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Items: 1 to 50 of 167

1.

FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation.

Visser LJ, Medina GN, Rabouw HH, de Groot RJ, Langereis MA, de Los Santos T, van Kuppeveld FJM.

J Virol. 2018 Nov 7. pii: JVI.00922-18. doi: 10.1128/JVI.00922-18. [Epub ahead of print]

PMID:
30404792
2.

Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces.

Guo H, Rabouw H, Slomp A, Dai M, van der Vegt F, van Lent JWM, McBride R, Paulson JC, de Groot RJ, van Kuppeveld FJM, de Vries E, de Haan CAM.

PLoS Pathog. 2018 Aug 13;14(8):e1007233. doi: 10.1371/journal.ppat.1007233. eCollection 2018 Aug.

3.

Substrate Binding by the Second Sialic Acid-Binding Site of Influenza A Virus N1 Neuraminidase Contributes to Enzymatic Activity.

Du W, Dai M, Li Z, Boons GJ, Peeters B, van Kuppeveld FJM, de Vries E, de Haan CAM.

J Virol. 2018 Sep 26;92(20). pii: e01243-18. doi: 10.1128/JVI.01243-18. Print 2018 Oct 15.

PMID:
30089692
4.

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice.

Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgärtner W, Wacker F, Kalinke U.

PLoS Pathog. 2018 Aug 3;14(8):e1007235. doi: 10.1371/journal.ppat.1007235. eCollection 2018 Aug.

5.

Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein.

Meutiawati F, Bezemer B, Strating JRPM, Overheul GJ, Žusinaite E, van Kuppeveld FJM, van Cleef KWR, van Rij RP.

Antiviral Res. 2018 Sep;157:68-79. doi: 10.1016/j.antiviral.2018.06.017. Epub 2018 Jul 3.

6.

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).

Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating JRPM.

Antiviral Res. 2018 Aug;156:55-63. doi: 10.1016/j.antiviral.2018.05.010. Epub 2018 May 26.

7.

Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility.

Li W, Hulswit RJG, Kenney SP, Widjaja I, Jung K, Alhamo MA, van Dieren B, van Kuppeveld FJM, Saif LJ, Bosch BJ.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5135-E5143. doi: 10.1073/pnas.1802879115. Epub 2018 May 14.

PMID:
29760102
8.

Publisher Correction: The life cycle of non-polio enteroviruses and how to target it.

Baggen J, Thibaut HJ, Strating JRPM, van Kuppeveld FJM.

Nat Rev Microbiol. 2018 Jun;16(6):391. doi: 10.1038/s41579-018-0022-3.

PMID:
29725113
9.

The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles.

Melia CE, van der Schaar HM, de Jong AWM, Lyoo HR, Snijder EJ, Koster AJ, van Kuppeveld FJM, Bárcena M.

MBio. 2018 Apr 17;9(2). pii: e00420-18. doi: 10.1128/mBio.00420-18.

10.

The life cycle of non-polio enteroviruses and how to target it.

Baggen J, Thibaut HJ, Strating JRPM, van Kuppeveld FJM.

Nat Rev Microbiol. 2018 Jun;16(6):368-381. doi: 10.1038/s41579-018-0005-4. Review. Erratum in: Nat Rev Microbiol. 2018 May 3;:.

PMID:
29626210
11.

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.

Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2371-2376. doi: 10.1073/pnas.1710617115. Epub 2018 Feb 20.

12.

Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.

Baggen J, Hurdiss DL, Zocher G, Mistry N, Roberts RW, Slager JJ, Guo H, van Vliet ALW, Wahedi M, Benschop K, Duizer E, de Haan CAM, de Vries E, Casasnovas JM, de Groot RJ, Arnberg N, Stehle T, Ranson NA, Thibaut HJ, van Kuppeveld FJM.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):397-402. doi: 10.1073/pnas.1713284115. Epub 2017 Dec 28.

13.

Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.

Melia CE, van der Schaar HM, Lyoo H, Limpens RWAL, Feng Q, Wahedi M, Overheul GJ, van Rij RP, Snijder EJ, Koster AJ, Bárcena M, van Kuppeveld FJM.

