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The cytoskeleton regulates symmetry transitions in moving amoeboid cells.

van Haastert PJM, Keizer-Gunnink I, Kortholt A.

J Cell Sci. 2018 Apr 9;131(7). pii: jcs208892. doi: 10.1242/jcs.208892.


A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W.

Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4.


Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement.

van Haastert PJ, Keizer-Gunnink I, Kortholt A.

Mol Biol Cell. 2017 Apr 1;28(7):922-934. doi: 10.1091/mbc.E16-10-0733. Epub 2017 Feb 1.


A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells.

Skoge M, Wong E, Hamza B, Bae A, Martel J, Kataria R, Keizer-Gunnink I, Kortholt A, Van Haastert PJ, Charras G, Janetopoulos C, Irimia D.

PLoS One. 2016 Jun 22;11(6):e0154491. doi: 10.1371/journal.pone.0154491. eCollection 2016.


Mathematics of Experimentally Generated Chemoattractant Gradients.

Postma M, van Haastert PJ.

Methods Mol Biol. 2016;1407:381-96. doi: 10.1007/978-1-4939-3480-5_26.


A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis.

Liu Y, Lacal J, Veltman DM, Fusetti F, van Haastert PJ, Firtel RA, Kortholt A.

Dev Cell. 2016 Jun 6;37(5):458-72. doi: 10.1016/j.devcel.2016.05.001. Epub 2016 May 26.


The small GTPases Ras and Rap1 bind to and control TORC2 activity.

Khanna A, Lotfi P, Chavan AJ, Montaño NM, Bolourani P, Weeks G, Shen Z, Briggs SP, Pots H, Van Haastert PJ, Kortholt A, Charest PG.

Sci Rep. 2016 May 13;6:25823. doi: 10.1038/srep25823.


Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells.

Plak K, Pots H, Van Haastert PJ, Kortholt A.

BMC Cell Biol. 2016 Jan 7;17:1. doi: 10.1186/s12860-015-0078-0.


Rap1-dependent pathways coordinate cytokinesis in Dictyostelium.

Plak K, Keizer-Gunnink I, van Haastert PJ, Kortholt A.

Mol Biol Cell. 2014 Dec 15;25(25):4195-204. doi: 10.1091/mbc.E14-08-1285. Epub 2014 Oct 8.


Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis.

Kataria R, van Haastert PJ, Kortholt A.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3149. No abstract available.


Ras activation and symmetry breaking during Dictyostelium chemotaxis.

Kortholt A, Keizer-Gunnink I, Kataria R, Van Haastert PJ.

J Cell Sci. 2013 Oct 1;126(Pt 19):4502-13. doi: 10.1242/jcs.132340. Epub 2013 Jul 25.


Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis.

Kataria R, Xu X, Fusetti F, Keizer-Gunnink I, Jin T, van Haastert PJ, Kortholt A.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6424-9. doi: 10.1073/pnas.1301851110. Epub 2013 Apr 1.


Extrachromosomal inducible expression.

Veltman DM, Van Haastert PJ.

Methods Mol Biol. 2013;983:269-81. doi: 10.1007/978-1-62703-302-2_14.


GxcC connects Rap and Rac signaling during Dictyostelium development.

Plak K, Veltman D, Fusetti F, Beeksma J, Rivero F, Van Haastert PJ, Kortholt A.

BMC Cell Biol. 2013 Jan 30;14:6. doi: 10.1186/1471-2121-14-6.


Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.

Gilsbach BK, Ho FY, Vetter IR, van Haastert PJ, Wittinghofer A, Kortholt A.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10322-7. doi: 10.1073/pnas.1203223109. Epub 2012 Jun 11.


Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC.

Kortholt A, van Egmond WN, Plak K, Bosgraaf L, Keizer-Gunnink I, van Haastert PJ.

J Biol Chem. 2012 Jan 20;287(4):2749-58. doi: 10.1074/jbc.M111.315739. Epub 2011 Nov 26.


