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Items: 1 to 50 of 105

1.

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.

Moya IM, Castaldo SA, Van den Mooter L, Soheily S, Sansores-Garcia L, Jacobs J, Mannaerts I, Xie J, Verboven E, Hillen H, Algueró-Nadal A, Karaman R, Van Haele M, Kowalczyk W, De Waegeneer M, Verhulst S, Karras P, van Huffel L, Zender L, Marine JC, Roskams T, Johnson R, Aerts S, van Grunsven LA, Halder G.

Science. 2019 Nov 22;366(6468):1029-1034. doi: 10.1126/science.aaw9886.

PMID:
31754005
2.

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.

Bonnardel J, T'Jonck W, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y, Guilliams M.

Immunity. 2019 Oct 15;51(4):638-654.e9. doi: 10.1016/j.immuni.2019.08.017. Epub 2019 Sep 24.

3.

Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles.

Verhulst S, Roskams T, Sancho-Bru P, van Grunsven LA.

Cells. 2019 Sep 20;8(10). pii: E1117. doi: 10.3390/cells8101117.

4.

The miRFIB-Score: A Serological miRNA-Based Scoring Algorithm for the Diagnosis of Significant Liver Fibrosis.

Lambrecht J, Verhulst S, Reynaert H, van Grunsven LA.

Cells. 2019 Aug 29;8(9). pii: E1003. doi: 10.3390/cells8091003.

5.

A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease.

Lambrecht J, Verhulst S, Mannaerts I, Sowa JP, Best J, Canbay A, Reynaert H, van Grunsven LA.

EBioMedicine. 2019 May;43:501-512. doi: 10.1016/j.ebiom.2019.04.036. Epub 2019 Apr 27.

6.

Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers.

Lesaffer B, Verboven E, Van Huffel L, Moya IM, van Grunsven LA, Leclercq IA, Lemaigre FP, Halder G.

Cells. 2019 Apr 25;8(4). pii: E380. doi: 10.3390/cells8040380.

7.

Unfolded protein response is an early, non-critical event during hepatic stellate cell activation.

Mannaerts I, Thoen LFR, Eysackers N, Cubero FJ, Batista Leite S, Coldham I, Colle I, Trautwein C, van Grunsven LA.

Cell Death Dis. 2019 Feb 4;10(2):98. doi: 10.1038/s41419-019-1327-5.

8.

Aldehyde dehydrogenase activity of Wharton jelly mesenchymal stromal cells: isolation and characterization.

Najar M, Crompot E, van Grunsven LA, Dollé L, Lagneaux L.

Cytotechnology. 2019 Feb;71(1):427-441. doi: 10.1007/s10616-018-0283-8. Epub 2019 Jan 4.

9.

P311, Friend, or Foe of Tissue Fibrosis?

Stradiot L, Mannaerts I, van Grunsven LA.

Front Pharmacol. 2018 Oct 12;9:1151. doi: 10.3389/fphar.2018.01151. eCollection 2018. Review.

10.

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.

Coll M, Perea L, Boon R, Leite SB, Vallverdú J, Mannaerts I, Smout A, El Taghdouini A, Blaya D, Rodrigo-Torres D, Graupera I, Aguilar-Bravo B, Chesne C, Najimi M, Sokal E, Lozano JJ, van Grunsven LA, Verfaillie CM, Sancho-Bru P.

Cell Stem Cell. 2018 Jul 5;23(1):101-113.e7. doi: 10.1016/j.stem.2018.05.027. Epub 2018 Jun 28.

11.

Foreskin-derived mesenchymal stromal cells with aldehyde dehydrogenase activity: isolation and gene profiling.

Najar M, Crompot E, van Grunsven LA, Dollé L, Lagneaux L.

BMC Cell Biol. 2018 Apr 6;19(1):4. doi: 10.1186/s12860-018-0157-0.

12.

Aldehyde Dehydrogenase Activity in Adipose Tissue: Isolation and Gene Expression Profile of Distinct Sub-population of Mesenchymal Stromal Cells.

Najar M, Crompot E, van Grunsven LA, Dollé L, Lagneaux L.

Stem Cell Rev Rep. 2018 Aug;14(4):599-611. doi: 10.1007/s12015-017-9777-6.

PMID:
29333563
13.

Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard?

Lambrecht J, Verhulst S, Mannaerts I, Reynaert H, van Grunsven LA.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1024-1036. doi: 10.1016/j.bbadis.2018.01.009. Epub 2018 Jan 9. Review.

14.

Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression.

De Smedt E, Maes K, Verhulst S, Lui H, Kassambara A, Maes A, Robert N, Heirman C, Cakana A, Hose D, Breckpot K, van Grunsven LA, De Veirman K, Menu E, Vanderkerken K, Moreaux J, De Bruyne E.

Cancer Res. 2018 Mar 1;78(5):1155-1168. doi: 10.1158/0008-5472.CAN-17-1544. Epub 2017 Dec 19.

15.

Immuno-biological comparison of hepatic stellate cells in a reverted and activated state.

Najar M, Fayyad-Kazan H, Faour WH, El Taghdouini A, Raicevic G, van Grunsven LA, Najimi M, Sokal E, Lagneaux L.

Biomed Pharmacother. 2018 Feb;98:52-62. doi: 10.1016/j.biopha.2017.12.027. Epub 2017 Dec 12.

PMID:
29245066
16.

Isolation and Characterization of Bone Marrow Mesenchymal Stromal Cell Subsets in Culture Based on Aldehyde Dehydrogenase Activity.

Najar M, Dollé L, Crompot E, Verhulst S, van Grunsven LA, Busser H, Lagneaux L.

Tissue Eng Part C Methods. 2018 Feb;24(2):89-98. doi: 10.1089/ten.TEC.2017.0312. Epub 2018 Jan 16.

PMID:
29241418
17.

RNA-sequencing-based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers.

Ceulemans A, Verhulst S, Van Haele M, Govaere O, Ventura JJ, van Grunsven LA, Roskams T.

Cell Death Dis. 2017 Nov 2;8(11):e3164. doi: 10.1038/cddis.2017.543.

18.

3D in vitro models of liver fibrosis.

van Grunsven LA.

Adv Drug Deliv Rev. 2017 Nov 1;121:133-146. doi: 10.1016/j.addr.2017.07.004. Epub 2017 Jul 8. Review.

PMID:
28697953
19.

Functionality based method for simultaneous isolation of rodent hepatic sinusoidal cells.

Stradiot L, Verhulst S, Roosens T, Øie CI, Moya IM, Halder G, Mannaerts I, van Grunsven LA.

Biomaterials. 2017 Sep;139:91-101. doi: 10.1016/j.biomaterials.2017.05.047. Epub 2017 May 30.

PMID:
28595132
20.

Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury.

Perea L, Coll M, Sanjurjo L, Blaya D, Taghdouini AE, Rodrigo-Torres D, Altamirano J, Graupera I, Aguilar-Bravo B, Llopis M, Vallverdú J, Caballeria J, van Grunsven LA, Sarrias MR, Ginès P, Sancho-Bru P.

Hepatology. 2017 Sep;66(3):953-968. doi: 10.1002/hep.29215. Epub 2017 Jul 18.

21.

Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis.

Lambrecht J, Jan Poortmans P, Verhulst S, Reynaert H, Mannaerts I, van Grunsven LA.

Front Pharmacol. 2017 Feb 9;8:56. doi: 10.3389/fphar.2017.00056. eCollection 2017.

22.

Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis.

Paridaens A, Raevens S, Devisscher L, Bogaerts E, Verhelst X, Hoorens A, Van Vlierberghe H, van Grunsven LA, Geerts A, Colle I.

Int J Mol Sci. 2017 Jan 20;18(1). pii: E214. doi: 10.3390/ijms18010214.

23.

The GALAD scoring algorithm based on AFP, AFP-L3, and DCP significantly improves detection of BCLC early stage hepatocellular carcinoma.

Best J, Bilgi H, Heider D, Schotten C, Manka P, Bedreli S, Gorray M, Ertle J, van Grunsven LA, Dechêne A.

Z Gastroenterol. 2016 Dec;54(12):1296-1305. Epub 2016 Dec 9.

PMID:
27936479
24.

Human hepatic stellate cells and inflammation: A regulated cytokine network balance.

Najar M, Fayyad-Kazan H, Faour WH, El Taghdouini A, Raicevic G, Najimi M, Toungouz M, van Grunsven LA, Sokal E, Lagneaux L.

