Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 135

1.

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.

Serresi M, Siteur B, Hulsman D, Company C, Schmitt MJ, Lieftink C, Morris B, Cesaroni M, Proost N, Beijersbergen RL, van Lohuizen M, Gargiulo G.

J Exp Med. 2018 Dec 3;215(12):3115-3135. doi: 10.1084/jem.20180801. Epub 2018 Nov 28.

2.

A new transgenic mouse model for conditional overexpression of the Polycomb Group protein EZH2.

Koppens MA, Tanger E, Nacerddine K, Westerman B, Song JY, van Lohuizen M.

Transgenic Res. 2017 Apr;26(2):187-196. doi: 10.1007/s11248-016-9993-x. Epub 2016 Nov 2.

PMID:
27807665
3.

TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming.

Miles DC, de Vries NA, Gisler S, Lieftink C, Akhtar W, Gogola E, Pawlitzky I, Hulsman D, Tanger E, Koppens M, Beijersbergen RL, van Lohuizen M.

Stem Cells. 2017 Jan;35(1):147-157. doi: 10.1002/stem.2453. Epub 2016 Jul 6.

4.

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition.

Koppens MA, Bounova G, Cornelissen-Steijger P, de Vries N, Sansom OJ, Wessels LF, van Lohuizen M.

Oncotarget. 2016 Oct 25;7(43):69816-69828. doi: 10.18632/oncotarget.12002.

5.

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.

Koppens MA, Bounova G, Gargiulo G, Tanger E, Janssen H, Cornelissen-Steijger P, Blom M, Song JY, Wessels LF, van Lohuizen M.

Gastroenterology. 2016 Oct;151(4):684-697.e12. doi: 10.1053/j.gastro.2016.06.020. Epub 2016 Jun 21.

PMID:
27342214
6.

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.

Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A, van Lohuizen M.

Cancer Cell. 2016 Jan 11;29(1):17-31. doi: 10.1016/j.ccell.2015.12.006. Erratum in: Cancer Cell. 2016 Feb 8;29(2):241.

7.

Applications of DNA integrating elements: Facing the bias bully.

de Jong J, Wessels LF, van Lohuizen M, de Ridder J, Akhtar W.

Mob Genet Elements. 2015 Mar 9;4(6):1-6. eCollection 2014 Nov-Dec. Review.

8.

Context-dependent actions of Polycomb repressors in cancer.

Koppens M, van Lohuizen M.

Oncogene. 2016 Mar 17;35(11):1341-52. doi: 10.1038/onc.2015.195. Epub 2015 Jun 8. Review.

PMID:
26050622
9.

Corrigendum: using TRIP for genome-wide position effect analysis in cultured cells.

Akhtar W, Pindyurin AV, de Jong J, Pagie L, Ten Hoeve J, Berns A, Wessels LF, van Steensel B, van Lohuizen M.

Nat Protoc. 2015 Apr;10(4):643. doi: 10.1038/nprot0415-644c. Epub 2015 Mar 26. No abstract available.

PMID:
25811898
10.

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

de Vries NA, Hulsman D, Akhtar W, de Jong J, Miles DC, Blom M, van Tellingen O, Jonkers J, van Lohuizen M.

Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01057-2. doi: 10.1016/j.celrep.2014.12.028. [Epub ahead of print]

11.

Loss of PRDM11 promotes MYC-driven lymphomagenesis.

Fog CK, Asmar F, Côme C, Jensen KT, Johansen JV, Kheir TB, Jacobsen L, Friis C, Louw A, Rosgaard L, Øbro NF, Marquart HV, Anthonsen K, Braat AK, van Lohuizen M, Ralfkiaer E, Grønbæk K, Lund AH.

Blood. 2015 Feb 19;125(8):1272-81. doi: 10.1182/blood-2014-03-560805. Epub 2014 Dec 12.

12.

In vivo shRNA screens in solid tumors.