Amoeboid cells use protrusions for walking, gliding and swimming.

Van Haastert PJ.

PLoS One. 2011;6(11):e27532. doi: 10.1371/journal.pone.0027532. Epub 2011 Nov 9.


Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification.

Kortholt A, Kataria R, Keizer-Gunnink I, Van Egmond WN, Khanna A, Van Haastert PJ.

EMBO Rep. 2011 Dec 1;12(12):1273-9. doi: 10.1038/embor.2011.210.


Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour.

Neilson MP, Veltman DM, van Haastert PJ, Webb SD, Mackenzie JA, Insall RH.

PLoS Biol. 2011 May;9(5):e1000618. doi: 10.1371/journal.pbio.1000618. Epub 2011 May 17.


How cells use pseudopods for persistent movement and navigation.

Van Haastert PJ.

Sci Signal. 2011 Feb 8;4(159):pe6. doi: 10.1126/scisignal.2001708.


A stochastic model for chemotaxis based on the ordered extension of pseudopods.

Van Haastert PJ.

Biophys J. 2010 Nov 17;99(10):3345-54. doi: 10.1016/j.bpj.2010.09.042.


Chemotaxis: insights from the extending pseudopod.

Van Haastert PJ.

J Cell Sci. 2010 Sep 15;123(Pt 18):3031-7. doi: 10.1242/jcs.071118. Review.


A model for a correlated random walk based on the ordered extension of pseudopodia.

Van Haastert PJ.

PLoS Comput Biol. 2010 Aug 12;6(8). pii: e1000874. doi: 10.1371/journal.pcbi.1000874.


Characterization of the Roco protein family in Dictyostelium discoideum.

van Egmond WN, van Haastert PJ.

Eukaryot Cell. 2010 May;9(5):751-61. doi: 10.1128/EC.00366-09. Epub 2010 Mar 26.


Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling.

Araki T, van Egmond WN, van Haastert PJ, Williams JG.

J Cell Sci. 2010 Mar 15;123(Pt 6):837-41. doi: 10.1242/jcs.064436. Epub 2010 Feb 16.


A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].

Kortholt A, Bolourani P, Rehmann H, Keizer-Gunnink I, Weeks G, Wittinghofer A, Van Haastert PJ.

Mol Biol Cell. 2010 Mar 15;21(6):936-45. doi: 10.1091/mbc.E09-03-0177. Epub 2010 Jan 20. Erratum in: Mol Biol Cell. 2010 Apr;21(7):1314.


The local cell curvature guides pseudopodia towards chemoattractants.

Van Haastert PJ, Bosgraaf L.

HFSP J. 2009 Aug;3(4):282-6. doi: 10.2976/1.3185725. Epub 2009 Aug 7.


Quimp3, an automated pseudopod-tracking algorithm.

Bosgraaf L, Van Haastert PJ.

Cell Adh Migr. 2010 Jan-Mar;4(1):46-55. Epub 2010 Jan 31.


Mathematics of experimentally generated chemoattractant gradients.

Postma M, van Haastert PJ.

Methods Mol Biol. 2009;571:473-88. doi: 10.1007/978-1-60761-198-1_31.


Navigation of chemotactic cells by parallel signaling to pseudopod persistence and orientation.

Bosgraaf L, Van Haastert PJ.

PLoS One. 2009 Aug 31;4(8):e6842. doi: 10.1371/journal.pone.0006842.


Food searching strategy of amoeboid cells by starvation induced run length extension.

Van Haastert PJ, Bosgraaf L.

PLoS One. 2009 Aug 28;4(8):e6814. doi: 10.1371/journal.pone.0006814.


The ordered extension of pseudopodia by amoeboid cells in the absence of external cues.

Bosgraaf L, Van Haastert PJ.

PLoS One. 2009;4(4):e5253. doi: 10.1371/journal.pone.0005253. Epub 2009 Apr 22.


Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling.

Sato MJ, Kuwayama H, van Egmond WN, Takayama AL, Takagi H, van Haastert PJ, Yanagida T, Ueda M.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6667-72. doi: 10.1073/pnas.0809974106. Epub 2009 Apr 3.


Analysis of cell movement by simultaneous quantification of local membrane displacement and fluorescent intensities using Quimp2.

Bosgraaf L, van Haastert PJ, Bretschneider T.

Cell Motil Cytoskeleton. 2009 Mar;66(3):156-65. doi: 10.1002/cm.20338.


A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum.

Veltman DM, Akar G, Bosgraaf L, Van Haastert PJ.

Plasmid. 2009 Mar;61(2):110-8. doi: 10.1016/j.plasmid.2008.11.003. Epub 2008 Dec 23.


PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients.

Bosgraaf L, Keizer-Gunnink I, Van Haastert PJ.

J Cell Sci. 2008 Nov 1;121(Pt 21):3589-97. doi: 10.1242/jcs.031781. Epub 2008 Oct 7.


Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

van Egmond WN, Kortholt A, Plak K, Bosgraaf L, Bosgraaf S, Keizer-Gunnink I, van Haastert PJ.

J Biol Chem. 2008 Oct 31;283(44):30412-20. doi: 10.1074/jbc.M804265200. Epub 2008 Aug 14.


Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.

Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A.

EMBO J. 2008 Aug 20;27(16):2239-49. doi: 10.1038/emboj.2008.150. Epub 2008 Jul 24. Erratum in: EMBO J. 2008 Sep 3;27(17):2352.


The Roco protein family: a functional perspective.

Marín I, van Egmond WN, van Haastert PJ.

FASEB J. 2008 Sep;22(9):3103-10. doi: 10.1096/fj.08-111310. Epub 2008 Jun 3. Review.


Highlighting the role of Ras and Rap during Dictyostelium chemotaxis.

Kortholt A, van Haastert PJ.

Cell Signal. 2008 Aug;20(8):1415-22. doi: 10.1016/j.cellsig.2008.02.006. Epub 2008 Apr 1. Review.


Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum.

Veltman DM, Keizer-Gunnik I, Van Haastert PJ.

J Cell Biol. 2008 Feb 25;180(4):747-53. doi: 10.1083/jcb.200709180.


The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming.

Veltman DM, van Haastert PJ.

J Cell Sci. 2008 Jan 1;121(Pt 1):120-7. Epub 2007 Dec 11.


Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis.

Kortholt A, King JS, Keizer-Gunnink I, Harwood AJ, Van Haastert PJ.

Mol Biol Cell. 2007 Dec;18(12):4772-9. Epub 2007 Sep 26. Erratum in: Mol Biol Cell. 2008 Aug;19(8):3613.


Chemotaxis: navigating by multiple signaling pathways.

Van Haastert PJ, Veltman DM.

Sci STKE. 2007 Jul 24;2007(396):pe40. Review.


Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.

van Haastert PJ, Keizer-Gunnink I, Kortholt A.

J Cell Biol. 2007 Jun 4;177(5):809-16. Epub 2007 May 29.


Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling.

Keizer-Gunnink I, Kortholt A, Van Haastert PJ.

J Cell Biol. 2007 May 21;177(4):579-85.


Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs.

Kae H, Kortholt A, Rehmann H, Insall RH, Van Haastert PJ, Spiegelman GB, Weeks G.

EMBO Rep. 2007 May;8(5):477-82. Epub 2007 Mar 23.


Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4.

Loovers HM, Kortholt A, de Groote H, Whitty L, Nussbaum RL, van Haastert PJ.

Traffic. 2007 May;8(5):618-28. Epub 2007 Mar 2.


Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP.

Bader S, Kortholt A, Van Haastert PJ.

Biochem J. 2007 Feb 15;402(1):153-61.

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