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Items: 1 to 50 of 105

1.

Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.

Carrier DJ, van Roermund CWT, Schaedler TA, Rong HL, IJlst L, Wanders RJA, Baldwin SA, Waterham HR, Theodoulou FL, Baker A.

Sci Rep. 2019 Jul 19;9(1):10502. doi: 10.1038/s41598-019-46685-9.

2.

Corrigendum to "Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function" [Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1864/5(2019) 654-661].

Raja V, Salsaa M, Joshi AS, Li Y, van Roermund CWT, Saadat N, Lazcano P, Schmidtke M, Hüttemann M, Gupta SV, Wanders RJA, Greenberg ML.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1183. doi: 10.1016/j.bbalip.2019.04.014. Epub 2019 May 4. No abstract available.

PMID:
31060928
3.

An UPLC-MS/MS Assay to Measure Glutathione as Marker for Oxidative Stress in Cultured Cells.

Herzog K, IJlst L, van Cruchten AG, van Roermund CWT, Kulik W, Wanders RJA, Waterham HR.

Metabolites. 2019 Mar 5;9(3). pii: E45. doi: 10.3390/metabo9030045.

4.

Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function.

Raja V, Salsaa M, Joshi AS, Li Y, van Roermund CWT, Saadat N, Lazcano P, Schmidtke M, Hüttemann M, Gupta SV, Wanders RJA, Greenberg ML.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):654-661. doi: 10.1016/j.bbalip.2019.02.001. Epub 2019 Feb 5. Erratum in: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1183.

PMID:
30731133
5.

PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights.

Johnstone DL, Al-Shekaili HH, Tarailo-Graovac M, Wolf NI, Ivy AS, Demarest S, Roussel Y, Ciapaite J, van Roermund CWT, Kernohan KD, Kosuta C, Ban K, Ito Y, McBride S, Al-Thihli K, Abdelrahim RA, Koul R, Al Futaisi A, Haaxma CA, Olson H, Sigurdardottir LY, Arnold GL, Gerkes EH, Boon M, Heiner-Fokkema MR, Noble S, Bosma M, Jans J, Koolen DA, Kamsteeg EJ, Drögemöller B, Ross CJ, Majewski J, Cho MT, Begtrup A, Wasserman WW, Bui T, Brimble E, Violante S, Houten SM, Wevers RA, van Faassen M, Kema IP, Lepage N; Care4Rare Canada Consortium, Lines MA, Dyment DA, Wanders RJA, Verhoeven-Duif N, Ekker M, Boycott KM, Friedman JM, Pena IA, van Karnebeek CDM.

Brain. 2019 Mar 1;142(3):542-559. doi: 10.1093/brain/awy346.

6.

Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4.

Violante S, Achetib N, van Roermund CWT, Hagen J, Dodatko T, Vaz FM, Waterham HR, Chen H, Baes M, Yu C, Argmann CA, Houten SM.

FASEB J. 2019 Mar;33(3):4355-4364. doi: 10.1096/fj.201801498R. Epub 2018 Dec 12.

7.

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact.

Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M, Zalckvar E.

Nat Commun. 2018 May 2;9(1):1761. doi: 10.1038/s41467-018-03957-8.

8.

A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase.

Ferdinandusse S, Denis S, van Roermund CWT, Preece MA, Koster J, Ebberink MS, Waterham HR, Wanders RJA.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):952-958. doi: 10.1016/j.bbadis.2017.12.032. Epub 2017 Dec 26.

9.

Two NAD-linked redox shuttles maintain the peroxisomal redox balance in Saccharomyces cerevisiae.

Al-Saryi NA, Al-Hejjaj MY, van Roermund CWT, Hulmes GE, Ekal L, Payton C, Wanders RJA, Hettema EH.

Sci Rep. 2017 Sep 19;7(1):11868. doi: 10.1038/s41598-017-11942-2.

10.

ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism.

Ferdinandusse S, Falkenberg KD, Koster J, Mooyer PA, Jones R, van Roermund CWT, Pizzino A, Schrader M, Wanders RJA, Vanderver A, Waterham HR.

