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Items: 1 to 50 of 386

1.

Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer).

Bernitz N, Kerr TJ, Goosen WJ, Higgitt RL, de Waal C, Clarke C, Cooper DV, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2019 Aug 8;217:109923. doi: 10.1016/j.vetimm.2019.109923. [Epub ahead of print]

PMID:
31470250
2.

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes.

Ronacher K, Chegou NN, Kleynhans L, Djoba Siawaya JF, du Plessis N, Loxton AG, Maasdorp E, Tromp G, Kidd M, Stanley K, Kriel M, Menezes A, Gutschmidt A, van der Spuy GD, Warren RM, Dietze R, Okwera A, Thiel B, Belisle JT, Cliff JM, Boom WH, Johnson JL, van Helden PD, Dockrell HM, Walzl G.

Tuberculosis (Edinb). 2019 Aug 12;118:101859. doi: 10.1016/j.tube.2019.101859. [Epub ahead of print]

3.

Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Bernitz N, Kerr TJ, Goosen WJ, Clarke C, Higgitt R, Roos EO, Cooper DV, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Prev Vet Med. 2019 Aug 1;169:104700. doi: 10.1016/j.prevetmed.2019.104700. Epub 2019 May 23.

PMID:
31311648
4.

Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host.

Tavalire HF, Hoal EG, le Roex N, van Helden PD, Ezenwa VO, Jolles AE.

Proc Biol Sci. 2019 Jul 24;286(1907):20190914. doi: 10.1098/rspb.2019.0914. Epub 2019 Jul 17.

5.

Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting.

Dippenaar A, De Vos M, Marx FM, Adroub SA, van Helden PD, Pain A, Sampson SL, Warren RM.

Infect Genet Evol. 2019 Jul 2;75:103948. doi: 10.1016/j.meegid.2019.103948. [Epub ahead of print]

PMID:
31276801
6.

Evolution of rifampicin treatment for tuberculosis.

Grobbelaar M, Louw GE, Sampson SL, van Helden PD, Donald PR, Warren RM.

Infect Genet Evol. 2019 Oct;74:103937. doi: 10.1016/j.meegid.2019.103937. Epub 2019 Jun 24.

PMID:
31247337
7.

Mycobacterium bovis Infection in African Wild Dogs, Kruger National Park, South Africa.

Higgitt RL, Louis van Schalkwyk O, de Klerk-Lorist LM, Buss PE, Caldwell P, Rossouw L, Manamela T, Hausler GA, Hewlett J, Mitchell EP, van Helden PD, Parsons SDC, Miller MA.

Emerg Infect Dis. 2019 Jul;25(7):1425-1427. doi: 10.3201/eid2507.181653.

8.

A commercial ELISA for detection of interferon gamma in white rhinoceros.

Chileshe J, Goosen WJ, Buss PE, van Helden PD, Warren R, Parsons SDC, Miller MA.

J Vet Diagn Invest. 2019 Jul;31(4):531-536. doi: 10.1177/1040638719843955. Epub 2019 Apr 11.

PMID:
30973098
9.

High Seroprevalence of Toxoplasma gondii in an Urban Caracal (Caracal caracal) Population in South Africa.

Serieys LEK, Hammond-Aryee K, Bishop J, Broadfield J, O'Riain MJ, van Helden PD.

J Wildl Dis. 2019 Oct;55(4):951-953. Epub 2019 Mar 28.

PMID:
30920906
10.

Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population.

Schurz H, Müller SJ, van Helden PD, Tromp G, Hoal EG, Kinnear CJ, Möller M.

Front Genet. 2019 Feb 5;10:34. doi: 10.3389/fgene.2019.00034. eCollection 2019.

11.

Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria.

Adesokan HK, Streicher EM, van Helden PD, Warren RM, Cadmus SIB.

PLoS One. 2019 Feb 20;14(2):e0211637. doi: 10.1371/journal.pone.0211637. eCollection 2019.

12.

A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array.

Schurz H, Kinnear CJ, Gignoux C, Wojcik G, van Helden PD, Tromp G, Henn B, Hoal EG, Möller M.

Front Genet. 2019 Jan 18;9:678. doi: 10.3389/fgene.2018.00678. eCollection 2018.

13.

Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host.

