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Items: 1 to 50 of 71

1.

Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation.

Streefkerk DE, Schmidt M, Ippel JH, Hackeng TM, Nuijens T, Timmerman P, van Maarseveen JH.

Org Lett. 2019 Apr 5;21(7):2095-2100. doi: 10.1021/acs.orglett.9b00378. Epub 2019 Mar 26.

2.

Efficient Enzymatic Cyclization of Disulfide-Rich Peptides by Using Peptide Ligases.

Schmidt M, Huang YH, Texeira de Oliveira EF, Toplak A, Wijma HJ, Janssen DB, van Maarseveen JH, Craik DJ, Nuijens T.

Chembiochem. 2019 Jun 14;20(12):1524-1529. doi: 10.1002/cbic.201900033. Epub 2019 Apr 25.

PMID:
30735312
3.

Stereoselective C-terminal peptide elongation from Chan-Lam-Evans reaction generated isopropenyl esters.

Steemers L, van Maarseveen JH.

Org Biomol Chem. 2019 Feb 20;17(8):2103-2106. doi: 10.1039/c8ob02102c.

PMID:
30714599
4.

Total Synthesis of the Ortho-Hydroxylated Protoberberines ( S)-Govaniadine, ( S)-Caseamine, and ( S)-Clarkeanidine via a Solvent-Directed Pictet-Spengler Reaction.

Horst B, Wanner MJ, Jørgensen SI, Hiemstra H, van Maarseveen JH.

J Org Chem. 2018 Dec 21;83(24):15110-15117. doi: 10.1021/acs.joc.8b02378. Epub 2018 Dec 3.

5.

Template-Directed Synthesis of an Inverted Spiro Architecture.

Wanner MJ, Steemers L, Uiterweerd MT, Klijn RS, Ehlers AW, van Maarseveen JH.

Chemistry. 2018 Sep 6;24(50):13114-13117. doi: 10.1002/chem.201803356. Epub 2018 Aug 10.

PMID:
29978923
6.

A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides.

Richelle GJJ, Schmidt M, Ippel H, Hackeng TM, van Maarseveen JH, Nuijens T, Timmerman P.

Chembiochem. 2018 Sep 17;19(18):1934-1938. doi: 10.1002/cbic.201800346. Epub 2018 Aug 2.

PMID:
29944773
7.

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1.

Schmidt M, Toplak A, Rozeboom HJ, Wijma HJ, Quaedflieg PJLM, van Maarseveen JH, Janssen DB, Nuijens T.

Org Biomol Chem. 2018 Jan 24;16(4):609-618. doi: 10.1039/c7ob02812a.

PMID:
29300408
8.

Enzyme-catalyzed peptide cyclization.

Schmidt M, Toplak A, Quaedflieg PJLM, van Maarseveen JH, Nuijens T.

Drug Discov Today Technol. 2017 Dec;26:11-16. doi: 10.1016/j.ddtec.2017.11.007. Epub 2017 Nov 26. Review.

PMID:
29249237
9.

Editorial for the special issue on "constrained peptides".

van Maarseveen JH, Timmerman P.

Drug Discov Today Technol. 2017 Dec;26:1-2. doi: 10.1016/j.ddtec.2017.12.001. No abstract available.

PMID:
29249236
10.

General and Facile Route to Isomerically Pure Tricyclic Peptides Based on Templated Tandem CLIPS/CuAAC Cyclizations.

Richelle GJJ, Ori S, Hiemstra H, van Maarseveen JH, Timmerman P.

Angew Chem Int Ed Engl. 2018 Jan 8;57(2):501-505. doi: 10.1002/anie.201709127. Epub 2017 Dec 14.

PMID:
29193727
11.

Identification and Characterization of (3Z):(2E)-Hexenal Isomerases from Cucumber.

Spyropoulou EA, Dekker HL, Steemers L, van Maarseveen JH, de Koster CG, Haring MA, Schuurink RC, Allmann S.

Front Plant Sci. 2017 Aug 2;8:1342. doi: 10.3389/fpls.2017.01342. eCollection 2017.

12.

Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy.

Steemers L, Wanner MJ, Lutz M, Hiemstra H, van Maarseveen JH.

Nat Commun. 2017 May 25;8:15392. doi: 10.1038/ncomms15392.

13.

In-Culture Cross-Linking of Bacterial Cells Reveals Large-Scale Dynamic Protein-Protein Interactions at the Peptide Level.

de Jong L, de Koning EA, Roseboom W, Buncherd H, Wanner MJ, Dapic I, Jansen PJ, van Maarseveen JH, Corthals GL, Lewis PJ, Hamoen LW, de Koster CG.

