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Items: 1 to 50 of 183

1.

Innate immune protection from pneumonia virus of mice induced by a novel immunomodulator is prolonged by dual treatment and mediated by macrophages.

Martinez EC, Garg R, van Drunen Littel-van den Hurk S.

Antiviral Res. 2019 Nov;171:104594. doi: 10.1016/j.antiviral.2019.104594. Epub 2019 Aug 27.

PMID:
31470041
2.

Selection of adjuvants for vaccines targeting specific pathogens.

Sarkar I, Garg R, van Drunen Littel-van den Hurk S.

Expert Rev Vaccines. 2019 May;18(5):505-521. doi: 10.1080/14760584.2019.1604231. Epub 2019 Apr 22.

PMID:
31009255
3.

Metabolomic and Immunological Profiling of Respiratory Syncytial Virus Infection after Intranasal Immunization with a Subunit Vaccine Candidate.

Sarkar I, Zardini Buzatto A, Garg R, Li L, van Drunen Littel-van den Hurk S.

J Proteome Res. 2019 Mar 1;18(3):1145-1161. doi: 10.1021/acs.jproteome.8b00806. Epub 2019 Feb 8.

PMID:
30706717
4.

US3 Kinase-Mediated Phosphorylation of Tegument Protein VP8 Plays a Critical Role in the Cellular Localization of VP8 and Its Effect on the Lipid Metabolism of Bovine Herpesvirus 1-Infected Cells.

Zhang K, Donovan T, Sucharita S, Brownlie R, Snider M, Tikoo SK, van Drunen Littel-van den Hurk S.

J Virol. 2019 Mar 5;93(6). pii: e02151-18. doi: 10.1128/JVI.02151-18. Print 2019 Mar 15.

5.

The bovine herpesvirus-1 major tegument protein, VP8, interacts with host HSP60 concomitant with deregulation of mitochondrial function.

Afroz S, Brownlie R, Fodje M, van Drunen Littel-van den Hurk S.

Virus Res. 2019 Feb;261:37-49. doi: 10.1016/j.virusres.2018.12.006. Epub 2018 Dec 11.

PMID:
30550895
6.

Maternal vaccination with a novel chimeric glycoprotein formulated with a polymer-based adjuvant provides protection from human parainfluenza virus type 3 in newborn lambs.

Garg R, Latimer L, Gomis S, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Antiviral Res. 2019 Feb;162:54-60. doi: 10.1016/j.antiviral.2018.12.010. Epub 2018 Dec 12.

PMID:
30550799
7.

A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3.

Garg R, Brownlie R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Antiviral Res. 2018 Oct;158:78-87. doi: 10.1016/j.antiviral.2018.07.021. Epub 2018 Jul 30.

PMID:
30071204
8.

The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis.

Afroz S, Garg R, Fodje M, van Drunen Littel-van den Hurk S.

J Virol. 2018 Jul 17;92(15). pii: e00773-18. doi: 10.1128/JVI.00773-18. Print 2018 Aug 1.

9.

The respiratory syncytial virus fusion protein formulated with a polymer-based adjuvant induces multiple signaling pathways in macrophages.

Sarkar I, Garg R, van Drunen Littel-van den Hurk S.

Vaccine. 2018 Apr 19;36(17):2326-2336. doi: 10.1016/j.vaccine.2018.03.016. Epub 2018 Mar 17.

PMID:
29559168
10.

Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity.

Garg R, Brownlie R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2017 Dec 18;35(51):7139-7146. doi: 10.1016/j.vaccine.2017.10.095. Epub 2017 Nov 16.

PMID:
29153777
11.

Defining a standard and weighted mathematical index for maturation of dendritic cells.

Landi A, Aligodarzi MT, Khodadadi A, Babiuk LA, van Drunen Littel-van den Hurk S.

Immunology. 2018 Apr;153(4):532-544. doi: 10.1111/imm.12856. Epub 2017 Nov 24.

12.

Intranasal immunization with a single dose of the fusion protein formulated with a combination adjuvant induces long-term protective immunity against respiratory syncytial virus.

Garg R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2894-2901. doi: 10.1080/21645515.2017.1349584. Epub 2017 Aug 21.

13.

A novel combination adjuvant platform for human and animal vaccines.

Garg R, Babiuk L, van Drunen Littel-van den Hurk S, Gerdts V.

