.1074/jbc.M114.547794. Epub 2014 Feb 20.

19.

Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA.

Doshi R, van Veen HW.

J Biol Chem. 2013 Jul 26;288(30):21638-47. doi: 10.1074/jbc.M113.485714. Epub 2013 Jun 13.

20.

Molecular disruption of the power stroke in the ATP-binding cassette transport protein MsbA.

Doshi R, Ali A, Shi W, Freeman EV, Fagg LA, van Veen HW.

J Biol Chem. 2013 Mar 8;288(10):6801-13. doi: 10.1074/jbc.M112.430074. Epub 2013 Jan 10.

21.

Basic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrP.

Wang W, van Veen HW.

PLoS One. 2012;7(6):e38715. doi: 10.1371/journal.pone.0038715. Epub 2012 Jun 20.

22.

The multidrug transporter LmrP protein mediates selective calcium efflux.

Schaedler TA, Tong Z, van Veen HW.

J Biol Chem. 2012 Aug 10;287(33):27682-90. doi: 10.1074/jbc.M112.372334. Epub 2012 Jun 22.

23.

Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders.

Seeger MA, Mittal A, Velamakanni S, Hohl M, Schauer S, Salaa I, Grütter MG, van Veen HW.

PLoS One. 2012;7(6):e37845. doi: 10.1371/journal.pone.0037845. Epub 2012 Jun 4.

24.

Probing the ATP hydrolysis cycle of the ABC multidrug transporter LmrA by pulsed EPR spectroscopy.

Hellmich UA, Lyubenova S, Kaltenborn E, Doshi R, van Veen HW, Prisner TF, Glaubitz C.

J Am Chem Soc. 2012 Apr 4;134(13):5857-62. doi: 10.1021/ja211007t. Epub 2012 Mar 21.

PMID:
22397466
25.

The choreography of multidrug export.

Doshi R, Gutmann DA, Khoo YS, Fagg LA, van Veen HW.

Biochem Soc Trans. 2011 Jun;39(3):807-11. doi: 10.1042/BST0390807. Review.

PMID:
21599652
26.

Structural biology: Last of the multidrug transporters.

van Veen HW.

Nature. 2010 Oct 21;467(7318):926-7. doi: 10.1038/467926a. No abstract available.

PMID:
20962836
27.

Dissection of the conformational cycle of the multidrug/lipidA ABC exporter MsbA.

Doshi R, Woebking B, van Veen HW.

Proteins. 2010 Nov 1;78(14):2867-72. doi: 10.1002/prot.22813.

PMID:
20715055
28.

Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa.

Welch A, Awah CU, Jing S, van Veen HW, Venter H.

Biochem J. 2010 Sep 1;430(2):355-64. doi: 10.1042/BJ20091860.

PMID:
20583998
29.

A flexible cation binding site in the multidrug major facilitator superfamily transporter LmrP is associated with variable proton coupling.

Schaedler TA, van Veen HW.

FASEB J. 2010 Oct;24(10):3653-61. doi: 10.1096/fj.10-156927. Epub 2010 May 14.

PMID:
20472749
30.

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.

Gutmann DA, Ward A, Urbatsch IL, Chang G, van Veen HW.

Trends Biochem Sci. 2010 Jan;35(1):36-42. doi: 10.1016/j.tibs.2009.07.009. Epub 2009 Oct 12. Review.

31.

A multidrug ABC transporter with a taste for salt.

Velamakanni S, Lau CH, Gutmann DA, Venter H, Barrera NP, Seeger MA, Woebking B, Matak-Vinkovic D, Balakrishnan L, Yao Y, U EC, Shilling RA, Robinson CV, Thorn P, van Veen HW.

PLoS One. 2009 Jul 10;4(7):e6137. doi: 10.1371/journal.pone.0006137.

32.

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions.

Barrera NP, Isaacson SC, Zhou M, Bavro VN, Welch A, Schaedler TA, Seeger MA, Miguel RN, Korkhov VM, van Veen HW, Venter H, Walmsley AR, Tate CG, Robinson CV.

Nat Methods. 2009 Aug;6(8):585-7. doi: 10.1038/nmeth.1347. Epub 2009 Jul 5.

33.

Molecular basis of multidrug transport by ABC transporters.

Seeger MA, van Veen HW.

Biochim Biophys Acta. 2009 May;1794(5):725-37. doi: 10.1016/j.bbapap.2008.12.004. Epub 2008 Dec 24. Review.

PMID:
19135557
34.

MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA.

Lin HT, Bavro VN, Barrera NP, Frankish HM, Velamakanni S, van Veen HW, Robinson CV, Borges-Walmsley MI, Walmsley AR.

J Biol Chem. 2009 Jan 9;284(2):1145-54. doi: 10.1074/jbc.M806964200. Epub 2008 Oct 27.

35.

Caught in the act: ATP hydrolysis of an ABC-multidrug transporter followed by real-time magic angle spinning NMR.