Gargiulo G, Serresi M, Cesaroni M, Hulsman D, van Lohuizen M.

Nat Protoc. 2014 Dec;9(12):2880-902. doi: 10.1038/nprot.2014.185. Epub 2014 Nov 20.

PMID:
25411954
13.

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

Lancini C, van den Berk PC, Vissers JH, Gargiulo G, Song JY, Hulsman D, Serresi M, Tanger E, Blom M, Vens C, van Lohuizen M, Jacobs H, Citterio E.

J Exp Med. 2014 Aug 25;211(9):1759-77. doi: 10.1084/jem.20131436. Epub 2014 Aug 11.

14.

Using TRIP for genome-wide position effect analysis in cultured cells.

Akhtar W, Pindyurin AV, de Jong J, Pagie L, Ten Hoeve J, Berns A, Wessels LF, van Steensel B, van Lohuizen M.

Nat Protoc. 2014;9(6):1255-81. doi: 10.1038/nprot.2014.072. Epub 2014 May 8. Erratum in: Nat Protoc. 2015 Apr;10(4):643.

PMID:
24810036
15.

Chromatin landscapes of retroviral and transposon integration profiles.

de Jong J, Akhtar W, Badhai J, Rust AG, Rad R, Hilkens J, Berns A, van Lohuizen M, Wessels LF, de Ridder J.

PLoS Genet. 2014 Apr 10;10(4):e1004250. doi: 10.1371/journal.pgen.1004250. eCollection 2014 Apr.

16.

Chromatin position effects assayed by thousands of reporters integrated in parallel.

Akhtar W, de Jong J, Pindyurin AV, Pagie L, Meuleman W, de Ridder J, Berns A, Wessels LF, van Lohuizen M, van Steensel B.

Cell. 2013 Aug 15;154(4):914-27. doi: 10.1016/j.cell.2013.07.018.

17.

Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.

Michalak EM, Nacerddine K, Pietersen A, Beuger V, Pawlitzky I, Cornelissen-Steijger P, Wientjens E, Tanger E, Seibler J, van Lohuizen M, Jonkers J.

Stem Cells. 2013 Sep;31(9):1910-20. doi: 10.1002/stem.1437.

18.

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

Klijn C, Koudijs MJ, Kool J, ten Hoeve J, Boer M, de Moes J, Akhtar W, van Miltenburg M, Vendel-Zwaagstra A, Reinders MJ, Adams DJ, van Lohuizen M, Hilkens J, Wessels LF, Jonkers J.

PLoS One. 2013 May 14;8(5):e62113. doi: 10.1371/journal.pone.0062113. Print 2013.

19.

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M.

Cancer Cell. 2013 May 13;23(5):660-76. doi: 10.1016/j.ccr.2013.03.030.

20.

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

Sparmann A, Xie Y, Verhoeven E, Vermeulen M, Lancini C, Gargiulo G, Hulsman D, Mann M, Knoblich JA, van Lohuizen M.

EMBO J. 2013 May 29;32(11):1598-612. doi: 10.1038/emboj.2013.93. Epub 2013 Apr 26.

21.

PRC1 coordinates timing of sexual differentiation of female primordial germ cells.

Yokobayashi S, Liang CY, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AH.

Nature. 2013 Mar 14;495(7440):236-40. doi: 10.1038/nature11918.

PMID:
23486062
22.

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins.

Zencak D, Schouwey K, Chen D, Ekström P, Tanger E, Bremner R, van Lohuizen M, Arsenijevic Y.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):E593-601. doi: 10.1073/pnas.1108297110. Epub 2013 Jan 28.

23.

The emerging role of Polycomb repressors in the response to DNA damage.

Vissers JH, van Lohuizen M, Citterio E.

J Cell Sci. 2012 Sep 1;125(Pt 17):3939-48. doi: 10.1242/jcs.107375. Review.

24.

The Polycomb group protein Ring1b is essential for pectoral fin development.

van der Velden YU, Wang L, van Lohuizen M, Haramis AP.

