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AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.

Rab MAE, van Oirschot BA, Kosinski PA, Hixon J, Johnson K, Chubukov V, Dang L, Pasterkamp G, van Straaten S, van Solinge WW, van Beers EJ, Kung C, van Wijk R.

Haematologica. 2020 Jan 23. pii: haematol.2019.238865. doi: 10.3324/haematol.2019.238865. [Epub ahead of print]


Reticulated Platelets as Predictor of Myocardial Injury and 30 Day Mortality After Non-cardiac Surgery.

Meershoek AJA, Leunissen TC, van Waes JAR, Klei WA, Huisman A, de Groot MCH, Hoefer IE, van Solinge WW, Moll FL, de Borst GJ.

Eur J Vasc Endovasc Surg. 2020 Feb;59(2):309-318. doi: 10.1016/j.ejvs.2019.06.027. Epub 2019 Dec 4.


Osteoprotegerin is Higher in Sepsis Than in Noninfectious SIRS and Predicts 30-Day Mortality of SIRS Patients in the Intensive Care.

Kemperman H, Schrijver IT, Roest M, Kesecioglu J, van Solinge WW, de Lange DW.

J Appl Lab Med. 2019 Jan;3(4):559-568. doi: 10.1373/jalm.2018.026559. Epub 2018 Jul 16.


A computerised decision support system for cardiovascular risk management 'live' in the electronic health record environment: development, validation and implementation-the Utrecht Cardiovascular Cohort Initiative.

Groenhof TKJ, Rittersma ZH, Bots ML, Brandjes M, Jacobs JJL, Grobbee DE, van Solinge WW, Visseren FLJ, Haitjema S, Asselbergs FW; Members of the UCC-CVRM Study Group.

Neth Heart J. 2019 Sep;27(9):435-442. doi: 10.1007/s12471-019-01308-w.


Association of a Multifaceted Intervention With Ordering of Unnecessary Laboratory Tests Among Caregivers in Internal Medicine Departments.

Bindraban RS, van Beneden M, Kramer MHH, van Solinge WW, van de Ven PM, Naaktgeboren CA, Al-Dulaimy M, van der Wekken LC, Bandt YC, Stam F, Neppelenbroek SIM, Griffioen-Keijzer A, Castelijn DAR, Wevers BA, Boerman AW, van Wijnen M, Ten Berg MJ, Nanayakkara PWB.

JAMA Netw Open. 2019 Jul 3;2(7):e197577. doi: 10.1001/jamanetworkopen.2019.7577.


SAFE@HOME - Feasibility study of a telemonitoring platform combining blood pressure and preeclampsia symptoms in pregnancy care.

van den Heuvel JFM, Kariman SS, van Solinge WW, Franx A, Lely AT, Bekker MN.

Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:226-231. doi: 10.1016/j.ejogrb.2019.07.012. Epub 2019 Jul 15.


Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis.

Huisjes R, Makhro A, Llaudet-Planas E, Hertz L, Petkova-Kirova P, Verhagen LP, Pignatelli S, Rab MAE, Schiffelers RM, Seiler E, van Solinge WW, Corrons JV, Kaestner L, Mañú-Pereira M, Bogdanov A, van Wijk R.

Haematologica. 2020 Jan 31;105(2):338-347. doi: 10.3324/haematol.2018.188151. Print 2020.


Unbound Fraction of Clozapine Significantly Decreases with Elevated Plasma Concentrations of the Inflammatory Acute-Phase Protein Alpha-1-Acid Glycoprotein.

Man WH, Wilting I, Heerdink ER, Hugenholtz GWK, Bognár T, Ten Berg MJ, van Solinge WW, Egberts TACG, van Maarseveen EM.

Clin Pharmacokinet. 2019 Aug;58(8):1069-1075. doi: 10.1007/s40262-019-00744-6.


Measuring Free-Living Physical Activity With Three Commercially Available Activity Monitors for Telemonitoring Purposes: Validation Study.

