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Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice.

Vries MJ, van der Meijden PE, Kuiper GJ, Nelemans PJ, Wetzels RJ, van Oerle RG, Lancé MD, Ten Cate H, Henskens YM.

Res Pract Thromb Haemost. 2018 Jul 27;2(4):767-777. doi: 10.1002/rth2.12114. eCollection 2018 Oct.


Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes.

Posthuma JJ, Posma JJN, Schep G, Bender MMH, van Oerle R, van der Wal AC, Ten Cate H, Spronk HMH.

J Vasc Surg. 2018 Oct 9. pii: S0741-5214(18)31630-6. doi: 10.1016/j.jvs.2018.05.220. [Epub ahead of print]


Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ.

Haematologica. 2018 Sep;103(9):1557-1567. doi: 10.3324/haematol.2017.185165. Epub 2018 Jun 7.


Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study.

Panova-Noeva M, Schulz A, Spronk HM, Beicht A, Laubert-Reh D, van Oerle R, Arnold N, Prochaska JH, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS.

Thromb Haemost. 2018 May;118(5):873-882. doi: 10.1055/s-0038-1641565. Epub 2018 Apr 3.


Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation.

Henskens YMC, Gulpen AJW, van Oerle R, Wetzels R, Verhezen P, Spronk H, Schalla S, Crijns HJ, Ten Cate H, Ten Cate-Hoek A.

Thromb J. 2018 Feb 1;16:3. doi: 10.1186/s12959-017-0160-2. eCollection 2018.


Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events.

Loeffen R, van Oerle R, Leers MP, Kragten JA, Crijns H, Spronk HM, Ten Cate H.

PLoS One. 2016 Jul 15;11(7):e0158355. doi: 10.1371/journal.pone.0158355. eCollection 2016.


Early platelet recovery following cardiac surgery with cardiopulmonary bypass.

Van Poucke S, Stevens K, Wetzels R, Kicken C, Verhezen P, Theunissen M, Kuiper G, van Oerle R, Henskens Y, Lancé M.

Platelets. 2016 Dec;27(8):751-757. Epub 2016 May 10.


OC-08 - Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy.

Baaten CC, Moenen FC, Henskens YM, Swieringa F, Wetzels R, van Oerle R, Ten Cate H, Beckers EA, Heemskerk JW, van der Meijden PE.

Thromb Res. 2016 Apr;140 Suppl 1:S171. doi: 10.1016/S0049-3848(16)30125-6. Epub 2016 Apr 8.


Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma.

van Beers JJ, van Egmond LT, Wetzels RJ, Verhezen PW, Beckers EA, van Oerle R, Spronk HM, Straat RJ, Henskens YM.

Vox Sang. 2016 Jul;111(1):33-42. doi: 10.1111/vox.12395. Epub 2016 Feb 29.


Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity.

Kuiper GJ, Kleinegris MC, van Oerle R, Spronk HM, Lancé MD, Ten Cate H, Henskens YM.

Thromb J. 2016 Jan 14;14:1. doi: 10.1186/s12959-016-0076-2. eCollection 2016.


Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia.

Spronk HM, Braunschweig T, Rossaint R, Wüst DC, van Oerle R, Lauritzen B, Tolba R, Grottke O.

PLoS One. 2015 Jun 22;10(6):e0113979. doi: 10.1371/journal.pone.0113979. eCollection 2015.


The hypercoagulable profile of patients with stent thrombosis.

Loeffen R, Godschalk TC, van Oerle R, Spronk HM, Hackeng CM, ten Berg JM, ten Cate H.

Heart. 2015 Jul;101(14):1126-32. doi: 10.1136/heartjnl-2014-306685. Epub 2015 May 21.


Desmopressin treatment improves platelet function under flow in patients with postoperative bleeding.

Swieringa F, Lancé MD, Fuchs B, Feijge MA, Solecka BA, Verheijen LP, Hughes KR, van Oerle R, Deckmyn H, Kannicht C, Heemskerk JW, van der Meijden PE.

J Thromb Haemost. 2015 Aug;13(8):1503-13. doi: 10.1111/jth.13007. Epub 2015 Jun 11.


Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies.

Boersma RS, Hamulyak K, van Oerle R, Tuinenburg A, Ten Cate-Hoek AJ, Schouten HC.

Clin Appl Thromb Hemost. 2016 Nov;22(8):779-784. Epub 2015 Apr 17.


Effects of ultrapure hemodialysis and low molecular weight heparin on the endothelial surface layer.

Cornelis T, Broers NJ, Titulaer DC, Henskens YM, van Oerle R, van der Sande FM, Spronk HM, Vink H, Leunissen KM, ten Cate H, Kooman JP.

Blood Purif. 2014;38(3-4):203-10. doi: 10.1159/000369055. Epub 2014 Dec 16.


Increased factor XIa levels in patients with a first acute myocardial infarction: the introduction of a new thrombin generation based factor XIa assay.

Loeffen R, van Oerle R, de Groot PG, Waltenberger J, Crijns HJ, Spronk HM, ten Cate H.

Thromb Res. 2014 Dec;134(6):1328-34. doi: 10.1016/j.thromres.2014.09.015. Epub 2014 Sep 28.


Long-term strenuous exercise induces a hypercoagulable state through contact activation.

Posthuma JJ, Loeffen R, van Oerle R, Henskens YM, ten Cate H, Spronk HM, van der Meijden PE.

Thromb Haemost. 2014 Jun;111(6):1197-9. doi: 10.1160/TH13-11-0963. Epub 2014 Jan 30. No abstract available.


Patients with antineutrophil cytoplasmic antibodies associated vasculitis in remission are hypercoagulable.

Hilhorst M, Winckers K, Wilde B, van Oerle R, ten Cate H, Tervaert JW.

J Rheumatol. 2013 Dec;40(12):2042-6. doi: 10.3899/jrheum.130200. Epub 2013 Oct 15.


Thrombin generation in the Glasgow Myocardial Infarction Study.

Smid M, Dielis AW, Spronk HM, Rumley A, van Oerle R, Woodward M, ten Cate H, Lowe G.

PLoS One. 2013 Jun 24;8(6):e66977. doi: 10.1371/journal.pone.0066977. Print 2013.


Platelet dysfunction in thrombosis patients treated with vitamin K antagonists and recurrent bleeding.

van der Meijden PE, Bouman AC, Feijge MA, van Oerle R, Spronk HM, Hamulyák K, ten Cate-Hoek AJ, ten Cate H, Heemskerk JW.

PLoS One. 2013 May 28;8(5):e64112. doi: 10.1371/journal.pone.0064112. Print 2013.


Thrombin generation capacity of prothrombin complex concentrate in an in vitro dilutional model.

Grottke O, Rossaint R, Henskens Y, van Oerle R, Ten Cate H, Spronk HM.

PLoS One. 2013 May 17;8(5):e64100. doi: 10.1371/journal.pone.0064100. Print 2013.


In vivo effects of foam sclerotherapy on coagulation.

Shadid NH, van der Velden SK, van Oerle R, Ten Cate H, Sommer A, Nelemans P.

Phlebology. 2014 Jun;29(5):287-92. doi: 10.1177/0268355513479590. Epub 2013 May 3.


Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project.

Strak M, Hoek G, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Janssen NA.

PLoS One. 2013;8(3):e58944. doi: 10.1371/journal.pone.0058944. Epub 2013 Mar 13.


Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.

Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H.

PLoS One. 2013;8(2):e55784. doi: 10.1371/journal.pone.0055784. Epub 2013 Feb 7.


Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project.

Strak M, Hoek G, Steenhof M, Kilinc E, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Kelly FJ, Harrison RM, Brunekreef B, Lebret E, Janssen NA.

Occup Environ Med. 2013 May;70(5):332-40. doi: 10.1136/oemed-2012-100992. Epub 2013 Feb 1.


Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method.

Loeffen R, Kleinegris MC, Loubele ST, Pluijmen PH, Fens D, van Oerle R, ten Cate H, Spronk HM.

J Thromb Haemost. 2012 Dec;10(12):2544-54. doi: 10.1111/jth.12012.


