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Prospects of Next-Generation Vaccines for Bluetongue.

van Rijn PA.

Front Vet Sci. 2019 Nov 21;6:407. doi: 10.3389/fvets.2019.00407. eCollection 2019. Review.


Vector competence is strongly affected by a small deletion or point mutations in bluetongue virus.

van Gennip RGP, Drolet BS, Rozo Lopez P, Roost AJC, Boonstra J, van Rijn PA.

Parasit Vectors. 2019 Oct 11;12(1):470. doi: 10.1186/s13071-019-3722-2.


Virus-induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade.

Avia M, Rojas JM, Miorin L, Pascual E, Van Rijn PA, Martín V, García-Sastre A, Sevilla N.

EMBO Rep. 2019 Nov 5;20(11):e48766. doi: 10.15252/embr.201948766. Epub 2019 Oct 11.


Improved PCR diagnostics using up-to-date in silico validation: An F-gene RT-qPCR assay for the detection of all four lineages of peste des petits ruminants virus.

Flannery J, Rajko-Nenow P, Arnold H, van Weezep E, van Rijn PA, Ngeleja C, Batten C.

J Virol Methods. 2019 Dec;274:113735. doi: 10.1016/j.jviromet.2019.113735. Epub 2019 Sep 14.


Novel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway.

Kundlacz C, Pourcelot M, Fablet A, Amaral Da Silva Moraes R, Léger T, Morlet B, Viarouge C, Sailleau C, Turpaud M, Gorlier A, Breard E, Lecollinet S, van Rijn PA, Zientara S, Vitour D, Caignard G.

J Virol. 2019 Jul 30;93(16). pii: e00336-19. doi: 10.1128/JVI.00336-19. Print 2019 Aug 15.


PCR diagnostics: In silico validation by an automated tool using freely available software programs.

van Weezep E, Kooi EA, van Rijn PA.

J Virol Methods. 2019 Aug;270:106-112. doi: 10.1016/j.jviromet.2019.05.002. Epub 2019 May 13.


Recombinant Newcastle disease viruses with targets for PCR diagnostics for rinderpest and peste des petits ruminants.

van Rijn PA, Boonstra J, van Gennip HGP.

J Virol Methods. 2018 Sep;259:50-53. doi: 10.1016/j.jviromet.2018.06.007. Epub 2018 Jun 12.


Diagnostic DIVA tests accompanying the Disabled Infectious Single Animal (DISA) vaccine platform for African horse sickness.

van Rijn PA, Maris-Veldhuis MA, Boonstra J, van Gennip RGP.

Vaccine. 2018 Jun 14;36(25):3584-3592. doi: 10.1016/j.vaccine.2018.05.044. Epub 2018 May 11.


African horse sickness virus (AHSV) with a deletion of 77 amino acids in NS3/NS3a protein is not virulent and a safe promising AHS Disabled Infectious Single Animal (DISA) vaccine platform.

van Rijn PA, Maris-Veldhuis MA, Potgieter CA, van Gennip RGP.

Vaccine. 2018 Apr 5;36(15):1925-1933. doi: 10.1016/j.vaccine.2018.03.003. Epub 2018 Mar 7.


One after the other: A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains.

Marcacci M, Sant S, Mangone I, Goria M, Dondo A, Zoppi S, van Gennip RGP, Radaelli MC, Cammà C, van Rijn PA, Savini G, Lorusso A.

Transbound Emerg Dis. 2018 Apr;65(2):370-374. doi: 10.1111/tbed.12822. Epub 2018 Feb 2.


Bluetongue Disabled Infectious Single Animal (DISA) vaccine: Studies on the optimal route and dose in sheep.

van Rijn PA, Daus FJ, Maris-Veldhuis MA, Feenstra F, van Gennip RGP.

Vaccine. 2017 Jan 5;35(2):231-237. doi: 10.1016/j.vaccine.2016.11.081. Epub 2016 Dec 1.


Structural Protein VP2 of African Horse Sickness Virus Is Not Essential for Virus Replication In Vitro.

van Gennip RGP, van de Water SGP, Potgieter CA, van Rijn PA.

J Virol. 2017 Jan 31;91(4). pii: e01328-16. doi: 10.1128/JVI.01328-16. Print 2017 Feb 15.


Current and next-generation bluetongue vaccines: Requirements, strategies, and prospects for different field situations.

Feenstra F, van Rijn PA.

Crit Rev Microbiol. 2017 Mar;43(2):142-155. doi: 10.1080/1040841X.2016.1186005. Epub 2016 Nov 1. Review.


Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines.