Breteler MJ, Janssen JH, Spiering W, Kalkman CJ, van Solinge WW, Dohmen DA.

JMIR Form Res. 2019 Apr 24;3(2):e11489. doi: 10.2196/11489.


A Human(e) Factor in Clinical Decision Support Systems.

Bezemer T, de Groot MC, Blasse E, Ten Berg MJ, Kappen TH, Bredenoord AL, van Solinge WW, Hoefer IE, Haitjema S.

J Med Internet Res. 2019 Mar 19;21(3):e11732. doi: 10.2196/11732.


Routine Blood Tests Do Not Predict Survival in Patients with Glioblastoma-Multivariable Analysis of 497 Patients.

Maas SLN, Draaisma K, Snijders TJ, Senders JT, Berendsen S, Seute T, Schiffelers RM, van Solinge WW, Ten Berg MJ, Robe PA, Broekman MLD.

World Neurosurg. 2019 Jun;126:e1081-e1091. doi: 10.1016/j.wneu.2019.03.053. Epub 2019 Mar 14.


[Data-driven integrated diagnostics: the natural evolution of clinical chemistry?]

van Solinge WW, Ten Berg MJ, Haitjema S.

Ned Tijdschr Geneeskd. 2019 Feb 28;163. pii: D3512. Dutch.


A single preoperative blood test predicts postoperative sepsis and pneumonia after coronary bypass or open aneurysm surgery.

van Koeverden ID, den Ruijter HM, Scholtes VPW, G E H Lam M, Haitjema S, Buijsrogge MP, J L Suyker W, van Wijk RH, de Groot MCH, van Herwaarden JA, van Solinge WW, de Borst GJ, Pasterkamp G, Hoefer IE.

Eur J Clin Invest. 2019 Mar;49(3):e13055. doi: 10.1111/eci.13055. Epub 2019 Jan 4.


Routinely measured hematological parameters and prediction of recurrent vascular events in patients with clinically manifest vascular disease.

Kofink D, Muller SA, Patel RS, Dorresteijn JAN, Berkelmans GFN, de Groot MCH, van Solinge WW, Haitjema S, Leiner T, Visseren FLJ, Hoefer IE, Asselbergs FW; SMART Study Group.

PLoS One. 2018 Sep 7;13(9):e0202682. doi: 10.1371/journal.pone.0202682. eCollection 2018.


A Multicenter Before-After Study on Reducing Unnecessary Diagnostics by Changing the Attitude of Caregivers: Protocol for the RODEO Project.

Bindraban RS, van Beneden ML, Kramer MH, van Solinge WW, Neppelenbroek SI, van Wijnen M, Griffioen-Keijzer A, Al-Dulaimy M, Ten Berg MJ, Nanayakkara PW.

JMIR Res Protoc. 2018 Aug 21;7(8):e10473. doi: 10.2196/10473.


An increase in myeloid cells after severe injury is associated with normal fracture healing: a retrospective study of 62 patients with a femoral fracture.

Hesselink L, Bastian OW, Heeres M, Ten Berg M, Huisman A, Hoefer IE, van Solinge WW, Koenderman L, van Wessem KJP, Leenen LPH, Hietbrink F.

Acta Orthop. 2018 Oct;89(5):585-590. doi: 10.1080/17453674.2018.1501974. Epub 2018 Aug 6.


Commonly available hematological biomarkers are associated with the extent of coronary calcifications.

den Harder AM, de Jong PA, de Groot MCH, Wolterink JM, Budde RPJ, Iŝgum I, van Solinge WW, Ten Berg MJ, Lutgens E, Veldhuis WB, Haitjema S, Hoefer IE, Leiner T.

Atherosclerosis. 2018 Aug;275:166-173. doi: 10.1016/j.atherosclerosis.2018.06.017. Epub 2018 Jun 12.


Squeezing for Life - Properties of Red Blood Cell Deformability.

Huisjes R, Bogdanova A, van Solinge WW, Schiffelers RM, Kaestner L, van Wijk R.

