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Items: 1 to 50 of 528

1.

Reverse zoonotic tuberculosis transmission from an emerging Uganda I strain between pastoralists and cattle in South-Eastern Nigeria.

Adesokan HK, Akinseye VO, Streicher EM, Van Helden P, Warren RM, Cadmus SI.

BMC Vet Res. 2019 Dec 4;15(1):437. doi: 10.1186/s12917-019-2185-1.

2.

Test Characteristics of Assays to Detect Mycobacterium bovis Infection in High-Prevalence African Buffalo (Syncerus caffer) Herds.

Bernitz N, Kerr TJ, de Waal C, Cooper DV, Warren RM, Van Helden PD, Parsons SDC, Miller MA.

J Wildl Dis. 2019 Nov 21. [Epub ahead of print]

PMID:
31750773
3.

Mycobacterium tuberculosis: concentrate resources on recent infections.

van Helden PD, Hoal EG.

BMJ. 2019 Nov 15;367:l6485. doi: 10.1136/bmj.l6485. No abstract available.

PMID:
31732487
4.

Cytokine gene expression assay as a diagnostic tool for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).

Roos EO, Scott LA, Ndou S, Olea-Popelka F, Buss PE, de Klerk-Lorist LM, Warren RM, van Helden PD, Sylvester TT, Miller MA, Parsons SDC.

Sci Rep. 2019 Nov 11;9(1):16525. doi: 10.1038/s41598-019-53045-0.

5.

An interferon-gamma release assay for the diagnosis of the Mycobacterium bovis infection in white rhinoceros (Ceratotherium simum).

Chileshe J, Roos EO, Goosen WJ, Buss P, Hausler G, Rossouw L, Manemela T, van Helden P, Warren R, Parsons SD, Miller M.

Vet Immunol Immunopathol. 2019 Nov;217:109931. doi: 10.1016/j.vetimm.2019.109931. Epub 2019 Aug 15.

PMID:
31522092
6.

Impact of Mycobacterium bovis-induced pathology on interpretation of QuantiFERON®-TB Gold assay results in African buffaloes (Syncerus caffer).

Bernitz N, Kerr TJ, Goosen WJ, Higgitt RL, de Waal C, Clarke C, Cooper DV, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2019 Nov;217:109923. doi: 10.1016/j.vetimm.2019.109923. Epub 2019 Aug 8.

PMID:
31470250
7.

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes.

Ronacher K, Chegou NN, Kleynhans L, Djoba Siawaya JF, du Plessis N, Loxton AG, Maasdorp E, Tromp G, Kidd M, Stanley K, Kriel M, Menezes A, Gutschmidt A, van der Spuy GD, Warren RM, Dietze R, Okwera A, Thiel B, Belisle JT, Cliff JM, Boom WH, Johnson JL, van Helden PD, Dockrell HM, Walzl G.

Tuberculosis (Edinb). 2019 Sep;118:101859. doi: 10.1016/j.tube.2019.101859. Epub 2019 Aug 12.

8.

Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer).

Bernitz N, Kerr TJ, Goosen WJ, Clarke C, Higgitt R, Roos EO, Cooper DV, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Prev Vet Med. 2019 Aug 1;169:104700. doi: 10.1016/j.prevetmed.2019.104700. Epub 2019 May 23.

PMID:
31311648
9.

Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host.

Tavalire HF, Hoal EG, le Roex N, van Helden PD, Ezenwa VO, Jolles AE.

Proc Biol Sci. 2019 Jul 24;286(1907):20190914. doi: 10.1098/rspb.2019.0914. Epub 2019 Jul 17.

10.

Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting.

Dippenaar A, De Vos M, Marx FM, Adroub SA, van Helden PD, Pain A, Sampson SL, Warren RM.

Infect Genet Evol. 2019 Nov;75:103948. doi: 10.1016/j.meegid.2019.103948. Epub 2019 Jul 2.

PMID:
31276801
11.

Evolution of rifampicin treatment for tuberculosis.

