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Items: 1 to 50 of 64

1.

Tumor suppressors BTG1 and BTG2: Beyond growth control.

Yuniati L, Scheijen B, van der Meer LT, van Leeuwen FN.

J Cell Physiol. 2019 May;234(5):5379-5389. doi: 10.1002/jcp.27407. Epub 2018 Oct 23. Review.

2.

TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4.

Kuipers AJ, Middelbeek J, Vrenken K, Pérez-González C, Poelmans G, Klarenbeek J, Jalink K, Trepat X, van Leeuwen FN.

Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2409-2419. doi: 10.1016/j.bbadis.2018.04.017. Epub 2018 Apr 21.

3.

The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia.

Marke R, van Leeuwen FN, Scheijen B.

Haematologica. 2018 Apr;103(4):565-574. doi: 10.3324/haematol.2017.185603. Epub 2018 Mar 8. Review.

4.

Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1.

Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Gerritsen M, van der Meer LT, Williams O, Hoogerbrugge PM, Scheijen B, van Leeuwen FN.

Exp Hematol. 2018 Apr;60:57-62.e3. doi: 10.1016/j.exphem.2018.01.006. Epub 2018 Feb 8.

PMID:
29408281
5.

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells.

Wortel IMN, van der Meer LT, Kilberg MS, van Leeuwen FN.

Trends Endocrinol Metab. 2017 Nov;28(11):794-806. doi: 10.1016/j.tem.2017.07.003. Epub 2017 Aug 7. Review.

6.

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA.

Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3.

7.

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.

Scheijen B, Boer JM, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer LT, Pieters R, Escherich G, Horstmann MA, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper RP, Hoogerbrugge PM, den Boer ML, van Leeuwen FN.

Haematologica. 2017 Mar;102(3):541-551. doi: 10.3324/haematol.2016.153023. Epub 2016 Dec 15.

8.

Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences.

Waanders E, Scheijen B, Jongmans MC, Venselaar H, van Reijmersdal SV, van Dijk AH, Pastorczak A, Weren RD, van der Schoot CE, van de Vorst M, Sonneveld E, Hoogerbrugge N, van der Velden VH, Gruhn B, Hoogerbrugge PM, van Dongen JJ, Geurts van Kessel A, van Leeuwen FN, Kuiper RP.

Leukemia. 2017 Apr;31(4):821-828. doi: 10.1038/leu.2016.277. Epub 2016 Oct 13.

PMID:
27733777
9.

In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow.

van der Meer LT, Terry SY, van Ingen Schenau DS, Andree KC, Franssen GM, Roeleveld DM, Metselaar JM, Reinheckel T, Hoogerbrugge PM, Boerman OC, van Leeuwen FN.

J Nucl Med. 2017 Feb;58(2):214-220. doi: 10.2967/jnumed.116.177741. Epub 2016 Aug 4.

10.

The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression.

Middelbeek J, Vrenken K, Visser D, Lasonder E, Koster J, Jalink K, Clark K, van Leeuwen FN.

Eur J Cell Biol. 2016 Nov;95(11):465-474. doi: 10.1016/j.ejcb.2016.06.008. Epub 2016 Jun 24.

PMID:
27402209
11.

Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development.

Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Havinga J, Rouault JP, Hoogerbrugge PM, van Leeuwen FN, Scheijen B.

Haematologica. 2016 Jul;101(7):e272-6. doi: 10.3324/haematol.2015.139675. Epub 2016 Apr 1. No abstract available.

12.

Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.

Kedziora KM, Leyton-Puig D, Argenzio E, Boumeester AJ, van Butselaar B, Yin T, Wu YI, van Leeuwen FN, Innocenti M, Jalink K, Moolenaar WH.

J Biol Chem. 2016 Feb 26;291(9):4323-33. doi: 10.1074/jbc.M115.695940. Epub 2016 Jan 6.

13.

Tumor suppressor IKZF1 mediates glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.

Marke R, Havinga J, Cloos J, Demkes M, Poelmans G, Yuniati L, van Ingen Schenau D, Sonneveld E, Waanders E, Pieters R, Kuiper RP, Hoogerbrugge PM, Kaspers GJ, van Leeuwen FN, Scheijen B.

Leukemia. 2016 Jul;30(7):1599-603. doi: 10.1038/leu.2015.359. Epub 2015 Dec 29. No abstract available.

PMID:
26713593
14.

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress.

