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Items: 1 to 50 of 99

1.

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae.

Rogiers O, Frising UC, Kucharíková S, Jabra-Rizk MA, van Loo G, Van Dijck P, Wullaert A.

MBio. 2019 Jan 8;10(1). pii: e02221-18. doi: 10.1128/mBio.02221-18.

2.

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.

Voet S, Prinz M, van Loo G.

Trends Mol Med. 2018 Dec 18. pii: S1471-4914(18)30223-5. doi: 10.1016/j.molmed.2018.11.005. [Epub ahead of print] Review.

PMID:
30578090
3.

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S, Gevaert K.

Sci Data. 2018 Dec 18;5:180289. doi: 10.1038/sdata.2018.289.

4.

BACE2 distribution in major brain cell types and identification of novel substrates.

Voytyuk I, Mueller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B.

Life Sci Alliance. 2018 Feb 15;1(1):e201800026. doi: 10.26508/lsa.201800026. eCollection 2018 Jan.

5.

House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent.

Vroman H, Das T, Bergen IM, van Hulst JAC, Ahmadi F, van Loo G, Lubberts E, Hendriks RW, Kool M.

Clin Exp Allergy. 2018 Dec;48(12):1705-1714. doi: 10.1111/cea.13262. Epub 2018 Sep 27.

PMID:
30171721
6.

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

Devos M, Mogilenko DA, Fleury S, Gilbert B, Becquart C, Quemener S, Dehondt H, Tougaard P, Staels B, Bachert C, Vandenabeele P, Van Loo G, Staumont-Salle D, Declercq W, Dombrowicz D.

J Invest Dermatol. 2019 Jan;139(1):135-145. doi: 10.1016/j.jid.2018.06.191. Epub 2018 Aug 14.

PMID:
30118730
7.

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G.

Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5.

8.

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20.

Van Quickelberghe E, Martens A, Goeminne LJE, Clement L, van Loo G, Gevaert K.

J Proteome Res. 2018 Jun 1;17(6):2182-2191. doi: 10.1021/acs.jproteome.8b00139. Epub 2018 May 11.

PMID:
29733654
9.

Optineurin Functions for Optimal Immunity.

Slowicka K, van Loo G.

Front Immunol. 2018 Apr 10;9:769. doi: 10.3389/fimmu.2018.00769. eCollection 2018. Review.

10.

Adipose tissue macrophages and their polarization in health and obesity.

Catrysse L, van Loo G.

Cell Immunol. 2018 Aug;330:114-119. doi: 10.1016/j.cellimm.2018.03.001. Epub 2018 Mar 5.

PMID:
29526353
11.

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.

EMBO J. 2018 Apr 13;37(8). pii: e97858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1.

PMID:
29496741
12.

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.

Lee JH, Jung SM, Yang KM, Bae E, Ahn SG, Park JS, Seo D, Kim M, Ha J, Lee J, Kim JH, Kim JH, Ooshima A, Park J, Shin D, Lee YS, Lee S, van Loo G, Jeong J, Kim SJ, Park SH.

Nat Cell Biol. 2017 Oct;19(10):1260-1273. doi: 10.1038/ncb3609. Epub 2017 Sep 11.

PMID:
28892081
13.

TNF-α-induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma.

Vroman H, Bergen IM, van Hulst JAC, van Nimwegen M, van Uden D, Schuijs MJ, Pillai SY, van Loo G, Hammad H, Lambrecht BN, Hendriks RW, Kool M.

J Allergy Clin Immunol. 2018 May;141(5):1620-1633.e12. doi: 10.1016/j.jaci.2017.08.012. Epub 2017 Sep 6.

PMID:
28888782
14.

A20 Restrains Thymic Regulatory T Cell Development.

Fischer JC, Otten V, Kober M, Drees C, Rosenbaum M, Schmickl M, Heidegger S, Beyaert R, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H.

J Immunol. 2017 Oct 1;199(7):2356-2365. doi: 10.4049/jimmunol.1602102. Epub 2017 Aug 25.

15.

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Fischer JC, Otten V, Steiger K, Schmickl M, Slotta-Huspenina J, Beyaert R, van Loo G, Peschel C, Poeck H, Haas T, Spoerl S.

Eur J Immunol. 2017 Nov;47(11):1982-1988. doi: 10.1002/eji.201646911. Epub 2017 Sep 15.

16.

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB.

Catrysse L, van Loo G.

Trends Cell Biol. 2017 Jun;27(6):417-429. doi: 10.1016/j.tcb.2017.01.006. Epub 2017 Feb 23. Review.

PMID:
28237661
17.

Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.

Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, Maher P, Methner A, Massie A.

J Neuroinflammation. 2017 Jan 13;14(1):9. doi: 10.1186/s12974-016-0787-0.

