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Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae.

Meyer Sauteur PM, de Bruijn ACJM, Graça C, Tio-Gillen AP, Estevão SC, Hoogenboezem T, Hendriks RW, Berger C, Jacobs BC, van Rossum AMC, Huizinga R, Unger WWJ.

Infect Immun. 2019 Jan 24;87(2). pii: e00663-18. doi: 10.1128/IAI.00663-18. Print 2019 Feb.


Priority Needs for Conducting Pandemic-Relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-Researchers.

Gal M, Gobat N, Francis NA, Hood K, Butler CC, Bielicki J, Fraaij PL, Sharland M, Jarvis J, van Rossum AMC, Heikkinen T, Martinon-Torres F, Herberg J, Watkins A, Webb SAR, Moore R, Sukumar P, Nichol A.

Pediatr Infect Dis J. 2018 Sep 25. doi: 10.1097/INF.0000000000002204. [Epub ahead of print]


The Art and Science of Diagnosing Mycoplasma pneumoniae Infection.

Meyer Sauteur PM, Unger WWJ, van Rossum AMC, Berger C.

Pediatr Infect Dis J. 2018 Nov;37(11):1192-1195. doi: 10.1097/INF.0000000000002171. No abstract available.


Perspectives of adolescents on decision making about participation in a biobank study: a pilot study.

Grootens-Wiegers P, Visser EG, van Rossum AMC, van Waardhuizen CN, de Wildt SN, Sweep B, van den Broek JM, de Vries MC.

BMJ Paediatr Open. 2017 Aug 23;1(1):e000111. doi: 10.1136/bmjpo-2017-000111. eCollection 2017.


Pharmacokinetics, Short-term Safety and Efficacy of the Approved Once-daily Darunavir/Ritonavir Dosing Regimen in HIV-infected Children.

Bastiaans DET, Geelen SPM, Visser EG, van der Flier M, Vermont CL, Colbers APH, Roukens M, Burger DM, van Rossum AMC; Dutch Paediatric HIV Study Group.

Pediatr Infect Dis J. 2018 Oct;37(10):1008-1010. doi: 10.1097/INF.0000000000001964.


Characterization of the nasopharyngeal and middle ear microbiota in gastroesophageal reflux-prone versus gastroesophageal reflux non-prone children.

Boers SA, de Zeeuw M, Jansen R, van der Schroeff MP, van Rossum AMC, Hays JP, Verhaegh SJC.

Eur J Clin Microbiol Infect Dis. 2018 May;37(5):851-857. doi: 10.1007/s10096-017-3178-2. Epub 2018 Feb 5.


Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae.

Meyer Sauteur PM, Huizinga R, Tio-Gillen AP, Drenthen J, Unger WWJ, Jacobs E, van Rossum AMC, Jacobs BC.

J Neuroimmunol. 2018 Jan 15;314:13-16. doi: 10.1016/j.jneuroim.2017.11.011. Epub 2017 Nov 16.


Antibody responses to GalC in severe and complicated childhood Guillain-Barré syndrome.

Meyer Sauteur PM, Huizinga R, Tio-Gillen AP, de Wit MY, Unger WWJ, Berger C, van Rossum AMC, Jacobs BC.

J Peripher Nerv Syst. 2018 Mar;23(1):67-69. doi: 10.1111/jns.12243. No abstract available.


The Role of B Cells in Carriage and Clearance of Mycoplasma pneumoniae From the Respiratory Tract of Mice.

Meyer Sauteur PM, de Groot RCA, Estevão SC, Hoogenboezem T, de Bruijn ACJM, Sluijter M, de Bruijn MJW, De Kleer IM, van Haperen R, van den Brand JMA, Bogaert D, Fraaij PLA, Vink C, Hendriks RW, Samsom JN, Unger WWJ, van Rossum AMC.

J Infect Dis. 2018 Jan 4;217(2):298-309. doi: 10.1093/infdis/jix559.


Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns).

