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Time-restricted feeding improves adaptation to chronically alternating light-dark cycles.

Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, Tambyrajah LL, Wackers P, Deboer T, Hulsegge G, Proper KI, van Steeg H, Roenneberg T, Biermasz NR, Rensen PCN, Kooijman S, van Kerkhof LWM.

Sci Rep. 2019 May 27;9(1):7874. doi: 10.1038/s41598-019-44398-7.


The transcriptomic response to irinotecan in colon carcinoma bearing mice preconditioned by fasting.

Jongbloed F, Huisman SA, van Steeg H, Pennings JLA, IJzermans JNM, Dollé MET, de Bruin RWF.

Oncotarget. 2019 Mar 15;10(22):2224-2234. doi: 10.18632/oncotarget.26776. eCollection 2019 Mar 15.


Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study.

Rietman ML, Spijkerman AMW, Wong A, van Steeg H, Bürkle A, Moreno-Villanueva M, Sindlinger T, Franceschi C, Grubeck-Loebenstein B, Bernhardt J, Slagboom PE, Toussaint O, Debacq-Chainiaux F, Sikora E, Gonos ES, Breusing N, Stuetz W, Weber D, Grune T, Basso A, Piacenza F, Malavolta M, Collino S, Jansen EHJM, Verschuren WMM, Dollé MET.

Mech Ageing Dev. 2019 Jan;177:135-143. doi: 10.1016/j.mad.2018.04.007. Epub 2018 Apr 30.


The Association between BMI and Different Frailty Domains: A U-Shaped Curve?

Rietman ML, van der A DL, van Oostrom SH, Picavet HSJ, Dollé MET, van Steeg H, Verschuren WMM, Spijkerman AMW.

J Nutr Health Aging. 2018;22(1):8-15. doi: 10.1007/s12603-016-0854-3.


Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/- mice.

Wu H, van Thiel BS, Bautista-Niño PK, Reiling E, Durik M, Leijten FPJ, Ridwan Y, Brandt RMC, van Steeg H, Dollé MET, Vermeij WP, Hoeijmakers JHJ, Essers J, van der Pluijm I, Danser AHJ, Roks AJM.

Clin Sci (Lond). 2017 Jul 13;131(15):1941-1953. doi: 10.1042/CS20170026. Print 2017 Aug 1.


A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.

Jongbloed F, Saat TC, Verweij M, Payan-Gomez C, Hoeijmakers JH, van den Engel S, van Oostrom CT, Ambagtsheer G, Imholz S, Pennings JL, van Steeg H, IJzermans JN, Dollé ME, de Bruin RW.

Sci Rep. 2017 Jan 19;7:40901. doi: 10.1038/srep40901.


Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH.

Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24.


Short-Term Preoperative Calorie and Protein Restriction Is Feasible in Healthy Kidney Donors and Morbidly Obese Patients Scheduled for Surgery.

Jongbloed F, de Bruin RW, Klaassen RA, Beekhof P, van Steeg H, Dor FJ, van der Harst E, Dollé ME, IJzermans JN.

Nutrients. 2016 May 20;8(5). pii: E306. doi: 10.3390/nu8050306.


Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice.

Mulder CK, Dong Y, Brugghe HF, Timmermans HA, Tilstra W, Westdijk J, van Riet E, van Steeg H, Hoogerhout P, Eisel UL.

J Alzheimers Dis. 2016;52(3):1111-23. doi: 10.3233/JAD-151136.


The Relationship Between Shift Work and Metabolic Risk Factors: A Systematic Review of Longitudinal Studies.

Proper KI, van de Langenberg D, Rodenburg W, Vermeulen RCH, van der Beek AJ, van Steeg H, van Kerkhof LWM.

Am J Prev Med. 2016 May;50(5):e147-e157. doi: 10.1016/j.amepre.2015.11.013. Epub 2016 Jan 22. Review.


TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.

Kucab JE, Zwart EP, van Steeg H, Luijten M, Schmeiser HH, Phillips DH, Arlt VM.

DNA Repair (Amst). 2016 Mar;39:21-33. doi: 10.1016/j.dnarep.2015.11.004. Epub 2015 Dec 8.


Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice.

Andriani GA, Faggioli F, Baker D, Dollé ME, Sellers RS, Hébert JM, Van Steeg H, Hoeijmakers J, Vijg J, Montagna C.

Hum Mol Genet. 2016 Feb 15;25(4):755-65. doi: 10.1093/hmg/ddv612. Epub 2015 Dec 17.


Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting.

van Kerkhof LW, Van Dycke KC, Jansen EH, Beekhof PK, van Oostrom CT, Ruskovska T, Velickova N, Kamcev N, Pennings JL, van Steeg H, Rodenburg W.

PLoS One. 2015 Aug 18;10(8):e0135652. doi: 10.1371/journal.pone.0135652. eCollection 2015.


Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

Van Dycke KC, Rodenburg W, van Oostrom CT, van Kerkhof LW, Pennings JL, Roenneberg T, van Steeg H, van der Horst GT.

