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Items: 1 to 50 of 86

1.

Farnesoid X receptor and bile acids regulate vitamin A storage.

Saeed A, Yang J, Heegsma J, Groen AK, van Mil SWC, Paulusma CC, Zhou L, Wang B, Faber KN.

Sci Rep. 2019 Dec 20;9(1):19493. doi: 10.1038/s41598-019-55988-w.

2.

Steroidogenic control of liver metabolism through a nuclear receptor-network.

Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson HAB, Bijsmans ITGW, Willemsen ECL, Ramos Pittol JM, Miguel-Aliaga I, Bosma P, Burgering BMT, Williamson C, Vernia S, Dhillo WS, van Mil SWC, Owen BM.

Mol Metab. 2019 Dec;30:221-229. doi: 10.1016/j.molmet.2019.09.007. Epub 2019 Sep 30.

3.

Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.

Passeri D, Carotti A, Pittol JMR, Ciaccioli G, Pellicciari R, van Mil SWC, Gioiello A.

Medchemcomm. 2019 Jun 24;10(8):1412-1419. doi: 10.1039/c9md00264b. eCollection 2019 Aug 1.

PMID:
31673308
4.

Structural and functional vascular improvement 1 year after bariatric surgery: a prospective cohort study.

Leeman M, van Mil SR, Al-Ghanam I, Biter LU, Dunkelgrun M, Castro Cabezas M.

Surg Obes Relat Dis. 2019 Oct;15(10):1773-1779. doi: 10.1016/j.soard.2019.08.012. Epub 2019 Aug 22.

PMID:
31558408
5.

A genetic model for multimorbidity in young adults.

Malecki SL, Van Mil S, Graffi J, Breetvelt E, Corral M, Boot E, Chow EWC, Sanches M, Verma AA, Bassett AS.

Genet Med. 2020 Jan;22(1):132-141. doi: 10.1038/s41436-019-0603-1. Epub 2019 Jul 31.

PMID:
31363180
6.

The effect of sex and menopause on carotid intima-media thickness and pulse wave velocity in morbid obesity.

van Mil SR, Biter LU, van de Geijn GJM, Birnie E, Dunkelgrun M, Ijzermans JNM, van der Meulen N, Mannaerts GHH, Castro Cabezas M.

Eur J Clin Invest. 2019 Jul;49(7):e13118. doi: 10.1111/eci.13118. Epub 2019 May 6.

7.

All-cause mortality and survival in adults with 22q11.2 deletion syndrome.

Van L, Heung T, Graffi J, Ng E, Malecki S, Van Mil S, Boot E, Corral M, Chow EWC, Hodgkinson KA, Silversides C, Bassett AS.

Genet Med. 2019 Oct;21(10):2328-2335. doi: 10.1038/s41436-019-0509-y. Epub 2019 Apr 5.

8.

Identification of FDA-approved drugs targeting the Farnesoid X Receptor.

van de Wiel SMW, Bijsmans ITGW, van Mil SWC, van de Graaf SFJ.

Sci Rep. 2019 Feb 18;9(1):2193. doi: 10.1038/s41598-019-38668-7.

9.

Programming Effects of Pubertal Lipopolysaccharide Treatment in Male and Female CD-1 Mice.

Sharma R, van Mil S, Melanson B, Thomas BJ, Rooke J, Mallet JF, Matar C, Schwarz JM, Ismail N.

J Immunol. 2019 Apr 1;202(7):2131-2140. doi: 10.4049/jimmunol.1801351. Epub 2019 Feb 8.

PMID:
30737275
10.

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair.

van de Vrugt HJ, Harmsen T, Riepsaame J, Alexantya G, van Mil SE, de Vries Y, Bin Ali R, Huijbers IJ, Dorsman JC, Wolthuis RMF, Te Riele H.

Sci Rep. 2019 Jan 25;9(1):768. doi: 10.1038/s41598-018-36506-w.

11.

A Stepwise Approach in Learning Surgical Residents a Roux-en-Y Gastric Bypass.

Walinga AB, van Mil SR, Biter LU, Dunkelgrün M, Vijgen GHEJ.

Obes Surg. 2019 Feb;29(2):414-419. doi: 10.1007/s11695-018-3533-0.

PMID:
30291579
12.

Progress and challenges of selective Farnesoid X Receptor modulation.

Massafra V, Pellicciari R, Gioiello A, van Mil SWC.

Pharmacol Ther. 2018 Nov;191:162-177. doi: 10.1016/j.pharmthera.2018.06.009. Epub 2018 Jun 20. Review.

13.

Discrepancies Between BMI and Classic Cardiovascular Risk Factors.

van Mil SR, Vijgen GHEJ, van Huisstede A, Klop B, van de Geijn GM, Birnie E, Braunstahl GJ, Mannaerts GHH, Biter LU, Castro Cabezas M.

