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Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms.

Dayang EZ, Plantinga J, Ter Ellen B, van Meurs M, Molema G, Moser J.

Front Immunol. 2019 May 24;10:1169. doi: 10.3389/fimmu.2019.01169. eCollection 2019.


Rapid free thiol rebound is a physiological response following cold-induced vasoconstriction in healthy humans, primary Raynaud and systemic sclerosis.

Abdulle AE, van Roon AM, Smit AJ, Pasch A, van Meurs M, Bootsma H, Bakker SJL, Said MY, Fernandez BO, Feelisch M, van Goor H, Mulder DJ.

Physiol Rep. 2019 Mar;7(6):e14017. doi: 10.14814/phy2.14017.


Commentary: Precision Immunotherapy for Sepsis.

Zijlstra JG, van Meurs M, Moser J.

Front Immunol. 2019 Jan 31;10:20. doi: 10.3389/fimmu.2019.00020. eCollection 2019. No abstract available.


Kidney histopathology in lethal human sepsis.

Aslan A, van den Heuvel MC, Stegeman CA, Popa ER, Leliveld AM, Molema G, Zijlstra JG, Moser J, van Meurs M.

Crit Care. 2018 Dec 27;22(1):359. doi: 10.1186/s13054-018-2287-3.


Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way.

Jongman RM, Zwiers PJ, van de Sluis B, van der Laan M, Moser J, Zijlstra JG, Dekker D, Huijkman N, Moorlag HE, Popa ER, Molema G, van Meurs M.

Shock. 2019 Jun;51(6):757-769. doi: 10.1097/SHK.0000000000001226.


Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis.

Reitsema VA, Star BS, de Jager VD, van Meurs M, Henning RH, Bouma HR.

Antioxid Redox Signal. 2019 Jul 10;31(2):134-152. doi: 10.1089/ars.2018.7537. Epub 2019 Jan 23.


Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname.

Zonneveld R, Jongman RM, Juliana A, Molema G, van Meurs M, Plötz FB.

BMJ Paediatr Open. 2018 Oct 9;2(1):e000312. doi: 10.1136/bmjpo-2018-000312. eCollection 2018.


Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats.

Dekker NAM, van Meurs M, van Leeuwen ALI, Hofland HM, van Slyke P, Vonk ABA, Boer C, van den Brom CE.

Br J Anaesth. 2018 Nov;121(5):1041-1051. doi: 10.1016/j.bja.2018.05.049. Epub 2018 Jun 19.


Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice.

Jou-Valencia D, Molema G, Popa E, Aslan A, van Dijk F, Mencke R, Hillebrands JL, Heeringa P, Hoenderop JG, Zijlstra JG, van Meurs M, Moser J.

Crit Care Med. 2018 Dec;46(12):e1196-e1203. doi: 10.1097/CCM.0000000000003427.


Repeated vital sign measurements in the emergency department predict patient deterioration within 72 hours: a prospective observational study.

Quinten VM, van Meurs M, Olgers TJ, Vonk JM, Ligtenberg JJM, Ter Maaten JC.

Scand J Trauma Resusc Emerg Med. 2018 Jul 13;26(1):57. doi: 10.1186/s13049-018-0525-y.


Molecular Regulation of Acute Tie2 Suppression in Sepsis.

Thamm K, Schrimpf C, Retzlaff J, Idowu TO, van Meurs M, Zijlstra JG, Ghosh CC, Zeitvogel J, Werfel TA, Haller H, Parikh SM, David S.

Crit Care Med. 2018 Sep;46(9):e928-e936. doi: 10.1097/CCM.0000000000003269.


Reduction of vascular leakage by imatinib is associated with preserved microcirculatory perfusion and reduced renal injury markers in a rat model of cardiopulmonary bypass.

Koning NJ, de Lange F, van Meurs M, Jongman RM, Ahmed Y, Schwarte LA, van Nieuw Amerongen GP, Vonk ABA, Niessen HW, Baufreton C, Boer C.