J Proteome Res. 2017 Jul 7;16(7):2457-2471. doi: 10.1021/acs.jproteome.7b00068. Epub 2017 May 26.

14.

A Short Covalent Synthesis of an All-Carbon-Ring [2]Rotaxane.

Steemers L, Wanner MJ, Ehlers AW, Hiemstra H, van Maarseveen JH.

Org Lett. 2017 May 5;19(9):2342-2345. doi: 10.1021/acs.orglett.7b00877. Epub 2017 Apr 24.

15.

Synthetic and Organocatalytic Studies of Quinidine Analogues with Ring-Size Modifications in the Quinuclidine Moiety.

Breman AC, van der Heijden G, van Maarseveen JH, Ingemann S, Hiemstra H.

Chemistry. 2016 Sep 26;22(40):14247-56. doi: 10.1002/chem.201601917. Epub 2016 Aug 17.

PMID:
27531315
16.

Formal Synthesis of Solanoeclepin A: Enantioselective Allene Diboration and Intramolecular [2+2] Photocycloaddition for the Construction of the Tricyclic Core.

Kleinnijenhuis RA, Timmer BJ, Lutteke G, Smits JM, de Gelder R, van Maarseveen JH, Hiemstra H.

Chemistry. 2016 Jan 22;22(4):1266-9. doi: 10.1002/chem.201504894. Epub 2015 Dec 21.

PMID:
26646583
17.

Cinchona Alkaloid Catalyzed Sulfa-Michael Addition Reactions Leading to Enantiopure β-Functionalized Cysteines.

Breman AC, Telderman SE, van Santen RP, Scott JI, van Maarseveen JH, Ingemann S, Hiemstra H.

J Org Chem. 2015 Nov 6;80(21):10561-74. doi: 10.1021/acs.joc.5b01660. Epub 2015 Oct 21.

PMID:
26451627
18.

Total Synthesis of Aquatolide.

Saya JM, Vos K, Kleinnijenhuis RA, van Maarseveen JH, Ingemann S, Hiemstra H.

Org Lett. 2015 Aug 7;17(15):3892-4. doi: 10.1021/acs.orglett.5b01888. Epub 2015 Jul 17.

PMID:
26186274
19.

Organocatalytic enantioselective Pictet-Spengler approach to biologically relevant 1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloids.

Ruiz-Olalla A, Würdemann MA, Wanner MJ, Ingemann S, van Maarseveen JH, Hiemstra H.

J Org Chem. 2015 May 15;80(10):5125-32. doi: 10.1021/acs.joc.5b00509. Epub 2015 May 7.

PMID:
25909585
20.

Enantioselective synthesis of tunable chiral Clickphine P,N-ligands and their application in Ir-catalyzed asymmetric hydrogenation.

Wassenaar J, Detz RJ, de Boer SY, Lutz M, van Maarseveen JH, Hiemstra H, Reek JN.

J Org Chem. 2015 Apr 3;80(7):3634-42. doi: 10.1021/acs.joc.5b00438. Epub 2015 Mar 16.

PMID:
25748824
21.

Reconstructing the discontinuous and conformational β1/β3-loop binding site on hFSH/hCG by using highly constrained multicyclic peptides.

Smeenk LE, Timmers-Parohi D, Benschop JJ, Puijk WC, Hiemstra H, van Maarseveen JH, Timmerman P.

Chembiochem. 2015 Jan 2;16(1):91-9. doi: 10.1002/cbic.201402540. Epub 2014 Dec 2.

PMID:
25469830
22.

Molecular beam and ab initio studies of photoactive yellow protein chromophores: influence of the thioester functionality and single bond rotation.

Tan EM, Amirjalayer S, Mazzella P, Bakker BH, van Maarseveen JH, Bieraugel H, Buma WJ.

J Phys Chem B. 2014 Oct 30;118(43):12395-403. doi: 10.1021/jp5075169. Epub 2014 Oct 17.

PMID:
25289691
23.

Organocatalytic enantioselective Pictet-Spengler reactions for the syntheses of 1-substituted 1,2,3,4-tetrahydroisoquinolines.

Mons E, Wanner MJ, Ingemann S, van Maarseveen JH, Hiemstra H.

J Org Chem. 2014 Aug 15;79(16):7380-90. doi: 10.1021/jo501099h. Epub 2014 Jul 30.

PMID:
25046801
24.

Epimerization-free C-terminal peptide activation.

Popovic S, Bieräugel H, Detz RJ, Kluwer AM, Koole JA, Streefkerk DE, Hiemstra H, van Maarseveen JH.

Chemistry. 2013 Dec 9;19(50):16934-7. doi: 10.1002/chem.201303347. Epub 2013 Nov 7. No abstract available.