Cell Rep. 2017 Oct 17;21(3):587-599. doi: 10.1016/j.celrep.2017.09.068.

14.

Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein.

Lyoo H, Dorobantu CM, van der Schaar HM, van Kuppeveld FJM.

Antiviral Res. 2017 Nov;147:86-90. doi: 10.1016/j.antiviral.2017.10.006. Epub 2017 Oct 9.

15.

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.

Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8508-E8517. doi: 10.1073/pnas.1712592114. Epub 2017 Sep 18.

16.

Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells.

Schuster S, Tholen LE, Overheul GJ, van Kuppeveld FJM, van Rij RP.

mSphere. 2017 Aug 16;2(4). pii: e00333-17. doi: 10.1128/mSphere.00333-17. eCollection 2017 Jul-Aug.

17.

Direct-acting antivirals and host-targeting strategies to combat enterovirus infections.

Bauer L, Lyoo H, van der Schaar HM, Strating JR, van Kuppeveld FJ.

Curr Opin Virol. 2017 Jun;24:1-8. doi: 10.1016/j.coviro.2017.03.009. Epub 2017 Apr 12. Review.

18.

Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.

Li W, Luo R, He Q, van Kuppeveld FJM, Rottier PJM, Bosch BJ.

Virus Res. 2017 May 2;235:6-13. doi: 10.1016/j.virusres.2017.03.018. Epub 2017 Mar 28.

PMID:
28363778
19.

Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity.

Bakkers MJ, Lang Y, Feitsma LJ, Hulswit RJ, de Poot SA, van Vliet AL, Margine I, de Groot-Mijnes JD, van Kuppeveld FJ, Langereis MA, Huizinga EG, de Groot RJ.

Cell Host Microbe. 2017 Mar 8;21(3):356-366. doi: 10.1016/j.chom.2017.02.008.

20.

Viral rewiring of cellular lipid metabolism to create membranous replication compartments.

Strating JR, van Kuppeveld FJ.

Curr Opin Cell Biol. 2017 Aug;47:24-33. doi: 10.1016/j.ceb.2017.02.005. Epub 2017 Feb 24. Review.

PMID:
28242560
21.

Mutation of the Second Sialic Acid-Binding Site, Resulting in Reduced Neuraminidase Activity, Preceded the Emergence of H7N9 Influenza A Virus.

Dai M, McBride R, Dortmans JC, Peng W, Bakkers MJ, de Groot RJ, van Kuppeveld FJ, Paulson JC, de Vries E, de Haan CA.

J Virol. 2017 Apr 13;91(9). pii: e00049-17. doi: 10.1128/JVI.00049-17. Print 2017 May 1.

22.

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.

Kindler E, Gil-Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw HH, Züst R, Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, van Kuppeveld FJ, Silverman RH, Keller M, Ludewig B, Bergmann CC, Ziebuhr J, Weiss SR, Kalinke U, Thiel V.

PLoS Pathog. 2017 Feb 3;13(2):e1006195. doi: 10.1371/journal.ppat.1006195. eCollection 2017 Feb.

23.

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

Albulescu L, Bigay J, Biswas B, Weber-Boyvat M, Dorobantu CM, Delang L, van der Schaar HM, Jung YS, Neyts J, Olkkonen VM, van Kuppeveld FJM, Strating JRPM.

Antiviral Res. 2017 Apr;140:37-44. doi: 10.1016/j.antiviral.2017.01.008. Epub 2017 Jan 11.

24.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR.

Nature. 2017 Jan 19;541(7637):412-416. doi: 10.1038/nature21032. Epub 2017 Jan 11.

PMID:
28077878
25.

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity.

Guo H, de Vries E, McBride R, Dekkers J, Peng W, Bouwman KM, Nycholat C, Verheije MH, Paulson JC, van Kuppeveld FJ, de Haan CA.

Emerg Infect Dis. 2017 Feb;23(2):220-231. doi: 10.3201/eid2302.161072. Epub 2017 Feb 15.

26.

Building Viral Replication Organelles: Close Encounters of the Membrane Types.

Nagy PD, Strating JR, van Kuppeveld FJ.

PLoS Pathog. 2016 Oct 27;12(10):e1005912. doi: 10.1371/journal.ppat.1005912. eCollection 2016 Oct. Review. No abstract available.

