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Items: 1 to 50 of 143

1.

The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis.

Kroon FPB, Veenbrink AI, de Mutsert R, Visser AW, van Dijk KW, le Cessie S, Rosendaal FR, Kloppenburg M.

Osteoarthritis Cartilage. 2019 Aug 23. pii: S1063-4584(19)31173-2. doi: 10.1016/j.joca.2019.08.003. [Epub ahead of print]

PMID:
31450004
2.

Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice.

Katiraei S, de Vries MR, Costain AH, Thiem K, Hoving LR, van Diepen JA, Smits HH, Bouter KE, Rensen PCN, Quax PHA, Nieuwdorp M, Netea MG, de Vos WM, Cani PD, Belzer C, van Dijk KW, Berbée JFP, van Harmelen V.

Mol Nutr Food Res. 2019 Aug 6:e1900732. doi: 10.1002/mnfr.201900732. [Epub ahead of print]

PMID:
31389129
3.

Hepatic triglyceride content does not affect circulating CETP: lessons from a liraglutide intervention trial and a population-based cohort.

van Eyk HJ, Blauw LL, Bizino MB, Wang Y, van Dijk KW, de Mutsert R, Smit JWA, Lamb HJ, Jazet IM, Rensen PCN.

Sci Rep. 2019 Jul 10;9(1):9996. doi: 10.1038/s41598-019-45593-2.

4.

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

Liu J, Carnero-Montoro E, van Dongen J, Lent S, Nedeljkovic I, Ligthart S, Tsai PC, Martin TC, Mandaviya PR, Jansen R, Peters MJ, Duijts L, Jaddoe VWV, Tiemeier H, Felix JF, Willemsen G, de Geus EJC, Chu AY, Levy D, Hwang SJ, Bressler J, Gondalia R, Salfati EL, Herder C, Hidalgo BA, Tanaka T, Moore AZ, Lemaitre RN, Jhun MA, Smith JA, Sotoodehnia N, Bandinelli S, Ferrucci L, Arnett DK, Grallert H, Assimes TL, Hou L, Baccarelli A, Whitsel EA, van Dijk KW, Amin N, Uitterlinden AG, Sijbrands EJG, Franco OH, Dehghan A, Spector TD, Dupuis J, Hivert MF, Rotter JI, Meigs JB, Pankow JS, van Meurs JBJ, Isaacs A, Boomsma DI, Bell JT, Demirkan A, van Duijn CM.

Nat Commun. 2019 Jun 13;10(1):2581. doi: 10.1038/s41467-019-10487-4.

5.

Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study.

Neeland IJ, Boone SC, Mook-Kanamori DO, Ayers C, Smit RAJ, Tzoulaki I, Karaman I, Boulange C, Vaidya D, Punjabi N, Allison M, Herrington DM, Jukema JW, Rosendaal FR, Lamb HJ, van Dijk KW, Greenland P, de Mutsert R.

J Am Heart Assoc. 2019 May 7;8(9):e010810. doi: 10.1161/JAHA.118.010810.

6.

Avoiding selection bias in metabolomics studies: a tutorial.

Boone SC, le Cessie S, van Dijk KW, de Mutsert R, Mook-Kanamori DO.

Metabolomics. 2019 Jan 3;15(1):7. doi: 10.1007/s11306-018-1463-4. Review.

PMID:
30830435
7.

Repeat length variations in polyglutamine disease-associated genes affect body mass index.

Gardiner SL, de Mutsert R, Trompet S, Boogaard MW, van Dijk KW, Jukema PJW, Slagboom PE, Roos RAC, Pijl H, Rosendaal FR, Aziz NA.

Int J Obes (Lond). 2019 Mar;43(3):440-449. doi: 10.1038/s41366-018-0161-7. Epub 2018 Aug 17.

PMID:
30120431
8.

Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin.

Christen T, Trompet S, Noordam R, van Klinken JB, van Dijk KW, Lamb HJ, Cobbaert CM, den Heijer M, Jazet IM, Jukema JW, Rosendaal FR, de Mutsert R.

Peptides. 2018 Sep;107:25-31. doi: 10.1016/j.peptides.2018.07.008. Epub 2018 Aug 1.

PMID:
30076861
9.

GC-MS Analysis of Medium- and Long-Chain Fatty Acids in Blood Samples.

Hoving LR, Heijink M, van Harmelen V, van Dijk KW, Giera M.

Methods Mol Biol. 2018;1730:257-265. doi: 10.1007/978-1-4939-7592-1_18.

