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FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.

Du Q, Huynh LK, Coskun F, Molina E, King MA, Raj P, Khan S, Dozmorov I, Seroogy CM, Wysocki CA, Padron GT, Yates TR, Markert ML, de la Morena MT, van Oers NS.

J Clin Invest. 2019 Nov 1;129(11):4724-4738. doi: 10.1172/JCI127565.


MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.

Du Q, Hoover AR, Dozmorov I, Raj P, Khan S, Molina E, Chang TC, de la Morena MT, Cleaver OB, Mendell JT, van Oers NSC.

Dev Cell. 2019 May 20;49(4):618-631.e5. doi: 10.1016/j.devcel.2019.03.012. Epub 2019 Apr 11.


Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations.

Maryoung L, Yue Y, Young A, Newton CA, Barba C, van Oers NS, Wang RC, Garcia CK.

J Clin Invest. 2017 Mar 1;127(3):982-986. doi: 10.1172/JCI91161. Epub 2017 Feb 13.


MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines.

Hoover AR, Dozmorov I, MacLeod J, Du Q, de la Morena MT, Forbess J, Guleserian K, Cleaver OB, van Oers NS.

J Biol Chem. 2016 Oct 28;291(44):23237-23247. Epub 2016 Sep 19.


STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells.

Gonzales-van Horn SR, Estrada LD, van Oers NS, Farrar JD.

Eur J Immunol. 2016 Jun;46(6):1504-10. doi: 10.1002/eji.201546050. Epub 2016 Apr 8.


RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8.

Khan S, Kuruvilla M, Hagin D, Wakeland B, Liang C, Vishwanathan K, Gatti RA, Torgersen TR, Abraham RS, Wakeland EK, van Oers NSC, de la Morena MT.

J Allergy Clin Immunol. 2016 Jul;138(1):289-292.e6. doi: 10.1016/j.jaci.2015.11.033. Epub 2016 Feb 13. No abstract available.


Pillars article: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 1994. 263: 1136-1139.

Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A.

J Immunol. 2014 Nov 1;193(9):4279-82. No abstract available.


The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.

Dodd DA, Worth RG, Rosen MK, Grinstein S, van Oers NS, Hansen EJ.

MBio. 2014 May 20;5(3):e01178-14. doi: 10.1128/mBio.01178-14.


Transgenic expression of microRNA-181d augments the stress-sensitivity of CD4(+)CD8(+) thymocytes.

Belkaya S, van Oers NS.

PLoS One. 2014 Jan 9;9(1):e85274. doi: 10.1371/journal.pone.0085274. eCollection 2014.


Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.

Belkaya S, Murray SE, Eitson JL, de la Morena MT, Forman JA, van Oers NS.

J Biol Chem. 2013 Oct 18;288(42):30752-62. doi: 10.1074/jbc.M113.503532. Epub 2013 Sep 6.


Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion/DiGeorge syndrome.

de la Morena MT, Eitson JL, Dozmorov IM, Belkaya S, Hoover AR, Anguiano E, Pascual MV, van Oers NSC.

Clin Immunol. 2013 Apr;147(1):11-22. doi: 10.1016/j.clim.2013.01.011. Epub 2013 Jan 30.


Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages.

Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS.

Appl Environ Microbiol. 2012 Oct;78(19):6829-37. doi: 10.1128/AEM.01674-12. Epub 2012 Jul 20.


The antibiotic resistance arrow of time: efflux pump induction is a general first step in the evolution of mycobacterial drug resistance.

Schmalstieg AM, Srivastava S, Belkaya S, Deshpande D, Meek C, Leff R, van Oers NS, Gumbo T.

Antimicrob Agents Chemother. 2012 Sep;56(9):4806-15. doi: 10.1128/AAC.05546-11. Epub 2012 Jul 2.


Dynamic modulation of thymic microRNAs in response to stress.

Belkaya S, Silge RL, Hoover AR, Medeiros JJ, Eitson JL, Becker AM, de la Morena MT, Bassel-Duby RS, van Oers NS.

PLoS One. 2011;6(11):e27580. doi: 10.1371/journal.pone.0027580. Epub 2011 Nov 16.


The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.

DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS.

J Immunol. 2011 Jun 15;186(12):6839-47. doi: 10.4049/jimmunol.1002721. Epub 2011 May 4.


Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.

de la Cruz J, Kruger T, Parks CA, Silge RL, van Oers NS, Luescher IF, Schrum AG, Gil D.

J Immunol. 2011 Feb 15;186(4):2282-90. doi: 10.4049/jimmunol.1003225. Epub 2011 Jan 12.


A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA subdural empyema.

Devora GA, Sun L, Chen Z, van Oers NS, Hanson EP, Orange JS, de la Morena MT.

J Clin Immunol. 2010 Nov;30(6):881-5. doi: 10.1007/s10875-010-9445-y. Epub 2010 Jul 23.


Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs.

Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS.

J Immunol. 2010 Jun 15;184(12):6822-32. doi: 10.4049/jimmunol.0902058. Epub 2010 May 14.


The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.

Deford-Watts LM, Tassin TC, Becker AM, Medeiros JJ, Albanesi JP, Love PE, Wülfing C, van Oers NS.