Grobbelaar M, Louw GE, Sampson SL, van Helden PD, Donald PR, Warren RM.

Infect Genet Evol. 2019 Oct;74:103937. doi: 10.1016/j.meegid.2019.103937. Epub 2019 Jun 24.

PMID:
31247337
12.

Mycobacterium bovis Infection in African Wild Dogs, Kruger National Park, South Africa.

Higgitt RL, Louis van Schalkwyk O, de Klerk-Lorist LM, Buss PE, Caldwell P, Rossouw L, Manamela T, Hausler GA, Hewlett J, Mitchell EP, van Helden PD, Parsons SDC, Miller MA.

Emerg Infect Dis. 2019 Jul;25(7):1425-1427. doi: 10.3201/eid2507.181653.

13.

A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia.

Bartels L, de Jong G, Gillissen MA, Yasuda E, Kattler V, Bru C, Fatmawati C, van Hal-van Veen SE, Cercel MG, Moiset G, Bakker AQ, van Helden PM, Villaudy J, Hazenberg MD, Spits H, Wagner K.

Cancer Res. 2019 Jul 1;79(13):3372-3382. doi: 10.1158/0008-5472.CAN-18-0189. Epub 2019 May 7.

14.

A commercial ELISA for detection of interferon gamma in white rhinoceros.

Chileshe J, Goosen WJ, Buss PE, van Helden PD, Warren R, Parsons SDC, Miller MA.

J Vet Diagn Invest. 2019 Jul;31(4):531-536. doi: 10.1177/1040638719843955. Epub 2019 Apr 11.

PMID:
30973098
15.

High Seroprevalence of Toxoplasma gondii in an Urban Caracal (Caracal caracal) Population in South Africa.

Serieys LEK, Hammond-Aryee K, Bishop J, Broadfield J, O'Riain MJ, van Helden PD.

J Wildl Dis. 2019 Oct;55(4):951-953. Epub 2019 Mar 28.

PMID:
30920906
16.

Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population.

Schurz H, Müller SJ, van Helden PD, Tromp G, Hoal EG, Kinnear CJ, Möller M.

Front Genet. 2019 Feb 5;10:34. doi: 10.3389/fgene.2019.00034. eCollection 2019.

17.

Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife.

Miller MA, Buss P, Roos EO, Hausler G, Dippenaar A, Mitchell E, van Schalkwyk L, Robbe-Austerman S, Waters WR, Sikar-Gang A, Lyashchenko KP, Parsons SDC, Warren R, van Helden P.

Front Vet Sci. 2019 Feb 6;6:18. doi: 10.3389/fvets.2019.00018. eCollection 2019.

18.

Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria.

Adesokan HK, Streicher EM, van Helden PD, Warren RM, Cadmus SIB.

PLoS One. 2019 Feb 20;14(2):e0211637. doi: 10.1371/journal.pone.0211637. eCollection 2019.

19.

A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array.

Schurz H, Kinnear CJ, Gignoux C, Wojcik G, van Helden PD, Tromp G, Henn B, Hoal EG, Möller M.

Front Genet. 2019 Jan 18;9:678. doi: 10.3389/fgene.2018.00678. eCollection 2018.

20.

Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host.

Tavalire HF, Beechler BR, Buss PE, Gorsich EE, Hoal EG, le Roex N, Spaan JM, Spaan RS, van Helden PD, Ezenwa VO, Jolles AE.

Ecol Evol. 2018 Dec 6;8(24):12712-12726. doi: 10.1002/ece3.4699. eCollection 2018 Dec.

21.

Parallel testing increases detection of Mycobacterium bovis-infected African buffaloes (Syncerus caffer).

Bernitz N, Goosen WJ, Clarke C, Kerr TJ, Higgitt R, Roos EO, Cooper DV, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Oct;204:40-43. doi: 10.1016/j.vetimm.2018.09.004. Epub 2018 Sep 18.

PMID:
30596379
22.