PMID:
29363079
10.

GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples.

Hoving LR, Heijink M, van Harmelen V, van Dijk KW, Giera M.

Methods Mol Biol. 2018;1730:247-256. doi: 10.1007/978-1-4939-7592-1_17.

PMID:
29363078
11.

IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.

van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V.

Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30.

PMID:
28852207
12.

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Liu J, van Klinken JB, Semiz S, van Dijk KW, Verhoeven A, Hankemeier T, Harms AC, Sijbrands E, Sheehan NA, van Duijn CM, Demirkan A.

Diabetes. 2017 Nov;66(11):2915-2926. doi: 10.2337/db17-0199. Epub 2017 Aug 28.

13.

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study.

Liu J, Semiz S, van der Lee SJ, van der Spek A, Verhoeven A, van Klinken JB, Sijbrands E, Harms AC, Hankemeier T, van Dijk KW, van Duijn CM, Demirkan A.

Metabolomics. 2017;13(9):104. doi: 10.1007/s11306-017-1239-2. Epub 2017 Jul 28.

14.

Genetic variation in the obesity gene FTO is not associated with decreased fat oxidation: the NEO study.

Blauw LL, Noordam R, Trompet S, Berbée JFP, Rosendaal FR, van Heemst D, van Dijk KW, Mook-Kanamori DO, de Mutsert R, Rensen PCN.

Int J Obes (Lond). 2017 Oct;41(10):1594-1600. doi: 10.1038/ijo.2017.146. Epub 2017 Jun 19.

PMID:
28626215
15.

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Barbieri CM, Boutin T, Campbell A, Demerath E, Giri A, He C, Hottenga JJ, Karlsson R, Kolcic I, Loh PR, Lunetta KL, Mangino M, Marco B, McMahon G, Medland SE, Nolte IM, Noordam R, Nutile T, Paternoster L, Perjakova N, Porcu E, Rose LM, Schraut KE, Segrè AV, Smith AV, Stolk L, Teumer A, Andrulis IL, Bandinelli S, Beckmann MW, Benitez J, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Brand JS, Brauch H, Brenner H, Broer L, Brüning T, Buring JE, Campbell H, Catamo E, Chanock S, Chenevix-Trench G, Corre T, Couch FJ, Cousminer DL, Cox A, Crisponi L, Czene K, Davey Smith G, de Geus EJCN, de Mutsert R, De Vivo I, Dennis J, Devilee P, Dos-Santos-Silva I, Dunning AM, Eriksson JG, Fasching PA, Fernández-Rhodes L, Ferrucci L, Flesch-Janys D, Franke L, Gabrielson M, Gandin I, Giles GG, Grallert H, Gudbjartsson DF, Guénel P, Hall P, Hallberg E, Hamann U, Harris TB, Hartman CA, Heiss G, Hooning MJ, Hopper JL, Hu F, Hunter DJ, Ikram MA, Im HK, Järvelin MR, Joshi PK, Karasik D, Kellis M, Kutalik Z, LaChance G, Lambrechts D, Langenberg C, Launer LJ, Laven JSE, Lenarduzzi S, Li J, Lind PA, Lindstrom S, Liu Y, Luan J, Mägi R, Mannermaa A, Mbarek H, McCarthy MI, Meisinger C, Meitinger T, Menni C, Metspalu A, Michailidou K, Milani L, Milne RL, Montgomery GW, Mulligan AM, Nalls MA, Navarro P, Nevanlinna H, Nyholt DR, Oldehinkel AJ, O'Mara TA, Padmanabhan S, Palotie A, Pedersen N, Peters A, Peto J, Pharoah PDP, Pouta A, Radice P, Rahman I, Ring SM, Robino A, Rosendaal FR, Rudan I, Rueedi R, Ruggiero D, Sala CF, Schmidt MK, Scott RA, Shah M, Sorice R, Southey MC, Sovio U, Stampfer M, Steri M, Strauch K, Tanaka T, Tikkanen E, Timpson NJ, Traglia M, Truong T, Tyrer JP, Uitterlinden AG, Edwards DRV, Vitart V, Völker U, Vollenweider P, Wang Q, Widen E, van Dijk KW, Willemsen G, Winqvist R, Wolffenbuttel BHR, Zhao JH, Zoledziewska M, Zygmunt M, Alizadeh BZ, Boomsma DI, Ciullo M, Cucca F, Esko T, Franceschini N, Gieger C, Gudnason V, Hayward C, Kraft P, Lawlor DA, Magnusson PKE, Martin NG, Mook-Kanamori DO, Nohr EA, Polasek O, Porteous D, Price AL, Ridker PM, Snieder H, Spector TD, Stöckl D, Toniolo D, Ulivi S, Visser JA, Völzke H, Wareham NJ, Wilson JF; LifeLines Cohort Study; InterAct Consortium; kConFab/AOCS Investigators; Endometrial Cancer Association Consortium; Ovarian Cancer Association Consortium; PRACTICAL consortium, Spurdle AB, Thorsteindottir U, Pollard KS, Easton DF, Tung JY, Chang-Claude J, Hinds D, Murray A, Murabito JM, Stefansson K, Ong KK, Perry JRB.