Celma CC, Stewart M, Wernike K, Eschbaumer M, Gonzalez-Molleda L, Breard E, Schulz C, Hoffmann B, Haegeman A, De Clercq K, Zientara S, van Rijn PA, Beer M, Roy P.

J Virol. 2016 Dec 16;91(1). pii: e01892-16. doi: 10.1128/JVI.01892-16. Print 2017 Jan 1.


Experimental infection of small ruminants with bluetongue virus expressing Toggenburg Orbivirus proteins.

van Rijn PA, van de Water SGP, Maris-Veldhuis MA, van Gennip RGP.

Vet Microbiol. 2016 Aug 30;192:145-151. doi: 10.1016/j.vetmic.2016.07.013. Epub 2016 Jul 18.


Requirements and comparative analysis of reverse genetics for bluetongue virus (BTV) and African horse sickness virus (AHSV).

van Rijn PA, van de Water SG, Feenstra F, van Gennip RG.

Virol J. 2016 Jul 2;13:119. doi: 10.1186/s12985-016-0574-7.


European Bluetongue Serotype 8: Disease Threat Assessment for U.S. Sheep.

Drolet BS, Reister-Hendricks LM, Podell BK, Breitenbach JE, McVey DS, van Rijn PA, Bowen RA.

Vector Borne Zoonotic Dis. 2016 Jun;16(6):400-7. doi: 10.1089/vbz.2015.1924. Epub 2016 Apr 25.


Effect of Culicoides sonorensis salivary proteins on clinical disease outcome in experimental bluetongue virus serotype 8 infection of Dorset sheep.

Drolet BS, Reister LM, Lehiy CJ, Van Rijn PA, Bowen RA.

Vet Ital. 2015 Oct-Dec;51(4):379-84. doi: 10.12834/VetIt.496.2398.1.


Balance of RNA sequence requirement and NS3/NS3a expression of segment 10 of orbiviruses.

Feenstra F, van Gennip RGP, Schreuder M, van Rijn PA.

J Gen Virol. 2016 Feb;97(2):411-421. doi: 10.1099/jgv.0.000359. Epub 2015 Dec 4.


Development of a competitive ELISA for NS3 antibodies as DIVA test accompanying the novel Disabled Infectious Single Animal (DISA) vaccine for Bluetongue.

Tacken MGJ, Daus FJ, Feenstra F, van Gennip RGP, van Rijn PA.

Vaccine. 2015 Oct 13;33(42):5539-5545. doi: 10.1016/j.vaccine.2015.09.020. Epub 2015 Sep 19.


Non-structural protein NS3/NS3a is required for propagation of bluetongue virus in Culicoides sonorensis.

Feenstra F, Drolet BS, Boonstra J, van Rijn PA.

Parasit Vectors. 2015 Sep 17;8:476. doi: 10.1186/s13071-015-1063-3.


Turnover Rate of NS3 Proteins Modulates Bluetongue Virus Replication Kinetics in a Host-Specific Manner.

Ftaich N, Ciancia C, Viarouge C, Barry G, Ratinier M, van Rijn PA, Breard E, Vitour D, Zientara S, Palmarini M, Terzian C, Arnaud F.

J Virol. 2015 Oct;89(20):10467-81. doi: 10.1128/JVI.01541-15. Epub 2015 Aug 5.


VP2 Exchange and NS3/NS3a Deletion in African Horse Sickness Virus (AHSV) in Development of Disabled Infectious Single Animal Vaccine Candidates for AHSV.

van de Water SG, van Gennip RG, Potgieter CA, Wright IM, van Rijn PA.

J Virol. 2015 Sep;89(17):8764-72. doi: 10.1128/JVI.01052-15. Epub 2015 Jun 10.


Application of bluetongue Disabled Infectious Single Animal (DISA) vaccine for different serotypes by VP2 exchange or incorporation of chimeric VP2.

Feenstra F, Pap JS, van Rijn PA.

Vaccine. 2015 Feb 4;33(6):812-8. doi: 10.1016/j.vaccine.2014.12.003. Epub 2014 Dec 13.


VP2-serotyped live-attenuated bluetongue virus without NS3/NS3a expression provides serotype-specific protection and enables DIVA.

Feenstra F, Maris-Veldhuis M, Daus FJ, Tacken MG, Moormann RJ, van Gennip RG, van Rijn PA.

Vaccine. 2014 Dec 12;32(52):7108-14. doi: 10.1016/j.vaccine.2014.10.033. Epub 2014 Oct 31.


Immunogenicity of recombinant VP2 proteins of all nine serotypes of African horse sickness virus.