Curr Biol. 2015 Jul 20;25(14):1932-7. doi: 10.1016/j.cub.2015.06.012.


Biomarkers for circadian rhythm disruption independent of time of day.

Van Dycke KC, Pennings JL, van Oostrom CT, van Kerkhof LW, van Steeg H, van der Horst GT, Rodenburg W.

PLoS One. 2015 May 18;10(5):e0127075. doi: 10.1371/journal.pone.0127075. eCollection 2015.


Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.

White RR, Milholland B, de Bruin A, Curran S, Laberge RM, van Steeg H, Campisi J, Maslov AY, Vijg J.

Nat Commun. 2015 Apr 10;6:6790. doi: 10.1038/ncomms7790.


Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model.

ter Braak B, Siezen C, Speksnijder EN, Koedoot E, van Steeg H, Salvatori DC, van de Water B, van der Laan JW.

Breast Cancer Res. 2015 Feb 18;17:14. doi: 10.1186/s13058-015-0518-y.


TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.

Kucab JE, van Steeg H, Luijten M, Schmeiser HH, White PA, Phillips DH, Arlt VM.

Mutat Res. 2015 Mar;773:48-62. doi: 10.1016/j.mrfmmm.2015.01.013. Epub 2015 Jan 30.


Relationship of night and shift work with weight change and lifestyle behaviors.

Bekkers MB, Koppes LL, Rodenburg W, van Steeg H, Proper KI.

J Occup Environ Med. 2015 Apr;57(4):e37-44. doi: 10.1097/JOM.0000000000000426.


An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J.

Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11.


Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.


A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Schaap MM, Wackers PF, Zwart EP, Huijskens I, Jonker MJ, Hendriks G, Breit TM, van Steeg H, van de Water B, Luijten M.

Arch Toxicol. 2015 Dec;89(12):2413-27. doi: 10.1007/s00204-014-1368-6. Epub 2014 Oct 2.


Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.

Jongbloed F, de Bruin RW, Pennings JL, Payán-Gómez C, van den Engel S, van Oostrom CT, de Bruin A, Hoeijmakers JH, van Steeg H, IJzermans JN, Dollé ME.

PLoS One. 2014 Jun 24;9(6):e100853. doi: 10.1371/journal.pone.0100853. eCollection 2014.


A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment.

Van Dycke KC, Nijman RM, Wackers PF, Jonker MJ, Rodenburg W, van Oostrom CT, Salvatori DC, Breit TM, van Steeg H, Luijten M, van der Horst GT.

Arch Toxicol. 2015 Feb;89(2):221-31. doi: 10.1007/s00204-014-1257-z. Epub 2014 May 13.


The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P.

PLoS One. 2014 Apr 16;9(4):e93568. doi: 10.1371/journal.pone.0093568. eCollection 2014.


Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition.

Reiling E, Speksnijder EN, Pronk AC, van den Berg SA, Neggers SJ, Rietbroek I, van Steeg H, Dollé ME.

Sci Rep. 2014 Feb 13;4:4091. doi: 10.1038/srep04091.


Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P.

PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014.


In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals.

Melis JP, Derks KW, Pronk TE, Wackers P, Schaap MM, Zwart E, van Ijcken WF, Jonker MJ, Breit TM, Pothof J, van Steeg H, Luijten M.

Arch Toxicol. 2014 Apr;88(4):1023-34. doi: 10.1007/s00204-013-1189-z. Epub 2014 Jan 5.


Aging on a different scale--chronological versus pathology-related aging.

Melis JP, Jonker MJ, Vijg J, Hoeijmakers JH, Breit TM, van Steeg H.

Aging (Albany NY). 2013 Oct;5(10):782-8.


Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.

Melis JP, Kuiper RV, Zwart E, Robinson J, Pennings JL, van Oostrom CT, Luijten M, van Steeg H.

DNA Repair (Amst). 2013 Dec;12(12):1081-6. doi: 10.1016/j.dnarep.2013.08.019. Epub 2013 Sep 29.


High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.

Gravina S, Dollé ME, Wang T, van Steeg H, Hasty P, Hoeijmakers J, Vijg J.

PLoS One. 2013 Sep 9;8(9):e73496. doi: 10.1371/journal.pone.0073496. eCollection 2013.


Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.

Jonker MJ, Melis JP, Kuiper RV, van der Hoeven TV, Wackers PFK, Robinson J, van der Horst GT, Dollé ME, Vijg J, Breit TM, Hoeijmakers JH, van Steeg H.

Aging Cell. 2013 Oct;12(5):901-909. doi: 10.1111/acel.12118. Epub 2013 Jul 14.


DNA damage in normally and prematurely aged mice.

Maslov AY, Ganapathi S, Westerhof M, Quispe-Tintaya W, White RR, Van Houten B, Reiling E, Dollé ME, van Steeg H, Hasty P, Hoeijmakers JH, Vijg J.

Aging Cell. 2013 Jun;12(3):467-77. doi: 10.1111/acel.12071. Epub 2013 Apr 24.


Oxidative DNA damage and nucleotide excision repair.

Melis JP, van Steeg H, Luijten M.

