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Items: 1 to 50 of 133

1.

Pak2 kinase promotes cellular senescence and organismal aging.

Lee JS, Mo Y, Gan H, Burgess RJ, Baker DJ, van Deursen JM, Zhang Z.

Proc Natl Acad Sci U S A. 2019 Jun 17. pii: 201903847. doi: 10.1073/pnas.1903847116. [Epub ahead of print]

PMID:
31209047
2.

Senolytic therapies for healthy longevity.

van Deursen JM.

Science. 2019 May 17;364(6441):636-637. doi: 10.1126/science.aaw1299. No abstract available.

PMID:
31097655
3.

Senescent cells in the development of cardiometabolic disease.

Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK.

Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602.

PMID:
30913069
4.

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.

Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Fierro Velasco RO, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores GJ, Li H, van Deursen JM.

Gastroenterology. 2019 Jul;157(1):210-226.e12. doi: 10.1053/j.gastro.2019.03.016. Epub 2019 Mar 13.

PMID:
30878468
5.

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.

Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S.

Hum Mol Genet. 2019 Jun 1;28(11):1822-1836. doi: 10.1093/hmg/ddz022.

PMID:
30668728
6.

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.

Cho CH, Yoo KH, Oliveros A, Paulson S, Hussaini SMQ, van Deursen JM, Jang MH.

Aging Cell. 2019 Apr;18(2):e12899. doi: 10.1111/acel.12899. Epub 2019 Jan 4.

7.

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.

Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ.

Nature. 2018 Oct;562(7728):578-582. doi: 10.1038/s41586-018-0543-y. Epub 2018 Sep 19.

8.

Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression.

Aziz K, Sieben CJ, Jeganathan KB, Hamada M, Davies BA, Velasco ROF, Rahman N, Katzmann DJ, van Deursen JM.

J Clin Invest. 2018 Aug 1;128(8):3517-3534. doi: 10.1172/JCI120316. Epub 2018 Jul 23.

9.

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.

Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, Jeganathan KB, Yu J, Zhang H, Ding W, van Deursen JM, Lou Z.

Nat Commun. 2018 Jul 16;9(1):2736. doi: 10.1038/s41467-018-05161-0.

10.

Two-Step Senescence-Focused Cancer Therapies.

Sieben CJ, Sturmlechner I, van de Sluis B, van Deursen JM.

Trends Cell Biol. 2018 Sep;28(9):723-737. doi: 10.1016/j.tcb.2018.04.006. Epub 2018 May 17. Review.

PMID:
29776716
11.

Senescent cells: a therapeutic target for cardiovascular disease.

Childs BG, Li H, van Deursen JM.

J Clin Invest. 2018 Apr 2;128(4):1217-1228. doi: 10.1172/JCI95146. Epub 2018 Apr 2. Review.

12.

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage.

Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z.

Nat Cell Biol. 2018 Apr;20(4):455-464. doi: 10.1038/s41556-018-0071-x. Epub 2018 Mar 26.

13.

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.

van der Pol A, Gil A, Silljé HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaam8574. doi: 10.1126/scitranslmed.aam8574.

PMID:
29118264
14.

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

El Yakoubi W, Buffin E, Cladière D, Gryaznova Y, Berenguer I, Touati SA, Gómez R, Suja JA, van Deursen JM, Wassmann K.

Nat Commun. 2017 Sep 25;8(1):694. doi: 10.1038/s41467-017-00774-3.

15.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT.

Cancer Cell. 2017 Sep 11;32(3):310-323.e5. doi: 10.1016/j.ccell.2017.08.002. Epub 2017 Aug 31.

16.

Senescent cells: an emerging target for diseases of ageing.

Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM.

Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21. Review.

17.

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.

18.

Oncogenic senescence: a multi-functional perspective.

Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J.

Oncotarget. 2017 Apr 18;8(16):27661-27672. doi: 10.18632/oncotarget.15742.

19.

Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH.

Aging Cell. 2017 Jun;16(3):598-601. doi: 10.1111/acel.12594. Epub 2017 Apr 6.

20.

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.

Choi KM, Hong SJ, van Deursen JM, Kim S, Kim KH, Lee CK.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):29-38. doi: 10.1093/gerona/glx024.

PMID:
28329151
21.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.

Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ.

Nucleic Acids Res. 2017 May 5;45(8):4564-4576. doi: 10.1093/nar/gkx107.

22.

Singling Out Chromosome Gains in Tumor Evolution.

Naylor RM, van Deursen JM.

Cancer Cell. 2017 Feb 13;31(2):165-166. doi: 10.1016/j.ccell.2017.01.011.

23.

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.

de Boer JF, Schonewille M, Boesjes M, Wolters H, Bloks VW, Bos T, van Dijk TH, Jurdzinski A, Boverhof R, Wolters JC, Kuivenhoven JA, van Deursen JM, Oude Elferink RPJ, Moschetta A, Kremoser C, Verkade HJ, Kuipers F, Groen AK.

