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Items: 1 to 50 of 62


Effect of C1-inhibitor in adults with mild asthma: a randomised controlled trial.

Yang J, van Engelen TSR, Haak BW, Bonta PI, Majoor CJ, van 't Veer C, de Vos AF, Kemper EM, Lutter R, van Mierlo G, Zeerleder SS, Bel EH, van der Poll T.

Allergy. 2019 Sep 19. doi: 10.1111/all.14053. [Epub ahead of print] No abstract available.


PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.

Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, Bracken AP.

Mol Cell. 2019 Sep 5. pii: S1097-2765(19)30628-8. doi: 10.1016/j.molcel.2019.08.012. [Epub ahead of print]


A Mass Spectrometry Survey of Chromatin-Associated Proteins in Pluripotency and Early Lineage Commitment.

van Mierlo G, Wester RA, Marks H.

Proteomics. 2019 Jul;19(14):e1900047. doi: 10.1002/pmic.201900047. Epub 2019 Jul 3.


The Complexity of PRC2 Subcomplexes.

van Mierlo G, Veenstra GJC, Vermeulen M, Marks H.

Trends Cell Biol. 2019 Aug;29(8):660-671. doi: 10.1016/j.tcb.2019.05.004. Epub 2019 Jun 6. Review.


Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states.

Dirks RAM, van Mierlo G, Kerstens HHD, Bernardo AS, Kobolák J, Bock I, Maruotti J, Pedersen RA, Dinnyés A, Huynen MA, Jouneau A, Marks H.

Epigenetics Chromatin. 2019 Feb 15;12(1):14. doi: 10.1186/s13072-019-0259-8.


Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency.

van Mierlo G, Dirks RAM, De Clerck L, Brinkman AB, Huth M, Kloet SL, Saksouk N, Kroeze LI, Willems S, Farlik M, Bock C, Jansen JH, Deforce D, Vermeulen M, Déjardin J, Dhaenens M, Marks H.

Cell Stem Cell. 2019 Jan 3;24(1):123-137.e8. doi: 10.1016/j.stem.2018.10.017. Epub 2018 Nov 21.


α1-Antichymotrypsin Present in Therapeutic C1-Inhibitor Products Competes with Selectin-Sialyl LewisX Interaction.

Engel R, Delvasto-Nuñez L, Roem D, van Mierlo G, Holst S, Hipgrave Ederveen AL, van Buul JD, Wuhrer M, Wouters D, Zeerleder S.

Thromb Haemost. 2018 Dec;118(12):2134-2144. doi: 10.1055/s-0038-1675601. Epub 2018 Nov 19.


Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.

Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA.

Elife. 2018 Nov 15;7. pii: e41305. doi: 10.7554/eLife.41305.


Quantitative subcellular proteomics using SILAC reveals enhanced metabolic buffering in the pluripotent ground state.

van Mierlo G, Wester RA, Marks H.

Stem Cell Res. 2018 Dec;33:135-145. doi: 10.1016/j.scr.2018.09.017. Epub 2018 Sep 24.


Substitution of Mannan-Binding Lectin (MBL)-Deficient Serum With Recombinant MBL Results in the Formation of New MBL/MBL-Associated Serine Protease Complexes.

Keizer MP, Kamp A, van Mierlo G, Kuijpers TW, Wouters D.

Front Immunol. 2018 Jun 27;9:1406. doi: 10.3389/fimmu.2018.01406. eCollection 2018.


MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding.

Perino M, van Mierlo G, Karemaker ID, van Genesen S, Vermeulen M, Marks H, van Heeringen SJ, Veenstra GJC.

Nat Genet. 2018 Jul;50(7):1002-1010. doi: 10.1038/s41588-018-0134-8. Epub 2018 May 28.


Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma.

van Beek AE, Pouw RB, Brouwer MC, van Mierlo G, Geissler J, Ooijevaar-de Heer P, de Boer M, van Leeuwen K, Rispens T, Wouters D, Kuijpers TW.

Front Immunol. 2017 Oct 18;8:1328. doi: 10.3389/fimmu.2017.01328. eCollection 2017.


Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice.

Stroo I, Yang J, Anas AA, de Boer JD, van Mierlo G, Roem D, Wouters D, Engel R, Roelofs JJTH, van 't Veer C, van der Poll T, Zeerleder S.

PLoS One. 2017 Oct 16;12(10):e0186652. doi: 10.1371/journal.pone.0186652. eCollection 2017.


Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia.

de Beer F, Lagrand W, Glas GJ, Beurskens CJ, van Mierlo G, Wouters D, Zeerleder S, Roelofs JJ, Juffermans NP, Horn J, Schultz MJ.

Cell Biochem Biophys. 2016 Dec;74(4):545-552. Epub 2016 Sep 28.


Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Marks H, Kerstens HH, Barakat TS, Splinter E, Dirks RA, van Mierlo G, Joshi O, Wang SY, Babak T, Albers CA, Kalkan T, Smith A, Jouneau A, de Laat W, Gribnau J, Stunnenberg HG.

Genome Biol. 2016 Feb 5;17:22. doi: 10.1186/s13059-016-0885-4. No abstract available.


Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial.

de Boer JD, Berger M, Majoor CJ, Kager LM, Meijers JC, Terpstra S, Nieuwland R, Boing AN, Lutter R, Wouters D, van Mierlo GJ, Zeerleder SS, Bel EH, van't Veer C, de Vos AF, van der Zee JS, van der Poll T.

Eur Respir J. 2015 Dec;46(6):1636-44. doi: 10.1183/13993003.00459-2015. Epub 2015 Sep 17.


Neutrophil activation and nucleosomes as markers of systemic inflammation in paroxysmal nocturnal hemoglobinuria: effects of eculizumab.

van Bijnen ST, Wouters D, van Mierlo GJ, Muus P, Zeerleder S.

J Thromb Haemost. 2015 Nov;13(11):2004-11. doi: 10.1111/jth.13125. Epub 2015 Oct 19.


Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Marks H, Kerstens HH, Barakat TS, Splinter E, Dirks RA, van Mierlo G, Joshi O, Wang SY, Babak T, Albers CA, Kalkan T, Smith A, Jouneau A, de Laat W, Gribnau J, Stunnenberg HG.

Genome Biol. 2015 Aug 3;16:149. doi: 10.1186/s13059-015-0698-x. Erratum in: Genome Biol. 2016;17:22.


Increased intra- and extracellular granzyme expression in patients with tuberculosis.

Garcia-Laorden MI, Blok DC, Kager LM, Hoogendijk AJ, van Mierlo GJ, Lede IO, Rahman W, Afroz R, Ghose A, Visser CE, Md Zahed AS, Husain MA, Alam KM, Chandra Barua P, Hassan M, Hossain A, Tayab MA, Day N, Dondorp AM, de Vos AF, van der Poll T.

Tuberculosis (Edinb). 2015 Sep;95(5):575-80. doi: 10.1016/ Epub 2015 Jun 20.


HIV infection is associated with elevated nucleosomes in asymptomatic patients and during sepsis or malaria.

Huson MA, Zeerleder SS, van Mierlo G, Wouters D, Grobusch MP, van der Poll T.

J Infect. 2015 Aug;71(2):266-9. doi: 10.1016/j.jinf.2015.03.008. Epub 2015 Apr 3. No abstract available.


HIV Coinfection Enhances Complement Activation During Sepsis.

Huson MA, Wouters D, van Mierlo G, Grobusch MP, Zeerleder SS, van der Poll T.

J Infect Dis. 2015 Aug 1;212(3):474-83. doi: 10.1093/infdis/jiv074. Epub 2015 Feb 5.


Interaction of Bordetella pertussis filamentous hemagglutinin with human TLR2: identification of the TLR2-binding domain.

Asgarian-Omran H, Amirzargar AA, Zeerleder S, Mahdavi M, van Mierlo G, Solati S, Jeddi-Tehrani M, Rabbani H, Aarden L, Shokri F.

APMIS. 2015 Feb;123(2):156-62. doi: 10.1111/apm.12332. Epub 2014 Oct 29.


Plasma-derived human C1-esterase inhibitor does not prevent mechanical ventilation-induced pulmonary complement activation in a rat model of Streptococcus pneumoniae pneumonia.

de Beer FM, Aslami H, Hoeksma J, van Mierlo G, Wouters D, Zeerleder S, Roelofs JJ, Juffermans NP, Schultz MJ, Lagrand WK.

Cell Biochem Biophys. 2014 Nov;70(2):795-803. doi: 10.1007/s12013-014-9983-7.


Nucleosomes and neutrophil activation in sickle cell disease painful crisis.

Schimmel M, Nur E, Biemond BJ, van Mierlo GJ, Solati S, Brandjes DP, Otten HM, Schnog JJ, Zeerleder S; Curama Study Group.

Haematologica. 2013 Nov;98(11):1797-803. doi: 10.3324/haematol.2013.088021. Epub 2013 Aug 2.


The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab.

van Mierlo GJ, Cnubben NH, Wouters D, Wolbink GJ, Hart MH, Rispens T, Ganderup NC, Kuper CF, Aarden L, Penninks AH.

J Immunotoxicol. 2014 Jan-Mar;11(1):62-71. doi: 10.3109/1547691X.2013.796023. Epub 2013 Jun 5.


The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: a demonstrator study using the IL-1 receptor antagonist anakinra.

van Mierlo GJ, Cnubben NH, Kuper CF, Wolthoorn J, van Meeteren-Kreikamp AP, Nagtegaal MM, Doornbos R, Ganderup NC, Penninks AH.

J Immunotoxicol. 2013 Jan-Mar;10(1):96-105. doi: 10.3109/1547691X.2012.735274. Epub 2012 Nov 7.


Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis.

van Montfoort ML, Stephan F, Lauw MN, Hutten BA, Van Mierlo GJ, Solati S, Middeldorp S, Meijers JC, Zeerleder S.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):147-51. doi: 10.1161/ATVBAHA.112.300498. Epub 2012 Oct 25.


Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators.

van Mierlo GJ, Scherer HU, Hameetman M, Morgan ME, Flierman R, Huizinga TW, Toes RE.