Kanai Y, van Rijn PA, Maris-Veldhuis M, Kaname Y, Athmaram TN, Roy P.

Vaccine. 2014 Sep 3;32(39):4932-7. doi: 10.1016/j.vaccine.2014.07.031. Epub 2014 Jul 18.


Virus and host factors affecting the clinical outcome of bluetongue virus infection.

Caporale M, Di Gialleonorado L, Janowicz A, Wilkie G, Shaw A, Savini G, Van Rijn PA, Mertens P, Di Ventura M, Palmarini M.

J Virol. 2014 Sep;88(18):10399-411. doi: 10.1128/JVI.01641-14. Epub 2014 Jul 2.


Bluetongue virus without NS3/NS3a expression is not virulent and protects against virulent bluetongue virus challenge.

Feenstra F, van Gennip RG, Maris-Veldhuis M, Verheij E, van Rijn PA.

J Gen Virol. 2014 Sep;95(Pt 9):2019-29. doi: 10.1099/vir.0.065615-0. Epub 2014 Jun 9.


Viral replication kinetics and in vitro cytopathogenicity of parental and reassortant strains of bluetongue virus serotype 1, 6 and 8.

Coetzee P, Van Vuuren M, Stokstad M, Myrmel M, van Gennip RG, van Rijn PA, Venter EH.

Vet Microbiol. 2014 Jun 25;171(1-2):53-65. doi: 10.1016/j.vetmic.2014.03.006. Epub 2014 Mar 12.


Bluetongue, Schmallenberg - what is next? Culicoides-borne viral diseases in the 21st Century.

Koenraadt CJ, Balenghien T, Carpenter S, Ducheyne E, Elbers AR, Fife M, Garros C, Ibáñez-Justicia A, Kampen H, Kormelink RJ, Losson B, van der Poel WH, De Regge N, van Rijn PA, Sanders C, Schaffner F, Sloet van Oldruitenborgh-Oosterbaan MM, Takken W, Werner D, Seelig F.

BMC Vet Res. 2014 Mar 31;10:77. doi: 10.1186/1746-6148-10-77.


RNA elements in open reading frames of the bluetongue virus genome are essential for virus replication.

Feenstra F, van Gennip RG, van de Water SG, van Rijn PA.

PLoS One. 2014 Mar 21;9(3):e92377. doi: 10.1371/journal.pone.0092377. eCollection 2014.


Bluetongue virus nonstructural protein NS3/NS3a is not essential for virus replication.

van Gennip RG, van de Water SG, van Rijn PA.

PLoS One. 2014 Jan 20;9(1):e85788. doi: 10.1371/journal.pone.0085788. eCollection 2014.


Bluetongue virus with mutated genome segment 10 to differentiate infected from vaccinated animals: a genetic DIVA approach.

van Rijn PA, van de Water SG, van Gennip HG.

Vaccine. 2013 Oct 17;31(44):5005-8. doi: 10.1016/j.vaccine.2013.08.089. Epub 2013 Sep 7.


Experimental infection of white-tailed deer (Odocoileus virginianus) with Northern European bluetongue virus serotype 8.

Drolet BS, Reister LM, Rigg TD, Nol P, Podell BK, Mecham JO, VerCauteren KC, van Rijn PA, Wilson WC, Bowen RA.

Vet Microbiol. 2013 Oct 25;166(3-4):347-55. doi: 10.1016/j.vetmic.2013.05.027. Epub 2013 Jun 19.


Preliminary mapping of non-conserved epitopes on envelope glycoprotein E2 of Bovine viral diarrhea virus type 1 and 2.

Jelsma H, Loeffen WL, van Beuningen A, van Rijn PA.

Vet Microbiol. 2013 Sep 27;166(1-2):195-9. doi: 10.1016/j.vetmic.2013.06.008. Epub 2013 Jun 21.


Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep.

Celma CC, Boyce M, van Rijn PA, Eschbaumer M, Wernike K, Hoffmann B, Beer M, Haegeman A, De Clercq K, Roy P.

J Virol. 2013 Sep;87(17):9856-64. doi: 10.1128/JVI.01514-13. Epub 2013 Jul 3.


Bluetongue viruses based on modified-live vaccine serotype 6 with exchanged outer shell proteins confer full protection in sheep against virulent BTV8.

van Gennip RG, van de Water SG, Maris-Veldhuis M, van Rijn PA.

PLoS One. 2012;7(9):e44619. doi: 10.1371/journal.pone.0044619. Epub 2012 Sep 25.


