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Items: 34


Osteoarthritis year in review 2019: biomarkers (biochemical markers).

van Spil WE, Szilagyi IA.

Osteoarthritis Cartilage. 2019 Dec 27. pii: S1063-4584(19)31294-4. doi: 10.1016/j.joca.2019.11.007. [Epub ahead of print] Review.


Recent advances in understanding the phenotypes of osteoarthritis.

Mobasheri A, Saarakkala S, Finnilä M, Karsdal MA, Bay-Jensen AC, van Spil WE.

F1000Res. 2019 Dec 12;8. pii: F1000 Faculty Rev-2091. doi: 10.12688/f1000research.20575.1. eCollection 2019. Review.


An automated workflow based on hip shape improves personalized risk prediction for hip osteoarthritis in the CHECK study.

Gielis WP, Weinans H, Welsing PMJ, van Spil WE, Agricola R, Cootes TF, de Jong PA, Lindner C.

Osteoarthritis Cartilage. 2020 Jan;28(1):62-70. doi: 10.1016/j.joca.2019.09.005. Epub 2019 Oct 8.


The clinical and radiographic course of early knee and hip osteoarthritis over 10 years in CHECK (Cohort Hip and Cohort Knee).

Schiphof D, Runhaar J, Waarsing JH, van Spil WE, van Middelkoop M, Bierma-Zeinstra SMA.

Osteoarthritis Cartilage. 2019 Oct;27(10):1491-1500. doi: 10.1016/j.joca.2019.06.002. Epub 2019 Jun 13.


Novel optical spectral transmission (OST)-guided versus conventionally disease activity-guided treatment: study protocol of a randomized clinical trial on guidance of a treat-to-target strategy for early rheumatoid arthritis.

Besselink NJ, Westgeest AAA, Klaasen R, Gamala M, van Woerkom JM, Tekstra J, Verhoeven MMA, Van Spil WE, Lafeber FPJG, Marijnissen ACA, Van Laar JM, Jacobs JWG.

Trials. 2019 Apr 17;20(1):226. doi: 10.1186/s13063-019-3285-8.


Osteoarthritis phenotypes and novel therapeutic targets.

Van Spil WE, Kubassova O, Boesen M, Bay-Jensen AC, Mobasheri A.

Biochem Pharmacol. 2019 Jul;165:41-48. doi: 10.1016/j.bcp.2019.02.037. Epub 2019 Mar 1. Review.


Bone texture analysis for prediction of incident radiographic hip osteoarthritis using machine learning: data from the Cohort Hip and Cohort Knee (CHECK) study.

Hirvasniemi J, Gielis WP, Arbabi S, Agricola R, van Spil WE, Arbabi V, Weinans H.

Osteoarthritis Cartilage. 2019 Jun;27(6):906-914. doi: 10.1016/j.joca.2019.02.796. Epub 2019 Feb 28.


Can optical spectral transmission assess ultrasound-detected synovitis in hand osteoarthritis?

Besselink NJ, Jacobs JWG, Westgeest AAA, van der Meijde P, Welsing PMJ, Marijnissen ACA, Lafeber FPJG, Van Spil WE.

PLoS One. 2019 Feb 22;14(2):e0209761. doi: 10.1371/journal.pone.0209761. eCollection 2019.


Efficacy of bisphosphonates in specific knee osteoarthritis subpopulations: protocol for an OA Trial Bank systematic review and individual patient data meta-analysis.

Deveza LA, Bierma-Zeinstra SMA, van Spil WE, Oo WM, Saragiotto BT, Neogi T, van Middelkoop M, Hunter DJ.

BMJ Open. 2018 Dec 19;8(12):e023889. doi: 10.1136/bmjopen-2018-023889.


Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes.

Mobasheri A, van Spil WE, Budd E, Uzieliene I, Bernotiene E, Bay-Jensen AC, Larkin J, Levesque MC, Gualillo O, Henrotin Y.

Curr Opin Rheumatol. 2019 Jan;31(1):80-89. doi: 10.1097/BOR.0000000000000567. Review.


Trajectories of femorotibial cartilage thickness among persons with or at risk of knee osteoarthritis: development of a prediction model to identify progressors.

Deveza LA, Downie A, Tamez-Peña JG, Eckstein F, Van Spil WE, Hunter DJ.

Osteoarthritis Cartilage. 2019 Feb;27(2):257-265. doi: 10.1016/j.joca.2018.09.015. Epub 2018 Oct 19.


Too much opioid, too much harm.

Deveza LA, Hunter DJ, Van Spil WE.

Osteoarthritis Cartilage. 2018 Mar;26(3):293-295. doi: 10.1016/j.joca.2017.12.003. Epub 2017 Dec 20. No abstract available.


Disease burden of knee osteoarthritis patients with a joint replacement compared to matched controls: a population-based analysis of a Dutch medical claims database.

Nielen JTH, Boonen A, Dagnelie PC, van den Bemt BJF, Emans PJ, Lafeber FPJG, van Spil WE, de Vries F, Welsing PMJ.

Osteoarthritis Cartilage. 2018 Feb;26(2):202-210. doi: 10.1016/j.joca.2017.11.012. Epub 2017 Dec 2.


A sex-specific association between incident radiographic osteoarthritis of hip or knee and incident peripheral arterial calcifications: 8-year prospective data from Cohort Hip and Cohort Knee (CHECK).

Gielis WP, Welsing PMJ, van Spil WE, Runhaar J, Weinans H, de Jong PA.

