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Items: 39

1.

Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.

van Roeyen CRC, Martin IV, Drescher A, Schuett KA, Hermert D, Raffetseder U, Otten S, Buhl EM, Braun GS, Kuppe C, Liehn E, Boor P, Weiskirchen R, Eriksson U, Gross O, Eitner F, Floege J, Ostendorf T.

Kidney Int. 2019 May;95(5):1103-1119. doi: 10.1016/j.kint.2018.11.031. Epub 2019 Feb 28.

PMID:
30827511
2.

CCR7 Is Important for Mesangial Cell Physiology and Repair.

Wurm S, Steege A, Rom-Jurek EM, van Roeyen CR, Kurtz A, Banas B, Banas MC.

J Histochem Cytochem. 2018 Jan;66(1):7-22. doi: 10.1369/0022155417737975. Epub 2017 Oct 27.

3.

Cold Shock Proteins Mediate GN with Mesangioproliferation.

Zhu C, Sauter E, Schreiter A, van Roeyen CR, Ostendorf T, Floege J, Gembardt F, Hugo CP, Isermann B, Lindquist JA, Mertens PR.

J Am Soc Nephrol. 2016 Dec;27(12):3678-3689. Epub 2016 May 5.

4.

The atypical cadherin Dachsous1 localizes to the base of the ciliary apparatus in airway epithelia.

Dau C, Fliegauf M, Omran H, Schlensog M, Dahl E, van Roeyen CR, Kriz W, Moeller MJ, Braun GS.

Biochem Biophys Res Commun. 2016 May 13;473(4):1177-1184. doi: 10.1016/j.bbrc.2016.04.036. Epub 2016 Apr 10.

PMID:
27074579
5.

Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery.

Görtz D, Braun GS, Maruta Y, Djudjaj S, van Roeyen CR, Martin IV, Küster A, Schmitz-Van de Leur H, Scheller J, Ostendorf T, Floege J, Müller-Newen G.

Sci Rep. 2015 Oct 1;5:14685. doi: 10.1038/srep14685.

6.

Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis.

Ostendorf T, Boor P, van Roeyen CR, Floege J.

Kidney Int Suppl (2011). 2014 Nov;4(1):65-69. Review.

7.

Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis.

Boor P, Bábíčková J, Steegh F, Hautvast P, Martin IV, Djudjaj S, Nakagawa T, Ehling J, Gremse F, Bücher E, Eriksson U, van Roeyen CR, Eitner F, Lammers T, Floege J, Peutz-Kootstra CJ, Ostendorf T.

Am J Pathol. 2015 Aug;185(8):2132-42. doi: 10.1016/j.ajpath.2015.04.022.

PMID:
26216283
8.

IL-6 Trans-Signaling Drives Murine Crescentic GN.

Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J.

J Am Soc Nephrol. 2016 Jan;27(1):132-42. doi: 10.1681/ASN.2014111147. Epub 2015 Jun 3.

9.

Urinary exosomes: a novel means to non-invasively assess changes in renal gene and protein expression.

Spanu S, van Roeyen CR, Denecke B, Floege J, Mühlfeld AS.

PLoS One. 2014 Oct 13;9(10):e109631. doi: 10.1371/journal.pone.0109631. eCollection 2014.

10.

Gp130-dependent signaling in the podocyte.

Nagayama Y, Braun GS, Jakobs CM, Maruta Y, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Raffetseder U, Trautwein C, Görtz D, Müller-Newen G, Ostendorf T, Floege J.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F346-55. doi: 10.1152/ajprenal.00620.2013. Epub 2014 Jun 4.

11.

Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential.

Klinkhammer BM, Kramann R, Mallau M, Makowska A, van Roeyen CR, Rong S, Buecher EB, Boor P, Kovacova K, Zok S, Denecke B, Stuettgen E, Otten S, Floege J, Kunter U.

PLoS One. 2014 Mar 25;9(3):e92115. doi: 10.1371/journal.pone.0092115. eCollection 2014.

12.

Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities.

van Roeyen CR, Scurt FG, Brandt S, Kuhl VA, Martinkus S, Djudjaj S, Raffetseder U, Royer HD, Stefanidis I, Dunn SE, Dooley S, Weng H, Fischer T, Lindquist JA, Mertens PR.

Cell Commun Signal. 2013 Aug 27;11:63. doi: 10.1186/1478-811X-11-63.

13.

Albumin is recycled from the primary urine by tubular transcytosis.

Tenten V, Menzel S, Kunter U, Sicking EM, van Roeyen CR, Sanden SK, Kaldenbach M, Boor P, Fuss A, Uhlig S, Lanzmich R, Willemsen B, Dijkman H, Grepl M, Wild K, Kriz W, Smeets B, Floege J, Moeller MJ.

