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Items: 1 to 50 of 79

1.

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, van Rheenen J, Vermeulen M, Clevers H.

Cell Stem Cell. 2019 Jun 6;24(6):927-943.e6. doi: 10.1016/j.stem.2019.04.017. Epub 2019 May 23.

PMID:
31130514
2.

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors.

Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, Germain RN, Sahai E, Klauschen F, Reis E Sousa C.

Sci Immunol. 2019 Mar 1;4(33). pii: eaaw1941. doi: 10.1126/sciimmunol.aaw1941.

PMID:
30824528
3.

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion.

Alieva M, Leidgens V, Riemenschneider MJ, Klein CA, Hau P, van Rheenen J.

Sci Rep. 2019 Feb 14;9(1):2054. doi: 10.1038/s41598-019-38625-4.

4.

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.

Steenbeek SC, Pham TV, de Ligt J, Zomer A, Knol JC, Piersma SR, Schelfhorst T, Huisjes R, Schiffelers RM, Cuppen E, Jimenez CR, van Rheenen J.

EMBO J. 2018 Aug 1;37(15). pii: e98357. doi: 10.15252/embj.201798357. Epub 2018 Jun 14.

5.

Potential impact of invasive surgical procedures on primary tumor growth and metastasis.

Alieva M, van Rheenen J, Broekman MLD.

Clin Exp Metastasis. 2018 Apr;35(4):319-331. doi: 10.1007/s10585-018-9896-8. Epub 2018 May 4. Review.

6.

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8.

Berenguer J, Lagerweij T, Zhao XW, Dusoswa S, van der Stoop P, Westerman B, de Gooijer MC, Zoetemelk M, Zomer A, Crommentuijn MHW, Wedekind LE, López-López À, Giovanazzi A, Bruch-Oms M, van der Meulen-Muileman IH, Reijmers RM, van Kuppevelt TH, García-Vallejo JJ, van Kooyk Y, Tannous BA, Wesseling P, Koppers-Lalic D, Vandertop WP, Noske DP, van Beusechem VW, van Rheenen J, Pegtel DM, van Tellingen O, Wurdinger T.

J Extracell Vesicles. 2018 Mar 13;7(1):1446660. doi: 10.1080/20013078.2018.1446660. eCollection 2018.

7.

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.

Huels DJ, Bruens L, Hodder MC, Cammareri P, Campbell AD, Ridgway RA, Gay DM, Solar-Abboud M, Faller WJ, Nixon C, Zeiger LB, McLaughlin ME, Morrissey E, Winton DJ, Snippert HJ, van Rheenen J, Sansom OJ.

Nat Commun. 2018 Mar 19;9(1):1132. doi: 10.1038/s41467-018-03426-2.

8.

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.

Oost KC, van Voorthuijsen L, Fumagalli A, Lindeboom RGH, Sprangers J, Omerzu M, Rodriguez-Colman MJ, Heinz MC, Verlaan-Klink I, Maurice MM, Burgering BMT, van Rheenen J, Vermeulen M, Snippert HJG.

Cell Rep. 2018 Feb 6;22(6):1600-1614. doi: 10.1016/j.celrep.2018.01.033.

9.

Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation.

Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Alphen F, Hordijk P, Stroes ESG, Strömblad S, van Rheenen J, van Buul JD.

J Immunol. 2018 Mar 1;200(5):1790-1801. doi: 10.4049/jimmunol.1700702. Epub 2018 Jan 31.

10.

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1157. doi: 10.1083/JCB.20170320601192018c. Epub 2018 Jan 23. No abstract available.

11.

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1129-1142. doi: 10.1083/jcb.201703206. Epub 2018 Jan 16. Erratum in: J Cell Biol. 2018 Jan 23;:.

12.

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression.

Fumagalli A, Suijkerbuijk SJE, Begthel H, Beerling E, Oost KC, Snippert HJ, van Rheenen J, Drost J.

Nat Protoc. 2018 Feb;13(2):235-247. doi: 10.1038/nprot.2017.137. Epub 2018 Jan 4.

