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Items: 1 to 50 of 110

1.

A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity.

Martens A, van Loo G.

Cold Spring Harb Perspect Biol. 2019 Aug 19. pii: a036418. doi: 10.1101/cshperspect.a036418. [Epub ahead of print]

PMID:
31427375
2.

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.

Vetters J, van Helden MJ, Wahlen S, Tavernier SJ, Martens A, Fayazpour F, Vergote K, Vanheerswynghels M, Deswarte K, Van Moorleghem J, De Prijck S, Takahashi N, Vandenabeele P, Boon L, van Loo G, Vivier E, Lambrecht BN, Janssens S.

J Exp Med. 2019 Jul 11. pii: jem.20182164. doi: 10.1084/jem.20182164. [Epub ahead of print]

PMID:
31296735
3.

The anti-inflammatory protein TNFAIP3/A20 binds the WD40 domain of ATG16L1 to control the autophagic response, NFKB/NF-κB activation and intestinal homeostasis.

Serramito-Gómez I, Boada-Romero E, Slowicka K, Vereecke L, Van Loo G, Pimentel-Muiños FX.

Autophagy. 2019 Sep;15(9):1657-1659. doi: 10.1080/15548627.2019.1628549. Epub 2019 Jun 16.

PMID:
31184523
4.

DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology.

Das T, Bergen IM, Koudstaal T, van Hulst JAC, van Loo G, Boonstra A, Vanwolleghem T, Leung PSC, Gershwin ME, Hendriks RW, Kool M.

J Autoimmun. 2019 Aug;102:167-178. doi: 10.1016/j.jaut.2019.05.007. Epub 2019 Jul 9.

PMID:
31151831
5.

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M.

Nat Cell Biol. 2019 Jun;21(6):731-742. doi: 10.1038/s41556-019-0324-3. Epub 2019 May 13.

PMID:
31086261
6.

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.

Dubois H, Sorgeloos F, Sarvestani ST, Martens L, Saeys Y, Mackenzie JM, Lamkanfi M, van Loo G, Goodfellow I, Wullaert A.

PLoS Pathog. 2019 Apr 24;15(4):e1007709. doi: 10.1371/journal.ppat.1007709. eCollection 2019 Apr.

7.

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis.

Slowicka K, Serramito-Gómez I, Boada-Romero E, Martens A, Sze M, Petta I, Vikkula HK, De Rycke R, Parthoens E, Lippens S, Savvides SN, Wullaert A, Vereecke L, Pimentel-Muiños FX, van Loo G.

Nat Commun. 2019 Apr 23;10(1):1834. doi: 10.1038/s41467-019-09667-z.

8.

Inflammasomes in neuroinflammatory and neurodegenerative diseases.

Voet S, Srinivasan S, Lamkanfi M, van Loo G.

EMBO Mol Med. 2019 Jun;11(6). pii: e10248. doi: 10.15252/emmm.201810248. Review.

9.

Author Correction: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M.

Nature. 2019 Apr;568(7751):E4. doi: 10.1038/s41586-019-1045-2.

PMID:
30918409
10.

Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal Viruses.

Dubois H, van Loo G, Wullaert A.

Int Rev Cell Mol Biol. 2019;345:137-171. doi: 10.1016/bs.ircmb.2018.08.003. Epub 2018 Oct 3.

PMID:
30904192
11.

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M.

Nature. 2019 Feb;566(7744):388-392. doi: 10.1038/s41586-019-0924-x. Epub 2019 Feb 13. Erratum in: Nature. 2019 Apr;568(7751):E4.

PMID:
30760929
12.

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae.

Rogiers O, Frising UC, Kucharíková S, Jabra-Rizk MA, van Loo G, Van Dijck P, Wullaert A.

MBio. 2019 Jan 8;10(1). pii: e02221-18. doi: 10.1128/mBio.02221-18.

13.

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.

Voet S, Prinz M, van Loo G.

Trends Mol Med. 2019 Feb;25(2):112-123. doi: 10.1016/j.molmed.2018.11.005. Epub 2018 Dec 18. Review.

PMID:
30578090
14.

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S, Gevaert K.

Sci Data. 2018 Dec 18;5:180289. doi: 10.1038/sdata.2018.289.

15.

BACE2 distribution in major brain cell types and identification of novel substrates.

Voytyuk I, Mueller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B.

Life Sci Alliance. 2018 Feb 15;1(1):e201800026. doi: 10.26508/lsa.201800026. eCollection 2018 Jan.

16.

House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent.

Vroman H, Das T, Bergen IM, van Hulst JAC, Ahmadi F, van Loo G, Lubberts E, Hendriks RW, Kool M.

Clin Exp Allergy. 2018 Dec;48(12):1705-1714. doi: 10.1111/cea.13262. Epub 2018 Sep 27.

PMID:
30171721
17.

