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Items: 1 to 50 of 172


Relationship between prescribing of antibiotics and other medicines in primary care: a cross-sectional study.

Li Y, Mölter A, White A, Welfare W, Palin V, Belmonte M, Ashcroft DM, Sperrin M, van Staa TP.

Br J Gen Pract. 2019 Jan;69(678):e42-e51. doi: 10.3399/bjgp18X700457. Epub 2018 Dec 17.


Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data.

Kwakkenbos L, Juszczak E, Hemkens LG, Sampson M, Fröbert O, Relton C, Gale C, Zwarenstein M, Langan SM, Moher D, Boutron I, Ravaud P, Campbell MK, Mc Cord KA, van Staa TP, Thabane L, Uher R, Verkooijen HM, Benchimol EI, Erlinge D, Sauvé M, Torgerson D, Thombs BD.

Res Integr Peer Rev. 2018 Oct 29;3:9. doi: 10.1186/s41073-018-0053-3. eCollection 2018.


Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records.

Joseph RM, Ray DW, Keevil B, van Staa TP, Dixon WG.

RMD Open. 2018 Oct 1;4(2):e000700. doi: 10.1136/rmdopen-2018-000700. eCollection 2018.


Exposure measurement error when assessing current glucocorticoid use using UK primary care electronic prescription data.

Joseph RM, van Staa TP, Lunt M, Abrahamowicz M, Dixon WG.

Pharmacoepidemiol Drug Saf. 2018 Sep 28. doi: 10.1002/pds.4649. [Epub ahead of print]


The limitations of using simple definitions of glucocorticoid exposure to predict fracture risk: A cohort study.

Robinson DE, van Staa TP, Dennison EM, Cooper C, Dixon WG.

Bone. 2018 Dec;117:83-90. doi: 10.1016/j.bone.2018.09.004. Epub 2018 Sep 13.


Protocol for a scoping review to support development of a CONSORT extension for randomised controlled trials using cohorts and routinely collected health data.

Kwakkenbos L, Imran M, McCord KA, Sampson M, Fröbert O, Gale C, Hemkens LG, Langan SM, Moher D, Relton C, Zwarenstein M, Benchimol EI, Boutron I, Campbell MK, Erlinge D, Jawad S, Ravaud P, Rice DB, Sauve M, van Staa TP, Thabane L, Uher R, Verkooijen HM, Juszczak E, Thombs BD.

BMJ Open. 2018 Aug 5;8(8):e025266. doi: 10.1136/bmjopen-2018-025266.


Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study.

Williams R, van Staa TP, Gallagher AM, Hammad T, Leufkens HGM, de Vries F.

BMJ Open. 2018 May 26;8(5):e020827. doi: 10.1136/bmjopen-2017-020827.


Assumptions made when preparing drug exposure data for analysis have an impact on results: An unreported step in pharmacoepidemiology studies.

Pye SR, Sheppard T, Joseph RM, Lunt M, Girard N, Haas JS, Bates DW, Buckeridge DL, van Staa TP, Tamblyn R, Dixon WG.

Pharmacoepidemiol Drug Saf. 2018 Jul;27(7):781-788. doi: 10.1002/pds.4440. Epub 2018 Apr 17.


Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink.

de Jong HJI, Cohen Tervaert JW, Lalmohamed A, de Vries F, Vandebriel RJ, van Loveren H, Klungel OH, van Staa TP.

PLoS One. 2018 Feb 23;13(2):e0193297. doi: 10.1371/journal.pone.0193297. eCollection 2018.


Response to: 'Statins in systemic lupus erythematosus' by Abud-Mendoza.

de Jong HJI, van Staa TP, Cohen Tervaert JW.

Ann Rheum Dis. 2018 Jan 22. pii: annrheumdis-2017-212902. doi: 10.1136/annrheumdis-2017-212902. [Epub ahead of print] No abstract available.


The use of random-effects models to identify health care center-related characteristics modifying the effect of antipsychotic drugs.

Nordon C, Battin C, Verdoux H, Haro JM, Belger M, Abenhaim L, van Staa TP.

Clin Epidemiol. 2017 Dec 14;9:689-698. doi: 10.2147/CLEP.S145353. eCollection 2017.


Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK.

Martín-Merino E, Petersen I, Hawley S, Álvarez-Gutierrez A, Khalid S, Llorente-Garcia A, Delmestri A, Javaid MK, Van Staa TP, Judge A, Cooper C, Prieto-Alhambra D.