J Am Soc Nephrol. 2013 Dec;24(12):1966-80. doi: 10.1681/ASN.2013010018. Epub 2013 Aug 22.

14.

YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo.

Hanssen L, Alidousty C, Djudjaj S, Frye BC, Rauen T, Boor P, Mertens PR, van Roeyen CR, Tacke F, Heymann F, Tittel AP, Koch A, Floege J, Ostendorf T, Raffetseder U.

J Immunol. 2013 Sep 1;191(5):2604-13. doi: 10.4049/jimmunol.1300416. Epub 2013 Jul 19.

15.

Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation.

van Roeyen CR, Zok S, Pruessmeyer J, Boor P, Nagayama Y, Fleckenstein S, Cohen CD, Eitner F, Gröne HJ, Ostendorf T, Ludwig A, Floege J.

Kidney Int. 2013 Feb;83(2):251-63. doi: 10.1038/ki.2012.400. Epub 2012 Dec 19.

16.

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts.

Seikrit C, Henkel C, van Roeyen CR, Bokemeyer D, Eitner F, Martin IV, Boor P, Knüchel R, Meyer HE, Müller-Newen G, Eriksson U, Floege J, Ostendorf T.

Nephrol Dial Transplant. 2013 Apr;28(4):889-900. doi: 10.1093/ndt/gfs509. Epub 2012 Dec 9.

PMID:
23229927
17.

Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms.

Villa L, Boor P, Konieczny A, Kunter U, van Roeyen CR, Denecke B, Gan L, Neusser MA, Cohen CD; ERCB Consortium;, Eitner F, Scholl T, Ostendorf T, Floege J.

J Pathol. 2013 Apr;229(5):672-84. doi: 10.1002/path.4151. Epub 2013 Mar 5.

PMID:
23192593
18.

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis.

Martin IV, Borkham-Kamphorst E, Zok S, van Roeyen CR, Eriksson U, Boor P, Hittatiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T.

Am J Pathol. 2013 Jan;182(1):107-17. doi: 10.1016/j.ajpath.2012.09.006. Epub 2012 Nov 7.

PMID:
23141925
19.

A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.

van Roeyen CR, Boor P, Borkham-Kamphorst E, Rong S, Kunter U, Martin IV, Kaitovic A, Fleckenstein S, Perbal B, Trautwein C, Weiskirchen R, Ostendorf T, Floege J.

Am J Pathol. 2012 May;180(5):1979-90. doi: 10.1016/j.ajpath.2012.01.031.

PMID:
22538190
20.

The platelet-derived growth factor system in renal disease: an emerging role of endogenous inhibitors.

van Roeyen CR, Ostendorf T, Floege J.

Eur J Cell Biol. 2012 Jun-Jul;91(6-7):542-51. doi: 10.1016/j.ejcb.2011.07.003. Epub 2011 Aug 27. Review.

PMID:
21872965
21.

Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D.

van Roeyen CR, Eitner F, Boor P, Moeller MJ, Raffetseder U, Hanssen L, Bücher E, Villa L, Banas MC, Hudkins KL, Alpers CE, Ostendorf T, Floege J.

Kidney Int. 2011 Dec;80(12):1292-305. doi: 10.1038/ki.2011.278. Epub 2011 Aug 24.

22.

CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC.

Borkham-Kamphorst E, van Roeyen CR, Van de Leur E, Floege J, Weiskirchen R.

J Cell Commun Signal. 2012 Mar;6(1):11-25. doi: 10.1007/s12079-011-0141-3. Epub 2011 Jul 5.

23.

Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis.

Villa L, Boor P, Konieczny A, Kunter U, van Roeyen CR, Denecke B, Gan L, Kupper MB, Hoffmann K, Eitner F, Ostendorf T, Floege J.

Nephrol Dial Transplant. 2011 Oct;26(10):3131-43. doi: 10.1093/ndt/gfr096. Epub 2011 Mar 17.

PMID:
21414972
24.

PDGF-C mediates glomerular capillary repair.

Boor P, van Roeyen CR, Kunter U, Villa L, Bücher E, Hohenstein B, Hugo CP, Eriksson U, Satchell SC, Mathieson PW, Eitner F, Floege J, Ostendorf T.

Am J Pathol. 2010 Jul;177(1):58-69. doi: 10.2353/ajpath.2010.091008. Epub 2010 May 20.

25.

Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury.

Borkham-Kamphorst E, Kovalenko E, van Roeyen CR, Gassler N, Bomble M, Ostendorf T, Floege J, Gressner AM, Weiskirchen R.

Lab Invest. 2008 Oct;88(10):1090-100. doi: 10.1038/labinvest.2008.71. Epub 2008 Jul 28.

