Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 218

1.

E2F7 is a potent inhibitor of liver tumor growth in adult mice.

Moreno E, Toussaint MJM, van Essen SC, Bongiovanni L, van Liere EA, Koster MH, Yuan R, van Deursen J, Westendorp B, de Bruin A.

Hepatology. 2020 Apr 7. doi: 10.1002/hep.31259. [Epub ahead of print]

PMID:
32259305
2.

Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication.

Wei Z, Kim TS, Ahn JI, Meng L, Chen Y, Ryu EK, Ku B, Zhou M, Kim SJ, Bang JK, van Deursen JM, Park JE, Lee KS.

Mol Cell Biol. 2020 Mar 9. pii: MCB.00535-19. doi: 10.1128/MCB.00535-19. [Epub ahead of print]

PMID:
32152252
3.

Therapy-Induced Senescence Drives Bone Loss.

Yao Z, Murali B, Ren Q, Luo X, Faget DV, Cole T, Ricci B, Thotala D, Monahan J, van Deursen JM, Baker D, Faccio R, Schwarz JK, Stewart SA.

Cancer Res. 2020 Mar 1;80(5):1171-1182. doi: 10.1158/0008-5472.CAN-19-2348. Epub 2020 Jan 13.

PMID:
31932453
4.

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.

Sieben CJ, Jeganathan KB, Nelson GG, Sturmlechner I, Zhang C, van Deursen WH, Bakker B, Foijer F, Li H, Baker DJ, van Deursen JM.

J Clin Invest. 2020 Jan 2;130(1):171-188. doi: 10.1172/JCI126863.

5.

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL.

Zhang Y, Gundelach J, Lindquist LD, Baker DJ, van Deursen J, Bram RJ.

PLoS One. 2019 Oct 29;14(10):e0224172. doi: 10.1371/journal.pone.0224172. eCollection 2019.

6.

Crystallizing BubR1's kinase activity.

Limzerwala JF, van Deursen JM.

Cell Res. 2019 Aug;29(8):605-606. doi: 10.1038/s41422-019-0199-7. No abstract available.

PMID:
31253942
7.

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements.

van Zutphen T, Stroeve JHM, Yang J, Bloks VW, Jurdzinski A, Roelofsen H, Huijkman NCA, van Dijk TH, Vonk RJ, van Deursen J, Staels B, Groen AK, Kuipers F.

J Lipid Res. 2019 Sep;60(9):1547-1561. doi: 10.1194/jlr.M094508. Epub 2019 Jun 28.

PMID:
31253637
8.

Pak2 kinase promotes cellular senescence and organismal aging.

Lee JS, Mo Y, Gan H, Burgess RJ, Baker DJ, van Deursen JM, Zhang Z.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13311-13319. doi: 10.1073/pnas.1903847116. Epub 2019 Jun 17.

9.

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes.

Aguayo-Mazzucato C, Andle J, Lee TB Jr, Midha A, Talemal L, Chipashvili V, Hollister-Lock J, van Deursen J, Weir G, Bonner-Weir S.

Cell Metab. 2019 Jul 2;30(1):129-142.e4. doi: 10.1016/j.cmet.2019.05.006. Epub 2019 May 30.

PMID:
31155496
10.

Senolytic therapies for healthy longevity.

van Deursen JM.

Science. 2019 May 17;364(6441):636-637. doi: 10.1126/science.aaw1299. No abstract available.

PMID:
31097655
11.

Senescent cells in the development of cardiometabolic disease.

Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK.

Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602.

12.

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.

Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Fierro Velasco RO, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores GJ, Li H, van Deursen JM.

Gastroenterology. 2019 Jul;157(1):210-226.e12. doi: 10.1053/j.gastro.2019.03.016. Epub 2019 Mar 13.

PMID:
30878468
13.

Inhibition of 'jumping genes' promotes healthy ageing.

Childs B, van Deursen J.

Nature. 2019 Feb;566(7742):46-48. doi: 10.1038/d41586-018-07553-0. No abstract available.

PMID:
30728507
14.

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.

Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S.

Hum Mol Genet. 2019 Jun 1;28(11):1822-1836. doi: 10.1093/hmg/ddz022.