J Immunol. 2008 Mar 1;180(5):2747-51.


Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice.

Westerterp M, Berbée JF, Pires NM, van Mierlo GJ, Kleemann R, Romijn JA, Havekes LM, Rensen PC.

Circulation. 2007 Nov 6;116(19):2173-81. Epub 2007 Oct 22.


Dendritic cells: vehicles for tolerance induction and prevention of autoimmune diseases.

van Duivenvoorde LM, van Mierlo GJ, Boonman ZF, Toes RE.

Immunobiology. 2006;211(6-8):627-32. Epub 2006 Jul 5. Review.


Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model.

Heijnen BH, Straatsburg IH, Padilla ND, Van Mierlo GJ, Hack CE, Van Gulik TM.

Clin Exp Immunol. 2006 Jan;143(1):15-23.


Impact of simvastatin on hemostatic and fibrinolytic regulators in Type 2 diabetes mellitus.

Ludwig S, Dharmalingam S, Erickson-Nesmith S, Ren S, Zhu F, Ma GM, Zhao R, Fenton JW 2nd, Ofosu FA, Velthuis HT, van Mierlo G, Shen GX.

Diabetes Res Clin Pract. 2005 Nov;70(2):110-8.


Maintenance of immune tolerance depends on normal tissue homeostasis.

Boonman ZF, van Mierlo GJ, Fransen MF, de Keizer RJ, Jager MJ, Melief CJ, Toes RE.

J Immunol. 2005 Oct 1;175(7):4247-54.


CD4+ T cells are able to promote tumor growth through inhibition of tumor-specific CD8+ T-cell responses in tumor-bearing hosts.

den Boer AT, van Mierlo GJ, Fransen MF, Melief CJ, Offringa R, Toes RE.

Cancer Res. 2005 Aug 1;65(15):6984-9.


Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction.

Zeerleder S, Hack CE, Caliezi C, van Mierlo G, Eerenberg-Belmer A, Wolbink A, Wuillenmin WA.

Clin Immunol. 2005 Aug;116(2):158-65.


Infliximab treatment reduces complement activation in patients with rheumatoid arthritis.

Familian A, Voskuyl AE, van Mierlo GJ, Heijst HA, Twisk JW, Dijkmans BA, Hack CE.

Ann Rheum Dis. 2005 Jul;64(7):1003-8.


Sustained activation of neutrophils in the course of Kawasaki disease: an association with matrix metalloproteinases.

Biezeveld MH, van Mierlo G, Lutter R, Kuipers IM, Dekker T, Hack CE, Newburger JW, Kuijpers TW.

Clin Exp Immunol. 2005 Jul;141(1):183-8.


Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication.

van Mierlo GJ, Boonman ZF, Dumortier HM, den Boer AT, Fransen MF, Nouta J, van der Voort EI, Offringa R, Toes RE, Melief CJ.

J Immunol. 2004 Dec 1;173(11):6753-9.


Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.

Boonman ZF, van Mierlo GJ, Fransen MF, Franken KL, Offringa R, Melief CJ, Jager MJ, Toes RE.

J Immunol. 2004 Feb 1;172(3):1567-74.


Rat C-reactive protein activates the autologous complement system.

Diaz Padilla N, Bleeker WK, Lubbers Y, Rigter GM, Van Mierlo GJ, Daha MR, Hack CE.

Immunology. 2003 Aug;109(4):564-71.


Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis.

Zeerleder S, Caliezi C, van Mierlo G, Eerenberg-Belmer A, Sulzer I, Hack CE, Wuillemin WA.

Clin Diagn Lab Immunol. 2003 Jul;10(4):529-35.


Elevated nucleosome levels in systemic inflammation and sepsis.

Zeerleder S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld AB, Caliezi C, van Nieuwenhuijze AE, van Mierlo GJ, Eerenberg AJ, Lämmle B, Hack CE.

Crit Care Med. 2003 Jul;31(7):1947-51.


Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections.

Hermsen CC, Konijnenberg Y, Mulder L, Loé C, van Deuren M, van der Meer JW, van Mierlo GJ, Eling WM, Hack CE, Sauerwein RW.

Clin Exp Immunol. 2003 Jun;132(3):467-72.


Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection.

Groeneveld AB, Tacx AN, Bossink AW, van Mierlo GJ, Hack CE.

Clin Immunol. 2003 Feb;106(2):106-15.


In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway.

Diehl L, van Mierlo GJ, den Boer AT, van der Voort E, Fransen M, van Bostelen L, Krimpenfort P, Melief CJ, Mittler R, Toes RE, Offringa R.

J Immunol. 2002 Apr 15;168(8):3755-62.


CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.

van Mierlo GJ, den Boer AT, Medema JP, van der Voort EI, Fransen MF, Offringa R, Melief CJ, Toes RE.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5561-6. Epub 2002 Apr 2.


Circulating inflammatory mediators in patients with fever: predicting bloodstream infection.

Groeneveld AB, Bossink AW, van Mierlo GJ, Hack CE.

Clin Diagn Lab Immunol. 2001 Nov;8(6):1189-95.

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