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Items: 42


Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map.

de Leeuw VC, Hessel EVS, Pennings JLA, Hodemaekers HM, Wackers PFK, van Oostrom CTM, Piersma AH.

Neurotoxicology. 2019 Oct 5;76:1-9. doi: 10.1016/j.neuro.2019.09.014. [Epub ahead of print]


Time-restricted feeding improves adaptation to chronically alternating light-dark cycles.

Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, Tambyrajah LL, Wackers P, Deboer T, Hulsegge G, Proper KI, van Steeg H, Roenneberg T, Biermasz NR, Rensen PCN, Kooijman S, van Kerkhof LWM.

Sci Rep. 2019 May 27;9(1):7874. doi: 10.1038/s41598-019-44398-7.


A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.

Jongbloed F, Saat TC, Verweij M, Payan-Gomez C, Hoeijmakers JH, van den Engel S, van Oostrom CT, Ambagtsheer G, Imholz S, Pennings JL, van Steeg H, IJzermans JN, Dollé ME, de Bruin RW.

Sci Rep. 2017 Jan 19;7:40901. doi: 10.1038/srep40901.


Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH.

Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24.


Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting.

van Kerkhof LW, Van Dycke KC, Jansen EH, Beekhof PK, van Oostrom CT, Ruskovska T, Velickova N, Kamcev N, Pennings JL, van Steeg H, Rodenburg W.

PLoS One. 2015 Aug 18;10(8):e0135652. doi: 10.1371/journal.pone.0135652. eCollection 2015.


Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

Van Dycke KC, Rodenburg W, van Oostrom CT, van Kerkhof LW, Pennings JL, Roenneberg T, van Steeg H, van der Horst GT.

Curr Biol. 2015 Jul 20;25(14):1932-7. doi: 10.1016/j.cub.2015.06.012.


Biomarkers for circadian rhythm disruption independent of time of day.

Van Dycke KC, Pennings JL, van Oostrom CT, van Kerkhof LW, van Steeg H, van der Horst GT, Rodenburg W.

PLoS One. 2015 May 18;10(5):e0127075. doi: 10.1371/journal.pone.0127075. eCollection 2015.


Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.

Jongbloed F, de Bruin RW, Pennings JL, Payán-Gómez C, van den Engel S, van Oostrom CT, de Bruin A, Hoeijmakers JH, van Steeg H, IJzermans JN, Dollé ME.

PLoS One. 2014 Jun 24;9(6):e100853. doi: 10.1371/journal.pone.0100853. eCollection 2014.


A range finding protocol to support design for transcriptomics experimentation: examples of in-vitro and in-vivo murine UV exposure.

Bruning O, Rodenburg W, van Oostrom CT, Jonker MJ, de Jong M, Dekker RJ, Rauwerda H, Ensink WA, de Vries A, Breit TM.

PLoS One. 2014 May 13;9(5):e97089. doi: 10.1371/journal.pone.0097089. eCollection 2014.


A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment.

Van Dycke KC, Nijman RM, Wackers PF, Jonker MJ, Rodenburg W, van Oostrom CT, Salvatori DC, Breit TM, van Steeg H, Luijten M, van der Horst GT.

Arch Toxicol. 2015 Feb;89(2):221-31. doi: 10.1007/s00204-014-1257-z. Epub 2014 May 13.


Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.

Melis JP, Kuiper RV, Zwart E, Robinson J, Pennings JL, van Oostrom CT, Luijten M, van Steeg H.

DNA Repair (Amst). 2013 Dec;12(12):1081-6. doi: 10.1016/j.dnarep.2013.08.019. Epub 2013 Sep 29.


A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum.

Opstal-van Winden AW, Rodenburg W, Pennings JL, van Oostrom CT, Beijnen JH, Peeters PH, van Gils CH, de Vries A.

Int J Mol Sci. 2012 Oct 22;13(10):13587-604. doi: 10.3390/ijms131013587.


Biomarker discovery using a comparative omics approach in a mouse model developing heterogeneous mammary cancer subtypes.

Pennings JL, Van Dycke KC, van Oostrom CT, Kuiper RV, Rodenburg W, de Vries A.

Proteomics. 2012 Jul;12(13):2149-57. doi: 10.1002/pmic.201100497.


Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening.

Pennings JL, Rodenburg W, Imholz S, Koster MP, van Oostrom CT, Breit TM, Schielen PC, de Vries A.

PLoS One. 2011 Apr 14;6(4):e18866. doi: 10.1371/journal.pone.0018866.


Serious complications in gene-expression studies with stress perturbation: An example of UV-exposed p53-mutant mouse embryonic fibroblasts.

Bruning O, Yuan X, Rodenburg W, Bruins W, van Oostrom CT, Rauwerda H, Wittink FR, Jonker MJ, de Vries A, Breit TM.

Transcription. 2010 Nov;1(3):159-164. Epub 2010 Aug 30.


Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoform.

Melis JP, Hoogervorst EM, van Oostrom CT, Zwart E, Breit TM, Pennings JL, de Vries A, van Steeg H.

Oncogene. 2011 Apr 14;30(15):1764-72. doi: 10.1038/onc.2010.552. Epub 2010 Dec 13.


Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach.

Rodenburg W, Pennings JL, van Oostrom CT, Roodbergen M, Kuiper RV, Luijten M, de Vries A.

Proteomics Clin Appl. 2010 Jul;4(6-7):603-12. doi: 10.1002/prca.200900175. Epub 2010 Mar 24.


Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells.

Verhofstad N, van Oostrom CT, Zwart E, Maas LM, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

Toxicol Sci. 2011 Jan;119(1):218-23. doi: 10.1093/toxsci/kfq325. Epub 2010 Oct 20.


Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice.