Stocker M, van Herk W, El Helou S, Dutta S, Fontana MS, Schuerman FABA, van den Tooren-de Groot RK, Wieringa JW, Janota J, van der Meer-Kappelle LH, Moonen R, Sie SD, de Vries E, Donker AE, Zimmerman U, Schlapbach LJ, de Mol AC, Hoffman-Haringsma A, Roy M, Tomaske M, Kornelisse RF, van Gijsel J, Visser EG, Willemsen SP, van Rossum AMC; NeoPInS Study Group.

Lancet. 2017 Aug 26;390(10097):871-881. doi: 10.1016/S0140-6736(17)31444-7. Epub 2017 Jul 12.


Things that could be Mycoplasma pneumoniae.

de Groot RCA, Meyer Sauteur PM, Unger WWJ, van Rossum AMC.

J Infect. 2017 Jun;74 Suppl 1:S95-S100. doi: 10.1016/S0163-4453(17)30198-6. Review.


Sustained Viral Suppression in HIV-infected Children on Once-daily Lopinavir/Ritonavir in Clinical Practice.

Gondrie IPE, Bastiaans DET, Fraaij PLA, Driessen GJA, van der Knaap LC, Visser EG, van Jaarsveld P, de Groot R, Hartwig NG, Burger DM, van Rossum AMC.

Pediatr Infect Dis J. 2017 Oct;36(10):976-980. doi: 10.1097/INF.0000000000001627.


Multi-center evaluation of one commercial and 12 in-house real-time PCR assays for detection of Mycoplasma pneumoniae.

Dumke R, Benitez AJ, Chalker V, Gullsby K, Henrich B, Hidalgo-Grass C, Hoogenboezem T, Kese D, Loens K, Maaskant J, Michael-Gayego A, Moses AE, Nir-Paz R, Pas SD, Pereyre S, Petersen RF, Rosenblatt M, van Rossum AMC, Uldum SA, Unger WWJ, Ursi D, Winchell JM, Bebear C; ESCMID Study Group for Mycoplasma Infections.

Diagn Microbiol Infect Dis. 2017 Jun;88(2):111-114. doi: 10.1016/j.diagmicrobio.2017.03.004. Epub 2017 Mar 8.


Dose evaluation of lamivudine in human immunodeficiency virus-infected children aged 5 months to 18 years based on a population pharmacokinetic analysis.

Janssen EJH, Bastiaans DET, Välitalo PAJ, van Rossum AMC, Jacqz-Aigrain E, Lyall H, Knibbe CAJ, Burger DM.

Br J Clin Pharmacol. 2017 Jun;83(6):1287-1297. doi: 10.1111/bcp.13227. Epub 2017 Feb 14.


Comparison of Mycoplasma pneumoniae Genome Sequences from Strains Isolated from Symptomatic and Asymptomatic Patients.

Spuesens EB, Brouwer RW, Mol KH, Hoogenboezem T, Kockx CE, Jansen R, Van IJcken WF, Van Rossum AM, Vink C.

Front Microbiol. 2016 Oct 27;7:1701. eCollection 2016.


Improved labelling of antiretrovirals for paediatric use.

Burger DM, van Rossum AM.

Lancet HIV. 2016 Dec;3(12):e550-e551. doi: 10.1016/S2352-3018(16)30175-8. Epub 2016 Oct 17. No abstract available.


Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study.

Meyer Sauteur PM, Huizinga R, Tio-Gillen AP, Roodbol J, Hoogenboezem T, Jacobs E, van Rijn M, van der Eijk AA, Vink C, de Wit MC, van Rossum AM, Jacobs BC.

Ann Neurol. 2016 Oct;80(4):566-80. doi: 10.1002/ana.24755. Epub 2016 Aug 26.


Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care.