Yuniati L, van der Meer LT, Tijchon E, van Ingen Schenau D, van Emst L, Levers M, Palit SA, Rodenbach C, Poelmans G, Hoogerbrugge PM, Shan J, Kilberg MS, Scheijen B, van Leeuwen FN.

Oncotarget. 2016 Jan 19;7(3):3128-43. doi: 10.18632/oncotarget.6519.

15.

Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis.

Vrenken KS, Jalink K, van Leeuwen FN, Middelbeek J.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1436-46. doi: 10.1016/j.bbamcr.2015.11.008. Epub 2015 Nov 14. Review.

16.

Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

van der Sligte NE, Scherpen FJ, Ter Elst A, Guryev V, van Leeuwen FN, de Bont ES.

Exp Hematol Oncol. 2015 Aug 12;4:23. doi: 10.1186/s40164-015-0017-y. eCollection 2015.

17.

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.

Tijchon E, van Ingen Schenau D, van Opzeeland F, Tirone F, Hoogerbrugge PM, Van Leeuwen FN, Scheijen B.

PLoS One. 2015 Jul 28;10(7):e0131481. doi: 10.1371/journal.pone.0131481. eCollection 2015.

18.

Independent development of lymphoid and histiocytic malignancies from a shared early precursor.

Waanders E, Hebeda KM, Kamping EJ, Groenen PJ, Simons A, Hoischen A, Jongmans MC, Hoogerbrugge PM, van Leeuwen FN, Kuiper RP, Te Loo DM.

Leukemia. 2016 Apr;30(4):955-8. doi: 10.1038/leu.2015.193. Epub 2015 Jul 23. No abstract available.

PMID:
26202925
19.

Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia.

van der Sligte NE, Kampen KR, ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Guryev V, van Leeuwen FN, Kornblau SM, de Bont ES.

Oncotarget. 2015 Jun 20;6(17):14970-81.

20.

A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment.

Hagleitner MM, Coenen MJ, Gelderblom H, Makkinje RR, Vos HI, de Bont ES, van der Graaf WT, Schreuder HW, Flucke U, van Leeuwen FN, Hoogerbrugge PM, Guchelaar HJ, te Loo DM.

Clin Cancer Res. 2015 Aug 1;21(15):3436-41. doi: 10.1158/1078-0432.CCR-14-2638. Epub 2015 Mar 31.

21.

TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation.

Middelbeek J, Visser D, Henneman L, Kamermans A, Kuipers AJ, Hoogerbrugge PM, Jalink K, van Leeuwen FN.

Oncotarget. 2015 Apr 20;6(11):8760-76.

22.

Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.

Hagleitner MM, Coenen MJ, Patino-Garcia A, de Bont ES, Gonzalez-Neira A, Vos HI, van Leeuwen FN, Gelderblom H, Hoogerbrugge PM, Guchelaar HJ, Te Loo MW.

PLoS One. 2014 Dec 31;9(12):e115869. doi: 10.1371/journal.pone.0115869. eCollection 2014.

23.

Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: a new approach for target discovery.

van der Sligte NE, Scherpen FJ, Meeuwsen-de Boer TG, Lourens HJ, Ter Elst A, Diks SH, Guryev V, Peppelenbosch MP, van Leeuwen FN, de Bont ES.

Proteomics. 2015 Apr;15(7):1245-54. doi: 10.1002/pmic.201400286. Epub 2015 Jan 21.

PMID:
25422122
24.

A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics.

van der Meer LT, Waanders E, Levers M, Venselaar H, Roeleveld D, Boos J, Lanvers C, Brüggemann RJ, Kuiper RP, Hoogerbrugge PM, van Leeuwen FN, te Loo DM.

Blood. 2014 Nov 6;124(19):3027-9. doi: 10.1182/blood-2014-06-582627. No abstract available.

PMID:
25377564
25.

Function and regulation of the channel-kinase TRPM7 in health and disease.

Visser D, Middelbeek J, van Leeuwen FN, Jalink K.

Eur J Cell Biol. 2014 Oct;93(10-12):455-65. doi: 10.1016/j.ejcb.2014.07.001. Epub 2014 Jul 8. Review.

PMID:
25073440
26.

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia.

van der Sligte NE, Krumbholz M, Pastorczak A, Scheijen B, Tauer JT, Nowasz C, Sonneveld E, de Bock GH, Meeuwsen-de Boer TG, van Reijmersdal S, Kuiper RP, Bradtke J, Metzler M, Suttorp M, de Bont ES, van Leeuwen FN.