Coagulation on endothelial cells: the underexposed part of Virchow's Triad.

Geenen IL, Post MJ, Molin DG, Schurink GW, Maessen JG, van Oerle R, ten Cate H, Spronk HM.

Thromb Haemost. 2012 Nov;108(5):863-71. doi: 10.1160/TH12-04-0269. Epub 2012 Sep 5.


Long-term estrogen treatment of mice with a prothrombotic phenotype induces sustained increases in thrombin generation without affecting tissue fibrin deposition.

Cleuren AC, Van Oerle R, Reitsma PH, Spronk HM, Van Vlijmen BJ.

J Thromb Haemost. 2012 Nov;10(11):2392-4. doi: 10.1111/j.1538-7836.2012.04916.x. No abstract available.


The effects of pneumatic tube system transport on ROTEM analysis and contact activation assessed by thrombin generation test.

Lancé MD, Kuiper GJ, Sloep M, Spronk HM, van Oerle R, ten Cate H, Marcus MA, Henskens YM.

Thromb Res. 2012 Sep;130(3):e147-50. doi: 10.1016/j.thromres.2012.05.002. Epub 2012 May 25.


Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa.

Van Der Meijden PE, Van Schilfgaarde M, Van Oerle R, Renné T, ten Cate H, Spronk HM.

J Thromb Haemost. 2012 Jul;10(7):1355-62. doi: 10.1111/j.1538-7836.2012.04758.x.


Platelet concentrate transport in pneumatic tube systems--does it work?

Lancé MD, Marcus MA, van Oerle R, Theunissen HM, Henskens YM.

Vox Sang. 2012 Jul;103(1):79-82. doi: 10.1111/j.1423-0410.2011.01580.x. Epub 2012 Jan 5.


ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation.

Lecut C, Faccinetto C, Delierneux C, van Oerle R, Spronk HM, Evans RJ, El Benna J, Bours V, Oury C.

J Thromb Haemost. 2012 Mar;10(3):453-65. doi: 10.1111/j.1538-7836.2011.04606.x.


Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia.

Honickel M, Rieg A, Rossaint R, Braunschweig T, Spronk HM, ten Cate H, van Oerle R, Tolba R, Grottke O.

Thromb Haemost. 2011 Oct;106(4):724-33. doi: 10.1160/TH11-02-0101. Epub 2011 Sep 8.


Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury.

Grottke O, Braunschweig T, Spronk HM, Esch S, Rieg AD, van Oerle R, ten Cate H, Fitzner C, Tolba R, Rossaint R.

Blood. 2011 Aug 18;118(7):1943-51. doi: 10.1182/blood-2011-03-343046. Epub 2011 Jun 13.


Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A.

Ninivaggi M, Dargaud Y, van Oerle R, de Laat B, Hemker HC, Lindhout T.

J Thromb Haemost. 2011 Aug;9(8):1549-55. doi: 10.1111/j.1538-7836.2011.04358.x.


Factor XII activation is essential to sustain the procoagulant effects of particulate matter.

Kilinç E, Van Oerle R, Borissoff JI, Oschatz C, Gerlofs-Nijland ME, Janssen NA, Cassee FR, Sandström T, Renné T, Ten Cate H, Spronk HM.

J Thromb Haemost. 2011 Jul;9(7):1359-67. doi: 10.1111/j.1538-7836.2011.04280.x.


Thrombin generation in patients with a first acute myocardial infarction.

Smid M, Dielis AW, Winkens M, Spronk HM, van Oerle R, Hamulyák K, Prins MH, Rosing J, Waltenberger JL, ten Cate H.

J Thromb Haemost. 2011 Mar;9(3):450-6. doi: 10.1111/j.1538-7836.2010.04162.x.


Do we need time adjusted mean platelet volume measurements?

Lancé MD, van Oerle R, Henskens YM, Marcus MA.

Lab Hematol. 2010 Sep;16(3):28-31. doi: 10.1532/LH96.10011.


Early atherosclerosis exhibits an enhanced procoagulant state.