Weijsenfeld AM, Smit C, Cohen S, Wit FWNM, Mutschelknauss M, van der Knaap LC, van Zonneveld LM, Zomer BJ, Nauta N, Patist JC, Kuipers-Jansen MHJ, Smit EP, Blokhuis C, Pajkrt D; Dutch HIV Adolescents and Young Adults (AYA) Study Group, Weijsenfeld AM, Cohen S, Blokhuis C, van der Plas A, Scherpbier HJ, Mutschelknauss M, Nellen FJB, Prins JM, Pajkrt D, Smit C, Wit FWNM, Reiss P, van der Knaap L, Visser E, van Zonneveld LM, Vriesde ME, Bassant NY, van der Ende ME, van Rossum AMC, Driessen GJA, Fraaij PLA, Smit JV, Smit EP, Kastelijns MPW, den Hollander JG, Pogány K, Moons C, Kroon FP, Oude Geerdink E, van der Meche IB, Schouten WEM, Brinkman K, Ter Beest G, Gisolf EH, Richter C, Zomer BJ, Strik-Albers R, van der Flier M, Henriet SS, Koopmans PP, Patist JC, Nauta N, Geelen SPM, Wolfs TFW, Hoepelman IM, Mudrikova T, van der Meulen PA, de Jonge H, Scholvink EH, Bierman WFW, van den Berg JF, Bouwhuis JW, Faber S, van Vonderen M, Schippers JA, Lowe SH, Kuipers-Jansen MHJ, van Kasteren MEE, Brouwer AE, Pronk DC, Kortmann W.

Clin Infect Dis. 2016 Oct 15;63(8):1105-1112. doi: 10.1093/cid/ciw487. Epub 2016 Jul 20.


Recognising early onset neonatal sepsis: an essential step in appropriate antimicrobial use.

van Herk W, Stocker M, van Rossum AM.

J Infect. 2016 Jul 5;72 Suppl:S77-82. doi: 10.1016/j.jinf.2016.04.026. Epub 2016 May 21.


Infection with and Carriage of Mycoplasma pneumoniae in Children.

Meyer Sauteur PM, Unger WW, Nadal D, Berger C, Vink C, van Rossum AM.

Front Microbiol. 2016 Mar 23;7:329. doi: 10.3389/fmicb.2016.00329. eCollection 2016. Review.


Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children.

Moesker FM, van Kampen JJ, van Rossum AM, de Hoog M, Koopmans MP, Osterhaus AD, Fraaij PL.

PLoS One. 2016 Mar 10;11(3):e0150776. doi: 10.1371/journal.pone.0150776. eCollection 2016.


Variation in Current Management of Term and Late-preterm Neonates at Risk for Early-onset Sepsis: An International Survey and Review of Guidelines.

van Herk W, el Helou S, Janota J, Hagmann C, Klingenberg C, Staub E, Giannoni E, Tissieres P, Schlapbach LJ, van Rossum AM, Pilgrim SB, Stocker M.

Pediatr Infect Dis J. 2016 May;35(5):494-500. doi: 10.1097/INF.0000000000001063.


Intrathecal Anti-GalC Antibodies in Bickerstaff Brain Stem Encephalitis.

Sauteur PM, Hackenberg A, Tio-Gillen AP, van Rossum AM, Berger C, Jacobs BC.

Neuropediatrics. 2015 Dec;46(6):428-30. doi: 10.1055/s-0035-1566730. Epub 2015 Nov 4. No abstract available.


Case report: an 11-year-old girl presenting with asymptomatic retinal vasculitis leading to diagnosis of HIV-1 infection.

Westland T, Kamphuis S, van Rossum AM, Rothova A.

AIDS. 2015 Sep 10;29(14):1901-2. doi: 10.1097/QAD.0000000000000818. No abstract available.


Persistent subclinical immune defects in HIV-1-infected children treated with antiretroviral therapy.

van den Heuvel D, Driessen GJ, Berkowska MA, van der Burg M, Langerak AW, Zhao D, Charif H, Hartwig NG, van Rossum AM, Fraaij PL, van Dongen JJ, van Zelm MC.

AIDS. 2015 Sep 10;29(14):1745-56. doi: 10.1097/QAD.0000000000000765.


Severe childhood Guillain-Barré syndrome associated with Mycoplasma pneumoniae infection: a case series.

Meyer Sauteur PM, Roodbol J, Hackenberg A, de Wit MC, Vink C, Berger C, Jacobs E, van Rossum AM, Jacobs BC.

J Peripher Nerv Syst. 2015 Jun;20(2):72-8. doi: 10.1111/jns.12121.


Human bocavirus infection as a cause of severe acute respiratory tract infection in children.