18.

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

Drennan MB, Govindarajan S, Verheugen E, Coquet JM, Staal J, McGuire C, Taghon T, Leclercq G, Beyaert R, van Loo G, Lambrecht BN, Elewaut D.

J Exp Med. 2016 Sep 19;213(10):1973-81. doi: 10.1084/jem.20151065. Epub 2016 Aug 22.

19.

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis.

De Wilde K, Martens A, Lambrecht S, Jacques P, Drennan MB, Debusschere K, Govindarajan S, Coudenys J, Verheugen E, Windels F, Catrysse L, Lories R, McGonagle D, Beyaert R, van Loo G, Elewaut D.

Ann Rheum Dis. 2017 Mar;76(3):585-592. doi: 10.1136/annrheumdis-2016-209454. Epub 2016 Aug 22.

PMID:
27551052
20.

Cellular Functions of Optineurin in Health and Disease.

Slowicka K, Vereecke L, van Loo G.

Trends Immunol. 2016 Sep;37(9):621-633. doi: 10.1016/j.it.2016.07.002. Epub 2016 Jul 30. Review.

PMID:
27480243
21.

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.

Catrysse L, Farhang Ghahremani M, Vereecke L, Youssef SA, Mc Guire C, Sze M, Weber A, Heikenwalder M, de Bruin A, Beyaert R, van Loo G.

Cell Death Dis. 2016 Jun 2;7(6):e2250. doi: 10.1038/cddis.2016.154.

22.

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.

Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A.

Cancer Res. 2016 May 1;76(9):2587-99. doi: 10.1158/0008-5472.CAN-15-1473. Epub 2016 Mar 15.

23.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs MJ, Willart M, Ibañez LI, Hammad H, Lambrecht BN, Beyaert R, Saelens X, van Loo G.

PLoS Pathog. 2016 Jan 27;12(1):e1005410. doi: 10.1371/journal.ppat.1005410. eCollection 2016 Jan.

24.

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, Saelens X, Beyaert R, van Loo G.

Eur J Immunol. 2016 Apr;46(4):971-80. doi: 10.1002/eji.201545863. Epub 2016 Jan 15.

25.

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.

Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, Mortensen HB, Pociot F, van Loo G, Størling J, Cardozo AK.

Mol Endocrinol. 2016 Jan;30(1):48-61. doi: 10.1210/me.2015-1176. Epub 2015 Dec 10.

26.

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo.

Catrysse L, Fukaya M, Sze M, Meyerovich K, Beyaert R, Cardozo AK, van Loo G.

Cell Death Dis. 2015 Oct 15;6:e1918. doi: 10.1038/cddis.2015.301. No abstract available.

27.

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.

Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, Madeira FB, Beyaert R, van Loo G, Bracher F, von Mutius E, Chanez P, Lambrecht BN, Hammad H.

Science. 2015 Sep 4;349(6252):1106-10. doi: 10.1126/science.aac6623.

28.

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice.

Vlantis K, Polykratis A, Welz PS, van Loo G, Pasparakis M, Wullaert A.

Gut. 2016 Jun;65(6):935-43. doi: 10.1136/gutjnl-2014-308323. Epub 2015 Mar 11.

29.

Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch.

Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N'Kuli F, Hoffmann D, Cnops Y, Rabolli V, van Loo G, Beyaert R, Huaux F, Devuyst O, Courtoy PJ.

PLoS One. 2015 Feb 26;10(2):e0117398. doi: 10.1371/journal.pone.0117398. eCollection 2015.

30.

MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway.

Kumar M, Sahu SK, Kumar R, Subuddhi A, Maji RK, Jana K, Gupta P, Raffetseder J, Lerm M, Ghosh Z, van Loo G, Beyaert R, Gupta UD, Kundu M, Basu J.

Cell Host Microbe. 2015 Mar 11;17(3):345-356. doi: 10.1016/j.chom.2015.01.007. Epub 2015 Feb 12.

31.

Evaluation and perceived results of moral case deliberation: A mixed methods study.

Janssens RM, van Zadelhoff E, van Loo G, Widdershoven G, Molewijk BA.

Nurs Ethics. 2015 Dec;22(8):870-80. doi: 10.1177/0969733014557115. Epub 2014 Dec 25.

PMID:
25542405
32.

A20 controls intestinal homeostasis through cell-specific activities.

Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G.

Nat Commun. 2014 Sep 30;5:5103. doi: 10.1038/ncomms6103.

PMID:
25267258
33.

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P.

Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706.

PMID:
25186904
34.

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.