J Med Genet. 2017 May;54(5):330-337. doi: 10.1136/jmedgenet-2016-104132. Epub 2016 Oct 31.

PMID:
27799409
11.

The Peroxisomal NAD Carrier from Arabidopsis Imports NAD in Exchange with AMP.

van Roermund CW, Schroers MG, Wiese J, Facchinelli F, Kurz S, Wilkinson S, Charton L, Wanders RJ, Waterham HR, Weber AP, Link N.

Plant Physiol. 2016 Jul;171(3):2127-39. doi: 10.1104/pp.16.00540. Epub 2016 May 2.

12.

Peroxisomal ABC transporters: functions and mechanism.

Baker A, Carrier DJ, Schaedler T, Waterham HR, van Roermund CW, Theodoulou FL.

Biochem Soc Trans. 2015 Oct;43(5):959-65. doi: 10.1042/BST20150127. Epub 2015 Oct 9. Review.

13.

A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3.

Ferdinandusse S, Jimenez-Sanchez G, Koster J, Denis S, Van Roermund CW, Silva-Zolezzi I, Moser AB, Visser WF, Gulluoglu M, Durmaz O, Demirkol M, Waterham HR, Gökcay G, Wanders RJ, Valle D.

Hum Mol Genet. 2015 Jan 15;24(2):361-70. doi: 10.1093/hmg/ddu448. Epub 2014 Aug 28.

PMID:
25168382
14.

Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.

Geillon F, Gondcaille C, Charbonnier S, Van Roermund CW, Lopez TE, Dias AM, Pais de Barros JP, Arnould C, Wanders RJ, Trompier D, Savary S.

J Biol Chem. 2014 Aug 29;289(35):24511-20. doi: 10.1074/jbc.M114.575506. Epub 2014 Jul 20.

15.

Barley has two peroxisomal ABC transporters with multiple functions in β-oxidation.

Mendiondo GM, Medhurst A, van Roermund CW, Zhang X, Devonshire J, Scholefield D, Fernández J, Axcell B, Ramsay L, Waterham HR, Waugh R, Theodoulou FL, Holdsworth MJ.

J Exp Bot. 2014 Sep;65(17):4833-47. doi: 10.1093/jxb/eru243. Epub 2014 Jun 9.

16.

A role for the human peroxisomal half-transporter ABCD3 in the oxidation of dicarboxylic acids.

van Roermund CW, Ijlst L, Wagemans T, Wanders RJ, Waterham HR.

Biochim Biophys Acta. 2014 Apr 4;1841(4):563-8. doi: 10.1016/j.bbalip.2013.12.001. Epub 2013 Dec 13.

PMID:
24333844
17.

The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae.

Lefevre SD, van Roermund CW, Wanders RJ, Veenhuis M, van der Klei IJ.

Aging Cell. 2013 Oct;12(5):784-93. doi: 10.1111/acel.12113. Epub 2013 Jul 8.

18.

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.

De Marcos Lousa C, van Roermund CW, Postis VL, Dietrich D, Kerr ID, Wanders RJ, Baldwin SA, Baker A, Theodoulou FL.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1279-84. doi: 10.1073/pnas.1218034110. Epub 2013 Jan 3.

19.

Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone.

Bartoszewska M, Williams C, Kikhney A, Opaliński Ł, van Roermund CW, de Boer R, Veenhuis M, van der Klei IJ.

J Biol Chem. 2012 Aug 10;287(33):27380-95. doi: 10.1074/jbc.M112.381566. Epub 2012 Jun 25.

20.

Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae.

van Roermund CW, Ijlst L, Majczak W, Waterham HR, Folkerts H, Wanders RJ, Hellingwerf KJ.

J Biol Chem. 2012 Jun 8;287(24):20144-53. doi: 10.1074/jbc.M111.332833. Epub 2012 Apr 9.

21.

Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation.

van Roermund CW, Visser WF, Ijlst L, Waterham HR, Wanders RJ.

