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Items: 1 to 50 of 175

1.

Monitoring of tobramycin serum concentrations in selected critically ill patients receiving selective decontamination of the digestive tract: a retrospective evaluation.

Möhlmann JE, van Luin M, Mascini EM, van Leeuwen HJ, de Maat MR.

Eur J Clin Pharmacol. 2019 Feb 18. doi: 10.1007/s00228-019-02644-x. [Epub ahead of print]

PMID:
30778624
2.

Biochemodynamic Features of Metal Ions Bound by Micro- and Nano-Plastics in Aquatic Media.

Town RM, van Leeuwen HP, Blust R.

Front Chem. 2018 Dec 14;6:627. doi: 10.3389/fchem.2018.00627. eCollection 2018.

3.

The Intrinsic Stability of Metal Ion Complexes with Nanoparticulate Fulvic Acids.

Town RM, Duval JFL, van Leeuwen HP.

Environ Sci Technol. 2018 Oct 2. doi: 10.1021/acs.est.8b02896. [Epub ahead of print]

PMID:
30226375
4.

Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.

Fleurbaaij F, Henneman AA, Corver J, Knetsch CW, Smits WK, Nauta ST, Giera M, Dragan I, Kumar N, Lawley TD, Verhoeven A, van Leeuwen HC, Kuijper EJ, Hensbergen PJ.

Sci Rep. 2018 May 25;8(1):8181. doi: 10.1038/s41598-018-26079-z.

5.

Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.

Klychnikov OI, Shamorkina TM, Weeks SD, van Leeuwen HC, Corver J, Drijfhout JW, van Veelen PA, Sluchanko NN, Strelkov SV, Hensbergen PJ.

J Biol Chem. 2018 Jul 13;293(28):11154-11165. doi: 10.1074/jbc.RA118.003244. Epub 2018 May 23.

PMID:
29794027
6.

Development and validation of an admission prediction tool for emergency departments in the Netherlands.

Kraaijvanger N, Rijpsma D, Roovers L, van Leeuwen H, Kaasjager K, van den Brand L, Horstink L, Edwards M.

Emerg Med J. 2018 Aug;35(8):464-470. doi: 10.1136/emermed-2017-206673. Epub 2018 Apr 7.

PMID:
29627769
7.

[Weak respiratory muscles as a first sign of ALS: symptoms may put the physician on the wrong track].

Kiers D, Meermans M, Verstraete E, van Leeuwen HJ.

Ned Tijdschr Geneeskd. 2018;162:D2189. Dutch.

PMID:
29393015
8.

Dietary trehalose enhances virulence of epidemic Clostridium difficile.

Collins J, Robinson C, Danhof H, Knetsch CW, van Leeuwen HC, Lawley TD, Auchtung JM, Britton RA.

Nature. 2018 Jan 18;553(7688):291-294. doi: 10.1038/nature25178. Epub 2018 Jan 3.

9.

Covalent attachment and Pro-Pro endopeptidase (PPEP-1)-mediated release of Clostridium difficile cell surface proteins involved in adhesion.

Corver J, Cordo' V, van Leeuwen HC, Klychnikov OI, Hensbergen PJ.

Mol Microbiol. 2017 Sep;105(5):663-673. doi: 10.1111/mmi.13736. Epub 2017 Jul 4. Review.

10.

Direct detection of extended-spectrum beta-lactamases (CTX-M) from blood cultures by LC-MS/MS bottom-up proteomics.

Fleurbaaij F, Goessens W, van Leeuwen HC, Kraakman MEM, Bernards ST, Hensbergen PJ, Kuijper EJ.

Eur J Clin Microbiol Infect Dis. 2017 Sep;36(9):1621-1628. doi: 10.1007/s10096-017-2975-y. Epub 2017 Apr 10.

11.

Population Pharmacokinetic Model and Pharmacokinetic Target Attainment of Micafungin in Intensive Care Unit Patients.

Martial LC, Ter Heine R, Schouten JA, Hunfeld NG, van Leeuwen HJ, Verweij PE, de Lange DW, Pickkers P, Brüggemann RJ.

Clin Pharmacokinet. 2017 Oct;56(10):1197-1206. doi: 10.1007/s40262-017-0509-5.

12.

Chemodynamics of Soft Nanoparticulate Metal Complexes: From the Local Particle/Medium Interface to a Macroscopic Sensor Surface.

Town RM, Pinheiro JP, van Leeuwen HP.

Langmuir. 2017 Jan 17;33(2):527-536. doi: 10.1021/acs.langmuir.6b03381. Epub 2016 Dec 30.

PMID:
27989214
13.

Why patients self-refer to the Emergency Department: A qualitative interview study.

Kraaijvanger N, Rijpsma D, Willink L, Lucassen P, van Leeuwen H, Edwards M.