J Immunol. 2009 Jul 15;183(2):1055-64. doi: 10.4049/jimmunol.0900404. Epub 2009 Jun 19.


Spatiotemporal patterning during T cell activation is highly diverse.

Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C.

Sci Signal. 2009 Apr 7;2(65):ra15. doi: 10.1126/scisignal.2000199.


Haemophilus ducreyi LspA proteins are tyrosine phosphorylated by macrophage-encoded protein tyrosine kinases.

Deng K, Mock JR, Greenberg S, van Oers NS, Hansen EJ.

Infect Immun. 2008 Oct;76(10):4692-702. doi: 10.1128/IAI.00513-08. Epub 2008 Aug 4.


The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.

Young JA, Becker AM, Medeiros JJ, Shapiro VS, Wang A, Farrar JD, Quill TA, Hooft van Huijsduijnen R, van Oers NS.

Mol Immunol. 2008 Aug;45(14):3756-66. doi: 10.1016/j.molimm.2008.05.023. Epub 2008 Jul 9.


Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.

Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA.

Nat Immunol. 2008 Jun;9(6):658-66. doi: 10.1038/ni.1611. Epub 2008 May 11.


The membrane-proximal portion of CD3 epsilon associates with the serine/threonine kinase GRK2.

DeFord-Watts LM, Young JA, Pitcher LA, van Oers NS.

J Biol Chem. 2007 Jun 1;282(22):16126-34. Epub 2007 Apr 9.


The constitutive tyrosine phosphorylation of CD3zeta results from TCR-MHC interactions that are independent of thymic selection.

Becker AM, DeFord-Watts LM, Wuelfing C, van Oers NS.

J Immunol. 2007 Apr 1;178(7):4120-8.


Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling.

Mock JR, Vakevainen M, Deng K, Latimer JL, Young JA, van Oers NS, Greenberg S, Hansen EJ.

Infect Immun. 2005 Dec;73(12):7808-16.


The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs.

Pitcher LA, Mathis MA, Young JA, DeFord LM, Purtic B, Wulfing C, van Oers NS.

Eur J Immunol. 2005 Dec;35(12):3643-54.


Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential.

Pitcher LA, Mathis MA, Subramanian S, Young JA, Wakeland EK, Love PE, van Oers NS.

J Immunol. 2005 May 15;174(10):6071-9.


Cell biology. Kinasing and clipping down the NF-kappa B trail.

van Oers NS, Chen ZJ.

Science. 2005 Apr 1;308(5718):65-6. No abstract available.


T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells.

Purtic B, Pitcher LA, van Oers NS, Wülfing C.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2904-9. Epub 2005 Feb 9.


PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.

Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS.

J Biol Chem. 2004 Feb 27;279(9):7760-9. Epub 2003 Dec 12.


T-cell receptor signal transmission: who gives an ITAM?

Pitcher LA, van Oers NS.

Trends Immunol. 2003 Oct;24(10):554-60. Review.


The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits.

Pitcher LA, Young JA, Mathis MA, Wrage PC, Bartók B, van Oers NS.

Immunol Rev. 2003 Feb;191:47-61. Review.


Positive selection by the pre-TCR yields mature CD8+ T cells.

Ito Y, Arai S, van Oers NS, Aifantis I, von Boehmer H, Miyazaki T.

J Immunol. 2002 Nov 1;169(9):4913-9.


I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function.

Ren H, Schmalstieg A, van Oers NS, Gaynor RB.

J Immunol. 2002 Apr 15;168(8):3721-31.


The 21- and 23-kD forms of TCR zeta are generated by specific ITAM phosphorylations.

van Oers NS, Tohlen B, Malissen B, Moomaw CR, Afendis S, Slaughter CA.

Nat Immunol. 2000 Oct;1(4):322-8.


Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression.

Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A.

J Immunol. 1999 Sep 1;163(5):2610-20.


T cell receptor-mediated signs and signals governing T cell development.

van Oers NS.

Semin Immunol. 1999 Aug;11(4):227-37. Review.


Differential requirements for ZAP-70 in TCR signaling and T cell development.

Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A.

J Immunol. 1998 Nov 1;161(9):4688-94.


Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs.

van Oers NS, Love PE, Shores EW, Weiss A.

J Immunol. 1998 Jan 1;160(1):163-70.


Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling.

Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A.

J Exp Med. 1997 Apr 7;185(7):1253-9.


Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development.

Page ST, van Oers NS, Perlmutter RM, Weiss A, Pullen AM.

Eur J Immunol. 1997 Feb;27(2):554-62.


alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.

van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A.

Immunity. 1996 Nov;5(5):429-36.


Syk mutation in Jurkat E6-derived clones results in lack of p72syk expression.

Fargnoli J, Burkhardt AL, Laverty M, Kut SA, van Oers NS, Weiss A, Bolen JB.

J Biol Chem. 1995 Nov 3;270(44):26533-7.


The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

van Oers NS, von Boehmer H, Weiss A.

J Exp Med. 1995 Nov 1;182(5):1585-90.


The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.

van Oers NS, Weiss A.

Semin Immunol. 1995 Aug;7(4):227-36. Review.


Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A.

J Immunol. 1994 May 15;152(10):4758-66.


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