26.

Y-box protein-1 controls transforming growth factor-beta1 translation in proximal tubular cells.

Fraser DJ, Phillips AO, Zhang X, van Roeyen CR, Muehlenberg P, En-Nia A, Mertens PR.

Kidney Int. 2008 Mar;73(6):724-32. Epub 2007 Dec 12.

27.

CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation.

van Roeyen CR, Eitner F, Scholl T, Boor P, Kunter U, Planque N, Gröne HJ, Bleau AM, Perbal B, Ostendorf T, Floege J.

Kidney Int. 2008 Jan;73(1):86-94. Epub 2007 Oct 10.

28.

Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.

Kunter U, Rong S, Boor P, Eitner F, Müller-Newen G, Djuric Z, van Roeyen CR, Konieczny A, Ostendorf T, Villa L, Milovanceva-Popovska M, Kerjaschki D, Floege J.

J Am Soc Nephrol. 2007 Jun;18(6):1754-64. Epub 2007 Apr 25.

29.

Pro-fibrogenic potential of PDGF-D in liver fibrosis.

Borkham-Kamphorst E, van Roeyen CR, Ostendorf T, Floege J, Gressner AM, Weiskirchen R.

J Hepatol. 2007 Jun;46(6):1064-74. Epub 2007 Feb 23.

PMID:
17397961
30.

Complement C5 mediates experimental tubulointerstitial fibrosis.

Boor P, Konieczny A, Villa L, Schult AL, Bücher E, Rong S, Kunter U, van Roeyen CR, Polakowski T, Hawlisch H, Hillebrandt S, Lammert F, Eitner F, Floege J, Ostendorf T.

J Am Soc Nephrol. 2007 May;18(5):1508-15. Epub 2007 Mar 27.

31.

PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis.

Boor P, Konieczny A, Villa L, Kunter U, van Roeyen CR, LaRochelle WJ, Smithson G, Arrol S, Ostendorf T, Floege J.

Nephrol Dial Transplant. 2007 May;22(5):1323-31. Epub 2007 Feb 17.

PMID:
17308324
32.

Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells.

van Roeyen CR, Ostendorf T, Denecke B, Bokemeyer D, Behrmann I, Strutz F, Lichenstein HS, LaRochelle WJ, Pena CE, Chaudhuri A, Floege J.

Kidney Int. 2006 Apr;69(8):1393-402.

33.

Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis.

Ostendorf T, Rong S, Boor P, Wiedemann S, Kunter U, Haubold U, van Roeyen CR, Eitner F, Kawachi H, Starling G, Alvarez E, Smithson G, Floege J.

J Am Soc Nephrol. 2006 Apr;17(4):1054-62. Epub 2006 Mar 1.

34.

Y-box protein 1 mediates PDGF-B effects in mesangioproliferative glomerular disease.

van Roeyen CR, Eitner F, Martinkus S, Thieltges SR, Ostendorf T, Bokemeyer D, Lüscher B, Lüscher-Firzlaff JM, Floege J, Mertens PR.

J Am Soc Nephrol. 2005 Oct;16(10):2985-96. Epub 2005 Aug 10.

35.

A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis.

Ostendorf T, van Roeyen CR, Peterson JD, Kunter U, Eitner F, Hamad AJ, Chan G, Jia XC, Macaluso J, Gazit-Bornstein G, Keyt BA, Lichenstein HS, LaRochelle WJ, Floege J.

J Am Soc Nephrol. 2003 Sep;14(9):2237-47.

36.

c-myc in bladder cancer. Clinical findings and analysis of mechanism.

Schmitz-Dräger BJ, Schulz WA, Jürgens B, Gerharz CD, van Roeyen CR, Bültel H, Ebert T, Ackermann R.

Urol Res. 1997;25 Suppl 1:S45-9.

PMID:
9079756
37.

Detection of sequential genetic alterations relevant for breast cancer development.

Niederacher D, Schnürch HG, An HX, Ellenberger I, Dall P, van Roeyen CR, Küppers V, Beckmann MW.

Eur J Cancer Prev. 1996 Dec;5(6):497-503.

PMID:
9061283
38.

Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer.

Beckmann MW, Picard F, An HX, van Roeyen CR, Dominik SI, Mosny DS, Schnürch HG, Bender HG, Niederacher D.

Br J Cancer. 1996 May;73(10):1220-6.

39.

P53 accumulation in precursor lesions and early stages of bladder cancer.

Schmitz-Dräger BJ, van Roeyen CR, Grimm MO, Gerharz CD, Decken K, Schulz WA, Bültel H, Makri D, Ebert T, Ackermann R.

World J Urol. 1994;12(2):79-83.

PMID:
8087143

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