J Eval Clin Pract. 2017 Jun;23(3):593-598. doi: 10.1111/jep.12680. Epub 2016 Dec 15.

PMID:
27976472
14.

Motives for self-referral to the emergency department: a systematic review of the literature.

Kraaijvanger N, van Leeuwen H, Rijpsma D, Edwards M.

BMC Health Serv Res. 2016 Dec 9;16(1):685. Review.

15.

[Acute respiratory failure caused by minocycline].

Kok B, van de Ven MJ, van Leeuwen HJ.

Ned Tijdschr Geneeskd. 2016;160:D635. Dutch.

PMID:
27879182
16.

Introducing copayments in the emergency department would deter appropriate visits in the Netherlands.

Kraaijvanger N, Rijpsma D, van Leeuwen H, Edwards M.

Eur J Emerg Med. 2018 Apr;25(2):147-152. doi: 10.1097/MEJ.0000000000000433.

PMID:
27870662
17.
18.

[Procalcitonin as biomarker for infections].

de Jonge JC, de Lange DW, Bij de Vaate EA, van Leeuwen H, Arends JE.

Ned Tijdschr Geneeskd. 2016;160:D282. Review. Dutch.

PMID:
27734774
19.

Inferring Human Activity Recognition with Ambient Sound on Wireless Sensor Nodes.

Salomons EL, Havinga PJ, van Leeuwen H.

Sensors (Basel). 2016 Sep 27;16(10). pii: E1586.

20.

Metal ion-humic acid nanoparticle interactions: role of both complexation and condensation mechanisms.

Town RM, van Leeuwen HP.

Phys Chem Chem Phys. 2016 Jul 21;18(27):18024-32. doi: 10.1039/c6cp02634f. Epub 2016 Jun 21.

PMID:
27327433
21.

Typing Pseudomonas aeruginosa Isolates with Ultrahigh Resolution MALDI-FTICR Mass Spectrometry.

Fleurbaaij F, Kraakman ME, Claas EC, Knetsch CW, van Leeuwen HC, van der Burgt YE, Veldkamp KE, Vos MC, Goessens W, Mertens BJ, Kuijper EJ, Hensbergen PJ, Nicolardi S.

Anal Chem. 2016 Jun 7;88(11):5996-6003. doi: 10.1021/acs.analchem.6b01037. Epub 2016 May 10.

PMID:
27123572
22.

A Novel Fic (Filamentation Induced by cAMP) Protein from Clostridium difficile Reveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism.

Dedic E, Alsarraf H, Welner DH, Østergaard O, Klychnikov OI, Hensbergen PJ, Corver J, van Leeuwen HC, Jørgensen R.

J Biol Chem. 2016 Jun 17;291(25):13286-300. doi: 10.1074/jbc.M115.705491. Epub 2016 Apr 13.

23.

Intraparticulate speciation analysis of soft nanoparticulate metal complexes. The impact of electric condensation on the binding of Cd²⁺/Pb²⁺/Cu²⁺ by humic acids.

Town RM, van Leeuwen HP.

Phys Chem Chem Phys. 2016 Apr 21;18(15):10049-58. doi: 10.1039/c6cp01229a. Epub 2016 Mar 23.

PMID:
27004844
24.

Dose Reduction of Caspofungin in Intensive Care Unit Patients with Child Pugh B Will Result in Suboptimal Exposure.

Martial LC, Brüggemann RJ, Schouten JA, van Leeuwen HJ, van Zanten AR, de Lange DW, Muilwijk EW, Verweij PE, Burger DM, Aarnoutse RE, Pickkers P, Dorlo TP.

Clin Pharmacokinet. 2016 Jun;55(6):723-33. doi: 10.1007/s40262-015-0347-2.

25.

Self-referrals in the emergency department: reasons why patients attend the emergency department without consulting a general practitioner first-a questionnaire study.

Kraaijvanger N, Rijpsma D, van Leeuwen H, Edwards M.

Int J Emerg Med. 2015 Dec;8(1):46. doi: 10.1186/s12245-015-0096-x. Epub 2015 Dec 7.

26.

Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831.

Hensbergen PJ, Klychnikov OI, Bakker D, Dragan I, Kelly ML, Minton NP, Corver J, Kuijper EJ, Drijfhout JW, van Leeuwen HC.

FEBS Lett. 2015 Dec 21;589(24 Pt B):3952-8. doi: 10.1016/j.febslet.2015.10.027. Epub 2015 Oct 29.

27.

Altered Micafungin Pharmacokinetics in Intensive Care Unit Patients.

Lempers VJ, Schouten JA, Hunfeld NG, Colbers A, van Leeuwen HJ, Burger DM, Verweij PE, Pickkers P, Brüggemann RJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4403-9. doi: 10.1128/AAC.00623-15. Epub 2015 May 11.

