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Items: 1 to 50 of 154

1.

A cellular census of human lungs identifies novel cell states in health and in asthma.

Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA.

Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17.

PMID:
31209336
2.

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation.

Kerscher B, Barlow JL, Rana BM, Jolin HE, Gogoi M, Bartholomew MA, Jhamb D, Pandey A, Tough DF, van Oosterhout AJM, McKenzie ANJ.

Front Immunol. 2019 Apr 9;10:678. doi: 10.3389/fimmu.2019.00678. eCollection 2019.

3.

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology.

Post S, Heijink IH, Hesse L, Koo HK, Shaheen F, Fouadi M, Kuchibhotla VNS, Lambrecht BN, Van Oosterhout AJM, Hackett TL, Nawijn MC.

Sci Rep. 2018 Sep 5;8(1):13275. doi: 10.1038/s41598-018-31500-8.

4.

Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma.

Hesse L, Brouwer U, Petersen AH, Gras R, Bosman L, Brimnes J, Oude Elberink JNG, van Oosterhout AJM, Nawijn MC.

Clin Exp Allergy. 2018 Aug;48(8):1035-1049. doi: 10.1111/cea.13169. Epub 2018 Jun 8.

PMID:
29752757
5.

Genetic variance is associated with susceptibility for cigarette smoke-induced DAMP release in mice.

Pouwels SD, Faiz A, den Boef LE, Gras R, van den Berge M, Boezen HM, Korstanje R, Ten Hacken NHT, van Oosterhout AJM, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L559-L580. doi: 10.1152/ajplung.00466.2016. Epub 2017 Jun 8.

6.

Viral mimic poly-(I:C) attenuates airway epithelial T-cell suppressive capacity: implications for asthma.

Schwarze J, Fitch PM, Heimweg J, Errington C, Matsuda R, de Bruin HG, van den Berge M, van Oosterhout AJ, Heijink IH.

Eur Respir J. 2016 Dec;48(6):1785-1788. doi: 10.1183/13993003.00841-2016. Epub 2016 Oct 6. No abstract available.

7.

Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD.

Pouwels SD, Hesse L, Faiz A, Lubbers J, Bodha PK, Ten Hacken NH, van Oosterhout AJ, Nawijn MC, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L881-L892. doi: 10.1152/ajplung.00135.2016. Epub 2016 Sep 9.

8.

Advanced glycation endproducts and their receptor in different body compartments in COPD.

Hoonhorst SJ, Lo Tam Loi AT, Pouwels SD, Faiz A, Telenga ED, van den Berge M, Koenderman L, Lammers JW, Boezen HM, van Oosterhout AJ, Lodewijk ME, Timens W, Postma DS, Ten Hacken NH.

Respir Res. 2016 Apr 26;17:46. doi: 10.1186/s12931-016-0363-2.

9.

Budesonide and fluticasone propionate differentially affect the airway epithelial barrier.

Heijink IH, Jonker MR, de Vries M, van Oosterhout AJ, Telenga E, Ten Hacken NH, Postma DS, van den Berge M.

Respir Res. 2016 Jan 6;17:2. doi: 10.1186/s12931-015-0318-z.

10.

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice.

Pouwels SD, Zijlstra GJ, van der Toorn M, Hesse L, Gras R, Ten Hacken NH, Krysko DV, Vandenabeele P, de Vries M, van Oosterhout AJ, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L377-86. doi: 10.1152/ajplung.00174.2015. Epub 2015 Dec 30.

11.

Pim1 kinase activity preserves airway epithelial integrity upon house dust mite exposure.

de Vries M, Hesse L, Jonker MR, van den Berge M, van Oosterhout AJ, Heijink IH, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1344-53. doi: 10.1152/ajplung.00043.2015. Epub 2015 Oct 9.

12.

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.

Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Andò F, Speciale G, Kilty I, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1112-23. doi: 10.1152/ajplung.00077.2015. Epub 2015 Aug 28.

13.

ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium.

Post S, Rozeveld D, Jonker MR, Bischoff R, van Oosterhout AJ, Heijink IH.

Allergy. 2015 Dec;70(12):1545-52. doi: 10.1111/all.12730. Epub 2015 Sep 11.

PMID:
26296735
14.

Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients.

Pouwels SD, Nawijn MC, Bathoorn E, Riezebos-Brilman A, van Oosterhout AJ, Kerstjens HA, Heijink IH.

Eur Respir J. 2015 May;45(5):1482-5. doi: 10.1183/09031936.00158414. No abstract available.

15.