Hellmich UA, Haase W, Velamakanni S, van Veen HW, Glaubitz C.

FEBS Lett. 2008 Oct 15;582(23-24):3557-62. doi: 10.1016/j.febslet.2008.09.033. Epub 2008 Sep 24.

36.

Functional role of transmembrane helix 6 in drug binding and transport by the ABC transporter MsbA.

Woebking B, Velamakanni S, Federici L, Seeger MA, Murakami S, van Veen HW.

Biochemistry. 2008 Oct 14;47(41):10904-14. doi: 10.1021/bi800778d. Epub 2008 Sep 20.

PMID:
18803398
37.

Multidrug transport by the ABC transporter Sav1866 from Staphylococcus aureus.

Velamakanni S, Yao Y, Gutmann DA, van Veen HW.

Biochemistry. 2008 Sep 2;47(35):9300-8. doi: 10.1021/bi8006737. Epub 2008 Aug 9.

PMID:
18690712
38.

A functional steroid-binding element in an ATP-binding cassette multidrug transporter.

Velamakanni S, Janvilisri T, Shahi S, van Veen HW.

Mol Pharmacol. 2008 Jan;73(1):12-7. Erratum in: Mol Pharmacol. 2008 Aug;74(2):538.

PMID:
18094074
39.

On the energy-dependence of Hoechst 33342 transport by the ABC transporter LmrA.

Venter H, Velamakanni S, Balakrishnan L, van Veen HW.

Biochem Pharmacol. 2008 Feb 15;75(4):866-74. Epub 2007 Oct 26.

PMID:
18061142
40.

ABCG transporters: structure, substrate specificities and physiological roles : a brief overview.

Velamakanni S, Wei SL, Janvilisri T, van Veen HW.

J Bioenerg Biomembr. 2007 Dec;39(5-6):465-71. Review.

PMID:
17990087
41.

New structure model for the ATP-binding cassette multidrug transporter LmrA.

Federici L, Woebking B, Velamakanni S, Shilling RA, Luisi B, van Veen HW.

Biochem Pharmacol. 2007 Sep 1;74(5):672-8. Epub 2007 May 24.

PMID:
17624317
42.

Two proton translocation pathways in a secondary active multidrug transporter.

Bapna A, Federici L, Venter H, Velamakanni S, Luisi B, Fan TP, van Veen HW.

J Mol Microbiol Biotechnol. 2007;12(3-4):197-209.

PMID:
17587868
43.

A high-throughput method for membrane protein solubility screening: the ultracentrifugation dispersity sedimentation assay.

Gutmann DA, Mizohata E, Newstead S, Ferrandon S, Postis V, Xia X, Henderson PJ, van Veen HW, Byrne B.

Protein Sci. 2007 Jul;16(7):1422-8. Epub 2007 Jun 13. Erratum in: Protein Sci. 2007 Dec;16(12):2775. Postis, Vincent [added]; Xia, Xiaobing [added].

44.

The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).

Hardwick LJ, Velamakanni S, van Veen HW.

Br J Pharmacol. 2007 May;151(2):163-74. Epub 2007 Mar 20. Review.

45.

Probing the molecular dynamics of the ABC multidrug transporter LmrA by deuterium solid-state nuclear magnetic resonance.

Siarheyeva A, Lopez JJ, Lehner I, Hellmich UA, van Veen HW, Glaubitz C.

Biochemistry. 2007 Mar 20;46(11):3075-83. Epub 2007 Feb 16.

PMID:
17302438
46.

Metabolites of ginsenosides as novel BCRP inhibitors.

Jin J, Shahi S, Kang HK, van Veen HW, Fan TP.

Biochem Biophys Res Commun. 2006 Jul 14;345(4):1308-14. Epub 2006 May 4.

PMID:
16729968
47.

New light on multidrug binding by an ATP-binding-cassette transporter.

Shilling RA, Venter H, Velamakanni S, Bapna A, Woebking B, Shahi S, van Veen HW.

Trends Pharmacol Sci. 2006 Apr;27(4):195-203. Epub 2006 Mar 20. Review.

PMID:
16545467
48.

Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids.

Cooray HC, Shahi S, Cahn AP, van Veen HW, Hladky SB, Barrand MA.

Eur J Pharmacol. 2006 Feb 15;531(1-3):25-33. Epub 2006 Jan 25.

PMID:
16442095
49.

Similarities between ATP-dependent and ion-coupled multidrug transporters.

Venter H, Shahi S, Balakrishnan L, Velamakanni S, Bapna A, Woebking B, van Veen HW.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1008-11. Review.

PMID:
16246033
50.

Drug-lipid A interactions on the Escherichia coli ABC transporter MsbA.

Woebking B, Reuter G, Shilling RA, Velamakanni S, Shahi S, Venter H, Balakrishnan L, van Veen HW.

J Bacteriol. 2005 Sep;187(18):6363-9.

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