Osteoporos Int. 2018 Feb;29(2):467-478. doi: 10.1007/s00198-017-4308-5. Epub 2017 Dec 3.


Supplementing electronic health records through sample collection and patient diaries: A study set within a primary care research database.

Joseph RM, Soames J, Wright M, Sultana K, van Staa TP, Dixon WG.

Pharmacoepidemiol Drug Saf. 2018 Feb;27(2):239-242. doi: 10.1002/pds.4323. Epub 2017 Sep 19.


Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom.

Braeken DC, Rohde GG, Franssen FM, Driessen JH, van Staa TP, Souverein PC, Wouters EF, de Vries F.

Int J Chron Obstruct Pulmon Dis. 2017 Aug 14;12:2425-2432. doi: 10.2147/COPD.S138435. eCollection 2017.


Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study.

Wing K, Bhaskaran K, Pealing L, Root A, Smeeth L, van Staa TP, Klungel OH, Reynolds RF, Douglas I.

J Antimicrob Chemother. 2017 Sep 1;72(9):2636-2646. doi: 10.1093/jac/dkx183.


Pattern of risks of systemic lupus erythematosus among statin users: a population-based cohort study.

De Jong HJI, van Staa TP, Lalmohamed A, de Vries F, Vandebriel RJ, Van Loveren H, Klungel OH, Cohen Tervaert JW.

Ann Rheum Dis. 2017 Oct;76(10):1723-1730. doi: 10.1136/annrheumdis-2016-210936. Epub 2017 Jul 6.


Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink.

Thompson A, Wright AK, Ashcroft DM, van Staa TP, Pirmohamed M.

PLoS One. 2017 Mar 31;12(3):e0174818. doi: 10.1371/journal.pone.0174818. eCollection 2017.


Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study.

Thompson A, Ashcroft DM, Owens L, van Staa TP, Pirmohamed M.

PLoS One. 2017 Mar 20;12(3):e0173272. doi: 10.1371/journal.pone.0173272. eCollection 2017.


Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity.

van der Velde RY, Wyers CE, Teesselink E, Geusens PPMM, van den Bergh JPW, de Vries F, Cooper C, Harvey NC, van Staa TP.

Bone. 2017 Jan;94:50-55. doi: 10.1016/j.bone.2016.10.013. Epub 2016 Oct 11.


Safety and efficacy of new oral anticoagulants and low-molecular-weight heparins compared with aspirin in patients undergoing total knee and hip replacements.

Nielen JT, Dagnelie PC, Emans PJ, Veldhorst-Janssen N, Lalmohamed A, van Staa TP, Boonen AE, van den Bemt BJ, de Vries F.

Pharmacoepidemiol Drug Saf. 2016 Nov;25(11):1245-1252. doi: 10.1002/pds.4089. Epub 2016 Sep 4.


On epidemiology of fractures and variation with age and ethnicity.

Harvey NC, Curtis EM, van der Velde R, Moon RJ, van den Bergh JP, Geusens P, de Vries F, van Staa TP, Cooper C.

Bone. 2016 Dec;93:230-231. doi: 10.1016/j.bone.2016.07.011. Epub 2016 Jul 17. No abstract available.


The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity.

Klop C, van Staa TP, Cooper C, Harvey NC, de Vries F.

Osteoporos Int. 2017 Jan;28(1):161-168. doi: 10.1007/s00198-016-3787-0. Epub 2016 Oct 8.


Optimising case detection within UK electronic health records: use of multiple linked databases for detecting liver injury.

Wing K, Bhaskaran K, Smeeth L, van Staa TP, Klungel OH, Reynolds RF, Douglas I.

BMJ Open. 2016 Sep 2;6(9):e012102. doi: 10.1136/bmjopen-2016-012102.


Cohort Multiple Randomised Controlled Trials (cmRCT) design: efficient but biased? A simulation study to evaluate the feasibility of the Cluster cmRCT design.

Pate A, Candlish J, Sperrin M, Van Staa TP; GetReal Work Package 2.

BMC Med Res Methodol. 2016 Aug 26;16(1):109. doi: 10.1186/s12874-016-0208-1.


Big health data: the need to earn public trust.

van Staa TP, Goldacre B, Buchan I, Smeeth L.

BMJ. 2016 Jul 14;354:i3636. doi: 10.1136/bmj.i3636. No abstract available.


Statins and Risk of Lower Limb Revision Surgery: The Influence of Differences in Study Design Using Electronic Health Records From the United Kingdom and Denmark.