Br J Haematol. 2014 Jul;166(2):250-3. doi: 10.1111/bjh.12850. Epub 2014 Mar 27. Erratum in: Br J Haematol. 2014 Nov;167(4):584.

PMID:
24673583
27.

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells.

Visser D, Langeslag M, Kedziora KM, Klarenbeek J, Kamermans A, Horgen FD, Fleig A, van Leeuwen FN, Jalink K.

Cell Calcium. 2013 Dec;54(6):404-15. doi: 10.1016/j.ceca.2013.09.003. Epub 2013 Oct 16.

28.

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, Huffman JE, Pučić M, Zgaga L, Adamczyk B, Mužinić A, Novokmet M, Polašek O, Gornik O, Krištić J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kolčić I, Lukić IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I.

PLoS Genet. 2013;9(1):e1003225. doi: 10.1371/journal.pgen.1003225. Epub 2013 Jan 31.

29.

B-lineage transcription factors and cooperating gene lesions required for leukemia development.

Tijchon E, Havinga J, van Leeuwen FN, Scheijen B.

Leukemia. 2013 Mar;27(3):541-52. doi: 10.1038/leu.2012.293. Epub 2012 Oct 10. Review.

PMID:
23047478
30.

TRPM7 is required for breast tumor cell metastasis.

Middelbeek J, Kuipers AJ, Henneman L, Visser D, Eidhof I, van Horssen R, Wieringa B, Canisius SV, Zwart W, Wessels LF, Sweep FC, Bult P, Span PN, van Leeuwen FN, Jalink K.

Cancer Res. 2012 Aug 15;72(16):4250-61. Epub 2012 Aug 7.

31.

Mechanoregulation of cytoskeletal dynamics by TRP channels.

Kuipers AJ, Middelbeek J, van Leeuwen FN.

Eur J Cell Biol. 2012 Nov-Dec;91(11-12):834-46. doi: 10.1016/j.ejcb.2012.05.006. Epub 2012 Jun 21. Review.

PMID:
22727433
32.

The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution.

Waanders E, Scheijen B, van der Meer LT, van Reijmersdal SV, van Emst L, Kroeze Y, Sonneveld E, Hoogerbrugge PM, van Kessel AG, van Leeuwen FN, Kuiper RP.

PLoS Genet. 2012;8(2):e1002533. doi: 10.1371/journal.pgen.1002533. Epub 2012 Feb 16.

33.

Revertant somatic mosaicism by mitotic recombination in dyskeratosis congenita.

Jongmans MC, Verwiel ET, Heijdra Y, Vulliamy T, Kamping EJ, Hehir-Kwa JY, Bongers EM, Pfundt R, van Emst L, van Leeuwen FN, van Gassen KL, Geurts van Kessel A, Dokal I, Hoogerbrugge N, Ligtenberg MJ, Kuiper RP.

Am J Hum Genet. 2012 Mar 9;90(3):426-33. doi: 10.1016/j.ajhg.2012.01.004. Epub 2012 Feb 16.

34.

Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes.

van den Dries K, van Helden SF, te Riet J, Diez-Ahedo R, Manzo C, Oud MM, van Leeuwen FN, Brock R, Garcia-Parajo MF, Cambi A, Figdor CG.

Cell Mol Life Sci. 2012 Jun;69(11):1889-901. doi: 10.1007/s00018-011-0908-y. Epub 2011 Dec 28.

35.

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia.

Waanders E, van der Velden VH, van der Schoot CE, van Leeuwen FN, van Reijmersdal SV, de Haas V, Veerman AJ, van Kessel AG, Hoogerbrugge PM, Kuiper RP, van Dongen JJ.

Leukemia. 2011 Feb;25(2):254-8. doi: 10.1038/leu.2010.275. Epub 2010 Nov 19.

PMID:
21102428
36.

Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium.

Montezano AC, Zimmerman D, Yusuf H, Burger D, Chignalia AZ, Wadhera V, van Leeuwen FN, Touyz RM.

Hypertension. 2010 Sep;56(3):453-62. doi: 10.1161/HYPERTENSIONAHA.110.152058. Epub 2010 Aug 9.

PMID:
20696983
37.

IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

Kuiper RP, Waanders E, van der Velden VH, van Reijmersdal SV, Venkatachalam R, Scheijen B, Sonneveld E, van Dongen JJ, Veerman AJ, van Leeuwen FN, van Kessel AG, Hoogerbrugge PM.