27.

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses.

Rabouw HH, Langereis MA, Knaap RC, Dalebout TJ, Canton J, Sola I, Enjuanes L, Bredenbeek PJ, Kikkert M, de Groot RJ, van Kuppeveld FJ.

PLoS Pathog. 2016 Oct 26;12(10):e1005982. doi: 10.1371/journal.ppat.1005982. eCollection 2016 Oct.

28.

Identification of Residues That Affect Oligomerization and/or Enzymatic Activity of Influenza Virus H5N1 Neuraminidase Proteins.

Dai M, Guo H, Dortmans JC, Dekkers J, Nordholm J, Daniels R, van Kuppeveld FJ, de Vries E, de Haan CA.

J Virol. 2016 Sep 29;90(20):9457-70. doi: 10.1128/JVI.01346-16. Print 2016 Oct 15.

29.

Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

Dorobantu CM, Harak C, Klein R, van der Linden L, Strating JR, van der Schaar HM, Lohmann V, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6. doi: 10.1128/AAC.01331-16. Print 2016 Oct.

30.

Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein.

van der Schaar HM, Melia CE, van Bruggen JA, Strating JR, van Geenen ME, Koster AJ, Bárcena M, van Kuppeveld FJ.

mSphere. 2016 Jul 6;1(4). pii: e00104-16. doi: 10.1128/mSphere.00104-16. eCollection 2016 Jul-Aug.

31.

Cellular entry of the porcine epidemic diarrhea virus.

Li W, van Kuppeveld FJM, He Q, Rottier PJM, Bosch BJ.

Virus Res. 2016 Dec 2;226:117-127. doi: 10.1016/j.virusres.2016.05.031. Epub 2016 Jun 15. Review.

32.

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein.

Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ.

mSphere. 2016 May 11;1(3). pii: e00068-16. doi: 10.1128/mSphere.00068-16. eCollection 2016 May-Jun.

33.

Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3.

Mullapudi E, Nováček J, Pálková L, Kulich P, Lindberg AM, van Kuppeveld FJ, Plevka P.

J Virol. 2016 Aug 12;90(17):7628-39. doi: 10.1128/JVI.00746-16. Print 2016 Sep 1.

34.

Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing a Host Shutoff That Requires Accessory Protein 5b.

Kint J, Langereis MA, Maier HJ, Britton P, van Kuppeveld FJ, Koumans J, Wiegertjes GF, Forlenza M.

J Virol. 2016 Jul 27;90(16):7519-7528. doi: 10.1128/JVI.00627-16. Print 2016 Aug 15.

35.

Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation.

Bakkers MJ, Zeng Q, Feitsma LJ, Hulswit RJ, Li Z, Westerbeke A, van Kuppeveld FJ, Boons GJ, Langereis MA, Huizinga EG, de Groot RJ.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3111-9. doi: 10.1073/pnas.1519881113. Epub 2016 May 16.

36.

Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy.

Arts P, van de Veerdonk FL, van der Lee R, Langereis MA, Gilissen C, van Zelst-Stams WAG, Huynen MA, van der Meer JWM, van Kuppeveld FJ, Veltman JA, Kullberg BJ, Hoischen A, Netea MG.

J Allergy Clin Immunol. 2016 Sep;138(3):895-898. doi: 10.1016/j.jaci.2016.02.025. Epub 2016 Apr 7. No abstract available.

PMID:
27132219
37.

Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV.

Widjaja I, Wicht O, Luytjes W, Leenhouts K, Rottier PJM, van Kuppeveld FJM, Haijema BJ, de Haan CAM.

J Virol. 2016 Jun 10;90(13):5965-5977. doi: 10.1128/JVI.00235-16. Print 2016 Jul 1.

38.

Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles.

van der Schaar HM, Dorobantu CM, Albulescu L, Strating JRPM, van Kuppeveld FJM.

Trends Microbiol. 2016 Jul;24(7):535-546. doi: 10.1016/j.tim.2016.02.017. Epub 2016 Mar 22. Review.

PMID:
27020598
39.

Neurotropism of Saffold virus in a mouse model.

Sorgeloos F, Lardinois C, Jacobs S, van Kuppeveld FJ, Kaspers B, Michiels T.

