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Items: 1 to 50 of 73

1.

Dietary Zinc Modulates Matrix Metalloproteinases in Traumatic Brain Injury.

Scrimgeour AG, Carrigan CT, Condlin ML, Urso ML, van den Berg RM, van Helden HPM, Montain SJ, Joosen MJA.

J Neurotrauma. 2018 Oct 15;35(20):2495-2506. doi: 10.1089/neu.2017.5614. Epub 2018 Jul 13.

PMID:
29774825
2.

Timing of decontamination and treatment in case of percutaneous VX poisoning: a mini review.

Joosen MJ, van der Schans MJ, Kuijpers WC, van Helden HP, Noort D.

Chem Biol Interact. 2013 Mar 25;203(1):149-53. doi: 10.1016/j.cbi.2012.10.002. Epub 2012 Oct 16. Review.

PMID:
23085122
3.

Toxic effects following phosgene exposure of human epithelial lung cells in vitro using a CULTEX® system.

Wijte D, Alblas MJ, Noort D, Langenberg JP, van Helden HP.

Toxicol In Vitro. 2011 Dec;25(8):2080-7. doi: 10.1016/j.tiv.2011.09.003. Epub 2011 Sep 12.

PMID:
21945045
4.

Increasing oxime efficacy by blood-brain barrier modulation.

Joosen MJ, van der Schans MJ, van Dijk CG, Kuijpers WC, Wortelboer HM, van Helden HP.

Toxicol Lett. 2011 Sep 25;206(1):67-71. doi: 10.1016/j.toxlet.2011.05.231. Epub 2011 May 11.

PMID:
21600273
5.

Non-enzymatic pretreatment of nerve agent (soman) poisoning: a brief state-of-the-art review.

van Helden HP, Joosen MJ, Philippens IH.

Toxicol Lett. 2011 Sep 25;206(1):35-40. doi: 10.1016/j.toxlet.2011.04.021. Epub 2011 Apr 28. Review.

PMID:
21554933
6.

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?

Joosen MJ, Smit AB, van Helden HP.

Arch Toxicol. 2011 Mar;85(3):227-37. doi: 10.1007/s00204-010-0571-3. Epub 2010 Sep 15.

7.

Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.

Joosen MJ, van der Schans MJ, van Helden HP.

Chem Biol Interact. 2010 Oct 6;188(1):255-63. doi: 10.1016/j.cbi.2010.06.010. Epub 2010 Jun 23.

PMID:
20599844
8.

Two new test methods to quantify motor deficits in a marmoset model for Parkinson's disease.

Verhave PS, Vanwersch RA, van Helden HP, Smit AB, Philippens IH.

Behav Brain Res. 2009 Jun 8;200(1):214-9.

PMID:
19378465
9.

Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning.

Joosen MJ, Jousma E, van den Boom TM, Kuijpers WC, Smit AB, Lucassen PJ, van Helden HP.

Neurotoxicology. 2009 Jan;30(1):72-80. doi: 10.1016/j.neuro.2008.11.010. Epub 2008 Nov 28.

PMID:
19100287
10.

Percutaneous exposure to VX: clinical signs, effects on brain acetylcholine levels and EEG.

Joosen MJ, van der Schans MJ, van Helden HP.

Neurochem Res. 2008 Feb;33(2):308-17. Epub 2007 Oct 17.

PMID:
17940880
11.
12.

Low levels of sarin affect the EEG in marmoset monkeys: a pilot study.

van Helden HP, Vanwersch RA, Kuijpers WC, Trap HC, Philippens IH, Benschop HP.

J Appl Toxicol. 2004 Nov-Dec;24(6):475-83.

PMID:
15558834
13.

Protection of rats against perfluoroisobutene (PFIB)-induced pulmonary edema by curosurf and N-acetylcysteine.

van Helden HP, van de Meent D, Oostdijk JP, Joosen MJ, van Esch JH, Hammer AH, Diemel RV.

Inhal Toxicol. 2004 Jul;16(8):549-64.

PMID:
15204746
15.

Low-level exposure of guinea pigs and marmosets to sarin vapour in air: lowest-observable-adverse-effect level (LOAEL) for miosis.

van Helden HP, Trap HC, Kuijpers WC, Oostdijk JP, Benschop HP, Langenberg JP.