Biochim Biophys Acta. 2011 Mar;1811(3):148-52. doi: 10.1016/j.bbalip.2010.11.010. Epub 2010 Dec 8.

PMID:
21145416
22.

The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.

Nyathi Y, De Marcos Lousa C, van Roermund CW, Wanders RJ, Johnson B, Baldwin SA, Theodoulou FL, Baker A.

J Biol Chem. 2010 Sep 24;285(39):29892-902. doi: 10.1074/jbc.M110.151225. Epub 2010 Jul 21.

23.

Contributions of carnitine acetyltransferases to intracellular acetyl unit transport in Candida albicans.

Strijbis K, van Roermund CW, van den Burg J, van den Berg M, Hardy GP, Wanders RJ, Distel B.

J Biol Chem. 2010 Aug 6;285(32):24335-46. doi: 10.1074/jbc.M109.094250. Epub 2010 Jun 3.

24.

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy.

Ofman R, Dijkstra IM, van Roermund CW, Burger N, Turkenburg M, van Cruchten A, van Engen CE, Wanders RJ, Kemp S.

EMBO Mol Med. 2010 Mar;2(3):90-7. doi: 10.1002/emmm.201000061.

25.

Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans.

Strijbis K, van Roermund CW, Hardy GP, van den Burg J, Bloem K, de Haan J, van Vlies N, Wanders RJ, Vaz FM, Distel B.

FASEB J. 2009 Aug;23(8):2349-59. doi: 10.1096/fj.08-127985. Epub 2009 Mar 16.

PMID:
19289605
26.

The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters.

van Roermund CW, Visser WF, Ijlst L, van Cruchten A, Boek M, Kulik W, Waterham HR, Wanders RJ.

FASEB J. 2008 Dec;22(12):4201-8. doi: 10.1096/fj.08-110866. Epub 2008 Aug 29.

PMID:
18757502
27.

Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation.

Strijbis K, van Roermund CW, Visser WF, Mol EC, van den Burg J, MacCallum DM, Odds FC, Paramonova E, Krom BP, Distel B.

Eukaryot Cell. 2008 Apr;7(4):610-8. doi: 10.1128/EC.00017-08. Epub 2008 Feb 15.

28.

A lethal defect of mitochondrial and peroxisomal fission.

Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, Leonard JV.

N Engl J Med. 2007 Apr 26;356(17):1736-41.

29.

Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency.

Ferdinandusse S, Denis S, Hogenhout EM, Koster J, van Roermund CW, IJlst L, Moser AB, Wanders RJ, Waterham HR.

Hum Mutat. 2007 Sep;28(9):904-12.

PMID:
17458872
30.

Demonstration of bile acid transport across the mammalian peroxisomal membrane.

Visser WF, van Roermund CW, Ijlst L, Waterham HR, Wanders RJ.

Biochem Biophys Res Commun. 2007 Jun 1;357(2):335-40. Epub 2007 Mar 26.

PMID:
17416343
31.

Metabolite transport across the peroxisomal membrane.

Visser WF, van Roermund CW, Ijlst L, Waterham HR, Wanders RJ.

Biochem J. 2007 Jan 15;401(2):365-75. Review.

32.

The peroxisomal ABC transporter family.

Wanders RJ, Visser WF, van Roermund CW, Kemp S, Waterham HR.

Pflugers Arch. 2007 Feb;453(5):719-34. Epub 2006 Oct 13. Review.

PMID:
17039367
33.

First identification of a 2-ketoglutarate/isocitrate transport system in mammalian peroxisomes and its characterization.

Visser WF, van Roermund CW, Ijlst L, Hellingwerf KJ, Waterham HR, Wanders RJ.

Biochem Biophys Res Commun. 2006 Oct 6;348(4):1224-31. Epub 2006 Jul 20.

PMID:
16919238
34.

Identification of the human mitochondrial FAD transporter and its potential role in multiple acyl-CoA dehydrogenase deficiency.

Spaan AN, Ijlst L, van Roermund CW, Wijburg FA, Wanders RJ, Waterham HR.

Mol Genet Metab. 2005 Dec;86(4):441-7. Epub 2005 Sep 13.