Borissoff JI, Heeneman S, Kilinç E, Kassák P, Van Oerle R, Winckers K, Govers-Riemslag JW, Hamulyák K, Hackeng TM, Daemen MJ, ten Cate H, Spronk HM.

Circulation. 2010 Aug 24;122(8):821-30. doi: 10.1161/CIRCULATIONAHA.109.907121. Epub 2010 Aug 9.


Endothelial activation in lacunar stroke subtypes.

Knottnerus IL, Govers-Riemslag JW, Hamulyak K, Rouhl RP, Staals J, Spronk HM, van Oerle R, van Raak EP, Lodder J, ten Cate H, van Oostenbrugge RJ.

Stroke. 2010 Aug;41(8):1617-22. doi: 10.1161/STROKEAHA.109.576223. Epub 2010 Jul 1.


A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control study.

Pönitz V, Govers-Riemslag JW, Ten Cate H, van Oerle R, Brügger-Andersen T, Grundt H, Næsgaard P, Pritchard D, Larsen AI, Nilsen DW.

Thromb J. 2010 Apr 15;8:6. doi: 10.1186/1477-9560-8-6.


Thrombin generation as an intermediate phenotype for venous thrombosis.

Segers O, van Oerle Rv, ten Cate Ht, Rosing J, Castoldi E.

Thromb Haemost. 2010 Jan;103(1):114-22. doi: 10.1160/TH09-06-0356. Epub 2009 Nov 13.


Monitoring thrombin generation: is addition of corn trypsin inhibitor needed?

Spronk HM, Dielis AW, Panova-Noeva M, van Oerle R, Govers-Riemslag JW, Hamulyák K, Falanga A, Cate HT.

Thromb Haemost. 2009 Jun;101(6):1156-62.


Activated protein C protects against myocardial ischemia/ reperfusion injury via inhibition of apoptosis and inflammation.

Loubele ST, Spek CA, Leenders P, van Oerle R, Aberson HL, Hamulyák K, Ferrell G, Esmon CT, Spronk HM, ten Cate H.

Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1087-92. doi: 10.1161/ATVBAHA.109.188656. Epub 2009 Apr 16.


Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice.

Loubele ST, Spek CA, Leenders P, van Oerle R, Aberson HL, van der Voort D, Hamulyák K, Petersen LC, Spronk HM, ten Cate H.

J Thromb Haemost. 2009 Feb;7(2):290-8. doi: 10.1111/j.1538-7836.2008.03232.x. Epub 2008 Nov 22.


A new method to determine tissue specific tissue factor thrombomodulin activities: endotoxin and particulate air pollution induced disbalance.

Frederix K, Kooter IM, van Oerle R, Fens D, Hamulyak K, Gerlofs-Nijland ME, Ten Cate H, Spronk HM.

Thromb J. 2008 Oct 1;6:14. doi: 10.1186/1477-9560-6-14.


Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera.

Marchetti M, Castoldi E, Spronk HM, van Oerle R, Balducci D, Barbui T, Rosing J, Ten Cate H, Falanga A.

Blood. 2008 Nov 15;112(10):4061-8. doi: 10.1182/blood-2008-06-164087. Epub 2008 Sep 3.


Assessment of thrombin generation II: Validation of the Calibrated Automated Thrombogram in platelet-poor plasma in a clinical laboratory.

Spronk HM, Dielis AW, De Smedt E, van Oerle R, Fens D, Prins MH, Hamulyák K, ten Cate H.

Thromb Haemost. 2008 Aug;100(2):362-4. No abstract available.


Thrombin generation in patients after acute deep-vein thrombosis.

ten Cate-Hoek AJ, Dielis AW, Spronk HM, van Oerle R, Hamulyák K, Prins MH, ten Cate H.

Thromb Haemost. 2008 Aug;100(2):240-5.


Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A.

Dielis AW, Balliël WM, van Oerle R, Hermens WT, Spronk HM, Ten Cate H, Hamulyák K.

Haematologica. 2008 Sep;93(9):1351-7. doi: 10.3324/haematol.13039. Epub 2008 Jul 18.

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