Cytokine. 2017 Feb;90:130-134. doi: 10.1016/j.cyto.2016.11.008. Epub 2016 Nov 17.

PMID:
27865205
25.

Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice.

Verhulst S, Best J, Syn WK, Reynaert H, Hellemans KH, Canbay A, Dolle L, van Grunsven LA.

Sci Rep. 2016 Nov 8;6:36586. doi: 10.1038/srep36586.

26.

Epigenetic regulation of hepatic stellate cell activation and liver fibrosis.

El Taghdouini A, van Grunsven LA.

Expert Rev Gastroenterol Hepatol. 2016 Dec;10(12):1397-1408. Epub 2016 Nov 2. Review.

PMID:
27762150
27.

Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication.

Paridaens A, Raevens S, Colle I, Bogaerts E, Vandewynckel YP, Verhelst X, Hoorens A, van Grunsven LA, Van Vlierberghe H, Geerts A, Devisscher L.

Liver Int. 2017 May;37(5):748-756. doi: 10.1111/liv.13261. Epub 2016 Oct 25.

PMID:
27706903
28.

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D.

Stem Cells. 2017 Mar;35(3):611-625. doi: 10.1002/stem.2521. Epub 2016 Nov 8.

29.

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis.

Verbeke L, Mannaerts I, Schierwagen R, Govaere O, Klein S, Vander Elst I, Windmolders P, Farre R, Wenes M, Mazzone M, Nevens F, van Grunsven LA, Trebicka J, Laleman W.

Sci Rep. 2016 Sep 16;6:33453. doi: 10.1038/srep33453.

30.

Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies.

Best J, Verhulst S, Syn WK, Lagaisse K, van Hul N, Heindryckx F, Sowa JP, Peeters L, Van Vlierberghe H, Leclercq IA, Canbay A, Dollé L, van Grunsven LA.

PLoS One. 2016 Sep 12;11(9):e0162286. doi: 10.1371/journal.pone.0162286. eCollection 2016.

31.

Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver.

Boens S, Verbinnen I, Verhulst S, Szekér K, Ferreira M, Gevaert T, Baes M, Roskams T, van Grunsven LA, Van Eynde A, Bollen M.

Stem Cells. 2016 Aug;34(8):2256-62. doi: 10.1002/stem.2375. Epub 2016 Jun 20.

32.

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro.

Leite SB, Roosens T, El Taghdouini A, Mannaerts I, Smout AJ, Najimi M, Sokal E, Noor F, Chesne C, van Grunsven LA.

Biomaterials. 2016 Feb;78:1-10. doi: 10.1016/j.biomaterials.2015.11.026. Epub 2015 Nov 17.

PMID:
26618472
33.

Advances in hepatic stem/progenitor cell biology.

Verhulst S, Best J, van Grunsven LA, Dollé L.

EXCLI J. 2015 Jan 6;14:33-47. doi: 10.17179/excli2014-576. eCollection 2015. Review.

34.

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

Govaere O, Wouters J, Petz M, Vandewynckel YP, Van den Eynde K, Van den Broeck A, Verhulst S, Dollé L, Gremeaux L, Ceulemans A, Nevens F, van Grunsven LA, Topal B, Vankelecom H, Giannelli G, Van Vlierberghe H, Mikulits W, Komuta M, Roskams T.

J Hepatol. 2016 Mar;64(3):609-17. doi: 10.1016/j.jhep.2015.11.011. Epub 2015 Nov 17.

35.

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells.

El Taghdouini A, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA.

Oncotarget. 2015 Sep 29;6(29):26729-45. doi: 10.18632/oncotarget.4925.

36.

The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis.

Lambrecht J, Mannaerts I, van Grunsven LA.

Front Physiol. 2015 Jul 28;6:209. doi: 10.3389/fphys.2015.00209. eCollection 2015. Review.

37.

In vitro reversion of activated primary human hepatic stellate cells.

El Taghdouini A, Najimi M, Sancho-Bru P, Sokal E, van Grunsven LA.

Fibrogenesis Tissue Repair. 2015 Aug 6;8:14. doi: 10.1186/s13069-015-0031-z. eCollection 2015.

38.

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells.