A pilot study evaluating the utility of commercially available antibodies for flow cytometric analysis of Panthera species lymphocytes.

Sylvester TT, Parsons SDC, van Helden PD, Miller MA, Loxton AG.

BMC Vet Res. 2018 Dec 19;14(1):410. doi: 10.1186/s12917-018-1717-4.

23.

TB Control in Humans and Animals in South Africa: A Perspective on Problems and Successes.

Meiring C, van Helden PD, Goosen WJ.

Front Vet Sci. 2018 Nov 27;5:298. doi: 10.3389/fvets.2018.00298. eCollection 2018.

24.

Measuring antigen-specific responses in Mycobacterium bovis-infected warthogs (Phacochoerus africanus) using the intradermal tuberculin test.

Roos EO, Olea-Popelka F, Buss P, Hausler GA, Warren R, van Helden PD, Parsons SDC, de Klerk-Lorist LM, Miller MA.

BMC Vet Res. 2018 Nov 20;14(1):360. doi: 10.1186/s12917-018-1685-8.

25.

Conservation of White Rhinoceroses Threatened by Bovine Tuberculosis, South Africa, 2016-2017.

Miller MA, Buss P, Parsons SDC, Roos E, Chileshe J, Goosen WJ, van Schalkwyk L, de Klerk-Lorist LM, Hofmeyr M, Hausler G, Rossouw L, Manamela T, Mitchell EP, Warren R, van Helden P.

Emerg Infect Dis. 2018 Dec;24(12):2373-2375. doi: 10.3201/eid2412.180293.

26.

Genetic Resistance to Mycobacterium tuberculosis Infection and Disease.

Möller M, Kinnear CJ, Orlova M, Kroon EE, van Helden PD, Schurr E, Hoal EG.

Front Immunol. 2018 Sep 27;9:2219. doi: 10.3389/fimmu.2018.02219. eCollection 2018. Review.

27.

Generation and characterization of thiol-deficient Mycobacterium tuberculosis mutants.

Sao Emani C, Williams MJ, Van Helden PD, Taylor MJC, Carolis C, Wiid IJ, Baker B.

Sci Data. 2018 Sep 25;5:180184. doi: 10.1038/sdata.2018.184.

28.

Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: A retrospective spatiotemporal analysis.

McIntosh AI, Jenkins HE, White LF, Barnard M, Thomson DR, Dolby T, Simpson J, Streicher EM, Kleinman MB, Ragan EJ, van Helden PD, Murray MB, Warren RM, Jacobson KR.

PLoS Med. 2018 Aug 21;15(8):e1002638. doi: 10.1371/journal.pmed.1002638. eCollection 2018 Aug.

29.

Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa.

Chihota VN, Niehaus A, Streicher EM, Wang X, Sampson SL, Mason P, Källenius G, Mfinanga SG, Pillay M, Klopper M, Kasongo W, Behr MA, Gey van Pittius NC, van Helden PD, Couvin D, Rastogi N, Warren RM.

PLoS One. 2018 Aug 1;13(8):e0200632. doi: 10.1371/journal.pone.0200632. eCollection 2018.

30.

Proteomic analysis reveals that sulfamethoxazole induces oxidative stress in M. tuberculosis.

Sarkar R, Mdladla C, Macingwana L, Pietersen RD, Ngwane AH, Tabb DL, van Helden PD, Wiid I, Baker B.

Tuberculosis (Edinb). 2018 Jul;111:78-85. doi: 10.1016/j.tube.2018.05.010. Epub 2018 May 17.

PMID:
30029919
31.

Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.

de Vos M, Derendinger B, Dolby T, Simpson J, van Helden PD, Rice JE, Wangh LJ, Theron G, Warren RM.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00531-18. doi: 10.1128/JCM.00531-18. Print 2018 Sep.

32.

Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii.