Antioxid Redox Signal. 2013 Jun 20;18(18):2409-19. doi: 10.1089/ars.2012.5036. Epub 2012 Dec 7. Review.


Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.

Melis JP, Speksnijder EN, Kuiper RV, Salvatori DC, Schaap MM, Maas S, Robinson J, Verhoef A, van Benthem J, Luijten M, van Steeg H.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):289-97. doi: 10.1016/j.taap.2012.11.004. Epub 2012 Nov 12.


Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.

van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M.

Arch Toxicol. 2013 Mar;87(3):505-15. doi: 10.1007/s00204-012-0949-5. Epub 2012 Oct 2.


Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.

Schaap MM, Zwart EP, Wackers PF, Huijskens I, van de Water B, Breit TM, van Steeg H, Jonker MJ, Luijten M.

Arch Toxicol. 2012 Nov;86(11):1717-27. doi: 10.1007/s00204-012-0883-6. Epub 2012 Jun 19.


Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro.

Zwart EP, Schaap MM, van den Dungen MW, Braakhuis HM, White PA, van Steeg H, van Benthem J, Luijten M.

Environ Mol Mutagen. 2012 Jun;53(5):1-8. doi: 10.1002/em.21700. Epub 2012 May 23.


Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA.

Tomasevic G, Laurer HL, Mattiasson G, van Steeg H, Wieloch T, McIntosh TK.

J Neurosurg. 2012 Jun;116(6):1368-78. doi: 10.3171/2012.2.JNS11888. Epub 2012 Mar 30.


Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.

Jaarsma D, van der Pluijm I, de Waard MC, Haasdijk ED, Brandt R, Vermeij M, Rijksen Y, Maas A, van Steeg H, Hoeijmakers JH, van der Horst GT.

PLoS Genet. 2011 Dec;7(12):e1002405. doi: 10.1371/journal.pgen.1002405. Epub 2011 Dec 8.


The role of XPC: implications in cancer and oxidative DNA damage.

Melis JP, Luijten M, Mullenders LH, van Steeg H.

Mutat Res. 2011 Nov-Dec;728(3):107-17. doi: 10.1016/j.mrrev.2011.07.001. Epub 2011 Jul 7.


Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.

van Kesteren PC, Zwart PE, Pennings JL, Gottschalk WH, Kleinjans JC, van Delft JH, van Steeg H, Luijten M.

Toxicol Sci. 2011 Sep;123(1):123-32. doi: 10.1093/toxsci/kfr169. Epub 2011 Jun 29.


Can carcinogenic potency be predicted from in vivo genotoxicity data?: a meta-analysis of historical data.

Hernández LG, Slob W, van Steeg H, van Benthem J.

Environ Mol Mutagen. 2011 Aug;52(7):518-28. doi: 10.1002/em.20651. Epub 2011 May 3.


Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice.

Dollé ME, Kuiper RV, Roodbergen M, Robinson J, de Vlugt S, Wijnhoven SW, Beems RB, de la Fonteyne L, de With P, van der Pluijm I, Niedernhofer LJ, Hasty P, Vijg J, Hoeijmakers JH, van Steeg H.

Pathobiol Aging Age Relat Dis. 2011;1. doi: 10.3402/pba.v1i0.7219. Epub 2011 Jun 1.


Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoform.

Melis JP, Hoogervorst EM, van Oostrom CT, Zwart E, Breit TM, Pennings JL, de Vries A, van Steeg H.

Oncogene. 2011 Apr 14;30(15):1764-72. doi: 10.1038/onc.2010.552. Epub 2010 Dec 13.


Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis.

Yuan X, Jonker MJ, de Wilde J, Verhoef A, Wittink FR, van Benthem J, Bessems JG, Hakkert BC, Kuiper RV, van Steeg H, Breit TM, Luijten M.

J Appl Toxicol. 2011 Jul;31(5):421-30. doi: 10.1002/jat.1601. Epub 2010 Nov 9.


Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells.

Verhofstad N, van Oostrom CT, Zwart E, Maas LM, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

Toxicol Sci. 2011 Jan;119(1):218-23. doi: 10.1093/toxsci/kfq325. Epub 2010 Oct 20.


Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.

Botter SM, Zar M, van Osch GJ, van Steeg H, Dollé ME, Hoeijmakers JH, Weinans H, van Leeuwen JP.

Age (Dordr). 2011 Sep;33(3):247-60. doi: 10.1007/s11357-010-9175-3. Epub 2010 Sep 7.


Mouse models for the p53 R72P polymorphism mimic human phenotypes.

Zhu F, Dollé ME, Berton TR, Kuiper RV, Capps C, Espejo A, McArthur MJ, Bedford MT, van Steeg H, de Vries A, Johnson DG.

Cancer Res. 2010 Jul 15;70(14):5851-9. doi: 10.1158/0008-5472.CAN-09-4646. Epub 2010 Jun 29.


Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice.

Verhofstad N, Pennings JL, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

BMC Genomics. 2010 May 26;11:333. doi: 10.1186/1471-2164-11-333.

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