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Items: 1 to 50 of 232

1.

Follistatin Effects in Migration, Vascularization, and Osteogenesis in vitro and Bone Repair in vivo.

Fahmy-Garcia S, Farrell E, Witte-Bouma J, Robbesom-van den Berge I, Suarez M, Mumcuoglu D, Walles H, Kluijtmans SGJM, van der Eerden BCJ, van Osch GJVM, van Leeuwen JPTM, van Driel M.

Front Bioeng Biotechnol. 2019 Mar 1;7:38. doi: 10.3389/fbioe.2019.00038. eCollection 2019.

2.

A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice.

Lodberg A, van der Eerden BCJ, Boers-Sijmons B, Thomsen JS, Brüel A, van Leeuwen JPTM, Eijken M.

FASEB J. 2019 May;33(5):6001-6010. doi: 10.1096/fj.201801969RR. Epub 2019 Feb 13.

PMID:
30759349
3.

Mucin 1 (Muc1) Deficiency in Female Mice Leads to Temporal Skeletal Changes During Aging.

Brum AM, van der Leije CS, Schreuders-Koedam M, Chaibi S, van Leeuwen JP, van der Eerden BC.

JBMR Plus. 2018 Jul 14;2(6):341-350. doi: 10.1002/jbm4.10061. eCollection 2018 Nov.

4.

Zika virus infection perturbs osteoblast function.

Mumtaz N, Koedam M, van den Doel PB, van Leeuwen JPTM, Koopmans MPG, van der Eerden BCJ, Rockx B.

Sci Rep. 2018 Nov 19;8(1):16975. doi: 10.1038/s41598-018-35422-3.

5.

Understanding age-induced cortical porosity in women: Is a negative BMU balance in quiescent osteons a major contributor?

Andreasen CM, Delaisse JM, van der Eerden BCJ, van Leeuwen JPTM, Ding M, Andersen TL.

Bone. 2018 Dec;117:70-82. doi: 10.1016/j.bone.2018.09.011. Epub 2018 Sep 18.

6.

Human mesenchymal stromal cells in adhesion to cell-derived extracellular matrix and titanium: Comparative kinome profile analysis.

Baroncelli M, Fuhler GM, van de Peppel J, Zambuzzi WF, van Leeuwen JP, van der Eerden BCJ, Peppelenbosch MP.

J Cell Physiol. 2019 Mar;234(3):2984-2996. doi: 10.1002/jcp.27116. Epub 2018 Jul 30.

7.

Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive.

Baroncelli M, van der Eerden BCJ, Chatterji S, Rull Trinidad E, Kan YY, Koedam M, van Hengel IAJ, Alves RDAM, Fratila-Apachitei LE, Demmers JAA, van de Peppel J, van Leeuwen JPTM.

Tissue Eng Part A. 2018 Sep;24(17-18):1377-1389. doi: 10.1089/ten.TEA.2017.0448. Epub 2018 May 21.

PMID:
29667532
8.

Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.

Mumcuoglu D, de Miguel L, Jekhmane S, Siverino C, Nickel J, Mueller TD, van Leeuwen JP, van Osch GJ, Kluijtmans SG.

Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:271-280. doi: 10.1016/j.msec.2017.11.031. Epub 2017 Dec 1.

PMID:
29519439
9.

Using the Connectivity Map to discover compounds influencing human osteoblast differentiation.

Brum AM, van de Peppel J, Nguyen L, Aliev A, Schreuders-Koedam M, Gajadien T, van der Leije CS, van Kerkwijk A, Eijken M, van Leeuwen JPTM, van der Eerden BCJ.

J Cell Physiol. 2018 Jun;233(6):4895-4906. doi: 10.1002/jcp.26298. Epub 2018 Jan 15.

PMID:
29194609
10.

Understanding Age-Induced Cortical Porosity in Women: The Accumulation and Coalescence of Eroded Cavities Upon Existing Intracortical Canals Is the Main Contributor.

Andreasen CM, Delaisse JM, van der Eerden BC, van Leeuwen JP, Ding M, Andersen TL.

J Bone Miner Res. 2018 Apr;33(4):606-620. doi: 10.1002/jbmr.3354. Epub 2018 Jan 4.

11.

Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro.

Both T, van de Peppel HJ, Zillikens MC, Koedam M, van Leeuwen JPTM, van Hagen PM, van Daele PLA, van der Eerden BCJ.

J Cell Mol Med. 2018 Feb;22(2):873-882. doi: 10.1111/jcmm.13373. Epub 2017 Oct 3.

12.