Shwab EK, Saraf P, Zhu XQ, Zhou DH, McFerrin BM, Ajzenberg D, Schares G, Hammond-Aryee K, van Helden P, Higgins SA, Gerhold RW, Rosenthal BM, Zhao X, Dubey JP, Su C.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6956-E6963. doi: 10.1073/pnas.1722202115. Epub 2018 Jul 2.

33.

Corrigendum to "Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA" [J. Vet. Immunol. Immunopathol. 196 (2018) 48-52].

Bernitz N, Clarke C, Roos EO, Goosen WJ, Cooper D, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Jul;201:88. doi: 10.1016/j.vetimm.2018.02.008. Epub 2018 Mar 7. No abstract available.

PMID:
29921441
34.

IP-10: A potential biomarker for detection of Mycobacterium bovis infection in warthogs (Phacochoerus africanus).

Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Jul;201:43-48. doi: 10.1016/j.vetimm.2018.05.007. Epub 2018 May 21.

PMID:
29914681
35.

Antigen-specific interferon-gamma release is decreased following the single intradermal comparative cervical skin test in African buffaloes (Syncerus caffer).

Clarke C, Cooper D, Goosen WJ, McFadyen R, Warren RM, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Jul;201:12-15. doi: 10.1016/j.vetimm.2018.05.002. Epub 2018 May 15.

PMID:
29914675
36.

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1208-1219. doi: 10.1164/rccm.201711-2333OC.

37.

Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient.

Glanzmann B, Möller M, Moncada-Velez M, Peter J, Urban M, van Helden PD, Hoal EG, de Villiers N, Glashoff RH, Nortje R, Bustamante J, Abel L, Casanova JL, Boisson-Dupuis S, Esser M, Kinnear CJ.

J Clin Immunol. 2018 May;38(4):460-463. doi: 10.1007/s10875-018-0509-8. Epub 2018 May 18. No abstract available.

38.

Papanicolaou induced fluorescence, Ziehl-Neelsen and Auramine O stains on lymph node fine needle aspiration biopsy specimens from children: A comparative study.

Selepe MM, van Wyk AC, Hoek KGP, Prince Y, van Helden PD, Warren RM, Wright CA.

Diagn Cytopathol. 2018 Jul;46(7):589-592. doi: 10.1002/dc.23956. Epub 2018 May 3.

PMID:
29722172
39.

Detection of Mycobacterium bovis infection in African buffaloes (Syncerus caffer) using QuantiFERON®-TB Gold (QFT) tubes and the Qiagen cattletype® IFN-gamma ELISA.

Bernitz N, Clarke C, Roos EO, Goosen WJ, Cooper D, van Helden PD, Parsons SDC, Miller MA.

Vet Immunol Immunopathol. 2018 Feb;196:48-52. doi: 10.1016/j.vetimm.2017.12.010. Epub 2017 Dec 22. Erratum in: Vet Immunol Immunopathol. 2018 Jul;201:88.

PMID:
29695324
40.

Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

Coll F, Phelan J, Hill-Cawthorne GA, Nair MB, Mallard K, Ali S, Abdallah AM, Alghamdi S, Alsomali M, Ahmed AO, Portelli S, Oppong Y, Alves A, Bessa TB, Campino S, Caws M, Chatterjee A, Crampin AC, Dheda K, Furnham N, Glynn JR, Grandjean L, Ha DM, Hasan R, Hasan Z, Hibberd ML, Joloba M, Jones-López EC, Matsumoto T, Miranda A, Moore DJ, Mocillo N, Panaiotov S, Parkhill J, Penha C, Perdigão J, Portugal I, Rchiad Z, Robledo J, Sheen P, Shesha NT, Sirgel FA, Sola C, Sousa EO, Streicher EM, Van Helden P, Viveiros M, Warren RM, McNerney R, Pain A, Clark TG.

Nat Genet. 2018 May;50(5):764. doi: 10.1038/s41588-018-0074-3.

PMID:
29674744
41.

Detection of tuberculosis by automatic cough sound analysis.

Botha GHR, Theron G, Warren RM, Klopper M, Dheda K, van Helden PD, Niesler TR.