Leukemia. 2010 Jul;24(7):1258-64. doi: 10.1038/leu.2010.87. Epub 2010 May 6.

PMID:
20445578
38.

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia.

van Galen JC, Kuiper RP, van Emst L, Levers M, Tijchon E, Scheijen B, Waanders E, van Reijmersdal SV, Gilissen C, van Kessel AG, Hoogerbrugge PM, van Leeuwen FN.

Blood. 2010 Jun 10;115(23):4810-9. doi: 10.1182/blood-2009-05-223081. Epub 2010 Mar 30.

PMID:
20354172
39.

TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation.

van Helden SF, van den Dries K, Oud MM, Raymakers RA, Netea MG, van Leeuwen FN, Figdor CG.

J Immunol. 2010 Feb 1;184(3):1280-91. doi: 10.4049/jimmunol.0900764. Epub 2009 Dec 28.

40.

The alpha-kinase family: an exceptional branch on the protein kinase tree.

Middelbeek J, Clark K, Venselaar H, Huynen MA, van Leeuwen FN.

Cell Mol Life Sci. 2010 Mar;67(6):875-90. doi: 10.1007/s00018-009-0215-z. Epub 2009 Dec 12. Review.

41.

Regulation of MYCN expression in human neuroblastoma cells.

Jacobs JF, van Bokhoven H, van Leeuwen FN, Hulsbergen-van de Kaa CA, de Vries IJ, Adema GJ, Hoogerbrugge PM, de Brouwer AP.

BMC Cancer. 2009 Jul 18;9:239. doi: 10.1186/1471-2407-9-239.

42.

Diffusion-driven device for a high-resolution dose-response profiling of combination chemotherapy.

Ganser A, Roth G, van Galen JC, Hilderink J, Wammes JJ, Müller I, van Leeuwen FN, Wiesmüller KH, Brock R.

Anal Chem. 2009 Jul 1;81(13):5233-40. doi: 10.1021/ac900415s.

PMID:
19476343
43.

The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.

Clark K, Middelbeek J, Dorovkov MV, Figdor CG, Ryazanov AG, Lasonder E, van Leeuwen FN.

FEBS Lett. 2008 Sep 3;582(20):2993-7. doi: 10.1016/j.febslet.2008.07.043. Epub 2008 Aug 7.

44.

TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.

Clark K, Middelbeek J, Lasonder E, Dulyaninova NG, Morrice NA, Ryazanov AG, Bresnick AR, Figdor CG, van Leeuwen FN.

J Mol Biol. 2008 May 9;378(4):790-803. doi: 10.1016/j.jmb.2008.02.057. Epub 2008 Mar 4.

45.

Human and murine model cell lines for dendritic cell biology evaluated.

van Helden SF, van Leeuwen FN, Figdor CG.

Immunol Lett. 2008 May 15;117(2):191-7. doi: 10.1016/j.imlet.2008.02.003. Epub 2008 Mar 11. Review.

PMID:
18384885
46.

Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

Clark K, Middelbeek J, Morrice NA, Figdor CG, Lasonder E, van Leeuwen FN.

PLoS One. 2008 Mar 26;3(3):e1876. doi: 10.1371/journal.pone.0001876.

47.

Interplay between TRP channels and the cytoskeleton in health and disease.

Clark K, Middelbeek J, van Leeuwen FN.

Eur J Cell Biol. 2008 Sep;87(8-9):631-40. doi: 10.1016/j.ejcb.2008.01.009. Epub 2008 Mar 14. Review.

PMID:
18342984
48.

Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis.

Kuiper JW, Pluk H, Oerlemans F, van Leeuwen FN, de Lange F, Fransen J, Wieringa B.

PLoS Biol. 2008 Mar 11;6(3):e51. doi: 10.1371/journal.pbio.0060051.

49.

PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis.

van Helden SF, Oud MM, Joosten B, Peterse N, Figdor CG, van Leeuwen FN.

J Cell Sci. 2008 Apr 1;121(Pt 7):1096-106. doi: 10.1242/jcs.020289. Epub 2008 Mar 11.

50.

Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy.

Te Riet J, Zimmerman AW, Cambi A, Joosten B, Speller S, Torensma R, van Leeuwen FN, Figdor CG, de Lange F.

J Cell Sci. 2007 Nov 15;120(Pt 22):3965-76. Epub 2007 Oct 30.

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