J Appl Toxicol. 2004 Jan-Feb;24(1):59-68.

PMID:
14745848
16.

Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree.

Bueters TJ, van Duivenvoorde LM, Danhof M, IJzerman AP, van Helden HP.

Eur J Pharmacol. 2003 Nov 28;481(2-3):141-6.

PMID:
14642778
17.
18.
19.

Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice.

Harrison PK, Bueters TJ, Ijzerman AP, van Helden HP, Tattersall JE.

Eur J Pharmacol. 2003 Jun 20;471(2):97-104.

PMID:
12818696
20.

Long-term, low-level exposure of guinea pigs and marmosets to sarin vapor in air: lowest observable effect level.

Van Helden HP, Trap HC, Oostdijk JP, Kuijpers WC, Langenberg JP, Benschop HP.

Toxicol Appl Pharmacol. 2003 Jun 15;189(3):170-9.

PMID:
12791302
21.

Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action.

Bueters TJ, van Helden HP, IJzerman AP, Danhof M.

Neurosci Lett. 2003 May 29;343(1):57-61.

PMID:
12749997
22.

Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin.

Bueters TJ, Joosen MJ, van Helden HP, Ijzerman AP, Danhof M.

J Pharmacol Exp Ther. 2003 Mar;304(3):1307-13.

PMID:
12604711
23.

Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release.

Bueters TJ, van Helden HP, Danhof M, IJzerman AP.

Eur J Pharmacol. 2002 Nov 15;454(2-3):177-82.

PMID:
12421644
24.

Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication.

Bueters TJ, Groen B, Danhof M, IJzerman AP, Van Helden HP.

Arch Toxicol. 2002 Nov;76(11):650-6. Epub 2002 Aug 21.

PMID:
12415428
25.

Molecular detection of Mycoplasma pneumoniae in adults with community-acquired pneumonia requiring hospitalization.

Dorigo-Zetsma JW, Verkooyen RP, van Helden HP, van der Nat H, van den Bosch JM.

J Clin Microbiol. 2001 Mar;39(3):1184-6.

26.

Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs.

Spruit HE, Langenberg JP, Trap HC, van der Wiel HJ, Helmich RB, van Helden HP, Benschop HP.

Toxicol Appl Pharmacol. 2000 Dec 15;169(3):249-54.

PMID:
11133347
27.

Protective activity of adenosine receptor agonists in the treatment of organophosphate poisoning.

van Helden HP, Bueters TJ.

Trends Pharmacol Sci. 1999 Nov;20(11):438-41. Review. No abstract available.

PMID:
10542440
28.

Aerosolized endotoxin is immediately bound by pulmonary surfactant protein D in vivo.

van Rozendaal BA, van de Lest CH, van Eijk M, van Golde LM, Voorhout WF, van Helden HP, Haagsman HP.

Biochim Biophys Acta. 1999 Aug 30;1454(3):261-9.

29.

New generic approach to the treatment of organophosphate poisoning: adenosine receptor mediated inhibition of ACh-release.

van Helden HP, Groen B, Moor E, Westerink BH, Bruijnzeel PL.

Drug Chem Toxicol. 1998;21 Suppl 1:171-81.

PMID:
10028409
30.

Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig.

Langenberg JP, van der Schans GP, Spruit HE, Kuijpers WC, Mars-Groenendijk RH, van Dijk-Knijnenburg HC, Trap HC, van Helden HP, Benschop HP.

Drug Chem Toxicol. 1998;21 Suppl 1:131-47.

PMID:
10028407
31.

Toxicologic evaluation of pepper spray as a possible weapon for the Dutch police force: risk assessment and efficacy.

Busker RW, van Helden HP.

Am J Forensic Med Pathol. 1998 Dec;19(4):309-16. Review.

PMID:
9885922
32.

Efficacy of Curosurf in a rat model of acute respiratory distress syndrome.

van Helden HP, Kuijpers WC, Langerwerf PE, Langen RC, Haagsman HP, Bruijnzeel PL.

Eur Respir J. 1998 Sep;12(3):533-9.

33.

Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor.

Langenberg JP, Spruit HE, van der Wiel HJ, Trap HC, Helmich RB, Bergers WW, van Helden HP, Benschop HP.