Nat Genet. 2017 Jun;49(6):834-841. doi: 10.1038/ng.3841. Epub 2017 Apr 24.

16.

LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men.

Boon MR, Bakker LEH, Prehn C, Adamski J, Vosselman MJ, Jazet IM, Arias-Bouda LMP, van Lichtenbelt WDM, van Dijk KW, Rensen PCN, Mook-Kanamori DO.

Metabolomics. 2017;13(5):48. doi: 10.1007/s11306-017-1185-z. Epub 2017 Mar 3.

17.

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, van Dijk KW, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M.

Nat Commun. 2016 Mar 23;7:11122. doi: 10.1038/ncomms11122.

18.

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.

van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, van Dijk KW, Pereira AM, Hunt H, Belanoff JK, Rensen PC, Meijer OC.

Br J Pharmacol. 2016 Jun;173(11):1793-804. doi: 10.1111/bph.13477. Epub 2016 Apr 24.

19.

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradhan AD, Rankinen T, Rasmussen-Torvik LJ, Rathmann W, Rice TK, Brent Richards J, Ridker PM, Sattar N, Savage DB, Söderberg S, Timpson NJ, Vandenput L, van Heemst D, Uh HW, Vohl MC, Walker M, Wichmann HE, Widén E, Wood AR, Yao J, Zeller T, Zhang Y, Meulenbelt I, Kloppenburg M, Astrup A, Sørensen TI, Sarzynski MA, Rao DC, Jousilahti P, Vartiainen E, Hofman A, Rivadeneira F, Uitterlinden AG, Kajantie E, Osmond C, Palotie A, Eriksson JG, Heliövaara M, Knekt PB, Koskinen S, Jula A, Perola M, Huupponen RK, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Mellström D, Lorentzon M, Casas JP, Bandinelli S, März W, Isaacs A, van Dijk KW, van Duijn CM, Harris TB, Bouchard C, Allison MA, Chasman DI, Ohlsson C, Lind L, Scott RA, Langenberg C, Wareham NJ, Ferrucci L, Frayling TM, Pramstaller PP, Borecki IB, Waterworth DM, Bergmann S, Waeber G, Vollenweider P, Vestergaard H, Hansen T, Pedersen O, Hu FB, Eline Slagboom P, Grallert H, Spector TD, Jukema JW, Klein RJ, Schadt EE, Franks PW, Lindgren CM, Leibel RL, Loos RJ.

Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494.

20.

Serum CETP concentration is not associated with measures of body fat: The NEO study.

Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, Wang Y, van Dijk KW, Rensen PC.

Atherosclerosis. 2016 Mar;246:267-73. doi: 10.1016/j.atherosclerosis.2016.01.031. Epub 2016 Jan 19.

21.

A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance.

van den Berg R, Mook-Kanamori DO, Donga E, van Dijk M, van Dijk JG, Lammers GJ, van Kralingen KW, Prehn C, Adamski J, Romijn JA, van Dijk KW, Corssmit EP, Rensen PC, Biermasz NR.

Arch Biochem Biophys. 2016 Jan 1;589:145-51. doi: 10.1016/j.abb.2015.09.017. Epub 2015 Sep 21.

PMID:
26393786
22.

Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.

Nahon KJ, Boon MR, Bakker LE, Prehn C, Adamski J, Jazet IM, van Dijk KW, Rensen PC, Mook-Kanamori DO.

Arch Biochem Biophys. 2016 Jan 1;589:152-7. doi: 10.1016/j.abb.2015.09.001. Epub 2015 Sep 16.

PMID:
26384768
23.

Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes.

Heemskerk MM, Giera M, Bouazzaoui FE, Lips MA, Pijl H, van Dijk KW, van Harmelen V.