Br J Anaesth. 2018 Jun;120(6):1165-1175. doi: 10.1016/j.bja.2017.11.095. Epub 2018 Jan 17.


Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia.

Li R, Kowalski PS, Morselt HWM, Schepel I, Jongman RM, Aslan A, Ruiters MHJ, Zijlstra JG, Molema G, van Meurs M, Kamps JAAM.

PLoS One. 2018 May 15;13(5):e0196976. doi: 10.1371/journal.pone.0196976. eCollection 2018.


Prehospital antibiotics for sepsis: beyond mortality?

Quinten VM, van Meurs M, Ligtenberg JJ, Ter Maaten JC.

Lancet Respir Med. 2018 Mar;6(3):e8. doi: 10.1016/S2213-2600(18)30061-4. No abstract available.


Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade.

Yan R, van Meurs M, Popa ER, Li R, Zwiers PJ, Zijlstra JG, Moser J, Molema G.

Shock. 2019 Feb;51(2):200-212. doi: 10.1097/SHK.0000000000001126.


The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.

Hope JL, Stairiker CJ, Spantidea PI, Gracias DT, Carey AJ, Fike AJ, van Meurs M, Brouwers-Haspels I, Rijsbergen LC, Fraietta JA, Mueller YM, Klop RC, Stelekati E, Wherry EJ, Erkeland SJ, Katsikis PD.

Front Immunol. 2017 Dec 6;8:1696. doi: 10.3389/fimmu.2017.01696. eCollection 2017.


Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease.

Mencke R, Harms G, Moser J, van Meurs M, Diepstra A, Leuvenink HG, Hillebrands JL.

JCI Insight. 2017 Oct 19;2(20). pii: 94375. doi: 10.1172/jci.insight.94375.


Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock.

Trieu M, van Meurs M, van Leeuwen ALI, Van Slyke P, Hoang V, Geeraedts LMG Jr, Boer C, van den Brom CE.

Anesthesiology. 2018 Feb;128(2):361-374. doi: 10.1097/ALN.0000000000001907.


Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB.

Yan R, van Meurs M, Popa ER, Jongman RM, Zwiers PJ, Niemarkt AE, Kuiper T, Kamps JA, Heeringa P, Zijlstra JG, Molema G, Moser J.

J Innate Immun. 2017;9(6):546-560. doi: 10.1159/000477211. Epub 2017 Jun 29.


There Are More Things in Heaven and Earth, Horatio, Than Are Dreamt of in Our Philosophy.

Moser J, van Meurs M, Zijlstra JG.

Crit Care Med. 2017 Jul;45(7):e740. doi: 10.1097/CCM.0000000000002426. No abstract available.


Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.

Zonneveld R, Jongman R, Juliana A, Zijlmans W, Plötz F, Molema G, van Meurs M.

Shock. 2017 Dec;48(6):638-643. doi: 10.1097/SHK.0000000000000903.


Sepsis patients in the emergency department: stratification using the Clinical Impression Score, Predisposition, Infection, Response and Organ dysfunction score or quick Sequential Organ Failure Assessment score?

Quinten VM, van Meurs M, Wolffensperger AE, Ter Maaten JC, Ligtenberg JJM.

Eur J Emerg Med. 2018 Oct;25(5):328-334. doi: 10.1097/MEJ.0000000000000460.


Naming and Blaming, SIRS-UO.

van Meurs M, Ligtenberg JJM, Zijlstra JG.

Chest. 2017 Mar;151(3):723-724. doi: 10.1016/j.chest.2016.10.062. No abstract available.


Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria.

Koeze J, Keus F, Dieperink W, van der Horst IC, Zijlstra JG, van Meurs M.

BMC Nephrol. 2017 Feb 20;18(1):70. doi: 10.1186/s12882-017-0487-8. Review.


Organ-Specific Differences in Endothelial Permeability-Regulating Molecular Responses in Mouse and Human Sepsis.

Aslan A, van Meurs M, Moser J, Popa ER, Jongman RM, Zwiers PJ, Molema G, Zijlstra JG.

Shock. 2017 Jul;48(1):69-77. doi: 10.1097/SHK.0000000000000841.