28.

Editorial: Launch of Biochemistry and Biophysics Reports.

van Leeuwen HJPTM.

Biochem Biophys Rep. 2015 Apr 15;1:108. doi: 10.1016/j.bbrep.2015.04.002. eCollection 2015 May. No abstract available.

29.

[Ceftriaxone-induced immune haemolytic anaemia and multi-organ failure].

Mulkens CE, van Lochem EG, Folman CC, van der Spek E, van Leeuwen HJ.

Ned Tijdschr Geneeskd. 2015;159:A8054. Dutch.

PMID:
25714764
30.

Partitioning of humic acids between aqueous solution and hydrogel. 3. Microelectrodic dynamic speciation analysis of free and bound humic metal complexes in the gel phase.

Yasadi K, Pinheiro JP, Zielińska K, Town RM, van Leeuwen HP.

Langmuir. 2015 Feb 10;31(5):1737-45. doi: 10.1021/la504885v. Epub 2015 Jan 29.

PMID:
25580682
31.

Partitioning of humic acids between aqueous solution and hydrogel. 2. Impact of physicochemical conditions.

Zielińska K, Town RM, Yasadi K, van Leeuwen HP.

Langmuir. 2015;31(1):283-91. doi: 10.1021/la504393r. Epub 2014 Dec 19.

PMID:
25479141
32.

Self-referrals in a Dutch Emergency Department: how appropriate are they?

Kraaijvanger N, Rijpsma D, van Leeuwen H, van Dijk N, Edwards M.

Eur J Emerg Med. 2016 Jun;23(3):194-202. doi: 10.1097/MEJ.0000000000000216.

PMID:
25380319
33.

Clostridium difficile sortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation.

van Leeuwen HC, Klychnikov OI, Menks MA, Kuijper EJ, Drijfhout JW, Hensbergen PJ.

FEBS Lett. 2014 Nov 28;588(23):4325-33. doi: 10.1016/j.febslet.2014.09.041. Epub 2014 Oct 23.

34.

Polyelectrolyte coatings prevent interferences from charged nanoparticles in SPME speciation analysis.

Zielińska K, van Leeuwen HP.

Anal Chim Acta. 2014 Sep 24;844:44-7. doi: 10.1016/j.aca.2014.07.038. Epub 2014 Jul 31.

PMID:
25172814
35.

Capillary-electrophoresis mass spectrometry for the detection of carbapenemases in (multi-)drug-resistant Gram-negative bacteria.

Fleurbaaij F, Heemskerk AA, Russcher A, Klychnikov OI, Deelder AM, Mayboroda OA, Kuijper EJ, van Leeuwen HC, Hensbergen PJ.

Anal Chem. 2014 Sep 16;86(18):9154-61. doi: 10.1021/ac502049p. Epub 2014 Sep 4.

PMID:
25155175
36.

Pharmacokinetics of caspofungin in ICU patients.

Muilwijk EW, Schouten JA, van Leeuwen HJ, van Zanten AR, de Lange DW, Colbers A, Verweij PE, Burger DM, Pickkers P, Brüggemann RJ.

J Antimicrob Chemother. 2014 Dec;69(12):3294-9. doi: 10.1093/jac/dku313. Epub 2014 Aug 19.

PMID:
25139840
37.

Exploring genetic variation in the tomato (Solanum section Lycopersicon) clade by whole-genome sequencing.

100 Tomato Genome Sequencing Consortium, Aflitos S, Schijlen E, de Jong H, de Ridder D, Smit S, Finkers R, Wang J, Zhang G, Li N, Mao L, Bakker F, Dirks R, Breit T, Gravendeel B, Huits H, Struss D, Swanson-Wagner R, van Leeuwen H, van Ham RC, Fito L, Guignier L, Sevilla M, Ellul P, Ganko E, Kapur A, Reclus E, de Geus B, van de Geest H, Te Lintel Hekkert B, van Haarst J, Smits L, Koops A, Sanchez-Perez G, van Heusden AW, Visser R, Quan Z, Min J, Liao L, Wang X, Wang G, Yue Z, Yang X, Xu N, Schranz E, Smets E, Vos R, Rauwerda J, Ursem R, Schuit C, Kerns M, van den Berg J, Vriezen W, Janssen A, Datema E, Jahrman T, Moquet F, Bonnet J, Peters S.

Plant J. 2014 Oct;80(1):136-48. doi: 10.1111/tpj.12616. Epub 2014 Sep 3.

38.

Protein expression, characterization, crystallization and preliminary X-ray crystallographic analysis of a Fic protein from Clostridium difficile.

Welner D, Dedic E, van Leeuwen HC, Kuijper E, Bjerrum MJ, Østergaard O, Jørgensen R.