Vitamin D endocrinology of bone mineralization.

van Driel M, van Leeuwen JPTM.

Mol Cell Endocrinol. 2017 Sep 15;453:46-51. doi: 10.1016/j.mce.2017.06.008. Epub 2017 Jun 9. Review.

PMID:
28606868
13.

Hydroxychloroquine affects bone resorption both in vitro and in vivo.

Both T, Zillikens MC, Schreuders-Koedam M, Vis M, Lam WK, Weel AEAM, van Leeuwen JPTM, van Hagen PM, van der Eerden BCJ, van Daele PLA.

J Cell Physiol. 2018 Feb;233(2):1424-1433. doi: 10.1002/jcp.26028. Epub 2017 Aug 3.

PMID:
28556961
14.

NELL-1, HMGB1, and CCN2 Enhance Migration and Vasculogenesis, But Not Osteogenic Differentiation Compared to BMP2.

Fahmy-Garcia S, van Driel M, Witte-Buoma J, Walles H, van Leeuwen JPTM, van Osch GJVM, Farrell E.

Tissue Eng Part A. 2018 Feb;24(3-4):207-218. doi: 10.1089/ten.TEA.2016.0537. Epub 2017 Dec 13.

PMID:
28463604
15.

A comparison of UVb compact lamps in enabling cutaneous vitamin D synthesis in growing bearded dragons.

Diehl JJE, Baines FM, Heijboer AC, van Leeuwen JP, Kik M, Hendriks WH, Oonincx DGAB.

J Anim Physiol Anim Nutr (Berl). 2018 Feb;102(1):308-316. doi: 10.1111/jpn.12728. Epub 2017 Apr 27.

PMID:
28452197
16.

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation.

Brum AM, van der Leije CS, Schreuders-Koedam M, Verhoeven J, Janssen M, Dekkers DH, Demmers JA, Eijken M, van de Peppel J, van Leeuwen JP, van der Eerden BC.

JBMR Plus. 2017 Apr 28;1(1):16-26. doi: 10.1002/jbm4.10003. eCollection 2017 Aug.

17.

Molecular characterization of human osteoblast-derived extracellular vesicle mRNA using next-generation sequencing.

Morhayim J, van de Peppel J, Dudakovic A, Chiba H, van Wijnen AJ, van Leeuwen JP.

Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1133-1141. doi: 10.1016/j.bbamcr.2017.03.011. Epub 2017 Mar 24.

18.

Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics.

van de Peppel J, Strini T, Tilburg J, Westerhoff H, van Wijnen AJ, van Leeuwen JP.

Stem Cell Reports. 2017 Apr 11;8(4):947-960. doi: 10.1016/j.stemcr.2017.02.018. Epub 2017 Mar 23.

19.

Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization.

Baroncelli M, van der Eerden BC, Kan YY, Alves RD, Demmers JA, van de Peppel J, van Leeuwen JP.

J Cell Physiol. 2018 Jan;233(1):387-395. doi: 10.1002/jcp.25898. Epub 2017 May 19.

PMID:
28272740
20.

Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS.

Campos-Obando N, Koek WNH, Hooker ER, van der Eerden BC, Pols HA, Hofman A, van Leeuwen JP, Uitterlinden AG, Nielson CM, Zillikens MC.

J Bone Miner Res. 2017 Jun;32(6):1182-1193. doi: 10.1002/jbmr.3094. Epub 2017 Mar 27.

21.

Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis.

Koek WNH, van der Eerden BCJ, Alves RDAM, van Driel M, Schreuders-Koedam M, Zillikens MC, van Leeuwen JPTM.

Bone. 2017 Feb;95:108-114. doi: 10.1016/j.bone.2016.11.010. Epub 2016 Nov 12.

PMID:
27845263
22.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

Zambetti NA, Ping Z, Chen S, Kenswil KJG, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EMJ, Adisty MN, Van Strien PMH, van der Leije CS, Westers TM, Cremers EMP, Milanese C, Mastroberardino PG, van Leeuwen JPTM, van der Eerden BCJ, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MHGP.

Cell Stem Cell. 2016 Nov 3;19(5):613-627. doi: 10.1016/j.stem.2016.08.021. Epub 2016 Sep 22.

23.

Osteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells.

Morhayim J, van de Peppel J, Braakman E, Rombouts EW, Ter Borg MN, Dudakovic A, Chiba H, van der Eerden BC, Raaijmakers MH, van Wijnen AJ, Cornelissen JJ, van Leeuwen JP.

Sci Rep. 2016 Sep 2;6:32034. doi: 10.1038/srep32034.

24.