Moesker FM, van Kampen JJ, van der Eijk AA, van Rossum AM, de Hoog M, Schutten M, Smits SL, Bodewes R, Osterhaus AD, Fraaij PL.

Clin Microbiol Infect. 2015 Oct;21(10):964.e1-8. doi: 10.1016/j.cmi.2015.06.014. Epub 2015 Jun 19.


Country of birth does not influence long-term clinical, virologic, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan Africa.

Cohen S, van Bilsen WP, Smit C, Fraaij PL, Warris A, Kuijpers TW, Geelen SP, Wolfs TF, Scherpbier HJ, van Rossum AM, Pajkrt D.

J Acquir Immune Defic Syndr. 2015 Feb 1;68(2):178-85. doi: 10.1097/QAI.0000000000000431.


Mycoplasma pneumoniae infections--does treatment help?

Spuesens EB, Meyer Sauteur PM, Vink C, van Rossum AM.

J Infect. 2014 Nov;69 Suppl 1:S42-6. doi: 10.1016/j.jinf.2014.07.017. Epub 2014 Sep 26. Review.


Antibody responses to Mycoplasma pneumoniae: role in pathogenesis and diagnosis of encephalitis?

Meyer Sauteur PM, Jacobs BC, Spuesens EB, Jacobs E, Nadal D, Vink C, van Rossum AM.

PLoS Pathog. 2014 Jun 12;10(6):e1003983. doi: 10.1371/journal.ppat.1003983. eCollection 2014 Jun. No abstract available.


Mycoplasma pneumoniae in children: carriage, pathogenesis, and antibiotic resistance.

Meyer Sauteur PM, van Rossum AM, Vink C.

Curr Opin Infect Dis. 2014 Jun;27(3):220-7. doi: 10.1097/QCO.0000000000000063. Review.


Uncoupling of the apyrimidinic/apurinic endonucleolytic and 3'→5' exonucleolytic activities of the Nfo protein of Mycoplasma pneumoniae through mutation of specific amino acid residues.

Estevão S, van der Spek PE, van Rossum AM, Vink C.

Microbiology. 2014 Jun;160(Pt 6):1087-100. doi: 10.1099/mic.0.077578-0. Epub 2014 Apr 2.


Evidence for influenza virus CNS invasion along the olfactory route in an immunocompromised infant.

van Riel D, Leijten LM, Verdijk RM, GeurtsvanKessel C, van der Vries E, van Rossum AM, Osterhaus AD, Kuiken T.

J Infect Dis. 2014 Aug 1;210(3):419-23. doi: 10.1093/infdis/jiu097. Epub 2014 Feb 18.


Feeding problems in a lethargic infant (discussion and diagnosis).

Wieringa JW, Stok JJ, van Rossum AM, Filippini LH.

Acta Paediatr. 2014 Mar;103(3):343-4. doi: 10.1111/apa.12510. No abstract available.


Feeding problems in a lethargic infant (case presentation).

Wieringa JW, Stok JJ, van Rossum AM, Filippini LH.

Acta Paediatr. 2014 Mar;103(3):236-7. doi: 10.1111/apa.12508. No abstract available.


Functional analysis of the superfamily 1 DNA helicases encoded by Mycoplasma pneumoniae and Mycoplasma genitalium.

Estevão S, van der Heul HU, Sluijter M, Hoogenboezem T, Hartwig NG, van Rossum AM, Vink C.

PLoS One. 2013 Jul 23;8(7):e70870. doi: 10.1371/journal.pone.0070870. Print 2013.


Long-term response to combination antiretroviral therapy in HIV-infected children in the Netherlands registered from 1996 to 2012.

Cohen S, Smit C, van Rossum AM, Fraaij PL, Wolfs TF, Geelen SP, Schölvinck EH, Warris A, Scherpbier HJ, Pajkrt D; Dutch Paediatric HIV Study Group.

AIDS. 2013 Oct 23;27(16):2567-75. doi: 10.1097/01.aids.0000432451.75980.1b.


Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: two different conditions within the same disease spectrum.

Driessen GJ, Dalm VA, van Hagen PM, Grashoff HA, Hartwig NG, van Rossum AM, Warris A, de Vries E, Barendregt BH, Pico I, Posthumus S, van Zelm MC, van Dongen JJ, van der Burg M.