Tavalire HF, Beechler BR, Buss PE, Gorsich EE, Hoal EG, le Roex N, Spaan JM, Spaan RS, van Helden PD, Ezenwa VO, Jolles AE.

Ecol Evol. 2018 Dec 6;8(24):12712-12726. doi: 10.1002/ece3.4699. eCollection 2018 Dec.

14.

Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer).

Bernitz N, Goosen WJ, Clarke C, Kerr TJ, Higgitt R, Roos EO, Cooper DV, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Oct;204:40-43. doi: 10.1016/j.vetimm.2018.09.004. Epub 2018 Sep 18.

PMID:
30596379
15.

A pilot study evaluating the utility of commercially available antibodies for flow cytometric analysis of Panthera species lymphocytes.

Sylvester TT, Parsons SDC, van Helden PD, Miller MA, Loxton AG.

BMC Vet Res. 2018 Dec 19;14(1):410. doi: 10.1186/s12917-018-1717-4.

16.

TB Control in Humans and Animals in South Africa: A Perspective on Problems and Successes.

Meiring C, van Helden PD, Goosen WJ.

Front Vet Sci. 2018 Nov 27;5:298. doi: 10.3389/fvets.2018.00298. eCollection 2018.

17.

Measuring antigen-specific responses in Mycobacterium bovis-infected warthogs (Phacochoerus africanus) using the intradermal tuberculin test.

Roos EO, Olea-Popelka F, Buss P, Hausler GA, Warren R, van Helden PD, Parsons SDC, de Klerk-Lorist LM, Miller MA.

BMC Vet Res. 2018 Nov 20;14(1):360. doi: 10.1186/s12917-018-1685-8.

18.

Genetic Resistance to Mycobacterium tuberculosis Infection and Disease.

Möller M, Kinnear CJ, Orlova M, Kroon EE, van Helden PD, Schurr E, Hoal EG.

Front Immunol. 2018 Sep 27;9:2219. doi: 10.3389/fimmu.2018.02219. eCollection 2018. Review.

19.

Generation and characterization of thiol-deficient Mycobacterium tuberculosis mutants.

Sao Emani C, Williams MJ, Van Helden PD, Taylor MJC, Carolis C, Wiid IJ, Baker B.

Sci Data. 2018 Sep 25;5:180184. doi: 10.1038/sdata.2018.184.

20.

Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis.

McIntosh AI, Jenkins HE, White LF, Barnard M, Thomson DR, Dolby T, Simpson J, Streicher EM, Kleinman MB, Ragan EJ, van Helden PD, Murray MB, Warren RM, Jacobson KR.

PLoS Med. 2018 Aug 21;15(8):e1002638. doi: 10.1371/journal.pmed.1002638. eCollection 2018 Aug.

21.

Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa.

Chihota VN, Niehaus A, Streicher EM, Wang X, Sampson SL, Mason P, Källenius G, Mfinanga SG, Pillay M, Klopper M, Kasongo W, Behr MA, Gey van Pittius NC, van Helden PD, Couvin D, Rastogi N, Warren RM.

PLoS One. 2018 Aug 1;13(8):e0200632. doi: 10.1371/journal.pone.0200632. eCollection 2018.

22.

Proteomic analysis reveals that sulfamethoxazole induces oxidative stress in M. tuberculosis.

Sarkar R, Mdladla C, Macingwana L, Pietersen RD, Ngwane AH, Tabb DL, van Helden PD, Wiid I, Baker B.

Tuberculosis (Edinb). 2018 Jul;111:78-85. doi: 10.1016/j.tube.2018.05.010. Epub 2018 May 17.

PMID:
30029919
23.

Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.

de Vos M, Derendinger B, Dolby T, Simpson J, van Helden PD, Rice JE, Wangh LJ, Theron G, Warren RM.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00531-18. doi: 10.1128/JCM.00531-18. Print 2018 Sep.

24.

Corrigendum to "Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA" [J. Vet. Immunol. Immunopathol. 196 (2018) 48-52].

Bernitz N, Clarke C, Roos EO, Goosen WJ, Cooper D, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Jul;201:88. doi: 10.1016/j.vetimm.2018.02.008. Epub 2018 Mar 7. No abstract available.