Paracrine Signaling by Extracellular Vesicles via Osteoblasts.

Morhayim J, Rudjito R, van Leeuwen JP, van Driel M.

Curr Mol Biol Rep. 2016;2:48-55. Epub 2016 Feb 23. Review.

25.

Novel Compound Heterozygous Mutations in the CYP27B1 Gene Lead to Pseudovitamin D-Deficient Rickets.

Koek WN, Zillikens MC, van der Eerden BC, van Leeuwen JP.

Calcif Tissue Int. 2016 Sep;99(3):326-31. doi: 10.1007/s00223-016-0165-z. Epub 2016 Jul 1.

PMID:
27364341
26.

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism.

van der Eerden BC, Koek WN, Roschger P, Zillikens MC, Waarsing JH, van der Kemp A, Schreuders-Koedam M, Fratzl-Zelman N, Leenen PJ, Hoenderop JG, Klaushofer K, Bindels RJ, van Leeuwen JP.

Oncotarget. 2016 May 3;7(18):24928-41. doi: 10.18632/oncotarget.8779.

27.
28.

25-Hydroxyvitamin D and osteoarthritis: A meta-analysis including new data.

Bergink AP, Zillikens MC, Van Leeuwen JP, Hofman A, Uitterlinden AG, van Meurs JB.

Semin Arthritis Rheum. 2016 Apr;45(5):539-46. doi: 10.1016/j.semarthrit.2015.09.010. Epub 2015 Oct 29.

PMID:
26522138
29.

Supporting data of spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo.

Higuera GA, Fernandes H, Spitters TW, van de Peppel J, Aufferman N, Truckenmueller R, Escalante M, Stoop R, van Leeuwen JP, de Boer J, Subramaniam V, Karperien M, van Blitterswijk C, van Boxtel A, Moroni L.

Data Brief. 2015 Aug 28;5:84-94. doi: 10.1016/j.dib.2015.08.012. eCollection 2015 Dec.

30.

Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway.

Brum AM, van de Peppel J, van der Leije CS, Schreuders-Koedam M, Eijken M, van der Eerden BC, van Leeuwen JP.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12711-6. doi: 10.1073/pnas.1501597112. Epub 2015 Sep 29.

31.

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo.

Higuera GA, Fernandes H, Spitters TW, van de Peppel J, Aufferman N, Truckenmueller R, Escalante M, Stoop R, van Leeuwen JP, de Boer J, Subramaniam V, Karperien M, van Blitterswijk C, van Boxtel A, Moroni L.

Biomaterials. 2015 Aug;61:190-202. doi: 10.1016/j.biomaterials.2015.05.017. Epub 2015 May 15.

PMID:
26004234
32.

Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation.

Ghali O, Broux O, Falgayrac G, Haren N, van Leeuwen JP, Penel G, Hardouin P, Chauveau C.

BMC Cell Biol. 2015 Mar 13;16:9. doi: 10.1186/s12860-015-0056-6.

33.

The diet of free-roaming Australian Central Bearded Dragons (Pogona vitticeps).

Oonincx DG, van Leeuwen JP, Hendriks WH, van der Poel AF.

Zoo Biol. 2015 May-Jun;34(3):271-7. doi: 10.1002/zoo.21209. Epub 2015 Mar 12.

PMID:
25773132
34.

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

Tudpor K, van der Eerden BC, Jongwattanapisan P, Roelofs JJ, van Leeuwen JP, Bindels RJ, Hoenderop JG.

Bone. 2015 Mar;72:14-22. doi: 10.1016/j.bone.2014.11.004. Epub 2014 Nov 18.

PMID:
25460576
35.

Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries.

Alves RD, Eijken M, van de Peppel J, van Leeuwen JP.

BMC Genomics. 2014 Nov 7;15:965. doi: 10.1186/1471-2164-15-965.

36.

Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth.

Morhayim J, van de Peppel J, Demmers JA, Kocer G, Nigg AL, van Driel M, Chiba H, van Leeuwen JP.

FASEB J. 2015 Jan;29(1):274-85. doi: 10.1096/fj.14-261404. Epub 2014 Oct 30.

PMID:
25359493
37.

Identification of microRNAs in human plasma.

van der Eerden BC, Alves RD, Kockx CE, Ozgur Z, Schreuders-Koedam M, van de Peppel J, van Ijcken WF, van Leeuwen JP.

Methods Mol Biol. 2015;1226:71-85. doi: 10.1007/978-1-4939-1619-1_7.

PMID:
25331044
38.