PMID:
29300390
13.

Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue.

van Rheenen J, Bruens L.

Swiss Med Wkly. 2017 Nov 8;147:w14539. doi: 10.4414/smw.2017.14539. eCollection 2017. Review.

14.

A Unifying Theory of Branching Morphogenesis.

Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD.

Cell. 2017 Sep 21;171(1):242-255.e27. doi: 10.1016/j.cell.2017.08.026.

15.

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior.

Alieva M, Margarido AS, Wieles T, Abels ER, Colak B, Boquetale C, Jan Noordmans H, Snijders TJ, Broekman ML, van Rheenen J.

Sci Rep. 2017 Aug 8;7(1):7529. doi: 10.1038/s41598-017-07660-4.

16.

In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine.

Bruens L, Ellenbroek SIJ, van Rheenen J, Snippert HJ.

Gastroenterology. 2017 Sep;153(3):674-677.e3. doi: 10.1053/j.gastro.2017.05.019. Epub 2017 May 26.

17.

From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells.

Suijkerbuijk SJE, van Rheenen J.

Dev Biol. 2017 Aug 15;428(2):328-337. doi: 10.1016/j.ydbio.2017.04.015. Epub 2017 May 1. Review.

18.

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2357-E2364. doi: 10.1073/pnas.1701219114. Epub 2017 Mar 7.

19.

Intravital characterization of tumor cell migration in pancreatic cancer.

Beerling E, Oosterom I, Voest E, Lolkema M, van Rheenen J.

Intravital. 2016 Nov 18;5(3):e1261773. doi: 10.1080/21659087.2016.1261773. eCollection 2016.

20.

Identity and dynamics of mammary stem cells during branching morphogenesis.

Scheele CL, Hannezo E, Muraro MJ, Zomer A, Langedijk NS, van Oudenaarden A, Simons BD, van Rheenen J.

Nature. 2017 Feb 16;542(7641):313-317. doi: 10.1038/nature21046. Epub 2017 Jan 30.

21.

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases.

Frentzas S, Simoneau E, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Nathan M, Wotherspoon A, Gao ZH, Shi Y, Van den Eynden G, Daley F, Peckitt C, Tan X, Salman A, Lazaris A, Gazinska P, Berg TJ, Eltahir Z, Ritsma L, Van Rheenen J, Khashper A, Brown G, Nystrom H, Sund M, Van Laere S, Loyer E, Dirix L, Cunningham D, Metrakos P, Reynolds AR.

Nat Med. 2016 Nov;22(11):1294-1302. doi: 10.1038/nm.4197. Epub 2016 Oct 17.

22.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29.

23.

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice.

van Gurp L, Loomans CJM, van Krieken PP, Dharmadhikari G, Jansen E, Ringnalda FCAS, Beerling E, van Rheenen J, de Koning EJP.

Diabetologia. 2016 Nov;59(11):2387-2392. doi: 10.1007/s00125-016-4049-6. Epub 2016 Jul 21.

24.

LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers.

Prunier C, Josserand V, Vollaire J, Beerling E, Petropoulos C, Destaing O, Montemagno C, Hurbin A, Prudent R, de Koning L, Kapur R, Cohen PA, Albiges-Rizo C, Coll JL, van Rheenen J, Billaud M, Lafanechère L.

Cancer Res. 2016 Jun 15;76(12):3541-52. doi: 10.1158/0008-5472.CAN-15-1864. Epub 2016 May 23.

25.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Vecchione L, Gambino V, Raaijmakers J, Schlicker A, Fumagalli A, Russo M, Villanueva A, Beerling E, Bartolini A, Mollevi DG, El-Murr N, Chiron M, Calvet L, Nicolazzi C, Combeau C, Henry C, Simon IM, Tian S, in 't Veld S, D'ario G, Mainardi S, Beijersbergen RL, Lieftink C, Linn S, Rumpf-Kienzl C, Delorenzi M, Wessels L, Salazar R, Di Nicolantonio F, Bardelli A, van Rheenen J, Medema RH, Tejpar S, Bernards R.