Obes Surg. 2018 Nov;28(11):3484-3491. doi: 10.1007/s11695-018-3359-9.

PMID:
29931482
14.

Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery.

Broekema MF, Hollman DAA, Koppen A, van den Ham HJ, Melchers D, Pijnenburg D, Ruijtenbeek R, van Mil SWC, Houtman R, Kalkhoven E.

Endocrinology. 2018 Jun 1;159(6):2397-2407. doi: 10.1210/en.2018-00149.

PMID:
29718163
15.

Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry.

Gilbert MS, Ijssennagger N, Kies AK, van Mil SWC.

Am J Physiol Gastrointest Liver Physiol. 2018 Aug 1;315(2):G159-G170. doi: 10.1152/ajpgi.00319.2017. Epub 2018 Mar 29. Review.

16.

Contribution of Type 2 Diabetes Mellitus to Subclinical Atherosclerosis in Subjects with Morbid Obesity.

van Mil SR, Biter LU, van de Geijn GM, Birnie E, Dunkelgrun M, IJzermans JNM, van der Meulen N, Mannaerts GHH, Castro Cabezas M.

Obes Surg. 2018 Aug;28(8):2509-2516. doi: 10.1007/s11695-018-3196-x.

PMID:
29536408
17.

Farnesoid X receptor: A "homeostat" for hepatic nutrient metabolism.

Massafra V, van Mil SWC.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):45-59. doi: 10.1016/j.bbadis.2017.10.003. Epub 2017 Oct 3. Review.

18.

The Standardized Postoperative Checklist for Bariatric Surgery; a Tool for Safe Early Discharge?

van Mil SR, Duinhouwer LE, Mannaerts GHH, Biter LU, Dunkelgrun M, Apers JA.

Obes Surg. 2017 Dec;27(12):3102-3109. doi: 10.1007/s11695-017-2746-y.

PMID:
28620895
19.

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation.

Massafra V, Milona A, Vos HR, Burgering BM, van Mil SW.

PLoS One. 2017 Feb 8;12(2):e0171185. doi: 10.1371/journal.pone.0171185. eCollection 2017.

20.

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.

Massafra V, Milona A, Vos HR, Ramos RJJ, Gerrits J, Willemsen ECL, Ramos Pittol JM, Ijssennagger N, Houweling M, Prinsen HCMT, Verhoeven-Duif NM, Burgering BMT, van Mil SWC.

Gastroenterology. 2017 May;152(6):1462-1476.e10. doi: 10.1053/j.gastro.2017.01.014. Epub 2017 Jan 25.

21.

Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology.

Bijsmans IT, Milona A, Ijssennagger N, Willemsen EC, Ramos Pittol JM, Jonker JW, Lange K, Hooiveld GJ, van Mil SW.

Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):687-700. doi: 10.1016/j.bbadis.2016.12.004. Epub 2016 Dec 10.

22.

Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma.

Kooi IE, van Mil SE, MacPherson D, Mol BM, Moll AC, Meijers-Heijboer H, Kaspers GJ, Cloos J, Te Riele H, Dorsman JC.

Genes Chromosomes Cancer. 2017 Mar;56(3):231-242. doi: 10.1002/gcc.22429. Epub 2016 Nov 21.

PMID:
27750399
23.

Gut Microbial Diversity Is Reduced in Smokers with Crohn's Disease.

Opstelten JL, Plassais J, van Mil SW, Achouri E, Pichaud M, Siersema PD, Oldenburg B, Cervino AC.

Inflamm Bowel Dis. 2016 Sep;22(9):2070-7. doi: 10.1097/MIB.0000000000000875.

24.

Age and sex differences in immune response following LPS treatment in mice.

Cai KC, van Mil S, Murray E, Mallet JF, Matar C, Ismail N.

Brain Behav Immun. 2016 Nov;58:327-337. doi: 10.1016/j.bbi.2016.08.002. Epub 2016 Aug 6.

PMID:
27506825
25.

Long-Term Results of Laparoscopic Sleeve Gastrectomy for Morbid Obesity: 5 to 8-Year Results.

Gadiot RP, Biter LU, van Mil S, Zengerink HF, Apers J, Mannaerts GH.

Obes Surg. 2017 Jan;27(1):59-63. doi: 10.1007/s11695-016-2235-8.

PMID:
27178407
26.

Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes.

Kooi IE, Mol BM, Massink MP, Ameziane N, Meijers-Heijboer H, Dommering CJ, van Mil SE, de Vries Y, van der Hout AH, Kaspers GJ, Moll AC, Te Riele H, Cloos J, Dorsman JC.