Gastroenterology. 2017 Apr;152(5):1126-1138.e6. doi: 10.1053/j.gastro.2016.12.037. Epub 2017 Jan 5.

PMID:
28065787
24.

Cellular senescence in renal ageing and disease.

Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM.

Nat Rev Nephrol. 2017 Feb;13(2):77-89. doi: 10.1038/nrneph.2016.183. Epub 2016 Dec 28. Review.

PMID:
28029153
25.

The progeroid gene BubR1 regulates axon myelination and motor function.

Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH.

Aging (Albany NY). 2016 Sep 12;8(11):2667-2688. doi: 10.18632/aging.101032.

26.

Aneuploidy in Cancer and Aging.

Naylor RM, van Deursen JM.

Annu Rev Genet. 2016 Nov 23;50:45-66. Review.

27.

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM.

Science. 2016 Oct 28;354(6311):472-477. Epub 2016 Oct 27.

28.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

29.

Deciphering the tumor suppressive mechanisms of Pten.

van Ree JH, van Deursen JM.

Cell Cycle. 2016 Dec 16;15(24):3329-3330. doi: 10.1080/15384101.2016.1229011. Epub 2016 Aug 30. No abstract available.

30.

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM.

Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620.

31.

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.

Booij HG, Yu H, De Boer RA, van de Kolk CW, van de Sluis B, Van Deursen JM, Van Gilst WH, Silljé HH, Westenbrink BD.

Cardiovasc Res. 2016 Aug 1;111(3):217-26. doi: 10.1093/cvr/cvw161. Epub 2016 Jun 14.

PMID:
27302402
32.

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.

Nat Cell Biol. 2016 Jul;18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30.

33.

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH.

Mol Cell. 2016 Apr 21;62(2):272-283. doi: 10.1016/j.molcel.2016.03.017. Epub 2016 Apr 14.

34.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

35.

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T.

Stroke. 2016 Apr;47(4):1068-77. doi: 10.1161/STROKEAHA.115.010835. Epub 2016 Feb 16.

36.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

37.

Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.

Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R.

J Clin Invest. 2016 Feb;126(2):706-20. doi: 10.1172/JCI78132. Epub 2016 Jan 5.

38.

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.

Naylor RM, Jeganathan KB, Cao X, van Deursen JM.

J Clin Invest. 2016 Feb;126(2):543-59. doi: 10.1172/JCI82277. Epub 2016 Jan 5.

39.

Cellular senescence in aging and age-related disease: from mechanisms to therapy.

Childs BG, Durik M, Baker DJ, van Deursen JM.

Nat Med. 2015 Dec;21(12):1424-35. doi: 10.1038/nm.4000. Review.

40.

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.

van Ree JH, Nam HJ, van Deursen JM.

Chromosome Res. 2016 Jan;24(1):67-76. doi: 10.1007/s10577-015-9501-9. Review.

41.

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E.

J Cell Biol. 2015 Nov 9;211(3):605-17. doi: 10.1083/jcb.201505108.

42.

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z.

Mol Cell. 2015 Oct 1;60(1):21-34. doi: 10.1016/j.molcel.2015.08.011. Epub 2015 Sep 17.

43.

B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.

Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L.

PLoS One. 2015 Jun 11;10(6):e0130126. doi: 10.1371/journal.pone.0130126. eCollection 2015.

44.

Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest.

Touati SA, Buffin E, Cladière D, Hached K, Rachez C, van Deursen JM, Wassmann K.

Nat Commun. 2015 Apr 21;6:6946. doi: 10.1038/ncomms7946.

45.

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ.

Oncogene. 2016 Jan 21;35(3):279-89. doi: 10.1038/onc.2015.92. Epub 2015 Apr 20.

46.

Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma.

Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, van Kuppevelt TH, van Deursen JM, Mounajjed T, Fernandez-Zapico ME, Roberts LR.

Hepatology. 2015 Apr;61(4):1269-83. doi: 10.1002/hep.27658. Epub 2015 Feb 13.

47.

Spartan deficiency causes genomic instability and progeroid phenotypes.

Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ.

Nat Commun. 2014 Dec 11;5:5744. doi: 10.1038/ncomms6744.

48.

Centrosome dynamics as a source of chromosomal instability.

Nam HJ, Naylor RM, van Deursen JM.

Trends Cell Biol. 2015 Feb;25(2):65-73. doi: 10.1016/j.tcb.2014.10.002. Epub 2014 Nov 7. Review.

49.

Senescence and apoptosis: dueling or complementary cell fates?

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM.

EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. Review.

50.

The role of senescent cells in ageing.

van Deursen JM.

Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193. Review.

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