Vaccine. 2017 Aug 16;35(35 Pt A):4486-4489. doi: 10.1016/j.vaccine.2017.05.067. Epub 2017 Jun 7.

PMID:
28599794
14.

Herpesvirus tegument and immediate early proteins are pioneers in the battle between viral infection and nuclear domain 10-related host defense.

Zhang K, van Drunen Littel-van den Hurk S.

Virus Res. 2017 Jun 15;238:40-48. doi: 10.1016/j.virusres.2017.05.023. Epub 2017 Jun 3. Review.

PMID:
28583441
15.

Local innate responses and protective immunity after intradermal immunization with bovine viral diarrhea virus E2 protein formulated with a combination adjuvant in cattle.

Sadat SMA, Snider M, Garg R, Brownlie R, van Drunen Littel-van den Hurk S.

Vaccine. 2017 Jun 14;35(27):3466-3473. doi: 10.1016/j.vaccine.2017.05.029. Epub 2017 May 17.

PMID:
28527686
16.

Us3 and Us9 proteins contribute to the stromal invasion of bovine herpesvirus 1 in the respiratory mucosa.

Zhao J, Poelaert KCK, Steukers L, Favoreel HW, Li Y, Chowdhury SI, van Drunen Littel-van den Hurk S, Caij B, Nauwynck HJ.

J Gen Virol. 2017 May 18. doi: 10.1099/jgv.0.000764. [Epub ahead of print]

PMID:
28516841
17.

Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal pneumonia virus of mice.

Martinez EC, Garg R, Shrivastava P, Gomis S, van Drunen Littel-van den Hurk S.

Antiviral Res. 2016 Nov;135:108-119. doi: 10.1016/j.antiviral.2016.10.008. Epub 2016 Oct 19.

PMID:
27771388
18.

Induction of functional interferon alpha and gamma responses during acute infection of cattle with non-cytopathic bovine viral diarrhea virus.

Van Wyk B, Snider M, Scruten E, van Drunen Littel-van den Hurk S, Napper S.

Vet Microbiol. 2016 Nov 15;195:104-114. doi: 10.1016/j.vetmic.2016.09.015. Epub 2016 Sep 22.

PMID:
27771055
19.

A single intranasal immunization with a subunit vaccine formulation induces higher mucosal IgA production than live respiratory syncytial virus.

Garg R, Theaker M, Martinez EC, van Drunen Littel-van den Hurk S.

Virology. 2016 Dec;499:288-297. doi: 10.1016/j.virol.2016.09.023. Epub 2016 Oct 6.

20.

Formulation of the respiratory syncytial virus fusion protein with a polymer-based combination adjuvant promotes transient and local innate immune responses and leads to improved adaptive immunity.

Sarkar I, Garg R, van Drunen Littel-van den Hurk S.

Vaccine. 2016 Sep 30;34(42):5114-5124. doi: 10.1016/j.vaccine.2016.08.053. Epub 2016 Aug 31.

PMID:
27591951
21.

IL-12p40 gene-deficient BALB/c mice exhibit lower weight loss, reduced lung pathology and decreased sensitization to allergen in response to infection with pneumonia virus of mice.

Shrivastava P, Sarkar I, Atanley E, Gomis S, van Drunen Littel-van den Hurk S.

Virology. 2016 Oct;497:1-10. doi: 10.1016/j.virol.2016.06.020. Epub 2016 Jul 9.

22.

Protection of neonates and infants by maternal immunization.

Gerdts V, van Drunen Littel-van den Hurk S, Potter A.

Expert Rev Vaccines. 2016 Nov;15(11):1347-1349. Epub 2016 Jun 8. No abstract available.

PMID:
27248694
23.

Phosphorylation of Bovine Herpesvirus 1 VP8 Plays a Role in Viral DNA Encapsidation and Is Essential for Its Cytoplasmic Localization and Optimal Virion Incorporation.

Zhang K, Brownlie R, Snider M, van Drunen Littel-van den Hurk S.

J Virol. 2016 Apr 14;90(9):4427-4440. doi: 10.1128/JVI.00219-16. Print 2016 May.

24.

VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling.

Afroz S, Brownlie R, Fodje M, van Drunen Littel-van den Hurk S.

J Virol. 2016 Apr 29;90(10):4889-4904. doi: 10.1128/JVI.00017-16. Print 2016 May 15.

25.

The response of aged mice to primary infection and re-infection with pneumonia virus of mice depends on their genetic background.

