Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 81

1.

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, van Rheenen J, Vermeulen M, Clevers H.

Cell Stem Cell. 2019 Jun 6;24(6):927-943.e6. doi: 10.1016/j.stem.2019.04.017. Epub 2019 May 23.

PMID:
31130514
2.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H.

Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3.

PMID:
31053628
3.

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

Gehart H, van Es JH, Hamer K, Beumer J, Kretzschmar K, Dekkers JF, Rios A, Clevers H.

Cell. 2019 Feb 21;176(5):1158-1173.e16. doi: 10.1016/j.cell.2018.12.029. Epub 2019 Jan 31.

PMID:
30712869
4.

Profiling proliferative cells and their progeny in damaged murine hearts.

Kretzschmar K, Post Y, Bannier-Hélaouët M, Mattiotti A, Drost J, Basak O, Li VSW, van den Born M, Gunst QD, Versteeg D, Kooijman L, van der Elst S, van Es JH, van Rooij E, van den Hoff MJB, Clevers H.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12245-E12254. doi: 10.1073/pnas.1805829115. Epub 2018 Dec 7.

5.

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.

Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H.

Nat Cell Biol. 2018 Aug;20(8):909-916. doi: 10.1038/s41556-018-0143-y. Epub 2018 Jul 23.

6.

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche.

Chakrabarti R, Celià-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, Clevers H, Kang Y.

Science. 2018 Jun 29;360(6396). pii: eaan4153. doi: 10.1126/science.aan4153. Epub 2018 May 17.

PMID:
29773667
7.

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.

Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E610-E619. doi: 10.1073/pnas.1715911114. Epub 2018 Jan 8.

8.

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche.

Artegiani B, Lyubimova A, Muraro M, van Es JH, van Oudenaarden A, Clevers H.

Cell Rep. 2017 Dec 12;21(11):3271-3284. doi: 10.1016/j.celrep.2017.11.050.

9.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin H, van Es JH, Offerhaus GJ, Clevers H.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11859-11864. Epub 2016 Oct 5.

10.

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Daly CS, Shaw P, Ordonez LD, Williams GT, Quist J, Grigoriadis A, Van Es JH, Clevers H, Clarke AR, Reed KR.

Oncogene. 2017 Mar 30;36(13):1793-1803. doi: 10.1038/onc.2016.342. Epub 2016 Oct 3.

11.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29.

12.

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.

Cell Stem Cell. 2016 Aug 4;19(2):205-216. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12.

13.

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, Parry L, Goldman SA, Clevers H, Lu QR.

Nat Commun. 2016 Mar 9;7:10883. doi: 10.1038/ncomms10883.

14.

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.

Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2016 Feb 4;18(2):203-13. doi: 10.1016/j.stem.2016.01.001. Epub 2016 Jan 28.

15.

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.

Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, van Es JH, Nieuwenhuis EE, Middendorp S.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12408-13. doi: 10.1073/pnas.1516672112. Epub 2015 Sep 21.

16.

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.

Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW.

Cell. 2015 Jun 18;161(7):1539-1552. doi: 10.1016/j.cell.2015.05.033.

17.

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.

Koo BK, van Es JH, van den Born M, Clevers H.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7548-50. doi: 10.1073/pnas.1508113112. Epub 2015 May 28.

18.

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.

van Es JH, Clevers H.

Methods Mol Biol. 2015;1267:125-44. doi: 10.1007/978-1-4939-2297-0_6.

PMID:
25636467
19.

Targeting development of incretin-producing cells increases insulin secretion.

Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ.

J Clin Invest. 2015 Jan;125(1):379-85. doi: 10.1172/JCI75838. Epub 2014 Dec 15.

20.

A20 controls intestinal homeostasis through cell-specific activities.

Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G.

Nat Commun. 2014 Sep 30;5:5103. doi: 10.1038/ncomms6103.

PMID:
25267258
21.

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.

Cell Rep. 2014 Sep 25;8(6):1919-1929. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.

22.

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.

Basak O, van de Born M, Korving J, Beumer J, van der Elst S, van Es JH, Clevers H.

EMBO J. 2014 Sep 17;33(18):2057-68. doi: 10.15252/embj.201488017. Epub 2014 Aug 4.

23.

Paneth cells.

van Es JH, Clevers H.

Curr Biol. 2014 Jun 16;24(12):R547-R548. doi: 10.1016/j.cub.2014.04.049. No abstract available.

24.

GRASP65 controls the cis Golgi integrity in vivo.

Veenendaal T, Jarvela T, Grieve AG, van Es JH, Linstedt AD, Rabouille C.

Biol Open. 2014 May 2;3(6):431-43. doi: 10.1242/bio.20147757.

25.

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.

Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H.