Verhofstad N, Pennings JL, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

BMC Genomics. 2010 May 26;11:333. doi: 10.1186/1471-2164-11-333.


DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene.

Verhofstad N, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW.

Environ Mol Mutagen. 2010 Mar;51(2):123-9. doi: 10.1002/em.20516.


High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.

Holstege H, Joosse SA, van Oostrom CT, Nederlof PM, de Vries A, Jonkers J.

Cancer Res. 2009 Apr 15;69(8):3625-33. doi: 10.1158/0008-5472.CAN-08-3426. Epub 2009 Mar 31.


Ozone induces clear cellular and molecular responses in the mouse lung independently of the transcription-coupled repair status.

Kooter IM, Pennings JL, Fokkens PH, Leseman DL, Boere AJ, Gerlofs-Nijland ME, Cassee FR, Schalk JA, Orzechowski TJ, Schaap MM, Breit TM, Dormans JA, van Oostrom CT, de Vries A, van Steeg H.

J Appl Physiol (1985). 2007 Mar;102(3):1185-92. Epub 2006 Nov 9.


Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.

Hoogervorst EM, Bruins W, Zwart E, van Oostrom CT, van den Aardweg GJ, Beems RB, van den Berg J, Jacks T, van Steeg H, de Vries A.

Cancer Res. 2005 May 1;65(9):3610-6.


2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair.

Hoogervorst EM, van Oostrom CT, Beems RB, van Benthem J, van den Berg J, van Kreijl CF, Vos JG, de Vries A, van Steeg H.

DNA Repair (Amst). 2005 Jan 2;4(1):3-9.


Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, van Oostrom CT, van den Berg J, van den Aardweg GJ, Lozano G, van Steeg H, Jacks T, de Vries A.

Mol Cell Biol. 2004 Oct;24(20):8884-94.


Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T.

EMBO J. 2004 Sep 15;23(18):3689-99. Epub 2004 Sep 2.


Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.

de Waard H, de Wit J, Andressoo JO, van Oostrom CT, Riis B, Weimann A, Poulsen HE, van Steeg H, Hoeijmakers JH, van der Horst GT.

Mol Cell Biol. 2004 Sep;24(18):7941-8.


p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.

Hoogervorst EM, van Oostrom CT, Beems RB, van Benthem J, Gielis S, Vermeulen JP, Wester PW, Vos JG, de Vries A, van Steeg H.

Cancer Res. 2004 Aug 1;64(15):5118-26.


Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice.

Hoogervorst EM, de Vries A, Beems RB, van Oostrom CT, Wester PW, Vos JG, Bruins W, Roodbergen M, Cassee FR, Vijg J, van Schooten FJ, van Steeg H.

Carcinogenesis. 2003 Mar;24(3):613-9.


Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function.

de Vries A, Flores ER, Miranda B, Hsieh HM, van Oostrom CT, Sage J, Jacks T.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2948-53. Epub 2002 Feb 26.


Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.

Tutt AN, van Oostrom CT, Ross GM, van Steeg H, Ashworth A.

EMBO Rep. 2002 Mar;3(3):255-60. Epub 2002 Feb 15.


DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models.

van Steeg H, de Vries A, van Oostrom CTh, van Benthem J, Beems RB, van Kreijl CF.

Toxicol Pathol. 2001;29 Suppl:109-16. Review.


The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.

Wijnhoven SW, Kool HJ, van Oostrom CT, Beems RB, Mullenders LH, van Zeeland AA, van der Horst GT, Vrieling H, van Steeg H.

Cancer Res. 2000 Oct 15;60(20):5681-7.


Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice.

van Oostrom CT, Boeve M, van Den Berg J, de Vries A, Dollé ME, Beems RB, van Kreijl CF, Vijg J, van Steeg H.

Environ Mol Mutagen. 1999;34(2-3):124-30.


Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo.

Bol SA, van Steeg H, van Oostrom CT, Tates AD, Vrieling H, de Groot AJ, Mullenders LH, van Zeeland AA, Jansen JG.

Mutagenesis. 1999 May;14(3):317-22.


Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice.

de Vries A, van Oostrom CT, Dortant PM, Beems RB, van Kreijl CF, Capel PJ, van Steeg H.

Mol Carcinog. 1997 May;19(1):46-53.


Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.

Kroese ED, Dortant PM, van Steeg H, van Oostrom CT, van der Houven van Oordt CW, van Kranen HJ, de Vries A, Wester PW, van Kreijl CF.

Carcinogenesis. 1997 May;18(5):975-80.


Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

de Vries A, van Oostrom CT, Hofhuis FM, Dortant PM, Berg RJ, de Gruijl FR, Wester PW, van Kreijl CF, Capel PJ, van Steeg H, Verbeek SJ.

Nature. 1995 Sep 14;377(6545):169-73.


Cloning and characterization of the mouse XPAC gene.

van Oostrom CT, de Vries A, Verbeek SJ, van Kreijl CF, van Steeg H.

Nucleic Acids Res. 1994 Jan 11;22(1):11-4.


The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent way.

Van Steeg H, Van Oostrom CT, Hodemaekers HM, Peters L, Thomas AA.

Biochem J. 1991 Mar 1;274 ( Pt 2):521-6.


Cloning and functional analysis of the rat ornithine decarboxylase-encoding gene.

van Steeg H, van Oostrom CT, Hodemaekers HM, van Kreyl CF.

Gene. 1990 Sep 14;93(2):249-56.


Nucleotide sequence of the human ornithine decarboxylase gene.

van Steeg H, van Oostrom CT, Martens JW, van Kreyl C, Schepens J, Wieringa B.

Nucleic Acids Res. 1989 Nov 11;17(21):8855-6. No abstract available.

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