Osteoarthritis Cartilage. 2017 Nov;25(11):1814-1821. doi: 10.1016/j.joca.2017.07.016. Epub 2017 Jul 28.


Osteoarthritis Year in Review 2016: biomarkers (biochemical markers).

Mobasheri A, Bay-Jensen AC, van Spil WE, Larkin J, Levesque MC.

Osteoarthritis Cartilage. 2017 Feb;25(2):199-208. doi: 10.1016/j.joca.2016.12.016. Epub 2017 Jan 16. Review.


A fatty cause of acute renal failure.

van Spil WE, Steenbergen E, Verhave JC.

Neth J Med. 2016 Oct;74(8):365. No abstract available.


Six weeks of continuous joint distraction appears sufficient for clinical benefit and cartilaginous tissue repair in the treatment of knee osteoarthritis.

van der Woude JA, van Heerwaarden RJ, Spruijt S, Eckstein F, Maschek S, van Roermund PM, Custers RJ, van Spil WE, Mastbergen SC, Lafeber FP.

Knee. 2016 Oct;23(5):785-91. doi: 10.1016/j.knee.2016.05.001. Epub 2016 May 26.


A rare complication of pneumonia. Infectious purulent pericarditis.

van Spil WE, Claessens N, le Cocq d'Armandville MC, Verhave JC.

Neth J Med. 2016 Mar;74(3):140-1. No abstract available.


[Outcomes of in-hospital resuscitation].

van Spil WE, van Vliet J, Bosch FH.

Ned Tijdschr Geneeskd. 2016;160:A9631. Review. Dutch.


Associations of markers of matrix metabolism, inflammation markers, and adipokines with superior cam deformity of the hip and their relation with future hip osteoarthritis.

van Spil WE, Agricola R, Drossaers-Bakker KW, Weinans H, Lafeber FP.

Osteoarthritis Cartilage. 2015 Nov;23(11):1897-905. doi: 10.1016/j.joca.2015.03.026.


[Cryptococcal meningitis].

van Spil WE, Nooijen S, de Jong PY, Aliredjo RP, de Sévaux RG, Verhave JC.

Ned Tijdschr Geneeskd. 2015;159:A8478. Review. Dutch.


The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK.

Van Spil WE, Welsing PM, Bierma-Zeinstra SM, Bijlsma JW, Roorda LD, Cats HA, Lafeber FP.

Osteoarthritis Cartilage. 2015 Aug;23(8):1388-97. doi: 10.1016/j.joca.2015.03.023. Epub 2015 Mar 26.


Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects.

Van Spil WE, Nair SC, Kinds MB, Emans PJ, Hilberdink WK, Welsing PM, Lafeber FP.

Osteoarthritis Cartilage. 2015 Jan;23(1):48-56. doi: 10.1016/j.joca.2014.09.003. Epub 2014 Sep 6.


Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK.

de Klerk B, Lafeber FP, van Spil WE.

Ann Rheum Dis. 2014 Jul;73(7):e39. doi: 10.1136/annrheumdis-2014-205494. Epub 2014 Apr 2. No abstract available.


Republished: Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Postgrad Med J. 2014 Mar;90(1061):171-8. doi: 10.1136/postgradmedj-2013-203726rep.


Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time.

Lafeber FP, van Spil WE.

Osteoarthritis Cartilage. 2013 Oct;21(10):1452-64. doi: 10.1016/j.joca.2013.08.012. Epub 2013 Aug 14. Review.


Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Ann Rheum Dis. 2013 Nov;72(11):1756-63. doi: 10.1136/annrheumdis-2013-203726. Epub 2013 Jul 29. Review. Erratum in: Ann Rheum Dis. 2017 May 25;:.


An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid.

Beekhuizen M, Gierman LM, van Spil WE, Van Osch GJ, Huizinga TW, Saris DB, Creemers LB, Zuurmond AM.

Osteoarthritis Cartilage. 2013 Jul;21(7):918-22. doi: 10.1016/j.joca.2013.04.002. Epub 2013 Apr 15.


Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK.

Van Spil WE, Welsing PM, Kloppenburg M, Bierma-Zeinstra SM, Bijlsma JW, Mastbergen SC, Lafeber FP.

Osteoarthritis Cartilage. 2012 Nov;20(11):1278-85. doi: 10.1016/j.joca.2012.08.001. Epub 2012 Aug 10.


Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis.

van Spil WE, Drossaers-Bakker KW, Lafeber FP.

Ann Rheum Dis. 2013 Jan;72(1):29-36. doi: 10.1136/annrheumdis-2011-201177. Epub 2012 Jun 11.


Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage.

de Boer TN, van Spil WE, Huisman AM, Polak AA, Bijlsma JW, Lafeber FP, Mastbergen SC.

Osteoarthritis Cartilage. 2012 Aug;20(8):846-53. doi: 10.1016/j.joca.2012.05.002. Epub 2012 May 14.


Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from CHECK, a large cohort of individuals with very early symptomatic osteoarthritis.

van Spil WE, Jansen NW, Bijlsma JW, Reijman M, DeGroot J, Welsing PM, Lafeber FP.

Osteoarthritis Cartilage. 2012 Jul;20(7):745-54. doi: 10.1016/j.joca.2012.04.004. Epub 2012 Apr 11.


Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria.

van Spil WE, DeGroot J, Lems WF, Oostveen JC, Lafeber FP.

Osteoarthritis Cartilage. 2010 May;18(5):605-12. doi: 10.1016/j.joca.2010.01.012. Epub 2010 Feb 6. Review.

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