J Gen Virol. 2016 Jun;97(6):1350-5. doi: 10.1099/jgv.0.000452. Epub 2016 Mar 9.

PMID:
26959376
40.

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C.

Ulferts R, de Boer SM, van der Linden L, Bauer L, Lyoo HR, Maté MJ, Lichière J, Canard B, Lelieveld D, Omta W, Egan D, Coutard B, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2627-38. doi: 10.1128/AAC.02182-15. Print 2016 May.

41.

Enterovirus D68 receptor requirements unveiled by haploid genetics.

Baggen J, Thibaut HJ, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet AL, Blomen VA, Overduin P, Sheng J, de Haan CA, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, van Kuppeveld FJ.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1399-404. doi: 10.1073/pnas.1524498113. Epub 2016 Jan 19. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1588. de Haan Xander, Cornelis A M [corrected to de Haan, Cornelis A M].

42.

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.

Baglio SR, van Eijndhoven MA, Koppers-Lalic D, Berenguer J, Lougheed SM, Gibbs S, Léveillé N, Rinkel RN, Hopmans ES, Swaminathan S, Verkuijlen SA, Scheffer GL, van Kuppeveld FJ, de Gruijl TD, Bultink IE, Jordanova ES, Hackenberg M, Piersma SR, Knol JC, Voskuyl AE, Wurdinger T, Jiménez CR, Middeldorp JM, Pegtel DM.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E587-96. doi: 10.1073/pnas.1518130113. Epub 2016 Jan 14.

43.

Sialic acid-dependent cell entry of human enterovirus D68.

Liu Y, Sheng J, Baggen J, Meng G, Xiao C, Thibaut HJ, van Kuppeveld FJ, Rossmann MG.

Nat Commun. 2015 Nov 13;6:8865. doi: 10.1038/ncomms9865.

44.

Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses.

Kang H, Kim C, Kim DE, Song JH, Choi M, Choi K, Kang M, Lee K, Kim HS, Shin JS, Kim J, Han SB, Lee MY, Lee SU, Lee CK, Kim M, Ko HJ, van Kuppeveld FJ, Cho S.

Antiviral Res. 2015 Dec;124:1-10. doi: 10.1016/j.antiviral.2015.10.011. Epub 2015 Oct 23.

PMID:
26526589
45.

Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.

van der Lee R, Feng Q, Langereis MA, Ter Horst R, Szklarczyk R, Netea MG, Andeweg AC, van Kuppeveld FJ, Huynen MA.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004553. doi: 10.1371/journal.pcbi.1004553. eCollection 2015 Oct.

46.

Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus.

Dorobantu CM, Albulescu L, Harak C, Feng Q, van Kampen M, Strating JR, Gorbalenya AE, Lohmann V, van der Schaar HM, van Kuppeveld FJ.

PLoS Pathog. 2015 Sep 25;11(9):e1005185. doi: 10.1371/journal.ppat.1005185. eCollection 2015 Sep.

47.

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Sun L, Meijer A, Froeyen M, Zhang L, Thibaut HJ, Baggen J, George S, Vernachio J, van Kuppeveld FJ, Leyssen P, Hilgenfeld R, Neyts J, Delang L.

Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5. doi: 10.1128/AAC.01375-15. Epub 2015 Sep 14.

48.

Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells.

Langereis MA, Rabouw HH, Holwerda M, Visser LJ, van Kuppeveld FJ.

J Virol. 2015 Nov;89(21):11169-73. doi: 10.1128/JVI.01781-15. Epub 2015 Aug 26.

49.

Replication and Inhibitors of Enteroviruses and Parechoviruses.

van der Linden L, Wolthers KC, van Kuppeveld FJ.

Viruses. 2015 Aug 10;7(8):4529-62. doi: 10.3390/v7082832. Review.

50.

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

Widjaja I, Rigter A, Jacobino S, van Kuppeveld FJ, Leenhouts K, Palomo C, Melero JA, Leusen JH, Haijema BJ, Rottier PJ, de Haan CA.

PLoS One. 2015 Jun 24;10(6):e0130829. doi: 10.1371/journal.pone.0130829. eCollection 2015.

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