Profiling over 1500 lipids in induced lung sputum and the implications in studying lung diseases.

t'Kindt R, Telenga ED, Jorge L, Van Oosterhout AJ, Sandra P, Ten Hacken NH, Sandra K.

Anal Chem. 2015;87(9):4957-64. doi: 10.1021/acs.analchem.5b00732. Epub 2015 Apr 24.

PMID:
25884268
16.

MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation.

Matusiak N, van Waarde A, Rozeveld D, van Oosterhout AJ, Heijink IH, Castelli R, Overkleeft HS, Bischoff R, Dierckx RA, Elsinga PH.

Mol Imaging Biol. 2015 Oct;17(5):680-7. doi: 10.1007/s11307-015-0847-3.

PMID:
25822732
17.

Metalloproteinase Profiling in Lung Transplant Recipients With Good Outcome and Bronchiolitis Obliterans Syndrome.

Heijink IH, Rozeveld D, van der Heide S, van der Bij W, Bischoff R, van Oosterhout AJ, van der Toorn M.

Transplantation. 2015 Sep;99(9):1946-52. doi: 10.1097/TP.0000000000000602.

PMID:
25651312
18.

Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice.

Pouwels SD, Heijink IH, Brouwer U, Gras R, den Boef LE, Boezen HM, Korstanje R, van Oosterhout AJ, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L693-709. doi: 10.1152/ajplung.00118.2014. Epub 2015 Jan 30.

19.

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD.

Hoonhorst SJ, Timens W, Koenderman L, Lo Tam Loi AT, Lammers JW, Boezen HM, van Oosterhout AJ, Postma DS, Ten Hacken NH.

Respir Res. 2014 Oct 10;15:121. doi: 10.1186/s12931-014-0121-2.

20.

Cigarette smoke-induced damage-associated molecular pattern release from necrotic neutrophils triggers proinflammatory mediator release.

Heijink IH, Pouwels SD, Leijendekker C, de Bruin HG, Zijlstra GJ, van der Vaart H, ten Hacken NH, van Oosterhout AJ, Nawijn MC, van der Toorn M.

Am J Respir Cell Mol Biol. 2015 May;52(5):554-62. doi: 10.1165/rcmb.2013-0505OC. Erratum in: Am J Respir Cell Mol Biol. 2016 Apr;54(4):597-9.

PMID:
25192219
21.

Basophil activation test in mastocytosis patients with and without wasp venom allergy.

Bidad K, Nawijn MC, van Oosterhout AJ, van der Heide S, Oude Elberink JN.

Cytometry B Clin Cytom. 2015 Jan;88(1):5. doi: 10.1002/cyto.b.21181. Epub 2014 Aug 28. No abstract available.

22.

Basophil activation test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy.

Bidad K, Nawijn M, van Oosterhout AJ, van der Heide S, Oude Elberink JN.

Cytometry B Clin Cytom. 2014 Aug 4. doi: 10.1002/cytob.21181. [Epub ahead of print] No abstract available.

23.

Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

Koning H, van Oosterhout AJ, Brouwer U, den Boef LE, Gras R, Reinders-Luinge M, Brandsma CA, van der Toorn M, Hylkema MN, Willemse BW, Sayers I, Koppelman GH, Nawijn MC.

PLoS One. 2014 Jul 3;9(7):e98197. doi: 10.1371/journal.pone.0098197. eCollection 2014.

24.

Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease.

Heijink IH, Noordhoek JA, Timens W, van Oosterhout AJ, Postma DS.

Am J Respir Crit Care Med. 2014 Jun 1;189(11):1439-42. doi: 10.1164/rccm.201311-1982LE. No abstract available.

PMID:
24881942
25.

Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids.

Telenga ED, Hoffmann RF, Ruben t'Kindt, Hoonhorst SJ, Willemse BW, van Oosterhout AJ, Heijink IH, van den Berge M, Jorge L, Sandra P, Postma DS, Sandra K, ten Hacken NH.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):155-64. doi: 10.1164/rccm.201312-2210OC.

PMID:
24871890
26.

Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation.

de Vries M, Heijink IH, Gras R, den Boef LE, Reinders-Luinge M, Pouwels SD, Hylkema MN, van der Toorn M, Brouwer U, van Oosterhout AJ, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L240-51. doi: 10.1152/ajplung.00156.2013. Epub 2014 May 9.

27.

Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice.

Post S, Heijink IH, Petersen AH, de Bruin HG, van Oosterhout AJ, Nawijn MC.

PLoS One. 2014 Mar 20;9(3):e91206. doi: 10.1371/journal.pone.0091206. eCollection 2014.