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

Devos M, Mogilenko DA, Fleury S, Gilbert B, Becquart C, Quemener S, Dehondt H, Tougaard P, Staels B, Bachert C, Vandenabeele P, Van Loo G, Staumont-Salle D, Declercq W, Dombrowicz D.

J Invest Dermatol. 2019 Jan;139(1):135-145. doi: 10.1016/j.jid.2018.06.191. Epub 2018 Aug 14.

PMID:
30118730
18.

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G.

Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5.

19.

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20.

Van Quickelberghe E, Martens A, Goeminne LJE, Clement L, van Loo G, Gevaert K.

J Proteome Res. 2018 Jun 1;17(6):2182-2191. doi: 10.1021/acs.jproteome.8b00139. Epub 2018 May 11.

PMID:
29733654
20.

Optineurin Functions for Optimal Immunity.

Slowicka K, van Loo G.

Front Immunol. 2018 Apr 10;9:769. doi: 10.3389/fimmu.2018.00769. eCollection 2018. Review.

21.

Adipose tissue macrophages and their polarization in health and obesity.

Catrysse L, van Loo G.

Cell Immunol. 2018 Aug;330:114-119. doi: 10.1016/j.cellimm.2018.03.001. Epub 2018 Mar 5. Review.

PMID:
29526353
22.

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.

EMBO J. 2018 Apr 13;37(8). pii: e97858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1.

23.

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.

Lee JH, Jung SM, Yang KM, Bae E, Ahn SG, Park JS, Seo D, Kim M, Ha J, Lee J, Kim JH, Kim JH, Ooshima A, Park J, Shin D, Lee YS, Lee S, van Loo G, Jeong J, Kim SJ, Park SH.

Nat Cell Biol. 2017 Oct;19(10):1260-1273. doi: 10.1038/ncb3609. Epub 2017 Sep 11.

PMID:
28892081
24.

TNF-α-induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma.

Vroman H, Bergen IM, van Hulst JAC, van Nimwegen M, van Uden D, Schuijs MJ, Pillai SY, van Loo G, Hammad H, Lambrecht BN, Hendriks RW, Kool M.

J Allergy Clin Immunol. 2018 May;141(5):1620-1633.e12. doi: 10.1016/j.jaci.2017.08.012. Epub 2017 Sep 6.

PMID:
28888782
25.

A20 Restrains Thymic Regulatory T Cell Development.

Fischer JC, Otten V, Kober M, Drees C, Rosenbaum M, Schmickl M, Heidegger S, Beyaert R, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H.

J Immunol. 2017 Oct 1;199(7):2356-2365. doi: 10.4049/jimmunol.1602102. Epub 2017 Aug 25.

26.

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Fischer JC, Otten V, Steiger K, Schmickl M, Slotta-Huspenina J, Beyaert R, van Loo G, Peschel C, Poeck H, Haas T, Spoerl S.

Eur J Immunol. 2017 Nov;47(11):1982-1988. doi: 10.1002/eji.201646911. Epub 2017 Sep 15.

27.

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB.

Catrysse L, van Loo G.

Trends Cell Biol. 2017 Jun;27(6):417-429. doi: 10.1016/j.tcb.2017.01.006. Epub 2017 Feb 23. Review.

PMID:
28237661
28.

Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.

Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, Maher P, Methner A, Massie A.

J Neuroinflammation. 2017 Jan 13;14(1):9. doi: 10.1186/s12974-016-0787-0.

29.

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

Drennan MB, Govindarajan S, Verheugen E, Coquet JM, Staal J, McGuire C, Taghon T, Leclercq G, Beyaert R, van Loo G, Lambrecht BN, Elewaut D.

J Exp Med. 2016 Sep 19;213(10):1973-81. doi: 10.1084/jem.20151065. Epub 2016 Aug 22.

30.

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis.

De Wilde K, Martens A, Lambrecht S, Jacques P, Drennan MB, Debusschere K, Govindarajan S, Coudenys J, Verheugen E, Windels F, Catrysse L, Lories R, McGonagle D, Beyaert R, van Loo G, Elewaut D.

Ann Rheum Dis. 2017 Mar;76(3):585-592. doi: 10.1136/annrheumdis-2016-209454. Epub 2016 Aug 22.

PMID:
27551052
31.

Cellular Functions of Optineurin in Health and Disease.

Slowicka K, Vereecke L, van Loo G.

Trends Immunol. 2016 Sep;37(9):621-633. doi: 10.1016/j.it.2016.07.002. Epub 2016 Jul 30. Review.

PMID:
27480243
32.

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.

Catrysse L, Farhang Ghahremani M, Vereecke L, Youssef SA, Mc Guire C, Sze M, Weber A, Heikenwalder M, de Bruin A, Beyaert R, van Loo G.

Cell Death Dis. 2016 Jun 2;7(6):e2250. doi: 10.1038/cddis.2016.154.

33.

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.

Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A.