How central obesity influences intra-abdominal pressure: a prospective, observational study in cardiothoracic surgical patients.

Smit M, Werner MJM, Lansink-Hartgring AO, Dieperink W, Zijlstra JG, van Meurs M.

Ann Intensive Care. 2016 Dec;6(1):99. doi: 10.1186/s13613-016-0195-8. Epub 2016 Oct 10.


Intra-Abdominal Pressure, Acute Kidney Injury, and Obesity in Critical Illness.

Smit M, van Meurs M, Zijlstra JG.

Crit Care Med. 2016 Aug;44(8):e766-7. doi: 10.1097/CCM.0000000000001779. No abstract available.


Pro-inflammatory cytokines in cryptoglandular anal fistulas.

van Onkelen RS, Gosselink MP, van Meurs M, Melief MJ, Schouten WR, Laman JD.

Tech Coloproctol. 2016 Sep;20(9):619-25. doi: 10.1007/s10151-016-1494-7. Epub 2016 Jul 11.


Trends in vital signs and routine biomarkers in patients with sepsis during resuscitation in the emergency department: a prospective observational pilot study.

Quinten VM, van Meurs M, Ter Maaten JC, Ligtenberg JJ.

BMJ Open. 2016 May 25;6(5):e009718. doi: 10.1136/bmjopen-2015-009718.


Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M.

J Immunol. 2016 Jun 1;196(11):4681-91. doi: 10.4049/jimmunol.1501819. Epub 2016 Apr 29.


Biomarkers or Clinical Observations to Identify (Outcome of) Emergency Department Patients With Infection?

Quinten VM, van Meurs M, Ter Maaten JC, Ligtenberg JJ.

Shock. 2016 Jul;46(1):108. doi: 10.1097/SHK.0000000000000582. No abstract available.


Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis.

van den Berg R, Laman JD, van Meurs M, Hintzen RQ, Hoogenraad CC.

J Neurosci Methods. 2016 Mar 15;262:66-76. doi: 10.1016/j.jneumeth.2016.01.013. Epub 2016 Jan 16.


Impaired microcirculatory perfusion in a rat model of cardiopulmonary bypass: the role of hemodilution.

Koning NJ, de Lange F, Vonk AB, Ahmed Y, van den Brom CE, Bogaards S, van Meurs M, Jongman RM, Schalkwijk CG, Begieneman MP, Niessen HW, Baufreton C, Boer C.

Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H550-8. doi: 10.1152/ajpheart.00913.2015. Epub 2016 Jan 8.


Elevated Expression of the Cerebrospinal Fluid Disease Markers Chromogranin A and Clusterin in Astrocytes of Multiple Sclerosis White Matter Lesions.

van Luijn MM, van Meurs M, Stoop MP, Verbraak E, Wierenga-Wolf AF, Melief MJ, Kreft KL, Verdijk RM, 't Hart BA, Luider TM, Laman JD, Hintzen RQ.

J Neuropathol Exp Neurol. 2016 Jan;75(1):86-98.


Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass.

Jongman RM, van Klarenbosch J, Molema G, Zijlstra JG, de Vries AJ, van Meurs M.

PLoS One. 2015 Aug 26;10(8):e0136205. doi: 10.1371/journal.pone.0136205. eCollection 2015.


Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.

Li R, Aslan A, Yan R, Jongman RM, Moser J, Zwiers PJ, Moorlag HE, Zijlstra JG, Molema G, van Meurs M.

Crit Care Med. 2015 Dec;43(12):e567-80. doi: 10.1097/CCM.0000000000001203.


Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.

van Luijn MM, Kreft KL, Jongsma ML, Mes SW, Wierenga-Wolf AF, van Meurs M, Melief MJ, der Kant Rv, Janssen L, Janssen H, Tan R, Priatel JJ, Neefjes J, Laman JD, Hintzen RQ.

Brain. 2015 Jun;138(Pt 6):1531-47. doi: 10.1093/brain/awv080. Epub 2015 Mar 29.