28.

Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium.

Zijlstra GJ, Fattahi F, Rozeveld D, Jonker MR, Kliphuis NM, van den Berge M, Hylkema MN, ten Hacken NH, van Oosterhout AJ, Heijink IH.

Eur Respir J. 2014 Aug;44(2):361-70. doi: 10.1183/09031936.00209513. Epub 2014 Mar 13.

29.

Shifted T-cell polarisation after agricultural dust exposure in mice and men.

Robbe P, Spierenburg EA, Draijer C, Brandsma CA, Telenga E, van Oosterhout AJ, van den Berge M, Luinge M, Melgert BN, Heederik D, Timens W, Wouters IM, Hylkema MN.

Thorax. 2014 Jul;69(7):630-7. doi: 10.1136/thoraxjnl-2013-204295. Epub 2014 Feb 17.

PMID:
24536057
30.

Basophil activation test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy on immunotherapy.

Bidad K, Nawijn MC, van Oosterhout AJ, van der Heide S, Elberink JN.

Cytometry B Clin Cytom. 2014 May;86(3):183-90. doi: 10.1002/cyto.b.21148. Epub 2014 Jan 29.

31.

Basophil Activation Test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy.

Bidad K, Nawijn MC, van Oosterhout AJ, van der Heide S, Elberink JN.

Cytometry B Clin Cytom. 2013 Dec 10. doi: 10.1002/cytob.21148. [Epub ahead of print]

32.

A specific DAMP profile identifies susceptibility to smoke-induced airway inflammation.

Pouwels SD, Heijink IH, van Oosterhout AJ, Nawijn MC.

Eur Respir J. 2014 Apr;43(4):1183-6. doi: 10.1183/09031936.00127813. Epub 2013 Dec 5. No abstract available.

33.

DAMPs activating innate and adaptive immune responses in COPD.

Pouwels SD, Heijink IH, ten Hacken NH, Vandenabeele P, Krysko DV, Nawijn MC, van Oosterhout AJ.

Mucosal Immunol. 2014 Mar;7(2):215-26. doi: 10.1038/mi.2013.77. Epub 2013 Oct 23. Review.

PMID:
24150257
34.

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells.

Hoffmann RF, Zarrintan S, Brandenburg SM, Kol A, de Bruin HG, Jafari S, Dijk F, Kalicharan D, Kelders M, Gosker HR, Ten Hacken NH, van der Want JJ, van Oosterhout AJ, Heijink IH.

Respir Res. 2013 Oct 2;14:97. doi: 10.1186/1465-9921-14-97.

35.

House dust mite-induced calcium signaling instigates epithelial barrier dysfunction and CCL20 production.

Post S, Nawijn MC, Jonker MR, Kliphuis N, van den Berge M, van Oosterhout AJ, Heijink IH.

Allergy. 2013 Sep;68(9):1117-25. doi: 10.1111/all.12202. Epub 2013 Aug 5.

PMID:
23915187
36.

Caveolin-1 controls airway epithelial barrier function. Implications for asthma.

Hackett TL, de Bruin HG, Shaheen F, van den Berge M, van Oosterhout AJ, Postma DS, Heijink IH.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):662-71. doi: 10.1165/rcmb.2013-0124OC.

PMID:
23742006
37.

Critical role of aldehydes in cigarette smoke-induced acute airway inflammation.

van der Toorn M, Slebos DJ, de Bruin HG, Gras R, Rezayat D, Jorge L, Sandra K, van Oosterhout AJ.

Respir Res. 2013 Apr 17;14:45. doi: 10.1186/1465-9921-14-45.

38.

Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy.

Maazi H, Shirinbak S, den Boef LE, Fallarino F, Volpi C, Nawijn MC, van Oosterhout AJ.

Clin Exp Immunol. 2013 Apr;172(1):113-20. doi: 10.1111/cei.12041.

39.

TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice.

Nawijn MC, Motta AC, Gras R, Shirinbak S, Maazi H, van Oosterhout AJ.

PLoS One. 2013;8(2):e55307. doi: 10.1371/journal.pone.0055307. Epub 2013 Feb 5.

40.

Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD: from specific disease phenotyping towards novel therapy. Protocol of a cross-sectional study.

Lo Tam Loi AT, Hoonhorst SJ, Franciosi L, Bischoff R, Hoffmann RF, Heijink I, van Oosterhout AJ, Boezen HM, Timens W, Postma DS, Lammers JW, Koenderman L, Ten Hacken NH.

BMJ Open. 2013 Feb 1;3(2). pii: e002178. doi: 10.1136/bmjopen-2012-002178. Print 2013.