Shrivastava P, Watkiss E, van Drunen Littel-van den Hurk S.

Immunobiology. 2016 Mar;221(3):494-502. doi: 10.1016/j.imbio.2015.10.008. Epub 2015 Nov 18.

PMID:
26621546
26.

Maternal immunization with respiratory syncytial virus fusion protein formulated with a novel combination adjuvant provides protection from RSV in newborn lambs.

Garg R, Latimer L, Wang Y, Simko E, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2016 Jan 4;34(2):261-269. doi: 10.1016/j.vaccine.2015.11.029. Epub 2015 Nov 24.

PMID:
26616551
27.

Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge.

UCVM Class of 2014, McCorkell R, Horsman SR, Wynne-Edwards K, Muench G, van Drunen Littel-van den Hurk S, Waeckerlin R, Eschbaumer M, Dardari R, Chaiyakul M, Gajda P, Czub M, van der Meer F.

Can Vet J. 2015 Oct;56(10):1075-83.

28.

Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice.

Shrivastava P, Atanley E, Sarkar I, Watkiss E, Gomis S, van Drunen Littel-van den Hurk S.

Virology. 2015 Nov;485:233-43. doi: 10.1016/j.virol.2015.07.019. Epub 2015 Aug 25.

29.

Large animal models for vaccine development and testing.

Gerdts V, Wilson HL, Meurens F, van Drunen Littel-van den Hurk S, Wilson D, Walker S, Wheler C, Townsend H, Potter AA.

ILAR J. 2015;56(1):53-62. doi: 10.1093/ilar/ilv009. Review.

PMID:
25991698
30.

Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1.

Zhang K, Afroz S, Brownlie R, Snider M, van Drunen Littel-van den Hurk S.

J Virol. 2015 Apr;89(8):4598-611. doi: 10.1128/JVI.03180-14. Epub 2015 Feb 11.

31.

The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies.

Garg R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2015 Mar 10;33(11):1338-44. doi: 10.1016/j.vaccine.2015.01.041. Epub 2015 Jan 28.

PMID:
25637860
32.

Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.

Schulz S, Landi A, Garg R, Wilson JA, van Drunen Littel-van den Hurk S.

Clin Exp Immunol. 2015 Jun;180(3):484-98. doi: 10.1111/cei.12586.

33.

Interaction of VP8 with mRNAs of bovine herpesvirus-1.

Islam A, Schulz S, Afroz S, Babiuk LA, van Drunen Littel-van den Hurk S.

Virus Res. 2015 Feb 2;197:116-26. doi: 10.1016/j.virusres.2014.12.017. Epub 2014 Dec 18. Erratum in: Virus Res. 2015 Dec 2;210():356.

PMID:
25529439
34.

The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle.

Snider M, Garg R, Brownlie R, van den Hurk JV, van Drunen Littel-van den Hurk S.

Vaccine. 2014 Nov 28;32(50):6758-64. doi: 10.1016/j.vaccine.2014.10.010. Epub 2014 Oct 25.

PMID:
25454860
35.

Immunogenicity of a bovine herpesvirus 1 glycoprotein D DNA vaccine complexed with bovine neutrophil beta-defensin 3.

Mackenzie-Dyck S, Latimer L, Atanley E, Kovacs-Nolan J, Attah-Poku S, Babiuk LA, van Drunen Littel-van den Hurk S.

Clin Vaccine Immunol. 2015 Jan;22(1):79-90. doi: 10.1128/CVI.00476-14. Epub 2014 Nov 5.

36.

Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology.

Alves Dummer L, Pereira Leivas Leite F, van Drunen Littel-van den Hurk S.

Vet Res. 2014 Oct 31;45:111. doi: 10.1186/s13567-014-0111-x. Review.

37.

Future considerations for dendritic cell immunotherapy against chronic viral infections.

Atanley E, van Drunen Littel-van den Hurk S.

Expert Rev Clin Immunol. 2014 Jun;10(6):801-13. doi: 10.1586/1744666X.2014.907742. Epub 2014 Apr 16. Review.

PMID:
24734867
38.

Immune responses of mice against recombinant bovine herpesvirus 5 glycoprotein D.

Dummer LA, Araujo IL, Finger PF, dos Santos AG Jr, da Rosa MC, Conceição FR, Fischer G, van Drunen Littel-van den Hurk S, Leite FP.

Vaccine. 2014 May 1;32(21):2413-9. doi: 10.1016/j.vaccine.2014.03.011. Epub 2014 Mar 20.

