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Items: 16

1.

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.

Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten CCFMJ.

Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019.

2.

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases.

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A.

Sci Rep. 2019 Jun 6;9(1):8333. doi: 10.1038/s41598-019-44751-w.

3.

High-throughput elucidation of thrombus formation reveals sources of platelet function variability.

van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM.

Haematologica. 2019 Jun;104(6):1256-1267. doi: 10.3324/haematol.2018.198853. Epub 2018 Dec 13.

4.

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.

Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijpers MJE, Heemskerk JWM, Eble JA, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Jarvis GE, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA.

Blood. 2018 Sep 27;132(13):1399-1412. doi: 10.1182/blood-2017-08-802769. Epub 2018 Jun 13.

5.

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.

Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith CW, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Eble JA, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA.

Blood. 2018 Sep 27;132(13):1413-1425. doi: 10.1182/blood-2017-10-802975. Epub 2018 Jun 11.

6.

High-throughput measurement of human platelet aggregation under flow: application in hemostasis and beyond.

Brouns SLN, van Geffen JP, Heemskerk JWM.

Platelets. 2018 Nov;29(7):662-669. doi: 10.1080/09537104.2018.1447660. Epub 2018 Mar 14. Review.

PMID:
29537929
7.

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.

Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA.

Blood. 2018 Mar 8;131(10):1122-1144. doi: 10.1182/blood-2017-02-768077. Epub 2018 Jan 4.

8.

Platelet function is modified by common sequence variation in megakaryocyte super enhancers.

Petersen R, Lambourne JJ, Javierre BM, Grassi L, Kreuzhuber R, Ruklisa D, Rosa IM, Tomé AR, Elding H, van Geffen JP, Jiang T, Farrow S, Cairns J, Al-Subaie AM, Ashford S, Attwood A, Batista J, Bouman H, Burden F, Choudry FA, Clarke L, Flicek P, Garner SF, Haimel M, Kempster C, Ladopoulos V, Lenaerts AS, Materek PM, McKinney H, Meacham S, Mead D, Nagy M, Penkett CJ, Rendon A, Seyres D, Sun B, Tuna S, van der Weide ME, Wingett SW, Martens JH, Stegle O, Richardson S, Vallier L, Roberts DJ, Freson K, Wernisch L, Stunnenberg HG, Danesh J, Fraser P, Soranzo N, Butterworth AS, Heemskerk JW, Turro E, Spivakov M, Ouwehand WH, Astle WJ, Downes K, Kostadima M, Frontini M.

Nat Commun. 2017 Jul 13;8:16058. doi: 10.1038/ncomms16058.

9.

Effect of platelet-derived β-thromboglobulins on coagulation.

Egan K, van Geffen JP, Ma H, Kevane B, Lennon A, Allen S, Neary E, Parsons M, Maguire P, Wynne K, O' Kennedy R, Heemskerk JWM, Áinle FN.

Thromb Res. 2017 Jun;154:7-15. doi: 10.1016/j.thromres.2017.03.023. Epub 2017 Mar 30.

PMID:
28384443
10.

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaah6650. doi: 10.1126/scitranslmed.aah6650.

PMID:
28381538
11.

Sunitinib uptake inhibits platelet function in cancer patients.

Sabrkhany S, Griffioen AW, Pineda S, Sanders L, Mattheij N, van Geffen JP, Aarts MJ, Heemskerk JW, Oude Egbrink MG, Kuijpers MJ.

Eur J Cancer. 2016 Oct;66:47-54. doi: 10.1016/j.ejca.2016.07.016. Epub 2016 Aug 12.

PMID:
27525572
12.

Platelets and coagulation in thrombus formation: aberrations in the Scott syndrome.

van Geffen JP, Swieringa F, Heemskerk JW.

Thromb Res. 2016 May;141 Suppl 2:S12-6. doi: 10.1016/S0049-3848(16)30355-3. Review.

PMID:
27207414
13.

Acute and persistent platelet and coagulant activities in atherothrombosis.

Mastenbroek TG, van Geffen JP, Heemskerk JW, Cosemans JM.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S272-80. doi: 10.1111/jth.12972. Review.

14.

Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication.

Baaten CC, Veenstra LF, Wetzels R, van Geffen JP, Swieringa F, de Witt SM, Henskens YM, Crijns H, Nylander S, van Giezen JJ, Heemskerk JW, van der Meijden PE.

Haematologica. 2015 Sep;100(9):1131-8. doi: 10.3324/haematol.2014.122457. Epub 2015 Jun 25.

15.

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α.

Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1374-81. doi: 10.1161/ATVBAHA.114.305127. Epub 2015 Apr 23.

PMID:
25908768
16.

Normal platelet activation profile in patients with peripheral arterial disease on aspirin.

van Geffen JP, Kleinegris MC, Verdoold R, Baaten CC, Cosemans JM, Clemetson KJ, Ten Cate H, Roest M, de Laat B, Heemskerk JW.

Thromb Res. 2015 Mar;135(3):513-20. doi: 10.1016/j.thromres.2014.12.029. Epub 2015 Jan 6.

PMID:
25600441

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