Front Physiol. 2018 Jun 1;9:656. doi: 10.3389/fphys.2018.00656. eCollection 2018. Review.


A Rise in Neutrophil Cell Size Precedes Organ Dysfunction After Trauma.

Hesselink L, Heeres M, Paraschiakos F, Ten Berg M, Huisman A, Hoefer IE, de Groot MCH, van Solinge WW, Dijkgraaf M, Hellebrekers P, Van Wessem KJP, Koenderman L, Leenen LPH, Hietbrink F.

Shock. 2019 Apr;51(4):439-446. doi: 10.1097/SHK.0000000000001200.


eHealth as the Next-Generation Perinatal Care: An Overview of the Literature.

van den Heuvel JF, Groenhof TK, Veerbeek JH, van Solinge WW, Lely AT, Franx A, Bekker MN.

J Med Internet Res. 2018 Jun 5;20(6):e202. doi: 10.2196/jmir.9262. Review.


Reducing Test Utilization in Hospital Settings: A Narrative Review.

Bindraban RS, Ten Berg MJ, Naaktgeboren CA, Kramer MHH, Van Solinge WW, Nanayakkara PWB.

Ann Lab Med. 2018 Sep;38(5):402-412. doi: 10.3343/alm.2018.38.5.402. Review.


Quantitative measurement of red cell surface protein expression reveals new biomarkers for hereditary spherocytosis.

Huisjes R, Satchwell TJ, Verhagen LP, Schiffelers RM, van Solinge WW, Toye AM, van Wijk R.

Int J Lab Hematol. 2018 Aug;40(4):e74-e77. doi: 10.1111/ijlh.12841. Epub 2018 May 10. No abstract available.


Development of a nomogram for the estimation of long-term adherence to clozapine therapy using neutrophil fluorescence.

Man WH, Pérez-Pitarch A, Wilting I, Heerdink ER, van Solinge WW, Egberts ACG, Huitema ADR.

Br J Clin Pharmacol. 2018 Jun;84(6):1228-1237. doi: 10.1111/bcp.13546. Epub 2018 Apr 2.


Exploring the value of routinely measured hematology parameters for identification of elderly patients at high risk of death at the Emergency Department.

Bindraban RS, Ten Berg MJ, Haitjema S, Hoefer IE, de Regt M, Kramer M, van Solinge WW, Nanayakkara P, Naaktgeboren CA.

Acute Med. 2018;17(4):188-202.


Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography.

Gijsberts CM, den Ruijter HM, de Kleijn DPV, Huisman A, Ten Berg M, de Groot M, van Wijk RHA, Asselbergs FW, Voskuil M, Pasterkamp G, van Solinge WW, Hoefer IE.

Angiology. 2018 Aug;69(7):600-608. doi: 10.1177/0003319717743679. Epub 2017 Dec 4.


Digital microscopy as a screening tool for the diagnosis of hereditary hemolytic anemia.

Huisjes R, van Solinge WW, Levin MD, van Wijk R, Riedl JA.

Int J Lab Hematol. 2018 Apr;40(2):159-168. doi: 10.1111/ijlh.12758. Epub 2017 Nov 1.


Effect of Monocyte-to-Lymphocyte Ratio on Heart Failure Characteristics and Hospitalizations in a Coronary Angiography Cohort.

Gijsberts CM, Ellenbroek GHJM, Ten Berg MJ, Huisman A, van Solinge WW, Lam CS, Asselbergs FW, den Ruijter HM, Pasterkamp G, Hoefer IE, de Kleijn DP.

Am J Cardiol. 2017 Sep 15;120(6):911-916. doi: 10.1016/j.amjcard.2017.06.020. Epub 2017 Jun 29.


New mAb therapies in multiple myeloma: interference with blood transfusion compatibility testing.

De Vooght KM, Oostendorp M, van Solinge WW.

Curr Opin Hematol. 2016 Nov;23(6):557-562. Review.