Nutrients. 2015 Sep 11;7(9):7676-90. doi: 10.3390/nu7095362.

24.

Smoking is associated with increased resting energy expenditure in the general population: The NEO study.

Blauw LL, Boon MR, Rosendaal FR, de Mutsert R, Gast KB, van Dijk KW, Rensen PC, Dekkers OM; NEO study group.

Metabolism. 2015 Nov;64(11):1548-55. doi: 10.1016/j.metabol.2015.08.008. Epub 2015 Aug 18.

PMID:
26363529
25.

Type 2 diabetes is associated with postprandial amino acid measures.

Mook-Kanamori DO, de Mutsert R, Rensen PC, Prehn C, Adamski J, den Heijer M, le Cessie S, Suhre K, Rosendaal FR, van Dijk KW.

Arch Biochem Biophys. 2016 Jan 1;589:138-44. doi: 10.1016/j.abb.2015.08.003. Epub 2015 Aug 10.

PMID:
26271442
26.

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.

Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R.

Diabetes Care. 2015 Oct;38(10):1858-67. doi: 10.2337/dc15-0658. Epub 2015 Aug 5.

PMID:
26251408
27.

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, van Dijk KW, Rensen PC.

Hepatology. 2015 Dec;62(6):1710-22. doi: 10.1002/hep.27985. Epub 2015 Aug 28.

PMID:
26174697
28.

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.

Draisma HHM, Pool R, Kobl M, Jansen R, Petersen AK, Vaarhorst AAM, Yet I, Haller T, Demirkan A, Esko T, Zhu G, Böhringer S, Beekman M, van Klinken JB, Römisch-Margl W, Prehn C, Adamski J, de Craen AJM, van Leeuwen EM, Amin N, Dharuri H, Westra HJ, Franke L, de Geus EJC, Hottenga JJ, Willemsen G, Henders AK, Montgomery GW, Nyholt DR, Whitfield JB, Penninx BW, Spector TD, Metspalu A, Slagboom PE, van Dijk KW, 't Hoen PAC, Strauch K, Martin NG, van Ommen GB, Illig T, Bell JT, Mangino M, Suhre K, McCarthy MI, Gieger C, Isaacs A, van Duijn CM, Boomsma DI.

Nat Commun. 2015 Jun 12;6:7208. doi: 10.1038/ncomms8208.

29.

Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism.

Heemskerk MM, van Harmelen VJ, van Dijk KW, van Klinken JB.

Eur J Hum Genet. 2016 Jan;24(1):142-5. doi: 10.1038/ejhg.2015.106. Epub 2015 May 27.

30.

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

Demirkan A, Henneman P, Verhoeven A, Dharuri H, Amin N, van Klinken JB, Karssen LC, de Vries B, Meissner A, Göraler S, van den Maagdenberg AM, Deelder AM, C 't Hoen PA, van Duijn CM, van Dijk KW.

PLoS Genet. 2015 Jan 8;11(1):e1004835. doi: 10.1371/journal.pgen.1004835. eCollection 2015 Jan.

31.

Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice.

Ciapaite J, van den Berg SA, Houten SM, Nicolay K, van Dijk KW, Jeneson JA.

J Nutr Biochem. 2015 Feb;26(2):155-64. doi: 10.1016/j.jnutbio.2014.09.014. Epub 2014 Oct 25.

PMID:
25516489
32.

Proteomic analysis in type 2 diabetes patients before and after a very low calorie diet reveals potential disease state and intervention specific biomarkers.

Sleddering MA, Markvoort AJ, Dharuri HK, Jeyakar S, Snel M, Juhasz P, Lynch M, Hines W, Li X, Jazet IM, Adourian A, Hilbers PA, Smit JW, Van Dijk KW.

PLoS One. 2014 Nov 21;9(11):e112835. doi: 10.1371/journal.pone.0112835. eCollection 2014.

33.

Preclinical studies on intestinal administration of antisense oligonucleotides as a model for oral delivery for treatment of duchenne muscular dystrophy.

van Putten M, Young C, van den Berg S, Pronk A, Hulsker M, Karnaoukh TG, Vermue R, van Dijk KW, de Kimpe S, Aartsma-Rus A.

Mol Ther Nucleic Acids. 2014 Nov 18;3:e211. doi: 10.1038/mtna.2014.62.

34.

Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile.

Heemskerk MM, Dharuri HK, van den Berg SA, Jónasdóttir HS, Kloos DP, Giera M, van Dijk KW, van Harmelen V.