Zabeau L, Jensen CJ, Seeuws S, Venken K, Verhee A, Catteeuw D, van Loo G, Chen H, Walder K, Hollis J, Foote S, Morris MJ, Van der Heyden J, Peelman F, Oldfield BJ, Rubio JP, Elewaut D, Tavernier J.

Cell Mol Life Sci. 2015 Feb;72(3):629-644. doi: 10.1007/s00018-014-1697-x. Epub 2014 Aug 7.

35.

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, Nagel D, Krappmann D, Prinz M, Beyaert R, van Loo G.

J Neuroinflammation. 2014 Jul 21;11:124. doi: 10.1186/1742-2094-11-124.

36.

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.

Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, Beyaert R, Elewaut D, Kanneganti TD, van Loo G, Lamkanfi M.

Nature. 2014 Aug 7;512(7512):69-73. doi: 10.1038/nature13322. Epub 2014 Jun 29.

37.

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells.

Giordano M, Roncagalli R, Bourdely P, Chasson L, Buferne M, Yamasaki S, Beyaert R, van Loo G, Auphan-Anezin N, Schmitt-Verhulst AM, Verdeil G.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11115-20. doi: 10.1073/pnas.1406259111. Epub 2014 Jul 14.

38.

A20: attractive without showing cleavage.

Verhelst K, van Loo G, Beyaert R.

EMBO Rep. 2014 Jul;15(7):734-5. doi: 10.15252/embr.201439014. Epub 2014 May 30. No abstract available.

39.

A20-deficient mast cells exacerbate inflammatory responses in vivo.

Heger K, Fierens K, Vahl JC, Aszodi A, Peschke K, Schenten D, Hammad H, Beyaert R, Saur D, van Loo G, Roers A, Lambrecht BN, Kool M, Schmidt-Supprian M.

PLoS Biol. 2014 Jan;12(1):e1001762. doi: 10.1371/journal.pbio.1001762. Epub 2014 Jan 14.

40.

A20 in inflammation and autoimmunity.

Catrysse L, Vereecke L, Beyaert R, van Loo G.

Trends Immunol. 2014 Jan;35(1):22-31. doi: 10.1016/j.it.2013.10.005. Epub 2013 Nov 15. Review.

PMID:
24246475
41.

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology.

Mc Guire C, Prinz M, Beyaert R, van Loo G.

Trends Mol Med. 2013 Oct;19(10):604-13. doi: 10.1016/j.molmed.2013.08.001. Epub 2013 Sep 2. Review.

PMID:
24007818
42.

The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome.

Mc Guire C, Rahman M, Schwaninger M, Beyaert R, van Loo G.

Cell Death Dis. 2013 Mar 7;4:e531. doi: 10.1038/cddis.2013.55. No abstract available.

43.

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.

Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R, van Loo G.

J Immunol. 2013 Mar 15;190(6):2896-903. doi: 10.4049/jimmunol.1201351. Epub 2013 Feb 11.

44.

A20 and CYLD do not share significant overlapping functions during B cell development and activation.

Chu Y, Soberon V, Glockner L, Beyaert R, Massoumi R, van Loo G, Krappmann D, Schmidt-Supprian M.

J Immunol. 2012 Nov 1;189(9):4437-43. doi: 10.4049/jimmunol.1200396. Epub 2012 Sep 21.

45.

Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis.

Polykratis A, van Loo G, Xanthoulea S, Hellmich M, Pasparakis M.

Circulation. 2012 Oct 2;126(14):1739-51. doi: 10.1161/CIRCULATIONAHA.112.100339. Epub 2012 Aug 30.

PMID:
22935568
46.

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M.

Cancer Cell. 2012 Jul 10;22(1):91-105. doi: 10.1016/j.ccr.2012.05.023.

47.

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.

Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA.

Blood. 2012 Jul 19;120(3):613-25. doi: 10.1182/blood-2012-01-403386. Epub 2012 May 10.

48.

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.

Maelfait J, Roose K, Bogaert P, Sze M, Saelens X, Pasparakis M, Carpentier I, van Loo G, Beyaert R.

PLoS Pathog. 2012;8(3):e1002570. doi: 10.1371/journal.ppat.1002570. Epub 2012 Mar 1. Erratum in: PLoS Pathog. 2012 Apr;8(4): doi/10.1371/annotation/a2136b9a-3cbf-426f-9cfb-73e3c9c6396d.

49.

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.

Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M.

Immunity. 2011 Oct 28;35(4):572-82. doi: 10.1016/j.immuni.2011.08.014. Epub 2011 Oct 13.

50.

Death receptor signalling in central nervous system inflammation and demyelination.

Mc Guire C, Beyaert R, van Loo G.

Trends Neurosci. 2011 Dec;34(12):619-28. doi: 10.1016/j.tins.2011.09.002. Epub 2011 Oct 13. Review.

PMID:
21999927

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