A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses.

van der Eerden BC, van der Heyden JC, van Hamburg JP, Schreuders-Koedam M, Asmawidjaja PS, de Muinck Keizer-Schrama SM, Boot AM, Lubberts E, Drop SL, van Leeuwen JP.

Bone. 2014 Dec;69:6-11. doi: 10.1016/j.bone.2014.08.005. Epub 2014 Sep 6.

PMID:
25201466
39.

Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling.

Delhanty PJ, van der Velde M, van der Eerden BC, Sun Y, Geminn JM, van der Lely AJ, Smith RG, van Leeuwen JP.

Endocrinology. 2014 Nov;155(11):4287-95. doi: 10.1210/en.2013-2055. Epub 2014 Jul 25.

PMID:
25060361
40.

Cancer and bone: a complex complex.

van Driel M, van Leeuwen JP.

Arch Biochem Biophys. 2014 Nov 1;561:159-66. doi: 10.1016/j.abb.2014.07.013. Epub 2014 Jul 18. Review.

PMID:
25046842
41.

UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet.

Rebel H, der Spek CD, Salvatori D, van Leeuwen JP, Robanus-Maandag EC, de Gruijl FR.

Int J Cancer. 2015 Jan 15;136(2):271-7. doi: 10.1002/ijc.29002. Epub 2014 Jun 5.

42.

Extracellular vesicles: specialized bone messengers.

Morhayim J, Baroncelli M, van Leeuwen JP.

Arch Biochem Biophys. 2014 Nov 1;561:38-45. doi: 10.1016/j.abb.2014.05.011. Epub 2014 May 22. Review.

PMID:
24858341
43.

Vitamin D and gene networks in human osteoblasts.

van de Peppel J, van Leeuwen JP.

Front Physiol. 2014 Apr 9;5:137. doi: 10.3389/fphys.2014.00137. eCollection 2014. Review.

44.

Vitamin D endocrine system and osteoblasts.

van Driel M, van Leeuwen JP.

Bonekey Rep. 2014 Feb 5;3:493. doi: 10.1038/bonekey.2013.227. eCollection 2014.

45.

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk.

van der Eerden BC, Oei L, Roschger P, Fratzl-Zelman N, Hoenderop JG, van Schoor NM, Pettersson-Kymmer U, Schreuders-Koedam M, Uitterlinden AG, Hofman A, Suzuki M, Klaushofer K, Ohlsson C, Lips PJ, Rivadeneira F, Bindels RJ, van Leeuwen JP.

Bone. 2013 Dec;57(2):443-54. doi: 10.1016/j.bone.2013.09.017. Epub 2013 Sep 29.

PMID:
24084385
46.

Effect of calcium and cholecalciferol supplementation on several parameters of calcium status in plasma and urine of captive Asian (Elephas maximus) and African elephants (Loxodonta africana).

van Sonsbeek GR, van der Kolk JH, van Leeuwen JP, Everts H, Marais J, Schaftenaar W.

J Zoo Wildl Med. 2013 Sep;44(3):529-40.

PMID:
24063079
47.

Ghrelin and bone.

Delhanty PJ, van der Eerden BC, van Leeuwen JP.

Biofactors. 2014 Jan-Feb;40(1):41-8. doi: 10.1002/biof.1120. Epub 2013 Jun 27. Review.

PMID:
23804549
48.

Activin A suppresses osteoblast mineralization capacity by altering extracellular matrix (ECM) composition and impairing matrix vesicle (MV) production.

Alves RD, Eijken M, Bezstarosti K, Demmers JA, van Leeuwen JP.

Mol Cell Proteomics. 2013 Oct;12(10):2890-900. doi: 10.1074/mcp.M112.024927. Epub 2013 Jun 17.

49.

Blood vitamin D(3) metabolite concentrations of adult female bearded dragons (Pogona vitticeps) remain stable after ceasing UVb exposure.

Oonincx DG, van de Wal MD, Bosch G, Stumpel JB, Heijboer AC, van Leeuwen JP, Hendriks WH, Kik M.

Comp Biochem Physiol B Biochem Mol Biol. 2013 Jul;165(3):196-200. doi: 10.1016/j.cbpb.2013.04.006. Epub 2013 May 3.

PMID:
23648288
50.

Bioinformatics-based selection of a model cell type for in vitro biomaterial testing.

Groen N, van de Peppel J, Yuan H, van Leeuwen JP, van Blitterswijk CA, de Boer J.

Biomaterials. 2013 Jul;34(22):5552-61. doi: 10.1016/j.biomaterials.2013.04.001. Epub 2013 Apr 28.

PMID:
23632322

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