Sustained high-throughput polymerase chain reaction diagnostics during the European epidemic of Bluetongue virus serotype 8.

van Rijn PA, Heutink RG, Boonstra J, Kramps HA, van Gennip RG.

J Vet Diagn Invest. 2012 May;24(3):469-78. doi: 10.1177/1040638712440986.


Rescue of recent virulent and avirulent field strains of bluetongue virus by reverse genetics.

van Gennip RG, van de Water SG, Potgieter CA, Wright IM, Veldman D, van Rijn PA.

PLoS One. 2012;7(2):e30540. doi: 10.1371/journal.pone.0030540. Epub 2012 Feb 17.


Bluetongue virus serotype 6 in Europe in 2008-Emergence and disappearance of an unexpected non-virulent BTV.

van Rijn PA, Geurts Y, van der Spek AN, Veldman D, van Gennip RG.

Vet Microbiol. 2012 Jul 6;158(1-2):23-32. doi: 10.1016/j.vetmic.2012.01.022. Epub 2012 Jan 31.


Genetic modification of Bluetongue virus by uptake of "synthetic" genome segments.

van Gennip RG, Veldman D, van de Water SG, van Rijn PA.

Virol J. 2010 Oct 7;7:261. doi: 10.1186/1743-422X-7-261.


Bluetongue virus serotype 8 (BTV-8) infection reduces fertility of Dutch dairy cattle and is vertically transmitted to offspring.

Santman-Berends IM, Hage JJ, van Rijn PA, Stegeman JA, van Schaik G.

Theriogenology. 2010 Nov;74(8):1377-84. doi: 10.1016/j.theriogenology.2010.06.008. Epub 2010 Aug 5.


Evaluation of an indirect ELISA for detection of antibodies in bulk milk against bluetongue virus infections in the Netherlands.

Mars MH, van Maanen C, Vellema P, Kramps JA, van Rijn PA.

Vet Microbiol. 2010 Dec 15;146(3-4):209-14. doi: 10.1016/j.vetmic.2010.05.009. Epub 2010 May 10.


Full genome characterisation of bluetongue virus serotype 6 from the Netherlands 2008 and comparison to other field and vaccine strains.

Maan S, Maan NS, van Rijn PA, van Gennip RG, Sanders A, Wright IM, Batten C, Hoffmann B, Eschbaumer M, Oura CA, Potgieter AC, Nomikou K, Mertens PP.

PLoS One. 2010 Apr 23;5(4):e10323. doi: 10.1371/journal.pone.0010323.


Potential role of ticks as vectors of bluetongue virus.

Bouwknegt C, van Rijn PA, Schipper JJ, Hölzel D, Boonstra J, Nijhof AM, van Rooij EM, Jongejan F.

Exp Appl Acarol. 2010 Oct;52(2):183-92. doi: 10.1007/s10493-010-9359-7. Epub 2010 Apr 1.


Questionnaire survey about the motives of commercial livestock farmers and hobby holders to vaccinate their animals against Bluetongue virus serotype 8 in 2008-2009 in the Netherlands.

Elbers AR, de Koeijer AA, Scolamacchia F, van Rijn PA.

Vaccine. 2010 Mar 16;28(13):2473-81. doi: 10.1016/j.vaccine.2010.01.047. Epub 2010 Jan 31.


Epidemiologic characteristics of bluetongue virus serotype 8 laboratory-confirmed outbreaks in The Netherlands in 2007 and a comparison with the situation in 2006.

Elbers AR, van der Spek AN, van Rijn PA.

Prev Vet Med. 2009 Nov 1;92(1-2):1-8. doi: 10.1016/j.prevetmed.2009.08.007. Epub 2009 Sep 8.


Detection of the European 'field' strain of bluetongue virus serotype 6 by real-time RT-PCR.

Batten CA, van Rijn PA, Oura CA.

Vet Microbiol. 2010 Feb 24;141(1-2):186-8. doi: 10.1016/j.vetmic.2009.08.008. Epub 2009 Aug 8. No abstract available.


Vertical transmission of bluetongue virus serotype 8 virus in Dutch dairy herds in 2007.

Santman-Berends IM, van Wuijckhuise L, Vellema P, van Rijn PA.

Vet Microbiol. 2010 Feb 24;141(1-2):31-5. doi: 10.1016/j.vetmic.2009.08.010. Epub 2009 Aug 8.


['Emerging vector-borne diseases' in the horse].

Sloet van Oldruitenborgh-Oosterbaan MM, Goehring LS, Koopmans MP, van Rijn PA, van Maanen C.

Tijdschr Diergeneeskd. 2009 May 15;134(10):439-47. Review. Dutch. No abstract available.


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