Cell. 2016 Apr 7;165(2):317-30. doi: 10.1016/j.cell.2016.02.059.

26.

Implications of Extracellular Vesicle Transfer on Cellular Heterogeneity in Cancer: What Are the Potential Clinical Ramifications?

Zomer A, van Rheenen J.

Cancer Res. 2016 Apr 15;76(8):2071-5. doi: 10.1158/0008-5472.CAN-15-2804. Epub 2016 Mar 31. Review.

27.

Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses.

Scheele CLGJ, Maynard C, van Rheenen J.

Trends Cancer. 2016 Apr;2(4):205-216. doi: 10.1016/j.trecan.2016.03.001. Epub 2016 Mar 28. Review.

PMID:
28741572
28.

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity.

Beerling E, Seinstra D, de Wit E, Kester L, van der Velden D, Maynard C, Schäfer R, van Diest P, Voest E, van Oudenaarden A, Vrisekoop N, van Rheenen J.

Cell Rep. 2016 Mar 15;14(10):2281-8. doi: 10.1016/j.celrep.2016.02.034. Epub 2016 Mar 3.

29.

Studying extracellular vesicle transfer by a Cre-loxP method.

Zomer A, Steenbeek SC, Maynard C, van Rheenen J.

Nat Protoc. 2016 Jan;11(1):87-101. doi: 10.1038/nprot.2015.138. Epub 2015 Dec 10.

PMID:
26658469
30.

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.

Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, Lauffenburger DA, Gertler FB.

Mol Biol Cell. 2015 Nov 1;26(21):3867-78. doi: 10.1091/mbc.E15-06-0442. Epub 2015 Sep 2.

31.

In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.

Zomer A, Maynard C, Verweij FJ, Kamermans A, Schäfer R, Beerling E, Schiffelers RM, de Wit E, Berenguer J, Ellenbroek SIJ, Wurdinger T, Pegtel DM, van Rheenen J.

Cell. 2015 May 21;161(5):1046-1057. doi: 10.1016/j.cell.2015.04.042.

32.

Imaging windows for long-term intravital imaging: General overview and technical insights.

Alieva M, Ritsma L, Giedt RJ, Weissleder R, van Rheenen J.

Intravital. 2014 Aug 11;3(2):e29917. doi: 10.4161/intv.29917. eCollection 2014.

33.

Imaging hallmarks of cancer in living mice.

Ellenbroek SI, van Rheenen J.

Nat Rev Cancer. 2014 Jun;14(6):406-18. doi: 10.1038/nrc3742. Review.

PMID:
24854083
34.

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

Ritsma L, Ellenbroek SIJ, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J.

Nature. 2014 Mar 20;507(7492):362-365. doi: 10.1038/nature12972. Epub 2014 Feb 16.

35.

The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury.

van Golen RF, Reiniers MJ, Vrisekoop N, Zuurbier CJ, Olthof PB, van Rheenen J, van Gulik TM, Parsons BJ, Heger M.

Antioxid Redox Signal. 2014 Sep 1;21(7):1098-118. doi: 10.1089/ars.2013.5751. Epub 2014 Feb 19. Review.

36.

In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique.

Ritsma L, Vrisekoop N, van Rheenen J.

Nat Commun. 2013;4:2366. doi: 10.1038/ncomms3366.

PMID:
23978961
37.

A versatile toolkit to produce sensitive FRET biosensors to visualize signaling in time and space.

Fritz RD, Letzelter M, Reimann A, Martin K, Fusco L, Ritsma L, Ponsioen B, Fluri E, Schulte-Merker S, van Rheenen J, Pertz O.

Sci Signal. 2013 Jul 23;6(285):rs12. doi: 10.1126/scisignal.2004135.

PMID:
23882122
38.

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy.

Janssen A, Beerling E, Medema R, van Rheenen J.