Acta Crystallogr F Struct Biol Commun. 2014 Jun;70(Pt 6):827-31. doi: 10.1107/S2053230X1400987X. Epub 2014 May 25.

39.

A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.

Hensbergen PJ, Klychnikov OI, Bakker D, van Winden VJ, Ras N, Kemp AC, Cordfunke RA, Dragan I, Deelder AM, Kuijper EJ, Corver J, Drijfhout JW, van Leeuwen HC.

Mol Cell Proteomics. 2014 May;13(5):1231-44. doi: 10.1074/mcp.M113.034728. Epub 2014 Mar 12.

40.

Partitioning of humic acids between aqueous solution and hydrogel: concentration profiling of humic acids in hydrogel phases.

Zielińska K, Town RM, Yasadi K, van Leeuwen HP.

Langmuir. 2014 Mar 4;30(8):2084-92. doi: 10.1021/la4050094. Epub 2014 Feb 19.

PMID:
24512499
41.

Understanding the extraordinary ionic reactivity of aqueous nanoparticles.

van Leeuwen HP, Buffle J, Duval JF, Town RM.

Langmuir. 2013 Aug 20;29(33):10297-302. doi: 10.1021/la401955x. Epub 2013 Aug 8.

PMID:
23909643
42.

Chemodynamics of soft charged nanoparticles in aquatic media: fundamental concepts.

Town RM, Buffle J, Duval JF, van Leeuwen HP.

J Phys Chem A. 2013 Aug 22;117(33):7643-54. doi: 10.1021/jp4044368. Epub 2013 Jul 19.

PMID:
23806009
43.

An Ultra-High-Density, Transcript-Based, Genetic Map of Lettuce.

Truco MJ, Ashrafi H, Kozik A, van Leeuwen H, Bowers J, Wo SR, Stoffel K, Xu H, Hill T, Van Deynze A, Michelmore RW.

G3 (Bethesda). 2013 Apr 9;3(4):617-631. doi: 10.1534/g3.112.004929.

44.

Clostridium difficile TcdC protein binds four-stranded G-quadruplex structures.

van Leeuwen HC, Bakker D, Steindel P, Kuijper EJ, Corver J.

Nucleic Acids Res. 2013 Feb 1;41(4):2382-93. doi: 10.1093/nar/gks1448. Epub 2013 Jan 8.

45.

A functional isopenicillin N synthase in an animal genome.

Roelofs D, Timmermans MJ, Hensbergen P, van Leeuwen H, Koopman J, Faddeeva A, Suring W, de Boer TE, Mariën J, Boer R, Bovenberg R, van Straalen NM.

Mol Biol Evol. 2013 Mar;30(3):541-8. doi: 10.1093/molbev/mss269. Epub 2012 Nov 29.

PMID:
23204388
46.

Speciation analysis of aqueous nanoparticulate diclofenac complexes by solid-phase microextraction.

Zielińska K, van Leeuwen HP, Thibault S, Town RM.

Langmuir. 2012 Oct 16;28(41):14672-80. doi: 10.1021/la303143w. Epub 2012 Oct 1.

PMID:
22989313
47.

Chemodynamics of soft nanoparticulate complexes: Cu(II) and Ni(II) complexes with fulvic acids and aquatic humic acids.

Town RM, van Leeuwen HP, Buffle J.

Environ Sci Technol. 2012 Oct 2;46(19):10487-98. doi: 10.1021/es3018013. Epub 2012 Sep 13.

PMID:
22934531
48.

Analysis of a Clostridium difficile PCR ribotype 078 100 kilobase island reveals the presence of a novel transposon, Tn6164.

Corver J, Bakker D, Brouwer MS, Harmanus C, Hensgens MP, Roberts AP, Lipman LJ, Kuijper EJ, van Leeuwen HC.

BMC Microbiol. 2012 Jul 2;12:130. doi: 10.1186/1471-2180-12-130.

49.

Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages.

Knetsch CW, Terveer EM, Lauber C, Gorbalenya AE, Harmanus C, Kuijper EJ, Corver J, van Leeuwen HC.

Infect Genet Evol. 2012 Oct;12(7):1577-85. doi: 10.1016/j.meegid.2012.06.003. Epub 2012 Jun 15.

PMID:
22705462
50.

Development and application of a 6.5 million feature Affymetrix Genechip® for massively parallel discovery of single position polymorphisms in lettuce (Lactuca spp.).

Stoffel K, van Leeuwen H, Kozik A, Caldwell D, Ashrafi H, Cui X, Tan X, Hill T, Reyes-Chin-Wo S, Truco MJ, Michelmore RW, Van Deynze A.

BMC Genomics. 2012 May 14;13:185. doi: 10.1186/1471-2164-13-185.

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