Lalmohamed A, van Staa TP, Vestergaard P, Leufkens HGM, de Boer A, Emans P, Cooper C, de Vries F.

Am J Epidemiol. 2016 Jul 1;184(1):58-66. doi: 10.1093/aje/kwv311. Epub 2016 Jun 16.


Secular trends in fracture incidence in the UK between 1990 and 2012.

van der Velde RY, Wyers CE, Curtis EM, Geusens PPMM, van den Bergh JPW, de Vries F, Cooper C, van Staa TP, Harvey NC.

Osteoporos Int. 2016 Nov;27(11):3197-3206. doi: 10.1007/s00198-016-3650-3. Epub 2016 Jun 9.


A review of the methods used to define glucocorticoid exposure and risk attribution when investigating the risk of fracture in a rheumatoid arthritis population.

Robinson DE, Dennison EM, Cooper C, van Staa TP, Dixon WG.

Bone. 2016 Sep;90:107-15. doi: 10.1016/j.bone.2016.06.001. Epub 2016 Jun 3. Review.


Reply: Comparing the ATRIA, CHADS2, and CHA2DS2-VASc Scores for Stroke Prediction in Atrial Fibrillation.

van den Ham HA, Klungel OH, Singer DE, Leufkens HGM, van Staa TP.

J Am Coll Cardiol. 2016 May 17;67(19):2317-2318. doi: 10.1016/j.jacc.2016.01.085. No abstract available.


Insulin glargine use and breast cancer risk: Associations with cumulative exposure.

Peeters PJ, Bazelier MT, Leufkens HG, Auvinen A, van Staa TP, de Vries F, De Bruin ML.

Acta Oncol. 2016 Jul;55(7):851-8. doi: 10.3109/0284186X.2016.1155736. Epub 2016 May 6.


Real-Life and RCT Participants: Alendronate Users Versus FITs' Trial Eligibility Criterion.

Reyes C, Pottegård A, Schwarz P, Javaid MK, Van Staa TP, Cooper C, Diez-Perez A, Abrahamsen B, Prieto-Alhambra D.

Calcif Tissue Int. 2016 Sep;99(3):243-9. doi: 10.1007/s00223-016-0141-7. Epub 2016 Apr 20.


Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures.

Souverein PC, Abbing-Karahagopian V, Martin E, Huerta C, de Abajo F, Leufkens HG, Candore G, Alvarez Y, Slattery J, Miret M, Requena G, Gil MJ, Groenwold RH, Reynolds R, Schlienger RG, Logie JW, de Groot MC, Klungel OH, van Staa TP, Egberts TC, De Bruin ML, Gardarsdottir H.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:88-102. doi: 10.1002/pds.3862.


Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status.

Curtis EM, van der Velde R, Moon RJ, van den Bergh JP, Geusens P, de Vries F, van Staa TP, Cooper C, Harvey NC.

Bone. 2016 Jun;87:19-26. doi: 10.1016/j.bone.2016.03.006. Epub 2016 Mar 9.


Risk of vertebral and non-vertebral fractures in patients with sarcoidosis: a population-based cohort.

Bours S, de Vries F, van den Bergh JPW, Lalmohamed A, van Staa TP, Leufkens HGM, Geusens PPP, Drent M, Harvey NC.

Osteoporos Int. 2016 Apr;27(4):1603-1610. doi: 10.1007/s00198-015-3426-1. Epub 2015 Dec 2.


Identification of antithrombotic drugs related to total joint replacement using anonymised free-text notes: a search strategy in the Clinical Practice Research Datalink.

Nielen JT, van den Bemt BJ, Boonen A, Dagnelie PC, Emans PJ, Veldhorst N, Lalmohamed A, van Staa TP, de Vries F.

BMJ Open. 2015 Nov 30;5(11):e009017. doi: 10.1136/bmjopen-2015-009017.


Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study.

Venkatesan S, Myles PR, McCann G, Kousoulis AA, Hashmi M, Belatri R, Boyle E, Barcroft A, van Staa TP, Kirkham JJ, Nguyen Van Tam JS, Williams TJ, Semple MG.

Health Technol Assess. 2015 Oct;19(89):1-132. doi: 10.3310/hta19890.


Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc Risk Scores Predicting Stroke in Patients With Atrial Fibrillation: Results From a National Primary Care Database.

van den Ham HA, Klungel OH, Singer DE, Leufkens HG, van Staa TP.

J Am Coll Cardiol. 2015 Oct 27;66(17):1851-9. doi: 10.1016/j.jacc.2015.08.033.


Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations.

Been JV, Szatkowski L, van Staa TP, Leufkens HG, van Schayck OC, Sheikh A, de Vries F, Souverein P.

Sci Rep. 2015 Oct 14;5:15246. doi: 10.1038/srep15246.


Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010.

Klop C, Gibson-Smith D, Elders PJ, Welsing PM, Leufkens HG, Harvey NC, Bijlsma JW, van Staa TP, de Vries F.

Osteoporos Int. 2015 Jul;26(7):1919-28. doi: 10.1007/s00198-015-3098-x. Epub 2015 May 12.


Left truncation results in substantial bias of the relation between time-dependent exposures and adverse events.

Hazelbag CM, Klungel OH, van Staa TP, de Boer A, Groenwold RH.

Ann Epidemiol. 2015 Aug;25(8):590-6. doi: 10.1016/j.annepidem.2015.03.019. Epub 2015 Apr 1.


Why do electronic health records reveal oral anticoagulant prescription after haemorrhagic stroke?

Forster AS, Dregan A, van Staa TP, McDermott L, McCann G, Wolfe CD, Rudd A, Gulliford MC.

Br J Clin Pharmacol. 2015 Jun;79(6):1037-9. doi: 10.1111/bcp.12570. No abstract available.


Performance of prior event rate ratio adjustment method in pharmacoepidemiology: a simulation study.

Uddin MJ, Groenwold RH, van Staa TP, de Boer A, Belitser SV, Hoes AW, Roes KC, Klungel OH.

Pharmacoepidemiol Drug Saf. 2015 May;24(5):468-77. doi: 10.1002/pds.3724. Epub 2014 Nov 20.


Prediction of cardiovascular risk using Framingham, ASSIGN and QRISK2: how well do they predict individual rather than population risk?

van Staa TP, Gulliford M, Ng ES, Goldacre B, Smeeth L.

PLoS One. 2014 Oct 1;9(10):e106455. doi: 10.1371/journal.pone.0106455. eCollection 2014.


Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort.

Atkinson RW, Carey IM, Kent AJ, van Staa TP, Anderson HR, Cook DG.

Occup Environ Med. 2015 Jan;72(1):42-8. doi: 10.1136/oemed-2014-102266. Epub 2014 Aug 20.


Benefit-risk assessment in a post-market setting: a case study integrating real-life experience into benefit-risk methodology.

Hallgreen CE, van den Ham HA, Mt-Isa S, Ashworth S, Hermann R, Hobbiger S, Luciani D, Micaleff A, Thomson A, Wang N, van Staa TP, Downey G, Hirsch I, Hockley K, Juhaeri J, Metcalf M, Mwangi J, Nixon R, Peters R, Stoeckert I, Waddingham E, Tzoulaki I, Ashby D, Wise L.

Pharmacoepidemiol Drug Saf. 2014 Sep;23(9):974-83. doi: 10.1002/pds.3676. Epub 2014 Jul 5.


The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials.

van Staa TP, Dyson L, McCann G, Padmanabhan S, Belatri R, Goldacre B, Cassell J, Pirmohamed M, Torgerson D, Ronaldson S, Adamson J, Taweel A, Delaney B, Mahmood S, Baracaia S, Round T, Fox R, Hunter T, Gulliford M, Smeeth L.

Health Technol Assess. 2014 Jul;18(43):1-146. doi: 10.3310/hta18430.


The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010.

Gibson-Smith D, Klop C, Elders PJ, Welsing PM, van Schoor N, Leufkens HG, Harvey NC, van Staa TP, de Vries F.

Osteoporos Int. 2014 Nov;25(11):2555-63. doi: 10.1007/s00198-014-2799-x. Epub 2014 Jul 8.


Cluster randomized trials utilizing primary care electronic health records: methodological issues in design, conduct, and analysis (eCRT Study).

Gulliford MC, van Staa TP, McDermott L, McCann G, Charlton J, Dregan A; eCRT Research Team.

Trials. 2014 Jun 11;15:220. doi: 10.1186/1745-6215-15-220.


Point-of-care cluster randomized trial in stroke secondary prevention using electronic health records.

Dregan A, van Staa TP, McDermott L, McCann G, Ashworth M, Charlton J, Wolfe CD, Rudd A, Yardley L, Gulliford MC; Data Monitoring Committee, Trial Steering Committee.

Stroke. 2014 Jul;45(7):2066-71. doi: 10.1161/STROKEAHA.114.005713. Epub 2014 Jun 5.


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