Development. 2012 Jun;139(12):2210-20. doi: 10.1242/dev.077156.

25.

GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M.

PLoS One. 2012;7(5):e35943. doi: 10.1371/journal.pone.0035943. Epub 2012 May 4.

26.

Chromosome conformation capture on chip in single Drosophila melanogaster tissues.

Tolhuis B, Blom M, van Lohuizen M.

Methods. 2012 Nov;58(3):231-42. doi: 10.1016/j.ymeth.2012.04.003. Epub 2012 Apr 16.

PMID:
22525789
27.

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S, van Lohuizen M.

J Clin Invest. 2012 May;122(5):1920-32. doi: 10.1172/JCI57477. Epub 2012 Apr 16.

28.

Polycomb function during oogenesis is required for mouse embryonic development.

Posfai E, Kunzmann R, Brochard V, Salvaing J, Cabuy E, Roloff TC, Liu Z, Tardat M, van Lohuizen M, Vidal M, Beaujean N, Peters AH.

Genes Dev. 2012 May 1;26(9):920-32. doi: 10.1101/gad.188094.112. Epub 2012 Apr 12.

29.

Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression.

Baradaran-Heravi A, Cho KS, Tolhuis B, Sanyal M, Morozova O, Morimoto M, Elizondo LI, Bridgewater D, Lubieniecka J, Beirnes K, Myung C, Leung D, Fam HK, Choi K, Huang Y, Dionis KY, Zonana J, Keller K, Stenzel P, Mayfield C, Lücke T, Bokenkamp A, Marra MA, van Lohuizen M, Lewis DB, Shaw C, Boerkoel CF.

Hum Mol Genet. 2012 Jun 1;21(11):2572-87. doi: 10.1093/hmg/dds083. Epub 2012 Feb 28.

30.

A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.

Westerman BA, Braat AK, Taub N, Potman M, Vissers JH, Blom M, Verhoeven E, Stoop H, Gillis A, Velds A, Nijkamp W, Beijersbergen R, Huber LA, Looijenga LH, van Lohuizen M.

J Exp Med. 2011 Dec 19;208(13):2675-89. doi: 10.1084/jem.20102037. Epub 2011 Dec 5.

31.

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.

Martin N, Benhamed M, Nacerddine K, Demarque MD, van Lohuizen M, Dejean A, Bischof O.

EMBO J. 2012 Jan 4;31(1):95-109. doi: 10.1038/emboj.2011.370. Epub 2011 Oct 14.

32.

Computational identification of insertional mutagenesis targets for cancer gene discovery.

de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M, Berns A, van Lohuizen M, Jonkers J, Adams DJ, Wessels LF.

Nucleic Acids Res. 2011 Aug;39(15):e105. doi: 10.1093/nar/gkr447. Epub 2011 Jun 7.

33.

Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.

Smith LL, Yeung J, Zeisig BB, Popov N, Huijbers I, Barnes J, Wilson AJ, Taskesen E, Delwel R, Gil J, Van Lohuizen M, So CW.

Cell Stem Cell. 2011 Jun 3;8(6):649-62. doi: 10.1016/j.stem.2011.05.004.

34.

Interactions among Polycomb domains are guided by chromosome architecture.

Tolhuis B, Blom M, Kerkhoven RM, Pagie L, Teunissen H, Nieuwland M, Simonis M, de Laat W, van Lohuizen M, van Steensel B.

PLoS Genet. 2011 Mar;7(3):e1001343. doi: 10.1371/journal.pgen.1001343. Epub 2011 Mar 24.

35.

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.

Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, Citterio E, van Lohuizen M, Ganesan S.

Mol Cell Biol. 2011 May;31(10):1972-82. doi: 10.1128/MCB.00981-10. Epub 2011 Mar 7.

36.

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.

van der Velden YU, Wang L, Zevenhoven J, van Rooijen E, van Lohuizen M, Giles RH, Clevers H, Haramis AP.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4358-63. doi: 10.1073/pnas.1010210108. Epub 2011 Mar 1.