Sci Rep. 2016 Apr 29;6:25264. doi: 10.1038/srep25264.

27.

Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?

Ijssennagger N, van der Meer R, van Mil SWC.

Trends Mol Med. 2016 Mar;22(3):190-199. doi: 10.1016/j.molmed.2016.01.002. Epub 2016 Feb 3. Review.

PMID:
26852376
28.

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid.

Ijssennagger N, Janssen AWF, Milona A, Ramos Pittol JM, Hollman DAA, Mokry M, Betzel B, Berends FJ, Janssen IM, van Mil SWC, Kersten S.

J Hepatol. 2016 May;64(5):1158-1166. doi: 10.1016/j.jhep.2016.01.016. Epub 2016 Jan 23.

PMID:
26812075
29.

Laparoscopic Sleeve Gastrectomy versus Gastric Bypass in Late Adolescents: What Is the Optimal Surgical Strategy for Morbid Obesity?

van Mil SR, Biter LU, Grotenhuis BA, Zengerink JF, Mannaerts GH.

Eur J Pediatr Surg. 2016 Dec;26(6):487-493. Epub 2016 Jan 8.

PMID:
26745522
30.

Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis.

Massafra V, Ijssennagger N, Plantinga M, Milona A, Ramos Pittol JM, Boes M, van Mil SW.

Biochim Biophys Acta. 2016 Feb;1862(2):166-73. doi: 10.1016/j.bbadis.2015.11.001. Epub 2015 Nov 7.

31.

The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.

Bijsmans IT, Guercini C, Ramos Pittol JM, Omta W, Milona A, Lelieveld D, Egan DA, Pellicciari R, Gioiello A, van Mil SW.

Sci Rep. 2015 Sep 15;5:14086. doi: 10.1038/srep14086.

32.

The Sleeve Bypass Trial: a multicentre randomized controlled trial comparing the long term outcome of laparoscopic sleeve gastrectomy and gastric bypass for morbid obesity in terms of excess BMI loss percentage and quality of life.

Biter LU, Gadiot RP, Grotenhuis BA, Dunkelgrün M, van Mil SR, Zengerink HJ, Smulders JF, Mannaerts GH.

BMC Obes. 2015 Aug 26;2:30. doi: 10.1186/s40608-015-0058-0. eCollection 2015.

33.

Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression.

Kooi IE, Mol BM, Moll AC, van der Valk P, de Jong MC, de Graaf P, van Mil SE, Schouten-van Meeteren AY, Meijers-Heijboer H, Kaspers GL, Te Riele H, Cloos J, Dorsman JC.

EBioMedicine. 2015 Jul 8;2(7):660-70. doi: 10.1016/j.ebiom.2015.06.022. eCollection 2015 Jul.

34.

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon.

Ijssennagger N, Belzer C, Hooiveld GJ, Dekker J, van Mil SW, Müller M, Kleerebezem M, van der Meer R.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10038-43. doi: 10.1073/pnas.1507645112. Epub 2015 Jul 27.

35.

Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.

Stoepker C, Ameziane N, van der Lelij P, Kooi IE, Oostra AB, Rooimans MA, van Mil SE, Brink A, Dietrich R, Balk JA, Ylstra B, Joenje H, Feller SM, Brakenhoff RH.

Cancer Res. 2015 Sep 1;75(17):3543-53. doi: 10.1158/0008-5472.CAN-15-0528. Epub 2015 Jun 29.

36.

Results of Implementing an Enhanced Recovery After Bariatric Surgery (ERABS) Protocol.

Mannaerts GH, van Mil SR, Stepaniak PS, Dunkelgrün M, de Quelerij M, Verbrugge SJ, Zengerink HF, Biter LU.

Obes Surg. 2016 Feb;26(2):303-12. doi: 10.1007/s11695-015-1742-3.

PMID:
26003552
37.

Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.

Massink MP, Kooi IE, van Mil SE, Jordanova ES, Ameziane N, Dorsman JC, van Beek DM, van der Voorn JP, Sie D, Ylstra B, van Deurzen CH, Martens JW, Smid M, Sieuwerts AM, de Weerd V, Foekens JA, van den Ouweland AM, van Dyk E, Nederlof PM, Waisfisz Q, Meijers-Heijboer H.

Mol Oncol. 2015 Apr;9(4):877-88. doi: 10.1016/j.molonc.2014.12.012. Epub 2015 Jan 13.

38.

DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity.

Stoepker C, Faramarz A, Rooimans MA, van Mil SE, Balk JA, Velleuer E, Ameziane N, Te Riele H, de Winter JP.

DNA Repair (Amst). 2015 Feb;26:54-64. doi: 10.1016/j.dnarep.2014.12.003. Epub 2014 Dec 24.