PMID:
24307358
25.

Folding dynamics of the Trp-cage miniprotein: evidence for a native-like intermediate from combined time-resolved vibrational spectroscopy and molecular dynamics simulations.

Meuzelaar H, Marino KA, Huerta-Viga A, Panman MR, Smeenk LE, Kettelarij AJ, van Maarseveen JH, Timmerman P, Bolhuis PG, Woutersen S.

J Phys Chem B. 2013 Oct 3;117(39):11490-501. doi: 10.1021/jp404714c. Epub 2013 Sep 19.

PMID:
24050152
26.

Total syntheses of mitragynine, paynantheine and speciogynine via an enantioselective thiourea-catalysed Pictet-Spengler reaction.

Kerschgens IP, Claveau E, Wanner MJ, Ingemann S, van Maarseveen JH, Hiemstra H.

Chem Commun (Camb). 2012 Dec 28;48(100):12243-5. doi: 10.1039/c2cc37023a.

PMID:
23150886
27.

Synthesis of strained cyclic peptides via an aza-Michael-acyl-transfer reaction cascade.

Rutters JP, Verdonk Y, de Vries R, Ingemann S, Hiemstra H, Levacher V, van Maarseveen JH.

Chem Commun (Camb). 2012 Aug 21;48(65):8084-6. doi: 10.1039/c2cc34121b. Epub 2012 Jul 6.

PMID:
22767326
28.

Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation.

Smeenk LE, Dailly N, Hiemstra H, van Maarseveen JH, Timmerman P.

Org Lett. 2012 Mar 2;14(5):1194-7. doi: 10.1021/ol203259a. Epub 2012 Feb 14.

PMID:
22332901
29.

Selective enrichment and identification of cross-linked peptides to study 3-D structures of protein complexes by mass spectrometry.

Buncherd H, Nessen MA, Nouse N, Stelder SK, Roseboom W, Dekker HL, Arents JC, Smeenk LE, Wanner MJ, van Maarseveen JH, Yang X, Lewis PJ, de Koning LJ, de Koster CG, de Jong L.

J Proteomics. 2012 Apr 3;75(7):2205-15. doi: 10.1016/j.jprot.2012.01.025. Epub 2012 Feb 4.

PMID:
22326961
30.

Enantioselective syntheses of corynanthe alkaloids by chiral Brønsted acid and palladium catalysis.

Wanner MJ, Claveau E, van Maarseveen JH, Hiemstra H.

Chemistry. 2011 Dec 2;17(49):13680-3. doi: 10.1002/chem.201103150. Epub 2011 Nov 8. No abstract available.

PMID:
22069165
31.

Total synthesis of (+)-yohimbine via an enantioselective organocatalytic Pictet-Spengler reaction.

Herlé B, Wanner MJ, van Maarseveen JH, Hiemstra H.

J Org Chem. 2011 Nov 4;76(21):8907-12. doi: 10.1021/jo201657n. Epub 2011 Oct 4.

PMID:
21950549
32.

Enantioselective copper-catalysed propargylic substitution: synthetic scope study and application in formal total syntheses of (+)-anisomycin and (-)-cytoxazone.

Detz RJ, Abiri Z, le Griel R, Hiemstra H, van Maarseveen JH.

Chemistry. 2011 May 16;17(21):5921-30. doi: 10.1002/chem.201003727. Epub 2011 Apr 15.

PMID:
21500294
33.

Expedient pyrrolizidine synthesis by propargylsilane addition to N-acyliminium ions followed by gold-catalyzed alpha-allenyl amide cyclization.

Breman AC, Dijkink J, van Maarseveen JH, Kinderman SS, Hiemstra H.

J Org Chem. 2009 Aug 21;74(16):6327-30. doi: 10.1021/jo901393y.

PMID:
20560574
34.

Organocatalytic enantioselective total synthesis of (-)-arboricine.

Wanner MJ, Boots RN, Eradus B, de Gelder R, van Maarseveen JH, Hiemstra H.

Org Lett. 2009 Jun 18;11(12):2579-81. doi: 10.1021/ol900888e.

PMID:
19514792
35.

Selective enrichment of azide-containing peptides from complex mixtures.

Nessen MA, Kramer G, Back J, Baskin JM, Smeenk LE, de Koning LJ, van Maarseveen JH, de Jong L, Bertozzi CR, Hiemstra H, de Koster CG.

J Proteome Res. 2009 Jul;8(7):3702-11. doi: 10.1021/pr900257z.

36.

Identification and quantitation of newly synthesized proteins in Escherichia coli by enrichment of azidohomoalanine-labeled peptides with diagonal chromatography.