PMID:
16165386
35.

dif-1 and colt, both implicated in early embryonic development, encode carnitine acylcarnitine translocase.

Oey NA, Ijlst L, van Roermund CW, Wijburg FA, Wanders RJ.

Mol Genet Metab. 2005 Jun;85(2):121-4. Epub 2005 Apr 1.

PMID:
15896656
36.

Demonstration and characterization of phosphate transport in mammalian peroxisomes.

Visser WF, Van Roermund CW, Ijlst L, Hellingwerf KJ, Wanders RJ, Waterham HR.

Biochem J. 2005 Aug 1;389(Pt 3):717-22.

37.

The peroxisomal lumen in Saccharomyces cerevisiae is alkaline.

van Roermund CW, de Jong M, IJlst L, van Marle J, Dansen TB, Wanders RJ, Waterham HR.

J Cell Sci. 2004 Aug 15;117(Pt 18):4231-7.

38.

Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids.

Ferdinandusse S, Denis S, Van Roermund CW, Wanders RJ, Dacremont G.

J Lipid Res. 2004 Jun;45(6):1104-11. Epub 2004 Apr 1.

39.

Peroxisomal fatty acid alpha- and beta-oxidation in health and disease: new insights.

Wanders RJ, van Roermund CW, Visser WF, Ferdinandusse S, Jansen GA, van den Brink DM, Gloerich J, Waterham HR.

Adv Exp Med Biol. 2003;544:293-302. Review. No abstract available.

PMID:
14713243
40.

Fatty acid metabolism in Saccharomyces cerevisiae.

van Roermund CW, Waterham HR, Ijlst L, Wanders RJ.

Cell Mol Life Sci. 2003 Sep;60(9):1838-51. Review.

PMID:
14523547
41.

Identification of human PMP34 as a peroxisomal ATP transporter.

Visser WF, van Roermund CW, Waterham HR, Wanders RJ.

Biochem Biophys Res Commun. 2002 Dec 6;299(3):494-7.

PMID:
12445829
42.

Reinvestigation of peroxisomal 3-ketoacyl-CoA thiolase deficiency: identification of the true defect at the level of d-bifunctional protein.

Ferdinandusse S, van Grunsven EG, Oostheim W, Denis S, Hogenhout EM, IJlst L, van Roermund CW, Waterham HR, Goldfischer S, Wanders RJ.

Am J Hum Genet. 2002 Jun;70(6):1589-93. Epub 2002 Apr 23.

43.

Identification of a peroxisomal ATP carrier required for medium-chain fatty acid beta-oxidation and normal peroxisome proliferation in Saccharomyces cerevisiae.

van Roermund CW, Drissen R, van Den Berg M, Ijlst L, Hettema EH, Tabak HF, Waterham HR, Wanders RJ.

Mol Cell Biol. 2001 Jul;21(13):4321-9.

44.

Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases.

Wanders RJ, Vreken P, Ferdinandusse S, Jansen GA, Waterham HR, van Roermund CW, Van Grunsven EG.

Biochem Soc Trans. 2001 May;29(Pt 2):250-67. Review.

PMID:
11356164
45.

Functional analysis of mutant human carnitine acylcarnitine translocases in yeast.

IJlst L, van Roermund CW, Iacobazzi V, Oostheim W, Ruiter JP, Williams JC, Palmieri F, Wanders RJ.

Biochem Biophys Res Commun. 2001 Jan 26;280(3):700-6.

PMID:
11162577
46.

Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae.

van Roermund CW, Tabak HF, van Den Berg M, Wanders RJ, Hettema EH.

J Cell Biol. 2000 Aug 7;150(3):489-98.

48.
49.

Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system.

Verleur N, Hettema EH, van Roermund CW, Tabak HF, Wanders RJ.

Eur J Biochem. 1997 Nov 1;249(3):657-61.

50.

Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae.

Verleur N, Elgersma Y, Van Roermund CW, Tabak HF, Wanders RJ.

Eur J Biochem. 1997 Aug 1;247(3):972-80.

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