J Lipid Res. 2014 Dec;55(12):2532-40. doi: 10.1194/jlr.M051938. Epub 2014 Oct 15.

35.

Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans.

Wijngaarden MA, Bakker LE, van der Zon GC, 't Hoen PA, van Dijk KW, Jazet IM, Pijl H, Guigas B.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E885-95. doi: 10.1152/ajpendo.00215.2014. Epub 2014 Sep 23.

36.

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.

Boon MR, Bakker LE, Haks MC, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, Van Harmelen V, Meinders AE, Ottenhoff TH, Van Dijk KW, Guigas B, Jazet IM, Rensen PC.

Clin Sci (Lond). 2015 Jan;128(2):143-51. doi: 10.1042/CS20140179.

PMID:
25148551
37.

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping.

de Vree PJ, de Wit E, Yilmaz M, van de Heijning M, Klous P, Verstegen MJ, Wan Y, Teunissen H, Krijger PH, Geeven G, Eijk PP, Sie D, Ylstra B, Hulsman LO, van Dooren MF, van Zutven LJ, van den Ouweland A, Verbeek S, van Dijk KW, Cornelissen M, Das AT, Berkhout B, Sikkema-Raddatz B, van den Berg E, van der Vlies P, Weening D, den Dunnen JT, Matusiak M, Lamkanfi M, Ligtenberg MJ, ter Brugge P, Jonkers J, Foekens JA, Martens JW, van der Luijt R, van Amstel HK, van Min M, Splinter E, de Laat W.

Nat Biotechnol. 2014 Oct;32(10):1019-25. doi: 10.1038/nbt.2959. Epub 2014 Aug 17.

PMID:
25129690
38.

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.

Broer L, Raschenberger J, Deelen J, Mangino M, Codd V, Pietiläinen KH, Albrecht E, Amin N, Beekman M, de Craen AJ, Gieger C, Haun M, Henneman P, Herder C, Hovatta I, Laser A, Kedenko L, Koenig W, Kollerits B, Moilanen E, Oostra BA, Paulweber B, Quaye L, Rissanen A, Roden M, Surakka I, Valdes AM, Vuolteenaho K, Thorand B, van Dijk KW, Kaprio J, Spector TD, Slagboom PE, Samani NJ, Kronenberg F, van Duijn CM, Ladwig KH.

Eur J Epidemiol. 2014 Sep;29(9):629-38. doi: 10.1007/s10654-014-9940-1. Epub 2014 Jul 27.

PMID:
25064619
39.

A metabolomic profile is associated with the risk of incident coronary heart disease.

Vaarhorst AA, Verhoeven A, Weller CM, Böhringer S, Göraler S, Meissner A, Deelder AM, Henneman P, Gorgels AP, van den Brandt PA, Schouten LJ, van Greevenbroek MM, Merry AH, Verschuren WM, van den Maagdenberg AM, van Dijk KW, Isaacs A, Boomsma D, Oostra BA, van Duijn CM, Jukema JW, Boer JM, Feskens E, Heijmans BT, Slagboom PE.

Am Heart J. 2014 Jul;168(1):45-52.e7. doi: 10.1016/j.ahj.2014.01.019. Epub 2014 Apr 4.

40.

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects.

Lips MA, de Groot GH, Berends FJ, Wiezer R, van Wagensveld BA, Swank DJ, Luijten A, van Dijk KW, Pijl H, Jansen PL, Schaap FG.

Clin Endocrinol (Oxf). 2014 Dec;81(6):862-70. doi: 10.1111/cen.12496. Epub 2014 Jun 12.

PMID:
24841294
41.

Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B.

Heemskerk MM, van den Berg SA, Pronk AC, van Klinken JB, Boon MR, Havekes LM, Rensen PC, van Dijk KW, van Harmelen V.

Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E808-13. doi: 10.1152/ajpendo.00641.2013. Epub 2014 Jan 28.

42.

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles.

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Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

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Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.

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FASEB J. 2013 Aug;27(8):3354-62. doi: 10.1096/fj.12-225367. Epub 2013 May 6.

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Practical aspects of estimating energy components in rodents.

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Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals.

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Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E1012-21. doi: 10.1152/ajpendo.00008.2013. Epub 2013 Mar 19.

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CD36 is important for adipocyte recruitment and affects lipolysis.

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The effects of antitussive treatment of ACE inhibitor-induced cough on therapy compliance: a prescription sequence symmetry analysis.

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