41.

Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease.

Heijink IH, de Bruin HG, van den Berge M, Bennink LJ, Brandenburg SM, Gosens R, van Oosterhout AJ, Postma DS.

Thorax. 2013 Aug;68(8):709-16. doi: 10.1136/thoraxjnl-2012-201667. Epub 2013 Jan 31.

PMID:
23370438
42.

Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy.

Maazi H, Shirinbak S, Willart M, Hammad HM, Cabanski M, Boon L, Ganesh V, Baru AM, Hansen G, Lambrecht BN, Sparwasser T, Nawijn MC, van Oosterhout AJ.

Clin Exp Allergy. 2012 Oct;42(10):1519-28. doi: 10.1111/j.1365-2222.2012.04064.x.

PMID:
22994349
43.

Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells.

Somborac-Bacura A, van der Toorn M, Franciosi L, Slebos DJ, Zanic-Grubisic T, Bischoff R, van Oosterhout AJ.

Exp Physiol. 2013 Jan;98(1):316-25. doi: 10.1113/expphysiol.2012.067249. Epub 2012 Jul 30.

44.

Quantification of matrix metalloprotease-9 in bronchoalveolar lavage fluid by selected reaction monitoring with microfluidics nano-liquid-chromatography-mass spectrometry.

Prely LM, Paal K, Hermans J, van der Heide S, van Oosterhout AJ, Bischoff R.

J Chromatogr A. 2012 Jul 13;1246:103-10. doi: 10.1016/j.chroma.2012.02.076. Epub 2012 Mar 6.

PMID:
22464002
45.

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar.

Antó JM, Pinart M, Akdis M, Auffray C, Bachert C, Basagaña X, Carlsen KH, Guerra S, von Hertzen L, Illi S, Kauffmann F, Keil T, Kiley JP, Koppelman GH, Lupinek C, Martinez FD, Nawijn MC, Postma DS, Siroux V, Smit HA, Sterk PJ, Sunyer J, Valenta R, Valverde S, Akdis CA, Annesi-Maesano I, Ballester F, Benet M, Cambon-Thomsen A, Chatzi L, Coquet J, Demoly P, Gan W, Garcia-Aymerich J, Gimeno-Santos E, Guihenneuc-Jouyaux C, Haahtela T, Heinrich J, Herr M, Hohmann C, Jacquemin B, Just J, Kerkhof M, Kogevinas M, Kowalski ML, Lambrecht BN, Lau S, Lødrup Carlsen KC, Maier D, Momas I, Noel P, Oddie S, Palkonen S, Pin I, Porta D, Punturieri A, Rancière F, Smith RA, Stanic B, Stein RT, van de Veen W, van Oosterhout AJ, Varraso R, Wickman M, Wijmenga C, Wright J, Yaman G, Zuberbier T, Bousquet J; WHO Collaborating Centre on Asthma and Rhinitis (Montpellier).

J Allergy Clin Immunol. 2012 Apr;129(4):943-54.e4. doi: 10.1016/j.jaci.2012.01.047. Epub 2012 Mar 3. Review.

PMID:
22386796
46.

The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation.

Post S, Nawijn MC, Hackett TL, Baranowska M, Gras R, van Oosterhout AJ, Heijink IH.

Thorax. 2012 Jun;67(6):488-95. doi: 10.1136/thoraxjnl-2011-200606. Epub 2011 Dec 13.

PMID:
22167364
47.

Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.

Koning H, Sayers I, Stewart CE, de Jong D, Ten Hacken NH, Postma DS, van Oosterhout AJ, Nawijn MC, Koppelman GH.

FASEB J. 2012 Jan;26(1):439-48. doi: 10.1096/fj.11-185207. Epub 2011 Oct 7.

PMID:
21982948
48.

Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.

Maazi H, Shirinbak S, Bloksma N, Nawijn MC, van Oosterhout AJ.

Clin Exp Immunol. 2011 Oct;166(1):80-6. doi: 10.1111/j.1365-2249.2011.04448.x.

49.

Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.

Heijink IH, Brandenburg SM, Noordhoek JA, Slebos DJ, Postma DS, van Oosterhout AJ.

Respir Res. 2011 Aug 23;12:110. doi: 10.1186/1465-9921-12-110.

50.

Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells.

Zijlstra GJ, Ten Hacken NH, Hoffmann RF, van Oosterhout AJ, Heijink IH.

Eur Respir J. 2012 Feb;39(2):439-45. doi: 10.1183/09031936.00017911. Epub 2011 Aug 4.

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