PMID:
24657716
39.

Vaccination with the RSV fusion protein formulated with a combination adjuvant induces long-lasting protective immunity.

Garg R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

J Gen Virol. 2014 May;95(Pt 5):1043-54. doi: 10.1099/vir.0.062570-0. Epub 2014 Feb 26.

PMID:
24572813
40.

Inclusion of the bovine neutrophil beta-defensin 3 with glycoprotein D of bovine herpesvirus 1 in a DNA vaccine modulates immune responses of mice and cattle.

Mackenzie-Dyck S, Kovacs-Nolan J, Snider M, Babiuk LA, van Drunen Littel-van den Hurk S.

Clin Vaccine Immunol. 2014 Apr;21(4):463-77. doi: 10.1128/CVI.00696-13. Epub 2014 Jan 22.

41.

Vaccine Potentiation by Combination Adjuvants.

Levast B, Awate S, Babiuk L, Mutwiri G, Gerdts V, van Drunen Littel-van den Hurk S.

Vaccines (Basel). 2014 Apr 14;2(2):297-322. doi: 10.3390/vaccines2020297. Review.

42.

Early postnatal immunisation against gonadotrophin-releasing hormone induces a high but differential immune response in heifer calves.

Hernandez-Medrano JH, Williams RW, van Drunen Littel-van den Hurk S, Peters AR, Hannant D, Campbell BK, Webb R.

Res Vet Sci. 2013 Oct;95(2):472-9. doi: 10.1016/j.rvsc.2013.05.014. Epub 2013 Jun 15.

PMID:
23778305
43.

A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain.

Ogunremi O, Pasick J, Kobinger GP, Hannaman D, Berhane Y, Clavijo A, van Drunen Littel-van den Hurk S.

Clin Vaccine Immunol. 2013 Apr;20(4):491-500. doi: 10.1128/CVI.00577-12. Epub 2013 Jan 30.

44.

Innate and adaptive immune response to pneumonia virus of mice in a resistant and a susceptible mouse strain.

Watkiss ER, Shrivastava P, Arsic N, Gomis S, van Drunen Littel-van den Hurk S.

Viruses. 2013 Jan 21;5(1):295-320. doi: 10.3390/v5010295.

45.

The role of dendritic cells in innate and adaptive immunity to respiratory syncytial virus, and implications for vaccine development.

Garg R, Shrivastava P, van Drunen Littel-van den Hurk S.

Expert Rev Vaccines. 2012 Dec;11(12):1441-57. doi: 10.1586/erv.12.117. Review.

PMID:
23252388
46.

Two doses of bovine viral diarrhea virus DNA vaccine delivered by electroporation induce long-term protective immune responses.

van Drunen Littel-van den Hurk S, Lawman Z, Snider M, Wilson D, van den Hurk JV, Ellefsen B, Hannaman D.

Clin Vaccine Immunol. 2013 Feb;20(2):166-73. doi: 10.1128/CVI.00565-12. Epub 2012 Dec 5.

47.

Carrier molecules for use in veterinary vaccines.

Gerdts V, Mutwiri G, Richards J, van Drunen Littel-van den Hurk S, Potter AA.

Vaccine. 2013 Jan 11;31(4):596-602. doi: 10.1016/j.vaccine.2012.11.067. Epub 2012 Dec 7. Review.

PMID:
23219438
48.

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.

Garlapati S, Garg R, Brownlie R, Latimer L, Simko E, Hancock RE, Babiuk LA, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2012 Jul 27;30(35):5206-14. doi: 10.1016/j.vaccine.2012.06.011. Epub 2012 Jun 17.

PMID:
22713718
49.

Pathogenesis of respiratory syncytial virus.

van Drunen Littel-van den Hurk S, Watkiss ER.

Curr Opin Virol. 2012 Jun;2(3):300-5. doi: 10.1016/j.coviro.2012.01.008. Epub 2012 Feb 23. Review.

PMID:
22709517
50.

Mucosal immune response in newborn Holstein calves that had maternally derived antibodies and were vaccinated with an intranasal multivalent modified-live virus vaccine.

Hill KL, Hunsaker BD, Townsend HG, van Drunen Littel-van den Hurk S, Griebel PJ.

J Am Vet Med Assoc. 2012 May 15;240(10):1231-40. doi: 10.2460/javma.240.10.1231.

PMID:
22559114

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