37.

[Job satisfaction among physicians during their career].

Jongbloed LJ, Borleffs JC, van Lohuizen MT, Cohen-Schotanus J.

Ned Tijdschr Geneeskd. 2010;154:A1691. Dutch.

PMID:
20619021
38.

Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.

Peric-Hupkes D, Meuleman W, Pagie L, Bruggeman SW, Solovei I, Brugman W, Gräf S, Flicek P, Kerkhoven RM, van Lohuizen M, Reinders M, Wessels L, van Steensel B.

Mol Cell. 2010 May 28;38(4):603-13. doi: 10.1016/j.molcel.2010.03.016.

39.

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

de Vries NA, Bruggeman SW, Hulsman D, de Vries HI, Zevenhoven J, Buckle T, Hamans BC, Leenders WP, Beijnen JH, van Lohuizen M, Berns AJ, van Tellingen O.

Clin Cancer Res. 2010 Jul 1;16(13):3431-41. doi: 10.1158/1078-0432.CCR-09-3414. Epub 2010 May 14.

40.

The reliability of in-training assessment when performance improvement is taken into account.

van Lohuizen MT, Kuks JB, van Hell EA, Raat AN, Stewart RE, Cohen-Schotanus J.

Adv Health Sci Educ Theory Pract. 2010 Dec;15(5):659-69. doi: 10.1007/s10459-010-9226-7. Epub 2010 Mar 28.

41.

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.

Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L, Largaespada DA, Stratton MR, Futreal PA, van Lohuizen M, Berns A, Collier LS, Hubbard T, Adams DJ.

Cancer Res. 2010 Feb 1;70(3):883-95. doi: 10.1158/0008-5472.CAN-09-1737. Epub 2010 Jan 26.

42.

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J, Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A, van Lohuizen M.

Cancer Res. 2010 Jan 15;70(2):520-31. doi: 10.1158/0008-5472.CAN-09-2736. Epub 2010 Jan 12.

43.

Learning strategies during clerkships and their effects on clinical performance.

van Lohuizen MT, Kuks JB, van Hell EA, Raat AN, Cohen-Schotanus J.

Med Teach. 2009 Nov;31(11):e494-9. doi: 10.3109/01421590902744894.

PMID:
19909026
44.

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.

Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen-Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM.

Breast Cancer Res. 2009;11(4):R63. doi: 10.1186/bcr2354. Epub 2009 Aug 26.

45.

A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.

Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M, Berns A, Adams DJ.

Nat Protoc. 2009;4(5):789-98. doi: 10.1038/nprot.2009.64. Epub 2009 Apr 30.

46.

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.

Boukarabila H, Saurin AJ, Batsché E, Mossadegh N, van Lohuizen M, Otte AP, Pradel J, Muchardt C, Sieweke M, Duprez E.

Genes Dev. 2009 May 15;23(10):1195-206. doi: 10.1101/gad.512009.

47.

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.

Prieur A, Nacerddine K, van Lohuizen M, Peeper DS.

PLoS One. 2009;4(5):e5542. doi: 10.1371/journal.pone.0005542. Epub 2009 May 14.

48.

Bmi1 regulates mitochondrial function and the DNA damage response pathway.

Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.

Nature. 2009 May 21;459(7245):387-392. doi: 10.1038/nature08040. Epub 2009 Apr 29.

49.

Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.

Bruggeman SW, Hulsman D, van Lohuizen M.

Biochim Biophys Acta. 2009 May;1790(5):351-60. doi: 10.1016/j.bbagen.2009.03.009. Epub 2009 Mar 16.

PMID:
19298843
50.

Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos.

Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, van Lohuizen M, Tanay A, Cavalli G.

PLoS Biol. 2009 Jan 13;7(1):e13. doi: 10.1371/journal.pbio.1000013.

Supplemental Content

Loading ...
Support Center