PMID:
29921441
25.

IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).

Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Jul;201:43-48. doi: 10.1016/j.vetimm.2018.05.007. Epub 2018 May 21.

PMID:
29914681
26.

Antigen-specific interferon-gamma release is decreased following the single intradermal comparative cervical skin test in African buffaloes (Syncerus caffer).

Clarke C, Cooper D, Goosen WJ, McFadyen R, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Jul;201:12-15. doi: 10.1016/j.vetimm.2018.05.002. Epub 2018 May 15.

PMID:
29914675
27.

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1208-1219. doi: 10.1164/rccm.201711-2333OC.

PMID:
29877726
28.

Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient.

Glanzmann B, Möller M, Moncada-Velez M, Peter J, Urban M, van Helden PD, Hoal EG, de Villiers N, Glashoff RH, Nortje R, Bustamante J, Abel L, Casanova JL, Boisson-Dupuis S, Esser M, Kinnear CJ.

J Clin Immunol. 2018 May;38(4):460-463. doi: 10.1007/s10875-018-0509-8. Epub 2018 May 18. No abstract available.

29.

Papanicolaou induced fluorescence, Ziehl-Neelsen and Auramine O stains on lymph node fine needle aspiration biopsy specimens from children: A comparative study.

Selepe MM, van Wyk AC, Hoek KGP, Prince Y, van Helden PD, Warren RM, Wright CA.

Diagn Cytopathol. 2018 Jul;46(7):589-592. doi: 10.1002/dc.23956. Epub 2018 May 3.

PMID:
29722172
30.

Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA.

Bernitz N, Clarke C, Roos EO, Goosen WJ, Cooper D, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Feb;196:48-52. doi: 10.1016/j.vetimm.2017.12.010. Epub 2017 Dec 22. Erratum in: Vet Immunol Immunopathol. 2018 Jul;201:88.

PMID:
29695324
31.

Detection of tuberculosis by automatic cough sound analysis.

Botha GHR, Theron G, Warren RM, Klopper M, Dheda K, van Helden PD, Niesler TR.

Physiol Meas. 2018 Apr 26;39(4):045005. doi: 10.1088/1361-6579/aab6d0.

PMID:
29543189
32.

Seroprevalence of Mycobacterium bovis infection in warthogs (Phacochoerus africanus) in bovine tuberculosis-endemic regions of South Africa.

Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, van Helden PD, Parsons SDC, Miller MA.

Transbound Emerg Dis. 2018 Oct;65(5):1182-1189. doi: 10.1111/tbed.12856. Epub 2018 Mar 8.

PMID:
29520985
33.

Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus).

Derendinger B, de Vos M, Nathavitharana RR, Dolby T, Simpson JA, van Helden PD, Warren RM, Theron G.

Sci Rep. 2018 Feb 16;8(1):3206. doi: 10.1038/s41598-018-21458-y.

34.

The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum).

Parsons SDC, Morar-Leather D, Buss P, Hofmeyr J, McFadyen R, Rutten VPMG, van Helden PD, Miller MA, Michel AL.

Front Immunol. 2017 Dec 22;8:1831. doi: 10.3389/fimmu.2017.01831. eCollection 2017.

35.

Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency.

Schlechter N, Glanzmann B, Hoal EG, Schoeman M, Petersen BS, Franke A, Lau YL, Urban M, van Helden PD, Esser MM, Möller M, Kinnear C.

Front Immunol. 2017 Nov 27;8:1624. doi: 10.3389/fimmu.2017.01624. eCollection 2017.

36.

Gamma-glutamylcysteine protects ergothioneine-deficient Mycobacterium tuberculosis mutants against oxidative and nitrosative stress.

Sao Emani C, Williams MJ, Van Helden PD, Taylor MJC, Wiid IJ, Baker B.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):174-178. doi: 10.1016/j.bbrc.2017.10.163. Epub 2017 Oct 31.

PMID:
29101028
37.

Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping.

Venter R, Derendinger B, de Vos M, Pillay S, Dolby T, Simpson J, Kitchin N, Ruiters A, van Helden PD, Warren RM, Theron G.

Sci Rep. 2017 Nov 1;7(1):14854. doi: 10.1038/s41598-017-14385-x.

38.

