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N-cadherin stabilises neural identity by dampening anti-neural signals.

Punovuori K, Migueles RP, Malaguti M, Blin G, Macleod KG, Carragher NO, Pieters T, van Roy F, Stemmler MP, Lowell S.

Development. 2019 Nov 8;146(21). pii: dev183269. doi: 10.1242/dev.183269.


A new mouse model to study the role of ectopic Nanos3 expression in cancer.

Andries V, De Keuckelaere E, Staes K, Hochepied T, Taminau J, Lemeire K, Birembaut P, Berx G, van Roy F.

BMC Cancer. 2019 Jun 17;19(1):598. doi: 10.1186/s12885-019-5807-x.


Armc8 is an evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions.

Gul IS, Hulpiau P, Sanders E, van Roy F, van Hengel J.

Biosci Rep. 2019 Aug 2;39(8). pii: BSR20180604. doi: 10.1042/BSR20180604. Print 2019 Aug 30.


Changing the name of the NBPF/DUF1220 domain to the Olduvai domain.

Sikela JM, van Roy F.

Version 2. F1000Res. 2017 Dec 28 [revised 2018 Jan 1];6:2185. doi: 10.12688/f1000research.13586.2. eCollection 2017.


Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.

Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, Gul IS, Sundararaman S, Gonçalves A, Dhondt I, Pinzón JH, Braeckman BP, Technau U, Saeys Y, van Roy F, Beyaert R.

Front Immunol. 2018 May 24;9:1136. doi: 10.3389/fimmu.2018.01136. eCollection 2018.


GC Content of Early Metazoan Genes and Its Impact on Gene Expression Levels in Mammalian Cell Lines.

Gul IS, Staal J, Hulpiau P, De Keuckelaere E, Kamm K, Deroo T, Sanders E, Staes K, Driege Y, Saeys Y, Beyaert R, Technau U, Schierwater B, van Roy F.

Genome Biol Evol. 2018 Mar 1;10(3):909-917. doi: 10.1093/gbe/evy040.


Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy.

Vanslembrouck B, Kremer A, Pavie B, van Roy F, Lippens S, van Hengel J.

Histochem Cell Biol. 2018 May;149(5):479-490. doi: 10.1007/s00418-018-1657-x. Epub 2018 Mar 5.


Nanos genes and their role in development and beyond.

De Keuckelaere E, Hulpiau P, Saeys Y, Berx G, van Roy F.

Cell Mol Life Sci. 2018 Jun;75(11):1929-1946. doi: 10.1007/s00018-018-2766-3. Epub 2018 Feb 3. Review.


Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange.

Pieters T, Haenebalcke L, Bruneel K, Vandamme N, Hochepied T, van Hengel J, Wirth D, Berx G, Haigh JJ, van Roy F, Goossens S.

J Vis Exp. 2017 Apr 27;(122). doi: 10.3791/55575.


Evolution and diversity of cadherins and catenins.

Gul IS, Hulpiau P, Saeys Y, van Roy F.

Exp Cell Res. 2017 Sep 1;358(1):3-9. doi: 10.1016/j.yexcr.2017.03.001. Epub 2017 Mar 6. Review.


Inactivation of p120 catenin in mice disturbs intrahepatic bile duct development and aggravates liver carcinogenesis.

van Hengel J, Van den Broeke C, Pieters T, Libbrecht L, Hofmann I, van Roy F.

Eur J Cell Biol. 2016 Dec;95(12):574-584. doi: 10.1016/j.ejcb.2016.10.003. Epub 2016 Oct 15.


Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma.

Faura Tellez G, Willemse BW, Brouwer U, Nijboer-Brinksma S, Vandepoele K, Noordhoek JA, Heijink I, de Vries M, Smithers NP, Postma DS, Timens W, Wiffen L, van Roy F, Holloway JW, Lackie PM, Nawijn MC, Koppelman GH.

PLoS One. 2016 Oct 4;11(10):e0163967. doi: 10.1371/journal.pone.0163967. eCollection 2016.


p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.

Pieters T, Goossens S, Haenebalcke L, Andries V, Stryjewska A, De Rycke R, Lemeire K, Hochepied T, Huylebroeck D, Berx G, Stemmler MP, Wirth D, Haigh JJ, van Hengel J, van Roy F.

PLoS Genet. 2016 Aug 24;12(8):e1006243. doi: 10.1371/journal.pgen.1006243. eCollection 2016 Aug.


Metazoan evolution of the armadillo repeat superfamily.

Gul IS, Hulpiau P, Saeys Y, van Roy F.

Cell Mol Life Sci. 2017 Feb;74(3):525-541. doi: 10.1007/s00018-016-2319-6. Epub 2016 Aug 6.


αT-catenin in restricted brain cell types and its potential connection to autism.

Folmsbee SS, Wilcox DR, Tyberghein K, De Bleser P, Tourtellotte WG, van Hengel J, van Roy F, Gottardi CJ.