The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction.

van Hout GP, Bosch L, Ellenbroek GH, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SC, Robertson AA, Pasterkamp G, Hoefer IE.

Eur Heart J. 2017 Mar 14;38(11):828-836. doi: 10.1093/eurheartj/ehw247.


Proteomics reveals reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients.

Barasa BA, van Oirschot BA, Bianchi P, van Solinge WW, Heck AJ, van Wijk R, Slijper M.

Proteomics Clin Appl. 2016 Aug;10(8):859-69. doi: 10.1002/prca.201500130.


Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma.

Bastian OW, Kuijer A, Koenderman L, Stellato RK, van Solinge WW, Leenen LP, Blokhuis TJ.

J Inflamm Res. 2016 May 18;9:69-78. doi: 10.2147/JIR.S101064. eCollection 2016.


Patient monitoring: the hidden costs of treatment with antipsychotics.

Nederlof M, Frederix GW, Stoker LJ, van Solinge WW, Egberts TC, Heerdink ER.

Br J Clin Pharmacol. 2016 Aug;82(2):570-2. doi: 10.1111/bcp.12982. Epub 2016 May 31. No abstract available.


Cetuximab treatment alters the content of extracellular vesicles released from tumor cells.

van Dommelen SM, van der Meel R, van Solinge WW, Coimbra M, Vader P, Schiffelers RM.

Nanomedicine (Lond). 2016 Apr;11(8):881-90. doi: 10.2217/nnm-2015-0009. Epub 2016 Mar 16.


Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting.

Kooijmans SA, Aleza CG, Roffler SR, van Solinge WW, Vader P, Schiffelers RM.

J Extracell Vesicles. 2016 Mar 14;5:31053. doi: 10.3402/jev.v5.31053. eCollection 2016.


Dealing with anti-CD38 (daratumumab) interference in blood compatibility testing.

De Vooght KM, Oostendorp M, van Solinge WW.

Transfusion. 2016 Mar;56(3):778-9. doi: 10.1111/trf.13474. No abstract available.


Routinely analyzed leukocyte characteristics improve prediction of mortality after coronary angiography.

Gijsberts CM, Ellenbroek GH, Ten Berg MJ, Huisman A, van Solinge WW, Asselbergs FW, den Ruijter HM, Pasterkamp G, de Kleijn DP, Hoefer IE.

Eur J Prev Cardiol. 2016 Jul;23(11):1211-20. doi: 10.1177/2047487315621832. Epub 2015 Dec 7.


Hematological Parameters Improve Prediction of Mortality and Secondary Adverse Events in Coronary Angiography Patients: A Longitudinal Cohort Study.

Gijsberts CM, den Ruijter HM, de Kleijn DP, Huisman A, ten Berg MJ, van Wijk RH, Asselbergs FW, Voskuil M, Pasterkamp G, van Solinge WW, Hoefer IE.

Medicine (Baltimore). 2015 Nov;94(45):e1992. doi: 10.1097/MD.0000000000001992.


Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models.

van Hout GP, Jansen of Lorkeers SJ, Wever KE, Sena ES, Kouwenberg LH, van Solinge WW, Macleod MR, Doevendans PA, Pasterkamp G, Chamuleau SA, Hoefer IE.

Cardiovasc Res. 2016 Feb 1;109(2):240-8. doi: 10.1093/cvr/cvv239. Epub 2015 Oct 20.


Elevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction.

van Hout GP, van Solinge WW, Gijsberts CM, Teuben MP, Leliefeld PH, Heeres M, Nijhoff F, de Jong S, Bosch L, de Jager SC, Huisman A, Stella PR, Pasterkamp G, Koenderman LJ, Hoefer IE.

Basic Res Cardiol. 2015 Nov;110(6):58. doi: 10.1007/s00395-015-0513-6. Epub 2015 Oct 14.


Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-line de novo mutation.

Mañú-Pereira Mdel M, Gonzalez-Roca E, van Solinge WW, Llaudet-Planas E, Sevilla J, Montllor L, Mensa-Vilaro A, Ploos van Amstel HK, van Wijk R, Vives-Corrons J.