EMBO Rep. 2014 Jan;15(1):62-9. doi: 10.1002/embr.201337799. Epub 2013 Dec 15.

26.

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.

Yin X, Farin HF, van Es JH, Clevers H, Langer R, Karp JM.

Nat Methods. 2014 Jan;11(1):106-12. doi: 10.1038/nmeth.2737. Epub 2013 Dec 1.

27.

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.

de Groot RE, Farin HF, Macůrková M, van Es JH, Clevers HC, Korswagen HC.

PLoS One. 2013 Oct 9;8(10):e76971. doi: 10.1371/journal.pone.0076971. eCollection 2013.

28.

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H.

Cell. 2013 Oct 10;155(2):357-68. doi: 10.1016/j.cell.2013.09.008.

29.

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H.

EMBO J. 2013 Oct 16;32(20):2708-21. doi: 10.1038/emboj.2013.204. Epub 2013 Sep 17.

30.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ.

Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15.

31.

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

Kaaij LT, van de Wetering M, Fang F, Decato B, Molaro A, van de Werken HJ, van Es JH, Schuijers J, de Wit E, de Laat W, Hannon GJ, Clevers HC, Smith AD, Ketting RF.

Genome Biol. 2013 May 28;14(5):R50. doi: 10.1186/gb-2013-14-5-r50.

32.

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.

Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone G, Cross JC, Wang H.

PLoS Biol. 2013;11(4):e1001536. doi: 10.1371/journal.pbio.1001536. Epub 2013 Apr 16.

33.

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H.

Nature. 2013 Feb 14;494(7436):247-50. doi: 10.1038/nature11826. Epub 2013 Jan 27.

34.

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

Boj SF, van Es JH, Huch M, Li VS, José A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H.

Cell. 2012 Dec 21;151(7):1595-607. doi: 10.1016/j.cell.2012.10.053.

35.

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

van Es JH, Sato T, van de Wetering M, Lyubimova A, Yee Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens ACM, Barker N, van Oudenaarden A, Clevers H.

Nat Cell Biol. 2012 Oct;14(10):1099-1104. doi: 10.1038/ncb2581. Epub 2012 Sep 23.

36.

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H.

Cell Rep. 2012 Sep 27;2(3):540-52. doi: 10.1016/j.celrep.2012.08.018. Epub 2012 Sep 20.

37.

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.

Farin HF, Van Es JH, Clevers H.

Gastroenterology. 2012 Dec;143(6):1518-1529.e7. doi: 10.1053/j.gastro.2012.08.031. Epub 2012 Aug 23.

PMID:
22922422
38.

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.

Nature. 2012 Aug 30;488(7413):665-9. doi: 10.1038/nature11308.

PMID:
22895187
39.

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H.

Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. Epub 2012 Aug 1.

40.

NOTCH1 signaling as a therapeutic target in Sézary syndrome.

van der Fits L, Qin Y, Out-Luiting JJ, Vermeer KG, Whittaker S, van Es JH, Tensen CP, Vermeer MH.

J Invest Dermatol. 2012 Dec;132(12):2810-7. doi: 10.1038/jid.2012.203. Epub 2012 Jun 21.

41.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H.

EMBO J. 2012 Jun 12;31(14):3079-91. doi: 10.1038/emboj.2012.166.

42.

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal.

van Es JH, Haegebarth A, Kujala P, Itzkovitz S, Koo BK, Boj SF, Korving J, van den Born M, van Oudenaarden A, Robine S, Clevers H.

Mol Cell Biol. 2012 May;32(10):1918-27. doi: 10.1128/MCB.06288-11. Epub 2012 Mar 5.

43.

Controlled gene expression in primary Lgr5 organoid cultures.

Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H.

Nat Methods. 2011 Dec 4;9(1):81-3. doi: 10.1038/nmeth.1802.

PMID:
22138822
44.

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H.

Gastroenterology. 2011 Nov;141(5):1762-72. doi: 10.1053/j.gastro.2011.07.050. Epub 2011 Sep 2.

PMID:
21889923
45.

The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.

Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ.

PLoS One. 2011;6(8):e22616. doi: 10.1371/journal.pone.0022616. Epub 2011 Aug 3.

46.

CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo.

Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S.

Circ Res. 2011 Aug 19;109(5):486-91. doi: 10.1161/CIRCRESAHA.111.250738. Epub 2011 Jul 21.

PMID:
21778431
47.

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.

Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P.

J Cell Biol. 2011 Mar 7;192(5):767-80. doi: 10.1083/jcb.201010127.

48.

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H.

Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28.

49.

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.

van Es JH, de Geest N, van de Born M, Clevers H, Hassan BA.

Nat Commun. 2010 May 17;1:18. doi: 10.1038/ncomms1017.

50.

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H.

Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016/j.cell.2010.09.016.

Supplemental Content

Loading ...
Support Center