PMID:
25583207
39.

A novel splice site mutation in the noncoding region of BRCA2: implications for Fanconi anemia and familial breast cancer diagnostics.

Bakker JL, Thirthagiri E, van Mil SE, Adank MA, Ikeda H, Verheul HM, Meijers-Heijboer H, de Winter JP, Sharan SK, Waisfisz Q.

Hum Mutat. 2014 Apr;35(4):442-6. doi: 10.1002/humu.22505. Epub 2014 Feb 15.

40.

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates.

Chatterjee S, Bijsmans IT, van Mil SW, Augustijns P, Annaert P.

Toxicol In Vitro. 2014 Mar;28(2):218-30. doi: 10.1016/j.tiv.2013.10.020. Epub 2013 Nov 7.

PMID:
24211540
41.

Androgen receptor distribution in the social decision-making network of eusocial naked mole-rats.

Holmes MM, Van Mil S, Bulkowski C, Goldman SL, Goldman BD, Forger NG.

Behav Brain Res. 2013 Nov 1;256:214-8. doi: 10.1016/j.bbr.2013.08.025. Epub 2013 Aug 21.

PMID:
23973387
42.

Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis.

van Schaik FD, Gadaleta RM, Schaap FG, van Mil SW, Siersema PD, Oldenburg B, van Erpecum KJ.

PLoS One. 2012;7(11):e49706. doi: 10.1371/journal.pone.0049706. Epub 2012 Nov 26.

43.

Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases.

Bakker JL, van Mil SE, Crossan G, Sabbaghian N, De Leeneer K, Poppe B, Adank M, Gille H, Verheul H, Meijers-Heijboer H, de Winter JP, Claes K, Tischkowitz M, Waisfisz Q.

Hum Mutat. 2013 Jan;34(1):70-3. doi: 10.1002/humu.22206. Epub 2012 Oct 11.

PMID:
22911665
44.

Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor.

van der Velden LM, Golynskiy MV, Bijsmans IT, van Mil SW, Klomp LW, Merkx M, van de Graaf SF.

Hepatology. 2013 Feb;57(2):740-52. doi: 10.1002/hep.26012. Epub 2013 Jan 8.

PMID:
22899095
45.

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

Hollman DA, Milona A, van Erpecum KJ, van Mil SW.

Biochim Biophys Acta. 2012 Nov;1821(11):1443-52. doi: 10.1016/j.bbalip.2012.07.004. Epub 2012 Jul 20. Review.

PMID:
22820415
46.

Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated.

Harinck F, Kluijt I, van Mil SE, Waisfisz Q, van Os TA, Aalfs CM, Wagner A, Olderode-Berends M, Sijmons RH, Kuipers EJ, Poley JW, Fockens P, Bruno MJ.

Eur J Hum Genet. 2012 May;20(5):577-9. doi: 10.1038/ejhg.2011.226. Epub 2011 Dec 14.

47.

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.

Adank MA, Jonker MA, Kluijt I, van Mil SE, Oldenburg RA, Mooi WJ, Hogervorst FB, van den Ouweland AM, Gille JJ, Schmidt MK, van der Vaart AW, Meijers-Heijboer H, Waisfisz Q.

J Med Genet. 2011 Dec;48(12):860-3. doi: 10.1136/jmedgenet-2011-100380. Epub 2011 Nov 5.

PMID:
22058428
48.

Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.

Nijmeijer RM, Gadaleta RM, van Mil SW, van Bodegraven AA, Crusius JB, Dijkstra G, Hommes DW, de Jong DJ, Stokkers PC, Verspaget HW, Weersma RK, van der Woude CJ, Stapelbroek JM, Schipper ME, Wijmenga C, van Erpecum KJ, Oldenburg B; Dutch Initiative on Crohn, Colitis (ICC).

PLoS One. 2011;6(8):e23745. doi: 10.1371/journal.pone.0023745. Epub 2011 Aug 22.

49.

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine.

Gadaleta RM, Oldenburg B, Willemsen EC, Spit M, Murzilli S, Salvatore L, Klomp LW, Siersema PD, van Erpecum KJ, van Mil SW.

Biochim Biophys Acta. 2011 Aug;1812(8):851-8. doi: 10.1016/j.bbadis.2011.04.005. Epub 2011 Apr 22.

50.

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.

Gadaleta RM, van Erpecum KJ, Oldenburg B, Willemsen EC, Renooij W, Murzilli S, Klomp LW, Siersema PD, Schipper ME, Danese S, Penna G, Laverny G, Adorini L, Moschetta A, van Mil SW.

Gut. 2011 Apr;60(4):463-72. doi: 10.1136/gut.2010.212159. Epub 2011 Jan 17.

PMID:
21242261

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