Haematologica. 2013 Oct;98(10):1617-23. doi: 10.3324/haematol.2013.085076. Epub 2013 Jun 10.


Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study.

Spuesens EB, Fraaij PL, Visser EG, Hoogenboezem T, Hop WC, van Adrichem LN, Weber F, Moll HA, Broekman B, Berger MY, van Rijsoort-Vos T, van Belkum A, Schutten M, Pas SD, Osterhaus AD, Hartwig NG, Vink C, van Rossum AM.

PLoS Med. 2013;10(5):e1001444. doi: 10.1371/journal.pmed.1001444. Epub 2013 May 14.


The RuvA homologues from Mycoplasma genitalium and Mycoplasma pneumoniae exhibit unique functional characteristics.

Sluijter M, Estevão S, Hoogenboezem T, Hartwig NG, van Rossum AM, Vink C.

PLoS One. 2012;7(5):e38301. doi: 10.1371/journal.pone.0038301. Epub 2012 May 30.


Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae in respiratory specimens collected between 1997 and 2008 in The Netherlands.

Spuesens EB, Meijer A, Bierschenk D, Hoogenboezem T, Donker GA, Hartwig NG, Koopmans MP, Vink C, van Rossum AM.

J Clin Microbiol. 2012 Jun;50(6):1999-2004. doi: 10.1128/JCM.00400-12. Epub 2012 Apr 11.


Sequence variation within the P1 gene of Mycoplasma pneumoniae.

Spuesens EB, Hartwig NG, van Rossum AM, Vink C.

J Clin Microbiol. 2011 Oct;49(10):3723; author reply 3723-4. doi: 10.1128/JCM.01318-11. No abstract available.


Functional characterization of the RuvB homologs from Mycoplasma pneumoniae and Mycoplasma genitalium.

Estevão S, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

J Bacteriol. 2011 Dec;193(23):6425-35. doi: 10.1128/JB.06003-11. Epub 2011 Sep 23.


Annual vaccination against influenza virus hampers development of virus-specific CD8⁺ T cell immunity in children.

Bodewes R, Fraaij PL, Geelhoed-Mieras MM, van Baalen CA, Tiddens HA, van Rossum AM, van der Klis FR, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.

J Virol. 2011 Nov;85(22):11995-2000. doi: 10.1128/JVI.05213-11. Epub 2011 Aug 31.


Identification of amino acid residues critical for catalysis of Holliday junction resolution by Mycoplasma genitalium RecU.

Sluijter M, Aslam M, Hartwig NG, van Rossum AM, Vink C.

J Bacteriol. 2011 Aug;193(15):3941-8. doi: 10.1128/JB.00247-11. Epub 2011 Jun 3.


Variation in a surface-exposed region of the Mycoplasma pneumoniae P40 protein as a consequence of homologous DNA recombination between RepMP5 elements.

Spuesens EB, van de Kreeke N, Estevão S, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

Microbiology. 2011 Feb;157(Pt 2):473-83. doi: 10.1099/mic.0.045591-0. Epub 2010 Oct 21.


The Mycoplasma genitalium MG352-encoded protein is a Holliday junction resolvase that has a non-functional orthologue in Mycoplasma pneumoniae.

Sluijter M, Kaptein E, Spuesens EB, Hoogenboezem T, Hartwig NG, Van Rossum AM, Vink C.

Mol Microbiol. 2010 Sep;77(5):1261-77. doi: 10.1111/j.1365-2958.2010.07288.x.


Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae by pyrosequencing.

Spuesens EB, Hoogenboezem T, Sluijter M, Hartwig NG, van Rossum AM, Vink C.

J Microbiol Methods. 2010 Sep;82(3):214-22. doi: 10.1016/j.mimet.2010.06.004. Epub 2010 Jun 11.


Identification and classification of P1 variants of Mycoplasma pneumoniae.

Spuesens EB, Hartwig NG, van Rossum AM, Vink C.

J Clin Microbiol. 2010 Feb;48(2):680; author reply 680. doi: 10.1128/JCM.02078-09. No abstract available.

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