J Mol Psychiatry. 2016 Jun 21;4:2. doi: 10.1186/s40303-016-0017-9. eCollection 2016.


Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.

Davison A, McDowell GS, Holden JM, Johnson HF, Koutsovoulos GD, Liu MM, Hulpiau P, Van Roy F, Wade CM, Banerjee R, Yang F, Chiba S, Davey JW, Jackson DJ, Levin M, Blaxter ML.

Curr Biol. 2016 Mar 7;26(5):654-60. doi: 10.1016/j.cub.2015.12.071. Epub 2016 Feb 25.


Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription.

Faura Tellez G, Vandepoele K, Brouwer U, Koning H, Elderman RM, Hackett TL, Willemse BW, Holloway J, Van Roy F, Koppelman GH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 1;309(7):L725-35. doi: 10.1152/ajplung.00346.2014. Epub 2015 Jul 24.


Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice.

Sklyarova T, van Hengel J, Van Wonterghem E, Libert C, van Roy F, Vandenbroucke RE.

Eur J Immunol. 2015 Oct;45(10):2898-910. doi: 10.1002/eji.201445440. Epub 2015 Aug 6.


TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis.

Van Nieuwenhuysen T, Naert T, Tran HT, Van Imschoot G, Geurs S, Sanders E, Creytens D, Van Roy F, Vleminckx K.

Oncoscience. 2015 May 19;2(5):555-66. eCollection 2015.


NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest.

Andries V, Vandepoele K, Staes K, Berx G, Bogaert P, Van Isterdael G, Ginneberge D, Parthoens E, Vandenbussche J, Gevaert K, van Roy F.

BMC Cancer. 2015 May 10;15:391. doi: 10.1186/s12885-015-1408-5.


The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition.

Grelet S, Andries V, Polette M, Gilles C, Staes K, Martin AP, Kileztky C, Terryn C, Dalstein V, Cheng CW, Shen CY, Birembaut P, Van Roy F, Nawrocki-Raby B.

J Pathol. 2015 Sep;237(1):25-37. doi: 10.1002/path.4549. Epub 2015 May 12.


Intercalated discs and arrhythmogenic cardiomyopathy.

Rampazzo A, Calore M, van Hengel J, van Roy F.

Circ Cardiovasc Genet. 2014 Dec;7(6):930-40. doi: 10.1161/CIRCGENETICS.114.000645. No abstract available.


The cardiac protein αT-catenin contributes to chemical-induced asthma.

Folmsbee SS, Morales-Nebreda L, Van Hengel J, Tyberghein K, Van Roy F, Budinger GR, Bryce PJ, Gottardi CJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L253-8. doi: 10.1152/ajplung.00331.2014. Epub 2014 Dec 5.


Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity.

Li J, Gao E, Vite A, Yi R, Gomez L, Goossens S, van Roy F, Radice GL.

Circ Res. 2015 Jan 2;116(1):70-9. doi: 10.1161/CIRCRESAHA.116.304472. Epub 2014 Oct 10.


Role of cell-cell adhesion complexes in embryonic stem cell biology.

Pieters T, van Roy F.

J Cell Sci. 2014 Jun 15;127(Pt 12):2603-13. doi: 10.1242/jcs.146720. Review.


Beyond E-cadherin: roles of other cadherin superfamily members in cancer.

van Roy F.

Nat Rev Cancer. 2014 Feb;14(2):121-34. doi: 10.1038/nrc3647. Epub 2014 Jan 20. Review.


PhysBinder: Improving the prediction of transcription factor binding sites by flexible inclusion of biophysical properties.

Broos S, Soete A, Hooghe B, Moran R, van Roy F, De Bleser P.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W531-4. doi: 10.1093/nar/gkt288. Epub 2013 Apr 24.


Molecular biology of cadherins. Preface.

van Roy F.

Prog Mol Biol Transl Sci. 2013;116:xv-xviii. doi: 10.1016/B978-0-12-394311-8.10000-7. No abstract available.


Delta-protocadherins in health and disease.

Kahr I, Vandepoele K, van Roy F.

Prog Mol Biol Transl Sci. 2013;116:169-92. doi: 10.1016/B978-0-12-394311-8.00008-X. Review.


New insights into the evolution of metazoan cadherins and catenins.

Hulpiau P, Gul IS, van Roy F.

Prog Mol Biol Transl Sci. 2013;116:71-94. doi: 10.1016/B978-0-12-394311-8.00004-2. Review.


N-cadherin is required for cytodifferentiation during zebrafish odontogenesis.

Verstraeten B, van Hengel J, Sanders E, Van Roy F, Huysseune A.

J Dent Res. 2013 Apr;92(4):365-70. doi: 10.1177/0022034513477424. Epub 2013 Feb 8.


Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.

van Hengel J, Calore M, Bauce B, Dazzo E, Mazzotti E, De Bortoli M, Lorenzon A, Li Mura IE, Beffagna G, Rigato I, Vleeschouwers M, Tyberghein K, Hulpiau P, van Hamme E, Zaglia T, Corrado D, Basso C, Thiene G, Daliento L, Nava A, van Roy F, Rampazzo A.