Am J Hematol. 2015 Dec;90(12):E217-9. doi: 10.1002/ajh.24178. Epub 2015 Nov 17. No abstract available.


Invasive surgery reduces infarct size and preserves cardiac function in a porcine model of myocardial infarction.

van Hout GP, Teuben MP, Heeres M, de Maat S, de Jong R, Maas C, Kouwenberg LH, Koenderman L, van Solinge WW, de Jager SC, Pasterkamp G, Hoefer IE.

J Cell Mol Med. 2015 Nov;19(11):2655-63. doi: 10.1111/jcmm.12656. Epub 2015 Aug 18.


Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis: Indications for Distinct Functional Roles of von Hippel-Lindau Tumor Suppressor Isoforms.

Bartels M, van der Zalm MM, van Oirschot BA, Lee FS, Giles RH, Kruip MJ, Gitz-Francois JJ, Van Solinge WW, Bierings M, van Wijk R.

Hum Mutat. 2015 Nov;36(11):1039-42. doi: 10.1002/humu.22846. Epub 2015 Aug 17.


Validity of diagnostic codes and laboratory measurements to identify patients with idiopathic acute liver injury in a hospital database.

Udo R, Maitland-van der Zee AH, Egberts TC, den Breeijen JH, Leufkens HG, van Solinge WW, De Bruin ML.

Pharmacoepidemiol Drug Saf. 2016 Mar;25 Suppl 1:21-8. doi: 10.1002/pds.3824. Epub 2015 Jul 5.


Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients.

Uijtendaal EV, Zwart-van Rijkom JE, de Lange DW, Lalmohamed A, van Solinge WW, Egberts TC.

Crit Care. 2015 Jun 22;19:270. doi: 10.1186/s13054-015-0959-9.


Adherence with Dosing Guideline in Patients with Impaired Renal Function at Hospital Discharge.

Drenth-van Maanen AC, van Marum RJ, Jansen PA, Zwart JE, van Solinge WW, Egberts TC.

PLoS One. 2015 Jun 8;10(6):e0128237. doi: 10.1371/journal.pone.0128237. eCollection 2015.


When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy.

Oostendorp M, Lammerts van Bueren JJ, Doshi P, Khan I, Ahmadi T, Parren PW, van Solinge WW, De Vooght KM.

Transfusion. 2015 Jun;55(6 Pt 2):1555-62. doi: 10.1111/trf.13150. Epub 2015 May 18.


Genome-wide association study of lymphoblast cell viability after clozapine exposure.

de With SA, Pulit SL, Wang T, Staal WG, van Solinge WW, de Bakker PI, Ophoff RA.

Am J Med Genet B Neuropsychiatr Genet. 2015 Mar;168B(2):116-22. doi: 10.1002/ajmg.b.32287. Epub 2015 Feb 5.


Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 deficiency in a family with hereditary spherocytosis.

van Zwieten R, van Oirschot BA, Veldthuis M, Dobbe JG, Streekstra GJ, van Solinge WW, Schutgens RE, van Wijk R.

Am J Hematol. 2015 Mar;90(3):E35-9. doi: 10.1002/ajh.23899. Epub 2014 Nov 24.


Extracellular vesicles as drug delivery systems: lessons from the liposome field.

van der Meel R, Fens MH, Vader P, van Solinge WW, Eniola-Adefeso O, Schiffelers RM.

J Control Release. 2014 Dec 10;195:72-85. doi: 10.1016/j.jconrel.2014.07.049. Epub 2014 Aug 2. Review.


Falsely elevated point-of-care hematocrit and calculated hemoglobin concentration due to extreme leukocytosis.

de Vooght KM, Groenendaal F, Bierings MB, van Solinge WW, Huisman A.

Ann Hematol. 2014 Nov;93(11):1949-50. doi: 10.1007/s00277-014-2092-2. Epub 2014 May 1. No abstract available.


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