Toxicol Appl Pharmacol. 1998 Jul;151(1):79-87.

PMID:
9705889
34.

Evaluation of PCR, culture, and serology for diagnosis of Chlamydia pneumoniae respiratory infections.

Verkooyen RP, Willemse D, Hiep-van Casteren SC, Joulandan SA, Snijder RJ, van den Bosch JM, van Helden HP, Peeters MF, Verbrugh HA.

J Clin Microbiol. 1998 Aug;36(8):2301-7.

35.

Pulmonary surfactant proteins A and D are involved in the early response to intratracheally aerosolized lipopolysaccharide.

Van Rozendaal BA, Van de Lest CH, Van Eijk M, Van Helden HP, Haagsman HP.

Biochem Soc Trans. 1997 Nov;25(4):S656. No abstract available.

PMID:
9450084
36.

Diagnosis of Chlamydia pneumoniae infection in patients with chronic obstructive pulmonary disease by micro-immunofluorescence and ELISA.

Verkooyen RP, Van Lent NA, Mousavi Joulandan SA, Snijder RJ, van den Bosch JM, Van Helden HP, Verbrugh HA.

J Med Microbiol. 1997 Nov;46(11):959-64.

PMID:
9368538
37.

Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome.

van Helden HP, Kuijpers WC, Steenvoorden D, Go C, Bruijnzeel PL, van Eijk M, Haagsman HP.

Exp Lung Res. 1997 Jul-Aug;23(4):297-316.

PMID:
9202956
38.

Pharmacological effects of oximes: how relevant are they?

van Helden HP, Busker RW, Melchers BP, Bruijnzeel PL.

Arch Toxicol. 1996;70(12):779-86. Review.

PMID:
8911635
39.

Effects of low doses of cholinesterase inhibitors on behavioral performance of robot-tested marmosets.

Wolthuis OL, Groen B, Busker RW, van Helden HP.

Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):443-56.

PMID:
7667367
40.

The functional role of molecular forms of acetylcholinesterase in neuromuscular transmission.

Busker RW, Zijlstra JJ, van der Wiel HJ, van Helden HP.

Neurochem Res. 1994 Jun;19(6):713-9.

PMID:
8065529
41.
42.

Non-reactivating effects of HI-6 on hippocampal neurotransmission.

Melchers BP, van der Laaken AL, Busker RW, Bruijnzeel PL, Van Helden HP.

Arch Toxicol. 1994;69(2):118-26.

PMID:
7717860
43.

Search for a therapy against soman-intoxication.

Wolthuis OL, van Helden HP, Melchers BP, Busker RW, de Groot DM.

Neurosci Biobehav Rev. 1994 Winter;18(4):469-86. Review.

PMID:
7708361
44.

Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys.

van Helden HP, van der Wiel HJ, de Lange J, Busker RW, Melchers BP, Wolthuis OL.

Toxicol Appl Pharmacol. 1992 Jul;115(1):50-6.

PMID:
1631893
45.

Age-related interference with Chlamydia pneumoniae microimmunofluorescence serology due to circulating rheumatoid factor.

Verkooyen RP, Hazenberg MA, Van Haaren GH, Van Den Bosch JM, Snijder RJ, Van Helden HP, Verbrugh HA.

J Clin Microbiol. 1992 May;30(5):1287-90.

46.

Soman levels in kidney and urine following administration to rat, guinea pig, and marmoset.

de Jong LP, Benschop HP, Due A, Van Dijk C, Trap HC, Van der Wiel HJ, Van Helden HP.

Life Sci. 1992;50(14):1057-62.

PMID:
1552824
47.
48.

Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.

van Helden HP, de Lange J, Busker RW, Melchers BP.

Arch Toxicol. 1991;65(7):586-93.

PMID:
1664202
49.

Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.

Busker RW, Zijlstra JJ, van der Wiel HJ, Melchers BP, van Helden HP.

Toxicology. 1991;69(3):331-44.

PMID:
1658986
50.

On the development of behavioral tolerance to organophosphates. II: Neurophysiological aspects.

Melchers BP, van Helden HP.

Pharmacol Biochem Behav. 1990 Feb;35(2):321-5.

PMID:
2157228

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