Cancer Res. 2016 May 1;76(9):2587-99. doi: 10.1158/0008-5472.CAN-15-1473. Epub 2016 Mar 15.

34.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs MJ, Willart M, Ibañez LI, Hammad H, Lambrecht BN, Beyaert R, Saelens X, van Loo G.

PLoS Pathog. 2016 Jan 27;12(1):e1005410. doi: 10.1371/journal.ppat.1005410. eCollection 2016 Jan.

35.

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, Saelens X, Beyaert R, van Loo G.

Eur J Immunol. 2016 Apr;46(4):971-80. doi: 10.1002/eji.201545863. Epub 2016 Jan 15.

36.

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.

Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, Mortensen HB, Pociot F, van Loo G, Størling J, Cardozo AK.

Mol Endocrinol. 2016 Jan;30(1):48-61. doi: 10.1210/me.2015-1176. Epub 2015 Dec 10.

37.

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo.

Catrysse L, Fukaya M, Sze M, Meyerovich K, Beyaert R, Cardozo AK, van Loo G.

Cell Death Dis. 2015 Oct 15;6:e1918. doi: 10.1038/cddis.2015.301. No abstract available.

38.

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.

Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, Madeira FB, Beyaert R, van Loo G, Bracher F, von Mutius E, Chanez P, Lambrecht BN, Hammad H.

Science. 2015 Sep 4;349(6252):1106-10. doi: 10.1126/science.aac6623.

39.

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice.

Vlantis K, Polykratis A, Welz PS, van Loo G, Pasparakis M, Wullaert A.

Gut. 2016 Jun;65(6):935-43. doi: 10.1136/gutjnl-2014-308323. Epub 2015 Mar 11.

40.

Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch.

Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N'Kuli F, Hoffmann D, Cnops Y, Rabolli V, van Loo G, Beyaert R, Huaux F, Devuyst O, Courtoy PJ.

PLoS One. 2015 Feb 26;10(2):e0117398. doi: 10.1371/journal.pone.0117398. eCollection 2015.

41.

MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway.

Kumar M, Sahu SK, Kumar R, Subuddhi A, Maji RK, Jana K, Gupta P, Raffetseder J, Lerm M, Ghosh Z, van Loo G, Beyaert R, Gupta UD, Kundu M, Basu J.

Cell Host Microbe. 2015 Mar 11;17(3):345-356. doi: 10.1016/j.chom.2015.01.007. Epub 2015 Feb 12.

42.

Evaluation and perceived results of moral case deliberation: A mixed methods study.

Janssens RM, van Zadelhoff E, van Loo G, Widdershoven G, Molewijk BA.

Nurs Ethics. 2015 Dec;22(8):870-80. doi: 10.1177/0969733014557115. Epub 2014 Dec 25.

PMID:
25542405
43.

A20 controls intestinal homeostasis through cell-specific activities.

Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G.

Nat Commun. 2014 Sep 30;5:5103. doi: 10.1038/ncomms6103.

PMID:
25267258
44.

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P.

Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706.

PMID:
25186904
45.

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.

Zabeau L, Jensen CJ, Seeuws S, Venken K, Verhee A, Catteeuw D, van Loo G, Chen H, Walder K, Hollis J, Foote S, Morris MJ, Van der Heyden J, Peelman F, Oldfield BJ, Rubio JP, Elewaut D, Tavernier J.

Cell Mol Life Sci. 2015 Feb;72(3):629-644. doi: 10.1007/s00018-014-1697-x. Epub 2014 Aug 7.

46.

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, Nagel D, Krappmann D, Prinz M, Beyaert R, van Loo G.

J Neuroinflammation. 2014 Jul 21;11:124. doi: 10.1186/1742-2094-11-124.

47.

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.

Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, Beyaert R, Elewaut D, Kanneganti TD, van Loo G, Lamkanfi M.

Nature. 2014 Aug 7;512(7512):69-73. doi: 10.1038/nature13322. Epub 2014 Jun 29.

48.

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells.

Giordano M, Roncagalli R, Bourdely P, Chasson L, Buferne M, Yamasaki S, Beyaert R, van Loo G, Auphan-Anezin N, Schmitt-Verhulst AM, Verdeil G.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11115-20. doi: 10.1073/pnas.1406259111. Epub 2014 Jul 14.

49.

A20: attractive without showing cleavage.

Verhelst K, van Loo G, Beyaert R.

EMBO Rep. 2014 Jul;15(7):734-5. doi: 10.15252/embr.201439014. Epub 2014 May 30. No abstract available.

50.

A20-deficient mast cells exacerbate inflammatory responses in vivo.

Heger K, Fierens K, Vahl JC, Aszodi A, Peschke K, Schenten D, Hammad H, Beyaert R, Saur D, van Loo G, Roers A, Lambrecht BN, Kool M, Schmidt-Supprian M.

PLoS Biol. 2014 Jan;12(1):e1001762. doi: 10.1371/journal.pbio.1001762. Epub 2014 Jan 14.

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