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Items: 18


Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration.

Clark PA, Bhattacharya S, Elmayan A, Darjatmoko SR, Thuro BA, Yan MB, van Ginkel PR, Polans AS, Kuo JS.

J Neurosurg. 2017 May;126(5):1448-1460. doi: 10.3171/2016.1.JNS152077. Epub 2016 Jul 15.


Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells.

van Ginkel PR, Yan MB, Bhattacharya S, Polans AS, Kenealey JD.

Toxicol Appl Pharmacol. 2015 Nov 1;288(3):453-62. doi: 10.1016/j.taap.2015.08.016. Epub 2015 Sep 1.


The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization.

Kanavi MR, Darjatmoko S, Wang S, Azari AA, Farnoodian M, Kenealey JD, van Ginkel PR, Albert DM, Sheibani N, Polans AS.

Molecules. 2014 Oct 30;19(11):17578-603. doi: 10.3390/molecules191117578.


Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells.

Kenealey JD, Subramanian L, Van Ginkel PR, Darjatmoko S, Lindstrom MJ, Somoza V, Ghosh SK, Song Z, Hsung RP, Kwon GS, Eliceiri KW, Albert DM, Polans AS.

J Agric Food Chem. 2011 May 11;59(9):4979-86. doi: 10.1021/jf104901g. Epub 2011 Apr 12.


Resveratrol: challenges in translation to the clinic--a critical discussion.

Subramanian L, Youssef S, Bhattacharya S, Kenealey J, Polans AS, van Ginkel PR.

Clin Cancer Res. 2010 Dec 15;16(24):5942-8. doi: 10.1158/1078-0432.CCR-10-1486. Epub 2010 Nov 2. Review.


Use of combination therapy with cisplatin and calcitriol in the treatment of Y-79 human retinoblastoma xenograft model.

Kulkarni AD, van Ginkel PR, Darjatmoko SR, Lindstrom MJ, Albert DM.

Br J Ophthalmol. 2009 Aug;93(8):1105-8. doi: 10.1136/bjo.2008.152843. Epub 2009 Mar 30.


Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction.

van Ginkel PR, Darjatmoko SR, Sareen D, Subramanian L, Bhattacharya S, Lindstrom MJ, Albert DM, Polans AS.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1299-306. doi: 10.1167/iovs.07-1233.


Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria.

van Ginkel PR, Sareen D, Subramanian L, Walker Q, Darjatmoko SR, Lindstrom MJ, Kulkarni A, Albert DM, Polans AS.

Clin Cancer Res. 2007 Sep 1;13(17):5162-9.


1 alpha-Hydroxyvitamin D2 inhibits growth of human neuroblastoma.

van Ginkel PR, Yang W, Marcet MM, Chow CC, Kulkarni AD, Darjatmoko S, Lindstrom MJ, Lokken J, Bhattacharya S, Albert DM.

J Neurooncol. 2007 Dec;85(3):255-62. Epub 2007 Jun 30.


Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells.

Sareen D, van Ginkel PR, Takach JC, Mohiuddin A, Darjatmoko SR, Albert DM, Polans AS.

Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3708-16.


Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.

Subramanian L, Crabb JW, Cox J, Durussel I, Walker TM, van Ginkel PR, Bhattacharya S, Dellaria JM, Palczewski K, Polans AS.

Biochemistry. 2004 Sep 7;43(35):11175-86.


Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival.

van Ginkel PR, Gee RL, Shearer RL, Subramanian L, Walker TM, Albert DM, Meisner LF, Varnum BC, Polans AS.

Cancer Res. 2004 Jan 1;64(1):128-34.


Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma.

Walker TM, Van Ginkel PR, Gee RL, Ahmadi H, Subramanian L, Ksander BR, Meisner LF, Albert DM, Polans AS.

Arch Ophthalmol. 2002 Dec;120(12):1719-25.


Calcium-binding proteins and their assessment in ocular diseases.

Polans AS, Gee RL, Walker TM, van Ginkel PR.

Methods Enzymol. 2000;316:103-21. No abstract available.


The identification and differential expression of calcium-binding proteins associated with ocular melanoma.

Van Ginkel PR, Gee RL, Walker TM, Hu DN, Heizmann CW, Polans AS.

Biochim Biophys Acta. 1998 Dec 10;1448(2):290-7.


E2F-mediated growth regulation requires transcription factor cooperation.

van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ.

J Biol Chem. 1997 Jul 18;272(29):18367-74.


Topographical regulation of cone and rod opsin genes: parallel, position dependent levels of transcription.

van Ginkel PR, Timmers AM, Szél A, Hauswirth WW.

Brain Res Dev Brain Res. 1995 Oct 27;89(1):146-9.


Parallel regulation of fetal gene expression in different photoreceptor cell types.

van Ginkel PR, Hauswirth WW.

J Biol Chem. 1994 Feb 18;269(7):4986-92.

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