Abundant kif21b is associated with accelerated progression in neurodegenerative diseases.

Kreft KL, van Meurs M, Wierenga-Wolf AF, Melief MJ, van Strien ME, Hol EM, Oostra BA, Laman JD, Hintzen RQ.

Acta Neuropathol Commun. 2014 Oct 3;2:144. doi: 10.1186/s40478-014-0144-4.


Augmented renal clearance in critically ill: advantage or threat.

Koeze J, Aardema H, van Meurs M, Zijlstra JG.

Crit Care Med. 2014 Aug;42(8):e602. No abstract available.


Abrupt reflow enhances cytokine-induced proinflammatory activation of endothelial cells during simulated shock and resuscitation.

Li R, Zijlstra JG, Kamps JA, van Meurs M, Molema G.

Shock. 2014 Oct;42(4):356-64. doi: 10.1097/SHK.0000000000000223.


Augmented renal clearance in critically ill: advantage or threat.

Koeze J, Aardema H, van Meurs M, Zijlstra JG.

Crit Care Med. 2014 Aug;42(8):e602. doi: 10.1097/CCM.0000000000000386. No abstract available.


The renal angiopoietin/Tie2 system in lethal human sepsis.

Aslan A, Jongman RM, Moser J, Stegeman CA, van Goor H, Diepstra A, van den Heuvel MC, Heeringa P, Molema G, Zijlstra JG, van Meurs M.

Crit Care. 2014 Mar 31;18(2):423. doi: 10.1186/cc13806. No abstract available.


Off-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized study.

Jongman RM, Zijlstra JG, Kok WF, van Harten AE, Mariani MA, Moser J, Struys MM, Absalom AR, Molema G, Scheeren TW, van Meurs M.

Shock. 2014 Aug;42(2):121-8. doi: 10.1097/SHK.0000000000000190.


No evidence for an association of osteopontin plasma levels with disease activity in multiple sclerosis.

Runia TF, van Meurs M, Nasserinejad K, Hintzen RQ.

Mult Scler. 2014 Oct;20(12):1670-1. doi: 10.1177/1352458514528765. Epub 2014 Mar 31. No abstract available.


Glutamine and antioxidants in critically ill patients.

Rodgers MG, van Meurs M, Zijlstra JG.

N Engl J Med. 2013 Aug 1;369(5):482. doi: 10.1056/NEJMc1306658. No abstract available.


CD44 variant isoforms control experimental autoimmune encephalomyelitis by affecting the lifespan of the pathogenic T cells.

Ghazi-Visser L, Laman JD, Nagel S, van Meurs M, van Riel D, Tzankov A, Frank S, Adams H, Wolk K, Terracciano L, Melief MJ, Sabat R, Günthert U.

FASEB J. 2013 Sep;27(9):3683-701. doi: 10.1096/fj.13-228809. Epub 2013 Jun 10.


A human model of intra-abdominal hypertension: even slightly elevated pressures lead to increased acute systemic inflammation and signs of acute kidney injury.

Smit M, Hofker HS, Leuvenink HG, Krikke C, Jongman RM, Zijlstra JG, van Meurs M.

Crit Care. 2013 Apr 4;17(2):425. doi: 10.1186/cc12568. No abstract available.


The flow dependency of Tie2 expression in endotoxemia.

Kurniati NF, Jongman RM, vom Hagen F, Spokes KC, Moser J, Regan ER, Krenning G, Moonen JR, Harmsen MC, Struys MM, Hammes HP, Zijlstra JG, Aird WC, Heeringa P, Molema G, van Meurs M.

Intensive Care Med. 2013 Jul;39(7):1262-71. doi: 10.1007/s00134-013-2899-7. Epub 2013 Apr 6.


Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia.

Padberg JS, Van Meurs M, Kielstein JT, Martens-Lobenhoffer J, Bode-Böger SM, Zijlstra JG, Kovesdy CP, Kümpers P.

Exp Transl Stroke Med. 2012 Dec 5;4(1):24. doi: 10.1186/2040-7378-4-24.

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