Eur Heart J. 2013 Jan;34(3):201-10. doi: 10.1093/eurheartj/ehs373. Epub 2012 Nov 7.


Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells.

Tian H, Sanders E, Reynolds A, van Roy F, van Hengel J.

Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5139-53. doi: 10.1167/iovs.12-9472.


Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle.

Oh HJ, Abraham LS, van Hengel J, Stove C, Proszynski TJ, Gevaert K, DiMario JX, Sanes JR, van Roy F, Kim H.

J Biol Chem. 2012 Jun 22;287(26):21717-28. doi: 10.1074/jbc.M112.369496. Epub 2012 May 10.


Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice.

Tyberghein K, Goossens S, Haigh JJ, van Roy F, van Hengel J.

Placenta. 2012 Jul;33(7):554-60. doi: 10.1016/j.placenta.2012.04.002. Epub 2012 Apr 23.


A flexible integrative approach based on random forest improves prediction of transcription factor binding sites.

Hooghe B, Broos S, van Roy F, De Bleser P.

Nucleic Acids Res. 2012 Aug;40(14):e106. doi: 10.1093/nar/gks283. Epub 2012 Apr 5.


Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.

Li J, Goossens S, van Hengel J, Gao E, Cheng L, Tyberghein K, Shang X, De Rycke R, van Roy F, Radice GL.

J Cell Sci. 2012 Feb 15;125(Pt 4):1058-67. doi: 10.1242/jcs.098640. Epub 2012 Mar 15.


Evolutionary functional analysis and molecular regulation of the ZEB transcription factors.

Gheldof A, Hulpiau P, van Roy F, De Craene B, Berx G.

Cell Mol Life Sci. 2012 Aug;69(15):2527-41. doi: 10.1007/s00018-012-0935-3. Epub 2012 Feb 21. Review.


Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling.

Pieters T, van Roy F, van Hengel J.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1669-94. Review.


Functions of p120ctn in development and disease.

Pieters T, van Hengel J, van Roy F.

Front Biosci (Landmark Ed). 2012 Jan 1;17:760-83. Review.


ARVCF depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus.

Tran HT, Delvaeye M, Verschuere V, Descamps E, Crabbe E, Van Hoorebeke L, McCrea P, Adriaens D, Van Roy F, Vleminckx K.

Dev Dyn. 2011 Dec;240(12):2680-7. doi: 10.1002/dvdy.22765. Epub 2011 Oct 25.


Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells.

Pieters T, Haenebalcke L, Hochepied T, D'Hont J, Haigh JJ, van Roy F, van Hengel J.

Stem Cell Rev Rep. 2012 Sep;8(3):768-78. doi: 10.1007/s12015-011-9323-x.


ConTra v2: a tool to identify transcription factor binding sites across species, update 2011.

Broos S, Hulpiau P, Galle J, Hooghe B, Van Roy F, De Bleser P.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W74-8. doi: 10.1093/nar/gkr355. Epub 2011 May 16.


Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus.

Janssens S, Denayer T, Deroo T, Van Roy F, Vleminckx K.

Int J Dev Biol. 2010;54(10):1435-42. doi: 10.1387/ijdb.092985sj.


Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.

Willemarck N, Rysman E, Brusselmans K, Van Imschoot G, Vanderhoydonc F, Moerloose K, Lerut E, Verhoeven G, van Roy F, Vleminckx K, Swinnen JV.

Cancer Res. 2010 Nov 15;70(22):9453-62. doi: 10.1158/0008-5472.CAN-10-2324. Epub 2010 Oct 1.


New insights into the evolution of metazoan cadherins.

Hulpiau P, van Roy F.

Mol Biol Evol. 2011 Jan;28(1):647-57. doi: 10.1093/molbev/msq233. Epub 2010 Sep 3.


Involvement of members of the cadherin superfamily in cancer.

Berx G, van Roy F.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a003129. doi: 10.1101/cshperspect.a003129. Epub 2009 Sep 23. Review.


Serum plakophilin-3 autoreactivity in paraneoplastic pemphigus.

Lambert J, Bracke S, van Roy F, Pas HH, Bonné S, De Schepper S.

Br J Dermatol. 2010 Sep;163(3):630-2. doi: 10.1111/j.1365-2133.2010.09845.x.


The transcriptional repressor Kaiso localizes at the mitotic spindle and is a constituent of the pericentriolar material.

Soubry A, Staes K, Parthoens E, Noppen S, Stove C, Bogaert P, van Hengel J, van Roy F.

PLoS One. 2010 Feb 15;5(2):e9203. doi: 10.1371/journal.pone.0009203.


Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.

Vandepoele K, Staes K, Andries V, van Roy F.

Exp Cell Res. 2010 Apr 15;316(7):1225-33. doi: 10.1016/j.yexcr.2010.01.019. Epub 2010 Jan 21.


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