Physiol Meas. 2018 Apr 26;39(4):045005. doi: 10.1088/1361-6579/aab6d0.

PMID:
29543189
42.

Mycobacterial nucleoid associated proteins: An added dimension in gene regulation.

Kriel NL, Gallant J, van Wyk N, van Helden P, Sampson SL, Warren RM, Williams MJ.

Tuberculosis (Edinb). 2018 Jan;108:169-177. doi: 10.1016/j.tube.2017.12.004. Epub 2017 Dec 13. Review.

PMID:
29523320
43.

Seroprevalence of Mycobacterium bovis infection in warthogs (Phacochoerus africanus) in bovine tuberculosis-endemic regions of South Africa.

Roos EO, Olea-Popelka F, Buss P, de Klerk-Lorist LM, Cooper D, van Helden PD, Parsons SDC, Miller MA.

Transbound Emerg Dis. 2018 Oct;65(5):1182-1189. doi: 10.1111/tbed.12856. Epub 2018 Mar 8.

PMID:
29520985
44.

Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus).

Derendinger B, de Vos M, Nathavitharana RR, Dolby T, Simpson JA, van Helden PD, Warren RM, Theron G.

Sci Rep. 2018 Feb 16;8(1):3206. doi: 10.1038/s41598-018-21458-y.

45.

Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique.

Machado A, Rito T, Ghebremichael S, Muhate N, Maxhuza G, Macuamule C, Moiane I, Macucule B, Marranangumbe AS, Baptista J, Manguele J, Koivula T, Streicher EM, Warren RM, Kallenius G, van Helden P, Correia-Neves M.

PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0006147. doi: 10.1371/journal.pntd.0006147. eCollection 2018 Jan.

46.

The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum).

Parsons SDC, Morar-Leather D, Buss P, Hofmeyr J, McFadyen R, Rutten VPMG, van Helden PD, Miller MA, Michel AL.

Front Immunol. 2017 Dec 22;8:1831. doi: 10.3389/fimmu.2017.01831. eCollection 2017.

47.

Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice.

Gillissen MA, de Jong G, Kedde M, Yasuda E, Levie SE, Moiset G, Hensbergen PJ, Bakker AQ, Wagner K, Villaudy J, van Helden PM, Spits H, Hazenberg MD.

Blood Adv. 2017 Aug 18;1(19):1551-1564. doi: 10.1182/bloodadvances.2017008342. eCollection 2017 Aug 22.

48.

Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency.

Schlechter N, Glanzmann B, Hoal EG, Schoeman M, Petersen BS, Franke A, Lau YL, Urban M, van Helden PD, Esser MM, Möller M, Kinnear C.

Front Immunol. 2017 Nov 27;8:1624. doi: 10.3389/fimmu.2017.01624. eCollection 2017.

49.

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

Wilson CR, Gessner RK, Moosa A, Seldon R, Warner DF, Mizrahi V, Soares de Melo C, Simelane SB, Nchinda A, Abay E, Taylor D, Njoroge M, Brunschwig C, Lawrence N, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden P, Harris CJ, Gordon R, Ghidelli-Disse S, Pflaumer H, Boesche M, Drewes G, Sanz O, Santos G, Rebollo-Lopez MJ, Urones B, Selenski C, Lafuente-Monasterio MJ, Axtman M, Lelièvre J, Ballell L, Mueller R, Street LJ, Ghorpade SR, Chibale K.

J Med Chem. 2017 Dec 28;60(24):10118-10134. doi: 10.1021/acs.jmedchem.7b01347. Epub 2017 Dec 7.

50.

Gamma-glutamylcysteine protects ergothioneine-deficient Mycobacterium tuberculosis mutants against oxidative and nitrosative stress.

Sao Emani C, Williams MJ, Van Helden PD, Taylor MJC, Wiid IJ, Baker B.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):174-178. doi: 10.1016/j.bbrc.2017.10.163. Epub 2017 Oct 31.

PMID:
29101028

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