Coll M, El Taghdouini A, Perea L, Mannaerts I, Vila-Casadesús M, Blaya D, Rodrigo-Torres D, Affò S, Morales-Ibanez O, Graupera I, Lozano JJ, Najimi M, Sokal E, Lambrecht J, Ginès P, van Grunsven LA, Sancho-Bru P.

Sci Rep. 2015 Jun 22;5:11549. doi: 10.1038/srep11549.

39.

Are dietary emulsifiers making us fat?

Dollé L, de La Serre CB, van Grunsven LA.

J Hepatol. 2015 Oct;63(4):1045-8. doi: 10.1016/j.jhep.2015.06.005. Epub 2015 Jun 18. No abstract available.

PMID:
26095182
40.

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.

Mannaerts I, Leite SB, Verhulst S, Claerhout S, Eysackers N, Thoen LF, Hoorens A, Reynaert H, Halder G, van Grunsven LA.

J Hepatol. 2015 Sep;63(3):679-88. doi: 10.1016/j.jhep.2015.04.011. Epub 2015 Apr 20.

PMID:
25908270
41.

Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors.

Bogaerts E, Heindryckx F, Devisscher L, Paridaens A, Vandewynckel YP, Van den Bussche A, Verhelst X, Libbrecht L, van Grunsven LA, Geerts A, Van Vlierberghe H.

PLoS One. 2015 Mar 20;10(3):e0119555. doi: 10.1371/journal.pone.0119555. eCollection 2015.

42.

Inhibitory effect of dietary capsaicin on liver fibrosis in mice.

Bitencourt S, Stradiot L, Verhulst S, Thoen L, Mannaerts I, van Grunsven LA.

Mol Nutr Food Res. 2015 Jun;59(6):1107-16. doi: 10.1002/mnfr.201400649. Epub 2015 Apr 29.

PMID:
25755097
43.

Role of liver progenitors in liver regeneration.

Best J, Manka P, Syn WK, Dollé L, van Grunsven LA, Canbay A.

Hepatobiliary Surg Nutr. 2015 Feb;4(1):48-58. doi: 10.3978/j.issn.2304-3881.2015.01.16. Review.

44.

Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model.

Dusabineza AC, Najimi M, van Hul N, Legry V, Khuu DN, van Grunsven LA, Sokal E, Leclercq IA.

Cell Transplant. 2015;24(12):2557-71. doi: 10.3727/096368915X686788. Epub 2015 Feb 20.

PMID:
25706818
45.

Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells.

Dollé L, Boulter L, Leclercq IA, van Grunsven LA.

Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G573-8. doi: 10.1152/ajpgi.00420.2014. Epub 2015 Feb 5. Review.

46.

EpCAM and the biology of hepatic stem/progenitor cells.

Dollé L, Theise ND, Schmelzer E, Boulter L, Gires O, van Grunsven LA.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G233-50. doi: 10.1152/ajpgi.00069.2014. Epub 2014 Dec 4. Review.

47.

Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells.

Raicevic G, Najar M, Najimi M, El Taghdouini A, van Grunsven LA, Sokal E, Toungouz M.

Cytotherapy. 2015 Feb;17(2):174-85. doi: 10.1016/j.jcyt.2014.10.001. Epub 2014 Nov 21.

PMID:
25455740
48.

P311 modulates hepatic stellate cells migration.

Guimarães EL, Stradiot L, Mannaerts I, Schroyen B, van Grunsven LA.

Liver Int. 2015 Apr;35(4):1253-64. doi: 10.1111/liv.12691. Epub 2014 Oct 10.

PMID:
25243526
49.

Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.

Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK.

Gut. 2015 Jul;64(7):1120-31. doi: 10.1136/gutjnl-2013-306484. Epub 2014 Jun 5.

50.

The biliary epithelium gives rise to liver progenitor cells.

Rodrigo-Torres D, Affò S, Coll M, Morales-Ibanez O, Millán C, Blaya D, Alvarez-Guaita A, Rentero C, Lozano JJ, Maestro MA, Solar M, Arroyo V, Caballería J, van Grunsven LA, Enrich C, Ginès P, Bataller R, Sancho-Bru P.

Hepatology. 2014 Oct;60(4):1367-77. doi: 10.1002/hep.27078. Epub 2014 Aug 21.

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