PLoS One. 2013 May 15;8(5):e64029. doi: 10.1371/journal.pone.0064029. Print 2013.

39.

Surgical implantation of an abdominal imaging window for intravital microscopy.

Ritsma L, Steller EJ, Ellenbroek SI, Kranenburg O, Borel Rinkes IH, van Rheenen J.

Nat Protoc. 2013 Mar;8(3):583-94. doi: 10.1038/nprot.2013.026. Epub 2013 Feb 21.

PMID:
23429719
40.

Intravital imaging of cancer stem cell plasticity in mammary tumors.

Zomer A, Ellenbroek SI, Ritsma L, Beerling E, Vrisekoop N, Van Rheenen J.

Stem Cells. 2013 Mar;31(3):602-6. doi: 10.1002/stem.1296.

41.

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

Ariotti S, Beltman JB, Chodaczek G, Hoekstra ME, van Beek AE, Gomez-Eerland R, Ritsma L, van Rheenen J, Marée AF, Zal T, de Boer RJ, Haanen JB, Schumacher TN.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19739-44. doi: 10.1073/pnas.1208927109. Epub 2012 Nov 12.

42.

Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis.

Ritsma L, Steller EJ, Beerling E, Loomans CJ, Zomer A, Gerlach C, Vrisekoop N, Seinstra D, van Gurp L, Schäfer R, Raats DA, de Graaff A, Schumacher TN, de Koning EJ, Rinkes IH, Kranenburg O, van Rheenen J.

Sci Transl Med. 2012 Oct 31;4(158):158ra145. doi: 10.1126/scitranslmed.3004394.

43.

If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer.

Bonapace L, Wyckoff J, Oertner T, Van Rheenen J, Junt T, Bentires-Alj M.

J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):125-9. doi: 10.1007/s10911-012-9250-8. Epub 2012 May 12. Review.

PMID:
22581273
44.

Real-time intravital imaging of cancer models.

Zomer A, Beerling E, Vlug EJ, van Rheenen J.

Clin Transl Oncol. 2011 Dec;13(12):848-54. doi: 10.1007/s12094-011-0745-3. Review.

PMID:
22126727
45.

MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions.

Stevens SJ, van Ravenswaaij-Arts CM, Janssen JW, Klein Wassink-Ruiter JS, van Essen AJ, Dijkhuizen T, van Rheenen J, Heuts-Vijgen R, Stegmann AP, Smeets EE, Engelen JJ.

Am J Med Genet A. 2011 Nov;155A(11):2739-45. doi: 10.1002/ajmg.a.34274. Epub 2011 Oct 11.

PMID:
21990140
46.

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.

Steller EJ, Ritsma L, Raats DA, Hoogwater FJ, Emmink BL, Govaert KM, Laoukili J, Rinkes IH, van Rheenen J, Kranenburg O.

EMBO Rep. 2011 Sep 1;12(9):931-7. doi: 10.1038/embor.2011.129.

47.

Intravital microscopy: new insights into metastasis of tumors.

Beerling E, Ritsma L, Vrisekoop N, Derksen PW, van Rheenen J.

J Cell Sci. 2011 Feb 1;124(Pt 3):299-310. doi: 10.1242/jcs.072728. Review.

48.

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H.

Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016/j.cell.2010.09.016.

49.

Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.

van Ham TJ, Holmberg MA, van der Goot AT, Teuling E, Garcia-Arencibia M, Kim HE, Du D, Thijssen KL, Wiersma M, Burggraaff R, van Bergeijk P, van Rheenen J, Jerre van Veluw G, Hofstra RM, Rubinsztein DC, Nollen EA.

Cell. 2010 Aug 20;142(4):601-12. doi: 10.1016/j.cell.2010.07.020.

50.

Nano-imaging of membrane topography affects interpretations in cell biology.

Jalink K, van Rheenen J.

Nat Methods. 2010 Jul;7(7):486. doi: 10.1038/nmeth0710-486. No abstract available.

PMID:
20588265

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