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Items: 26


Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia.

Kiers D, van Eijk LT, van der Hoeven JG, Swinkels DW, Pickkers P, Kox M.

Haematologica. 2019 Jun;104(6):e230-e232. doi: 10.3324/haematol.2018.202796. Epub 2019 Jan 17. No abstract available.


Colloids in Major Abdominal Surgery: Are They Really Better?

Slagt C, van Eijk LT.

Anesthesiology. 2018 Aug;129(2):385-386. doi: 10.1097/ALN.0000000000002291. No abstract available.


Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.


Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.

van Groenendael R, Kox M, van Eijk LT, Pickkers P.

Nephron. 2018;140(2):148-151. doi: 10.1159/000490772. Epub 2018 Jul 6.


Man flu: less inflammation but more consequences in men than women.

van Eijk LT, Pickkers P.

BMJ. 2018 Feb 7;360:k439. doi: 10.1136/bmj.k439. No abstract available.


Inflammation-associated changes in lipid composition and the organization of the erythrocyte membrane.

Dinkla S, van Eijk LT, Fuchs B, Schiller J, Joosten I, Brock R, Pickkers P, Bosman GJ.

BBA Clin. 2016 Apr 3;5:186-92. doi: 10.1016/j.bbacli.2016.03.007. eCollection 2016 Jun.


Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study.

Kox M, van Eijk LT, Verhaak T, Frenzel T, Kiers HD, Gerretsen J, van der Hoeven JG, Kornet L, Scheiner A, Pickkers P.

Arthritis Res Ther. 2015 Jun 7;17:150. doi: 10.1186/s13075-015-0667-5.


Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo.

Cox LA, van Eijk LT, Ramakers BP, Dorresteijn MJ, Gerretsen J, Kox M, Pickkers P.

Shock. 2015 Apr;43(4):322-6. doi: 10.1097/SHK.0000000000000320.


Hepcidin as a target of therapy in the treatment of anemia after trauma.

van Eijk LT, Kox M, Pickkers P.

Crit Care Med. 2015 Jan;43(1):e36-7. doi: 10.1097/CCM.0000000000000689. No abstract available.


Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans.

van Eijk LT, John AS, Schwoebel F, Summo L, Vauléon S, Zöllner S, Laarakkers CM, Kox M, van der Hoeven JG, Swinkels DW, Riecke K, Pickkers P.

Blood. 2014 Oct 23;124(17):2643-6. doi: 10.1182/blood-2014-03-559484. Epub 2014 Aug 27.


Gender-specific differences in outcome after trauma may be explained by differences in immunity.

van Eijk LT, Kox M, Pickkers P.

Crit Care. 2014 Mar 17;18(2):418. doi: 10.1186/cc13768. No abstract available.


Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans.

Kox M, van Eijk LT, Zwaag J, van den Wildenberg J, Sweep FC, van der Hoeven JG, Pickkers P.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7379-84. doi: 10.1073/pnas.1322174111. Epub 2014 May 5.


Systemic inflammation decreases pain threshold in humans in vivo.

de Goeij M, van Eijk LT, Vanelderen P, Wilder-Smith OH, Vissers KC, van der Hoeven JG, Kox M, Scheffer GJ, Pickkers P.

PLoS One. 2013 Dec 17;8(12):e84159. doi: 10.1371/journal.pone.0084159. eCollection 2013.


The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial.

van Eijk LT, Heemskerk S, van der Pluijm RW, van Wijk SM, Peters WH, van der Hoeven JG, Kox M, Swinkels DW, Pickkers P.

Haematologica. 2014 Mar;99(3):579-87. doi: 10.3324/haematol.2013.088047. Epub 2013 Nov 15.


Body mass index is not associated with cytokine induction during experimental human endotoxemia.

van Eijk LT, van der Pluijm RW, Ramakers BP, Dorresteijn MJ, van der Hoeven JG, Kox M, Pickkers P.

Innate Immun. 2014 Jan;20(1):61-7. doi: 10.1177/1753425913481821. Epub 2013 Apr 19.


The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

Schwoebel F, van Eijk LT, Zboralski D, Sell S, Buchner K, Maasch C, Purschke WG, Humphrey M, Zöllner S, Eulberg D, Morich F, Pickkers P, Klussmann S.

Blood. 2013 Mar 21;121(12):2311-5. doi: 10.1182/blood-2012-09-456756. Epub 2013 Jan 24.


Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study.

van Eijk LT, Kroot JJ, Tromp M, van der Hoeven JG, Swinkels DW, Pickkers P.

Crit Care. 2011;15(1):R9. doi: 10.1186/cc9408. Epub 2011 Jan 10.


Endothelium-dependent vascular dysfunction in septic patients.

van Eijk LT, van der Hoeven JG, Pickkers P.

Anaesthesia. 2008 Aug;63(8):883-4; author reply 884-5. doi: 10.1111/j.1365-2044.2008.05613_1.x. No abstract available.


Gender influences in vivo human responses to endotoxin.

van Eijk LT, Dorresteijn MJ, Pikkers P.

Shock. 2008 Mar;29(3):422; author reply 422-3. doi: 10.1097/01.shk.0000286274.70563.99. No abstract available.


Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers.

van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P.

Crit Care Med. 2007 Jun;35(6):1464-9.


Plasma obtained during human endotoxemia increases endothelial albumin permeability in vitro.

van Eijk LT, Nooteboom A, Hendriks T, Sprong T, Netea MG, Smits P, van der Hoeven JG, Pickkers P.

Shock. 2006 Apr;25(4):358-62.


Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia.

Dorresteijn MJ, van Eijk LT, Netea MG, Smits P, van der Hoeven JG, Pickkers P.

J Endotoxin Res. 2005;11(5):287-93.


Small increases in the urinary excretion of glutathione S-transferase A1 and P1 after cardiac surgery are not associated with clinically relevant renal injury.

Eijkenboom JJ, van Eijk LT, Pickkers P, Peters WH, Wetzels JF, van der Hoeven HG.

Intensive Care Med. 2005 May;31(5):664-7. Epub 2005 Apr 6.


Microvascular permeability during experimental human endotoxemia: an open intervention study.

van Eijk LT, Pickkers P, Smits P, van den Broek W, Bouw MP, van der Hoeven JG.

Crit Care. 2005 Apr;9(2):R157-64. Epub 2005 Feb 21.


Severe vagal response after endotoxin administration in humans.

van Eijk LT, Pickkers P, Smits P, Bouw MP, van der Hoeven JG.

Intensive Care Med. 2004 Dec;30(12):2279-81. Epub 2004 Oct 26.


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