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Items: 18


Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017.

Uitdehaag JCM, Kooijman JJ, de Roos JADM, Prinsen MBW, Dylus J, Willemsen-Seegers N, Kawase Y, Sawa M, de Man J, van Gerwen SJC, Buijsman RC, Zaman GJR.

Mol Cancer Ther. 2019 Feb;18(2):470-481. doi: 10.1158/1535-7163.MCT-18-0877. Epub 2018 Oct 31.


Basis of catalytic assembly of the mitotic checkpoint complex.

Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A.

Nature. 2017 Feb 23;542(7642):498-502. doi: 10.1038/nature21384. Epub 2017 Jan 19.


Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.

Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, Musacchio A.

Cell. 2016 Nov 3;167(4):1028-1040.e15. doi: 10.1016/j.cell.2016.10.005. Epub 2016 Oct 27.


Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors.

Uitdehaag JC, de Roos JA, Prinsen MB, Willemsen-Seegers N, de Vetter JR, Dylus J, van Doornmalen AM, Kooijman J, Sawa M, van Gerwen SJ, de Man J, Buijsman RC, Zaman GJ.

Mol Cancer Ther. 2016 Dec;15(12):3097-3109. Epub 2016 Sep 1.


The pseudo GTPase CENP-M drives human kinetochore assembly.

Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A.

Elife. 2014 Jul 8;3:e02978. doi: 10.7554/eLife.02978.


KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats.

Krenn V, Overlack K, Primorac I, van Gerwen S, Musacchio A.

Curr Biol. 2014 Jan 6;24(1):29-39. doi: 10.1016/j.cub.2013.11.046. Epub 2013 Dec 19.


Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling.

Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A, Musacchio A.

Elife. 2013 Sep 24;2:e01030. doi: 10.7554/eLife.01030.


Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19807-12. doi: 10.1073/pnas.0905281106. Epub 2009 Nov 11.


Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.

Romier C, Ben Jelloul M, Albeck S, Buchwald G, Busso D, Celie PH, Christodoulou E, De Marco V, van Gerwen S, Knipscheer P, Lebbink JH, Notenboom V, Poterszman A, Rochel N, Cohen SX, Unger T, Sussman JL, Moras D, Sixma TK, Perrakis A.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1232-42. Epub 2006 Sep 19.


Variation in the SHC1 gene and longevity in humans.

Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG; 'Long Life' Study Group.

Exp Gerontol. 2004 Feb;39(2):263-8.


Estimating the probability of recontamination via the air using Monte Carlo simulations.

den Aantrekker ED, Beumer RR, van Gerwen SJ, Zwietering MH, van Schothorst M, Boom RM.

Int J Food Microbiol. 2003 Oct 15;87(1-2):1-15.


Physiological and mathematical aspects in setting criteria for decontamination of foods by physical means.

Smelt JP, Hellemons JC, Wouters PC, van Gerwen SJ.

Int J Food Microbiol. 2002 Sep 15;78(1-2):57-77. Review.


Sensitivity analysis in quantitative microbial risk assessment.

Zwieterin MH, van Gerwen SJ.

Int J Food Microbiol. 2000 Jul 15;58(3):213-21.


Stepwise quantitative risk assessment as a tool for characterization of microbiological food safety.

van Gerwen SJ, te Giffel MC, van't Riet K, Beumer RR, Zwietering MH.

J Appl Microbiol. 2000 Jun;88(6):938-51.


A data analysis of the irradiation parameter D10 for bacteria and spores under various conditions.

van Gerwen SJ, Rombouts FM, van't Riet K, Zwietering MH.

J Food Prot. 1999 Sep;62(9):1024-32.


Growth and inactivation models to be used in quantitative risk assessments.

van Gerwen SJ, Zwietering MH.

J Food Prot. 1998 Nov;61(11):1541-9.


An identification procedure for foodborne microbial hazards.

van Gerwen SJ, de Wit JC, Notermans S, Zwietering MH.

Int J Food Microbiol. 1997 Aug 19;38(1):1-15.


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