Kramer G, Sprenger RR, Back J, Dekker HL, Nessen MA, van Maarseveen JH, de Koning LJ, Hellingwerf KJ, de Jong L, de Koster CG.

Mol Cell Proteomics. 2009 Jul;8(7):1599-611. doi: 10.1074/mcp.M800392-MCP200. Epub 2009 Mar 25.

37.

Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues.

Beierle JM, Horne WS, van Maarseveen JH, Waser B, Reubi JC, Ghadiri MR.

Angew Chem Int Ed Engl. 2009;48(26):4725-9. doi: 10.1002/anie.200805901.

38.

Enantioselective BINOL-phosphoric acid catalyzed Pictet-Spengler reactions of N-benzyltryptamine.

Sewgobind NV, Wanner MJ, Ingemann S, de Gelder R, van Maarseveen JH, Hiemstra H.

J Org Chem. 2008 Aug 15;73(16):6405-8. doi: 10.1021/jo8010478. Epub 2008 Jul 11.

PMID:
18616320
39.

Enantioselective copper-catalyzed propargylic amination.

Detz RJ, Delville MM, Hiemstra H, van Maarseveen JH.

Angew Chem Int Ed Engl. 2008;47(20):3777-80. doi: 10.1002/anie.200705264. No abstract available.

PMID:
18283687
40.

Catalytic asymmetric Pictet-Spengler reactions via sulfenyliminium ions.

Wanner MJ, van der Haas RN, de Cuba KR, van Maarseveen JH, Hiemstra H.

Angew Chem Int Ed Engl. 2007;46(39):7485-7. No abstract available.

PMID:
17702087
41.

An aptly positioned azido group in the spacer of a protein cross-linker for facile mapping of lysines in close proximity.

Kasper PT, Back JW, Vitale M, Hartog AF, Roseboom W, de Koning LJ, van Maarseveen JH, Muijsers AO, de Koster CG, de Jong L.

Chembiochem. 2007 Jul 23;8(11):1281-92.

PMID:
17600791
42.

1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics.

Bock VD, Speijer D, Hiemstra H, van Maarseveen JH.

Org Biomol Chem. 2007 Mar 21;5(6):971-5. Epub 2007 Feb 6.

PMID:
17340013
43.

Cupreines and cupreidines: an emerging class of bifunctional cinchona organocatalysts.

Marcelli T, van Maarseveen JH, Hiemstra H.

Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7496-504.

PMID:
17051626
44.

"Clickphine": a novel and highly versatile P,N ligand class via click chemistry.

Detz RJ, Heras SA, de Gelder R, van Leeuwen PW, Hiemstra H, Reek JN, van Maarseveen JH.

Org Lett. 2006 Jul 20;8(15):3227-30. Erratum in: Org Lett. 2008 Mar 20;10(6):1323.

PMID:
16836372
45.

Carbosilane dendrimeric carbodiimides: site isolation as a lactamization tool.

Amore A, van Heerbeek R, Zeep N, van Esch J, Reek JN, Hiemstra H, van Maarseveen JH.

J Org Chem. 2006 Mar 3;71(5):1851-60.

PMID:
16496969
46.

Click chemistry as a route to cyclic tetrapeptide analogues: synthesis of cyclo-[Pro-Val-psi(triazole)-Pro-Tyr].

Bock VD, Perciaccante R, Jansen TP, Hiemstra H, van Maarseveen JH.

Org Lett. 2006 Mar 2;8(5):919-22.

PMID:
16494474
47.

Transition-metal catalysis as a tool for the covalent labeling of proteins.

van Maarseveen JH, Reek JN, Back JW.

Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1841-3. No abstract available.

PMID:
16493720
48.

PegPhos: a monodentate phosphoramidite ligand for enantioselective rhodium-catalysed hydrogenation in water.

Hoen R, Leleu S, Botman PN, Appelman VA, Feringa BL, Hiemstra H, Minnaard AJ, van Maarseveen JH.

Org Biomol Chem. 2006 Feb 21;4(4):613-5. Epub 2006 Jan 13.

PMID:
16467933
49.

Asymmetric organocatalytic Henry reaction.

Marcelli T, van der Haas RN, van Maarseveen JH, Hiemstra H.

Angew Chem Int Ed Engl. 2006 Jan 30;45(6):929-31. No abstract available.

PMID:
16429453
50.

Piperazinyl oxime ethers as NK-1 receptor antagonists.

van den Hoogenband A, van Maarseveen JH, McCreary AC, Mulder AT, van Scharrenburg GJ, van Stuivenberg HH, Zethof TJ, Zijta B, Iwema Bakker WI.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):1045-8. Epub 2005 Nov 11.

PMID:
16289817

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