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Items: 4

1.

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.

Prager I, Liesche C, van Ooijen H, Urlaub D, Verron Q, Sandström N, Fasbender F, Claus M, Eils R, Beaudouin J, Önfelt B, Watzl C.

J Exp Med. 2019 Sep 2;216(9):2113-2127. doi: 10.1084/jem.20181454. Epub 2019 Jul 3.

PMID:
31270246
2.

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types.

Stolpe AV, Holtzer L, van Ooijen H, de Inda MA, Verhaegh W.

Sci Rep. 2019 Feb 7;9(1):1603. doi: 10.1038/s41598-018-38179-x.

3.

Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model.

van Ooijen H, Hornsveld M, Dam-de Veen C, Velter R, Dou M, Verhaegh W, Burgering B, van de Stolpe A.

Am J Pathol. 2018 Sep;188(9):1956-1972. doi: 10.1016/j.ajpath.2018.05.020. Epub 2018 Jul 6.

4.

Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.

Verhaegh W, van Ooijen H, Inda MA, Hatzis P, Versteeg R, Smid M, Martens J, Foekens J, van de Wiel P, Clevers H, van de Stolpe A.

Cancer Res. 2014 Jun 1;74(11):2936-45. doi: 10.1158/0008-5472.CAN-13-2515. Epub 2014 Apr 2.

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