Isoniazid Resistance and Dosage as Treatment for Patients with Tuberculosis.

Nagel S, Streicher EM, Klopper M, Warren RM, Van Helden PD.

Curr Drug Metab. 2017;18(11):1030-1039. doi: 10.2174/1389200218666171031121905. Review.

PMID:
29086682
39.

The arms race between man and Mycobacterium tuberculosis: Time to regroup.

Hoal EG, Dippenaar A, Kinnear C, van Helden PD, Möller M.

Infect Genet Evol. 2018 Dec;66:361-375. doi: 10.1016/j.meegid.2017.08.021. Epub 2017 Aug 23. Review.

PMID:
28843547
40.

Proteogenomic Investigation of Strain Variation in Clinical Mycobacterium tuberculosis Isolates.

Heunis T, Dippenaar A, Warren RM, van Helden PD, van der Merwe RG, Gey van Pittius NC, Pain A, Sampson SL, Tabb DL.

J Proteome Res. 2017 Oct 6;16(10):3841-3851. doi: 10.1021/acs.jproteome.7b00483. Epub 2017 Sep 11.

PMID:
28820946
41.

The role of human host genetics in tuberculosis resistance.

Kinnear C, Hoal EG, Schurz H, van Helden PD, Möller M.

Expert Rev Respir Med. 2017 Sep;11(9):721-737. doi: 10.1080/17476348.2017.1354700. Epub 2017 Jul 20. Review.

PMID:
28703045
42.

Changes in Host Immune-Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes.

Kleynhans L, Ruzive S, Ehlers L, Thiart L, Chegou NN, Conradie M, Kriel M, Stanley K, van der Spuy GD, Kidd M, van Helden PD, Walzl G, Ronacher K.

Front Immunol. 2017 Jun 15;8:690. doi: 10.3389/fimmu.2017.00690. eCollection 2017.

43.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

44.

Structural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1.

Cloete R, Akurugu WA, Werely CJ, van Helden PD, Christoffels A.

J Mol Graph Model. 2017 Aug;75:330-339. doi: 10.1016/j.jmgm.2017.04.026. Epub 2017 Jun 10.

45.

Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem.

Dippenaar A, Parsons SDC, Miller MA, Hlokwe T, Gey van Pittius NC, Adroub SA, Abdallah AM, Pain A, Warren RM, Michel AL, van Helden PD.

Infect Genet Evol. 2017 Jul;51:235-238. doi: 10.1016/j.meegid.2017.04.012. Epub 2017 Apr 13.

PMID:
28412523
46.

Paratuberculosis in a domestic dog in South Africa.

Miller MA, Davey SC, Van Helden LS, Kettner F, May SM, Last R, Grewar JD, Botha L, Van Helden PD.

J S Afr Vet Assoc. 2017 Mar 30;88(0):e1-e5. doi: 10.4102/jsava.v88i0.1441.

47.

A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility.

Uren C, Henn BM, Franke A, Wittig M, van Helden PD, Hoal EG, Möller M.

PLoS One. 2017 Apr 6;12(4):e0174738. doi: 10.1371/journal.pone.0174738. eCollection 2017.

48.

Exome sequencing identifies a novel TTC37 mutation in the first reported case of Trichohepatoenteric syndrome (THE-S) in South Africa.

Kinnear C, Glanzmann B, Banda E, Schlechter N, Durrheim G, Neethling A, Nel E, Schoeman M, Johnson G, van Helden PD, Hoal EG, Esser M, Urban M, Möller M.

BMC Med Genet. 2017 Mar 14;18(1):26. doi: 10.1186/s12881-017-0388-5.

49.

Population structure and infectious disease risk in southern Africa.

Uren C, Möller M, van Helden PD, Henn BM, Hoal EG.

Mol Genet Genomics. 2017 Jun;292(3):499-509. doi: 10.1007/s00438-017-1296-2. Epub 2017 Feb 22. Review.

PMID:
28229227
50.

Mycobacterium bovis in a Free-Ranging Black Rhinoceros, Kruger National Park, South Africa, 2016.

Miller MA, Buss PE, van Helden PD, Parsons SD.

Emerg Infect Dis. 2017 Mar;23(3):557-558. doi: 10.3201/eid2303.161622.

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