PMID:
30668728
15.

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.

Cho CH, Yoo KH, Oliveros A, Paulson S, Hussaini SMQ, van Deursen JM, Jang MH.

Aging Cell. 2019 Apr;18(2):e12899. doi: 10.1111/acel.12899. Epub 2019 Jan 4.

16.

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.

Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ.

Nature. 2018 Oct;562(7728):578-582. doi: 10.1038/s41586-018-0543-y. Epub 2018 Sep 19.

17.

Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression.

Aziz K, Sieben CJ, Jeganathan KB, Hamada M, Davies BA, Velasco ROF, Rahman N, Katzmann DJ, van Deursen JM.

J Clin Invest. 2018 Aug 1;128(8):3517-3534. doi: 10.1172/JCI120316. Epub 2018 Jul 23.

18.

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.

Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, Jeganathan KB, Yu J, Zhang H, Ding W, van Deursen JM, Lou Z.

Nat Commun. 2018 Jul 16;9(1):2736. doi: 10.1038/s41467-018-05161-0.

19.

FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis.

Heim JB, McDonald CA, Wyles SP, Sominidi-Damodaran S, Squirewell EJ, Li M, Motsonelidze C, Böttcher RT, van Deursen J, Meves A.

PLoS One. 2018 Jul 12;13(7):e0200558. doi: 10.1371/journal.pone.0200558. eCollection 2018.

20.

Two-Step Senescence-Focused Cancer Therapies.

Sieben CJ, Sturmlechner I, van de Sluis B, van Deursen JM.

Trends Cell Biol. 2018 Sep;28(9):723-737. doi: 10.1016/j.tcb.2018.04.006. Epub 2018 May 17. Review.

21.

Senescent cells: a therapeutic target for cardiovascular disease.

Childs BG, Li H, van Deursen JM.

J Clin Invest. 2018 Apr 2;128(4):1217-1228. doi: 10.1172/JCI95146. Epub 2018 Apr 2. Review.

22.

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage.

Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z.

Nat Cell Biol. 2018 Apr;20(4):455-464. doi: 10.1038/s41556-018-0071-x. Epub 2018 Mar 26.

23.

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B.

Circ Res. 2018 Jun 8;122(12):1648-1660. doi: 10.1161/CIRCRESAHA.117.312004. Epub 2018 Mar 15.

PMID:
29545368
24.

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.

Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N.

Gastroenterology. 2018 Jun;154(8):2209-2221.e14. doi: 10.1053/j.gastro.2018.02.015. Epub 2018 Feb 15.

25.

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.

van der Pol A, Gil A, Silljé HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaam8574. doi: 10.1126/scitranslmed.aam8574.

PMID:
29118264
26.

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

El Yakoubi W, Buffin E, Cladière D, Gryaznova Y, Berenguer I, Touati SA, Gómez R, Suja JA, van Deursen JM, Wassmann K.

Nat Commun. 2017 Sep 25;8(1):694. doi: 10.1038/s41467-017-00774-3.

27.

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.

Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT.

Cancer Cell. 2017 Sep 11;32(3):310-323.e5. doi: 10.1016/j.ccell.2017.08.002. Epub 2017 Aug 31.

28.

Generation and phenotypic characterization of Pde1a mutant mice.

Wang X, Yamada S, LaRiviere WB, Ye H, Bakeberg JL, Irazabal MV, Chebib FT, van Deursen J, Harris PC, Sussman CR, Behfar A, Ward CJ, Torres VE.

PLoS One. 2017 Jul 27;12(7):e0181087. doi: 10.1371/journal.pone.0181087. eCollection 2017.

29.

Senescent cells: an emerging target for diseases of ageing.

Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM.

Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21. Review.

30.

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1785-1798. doi: 10.1016/j.bbamcr.2017.07.005. Epub 2017 Jul 16.

31.

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.

32.

Oncogenic senescence: a multi-functional perspective.

Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J.

Oncotarget. 2017 Apr 18;8(16):27661-27672. doi: 10.18632/oncotarget.15742.

33.

Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH.

Aging Cell. 2017 Jun;16(3):598-601. doi: 10.1111/acel.12594. Epub 2017 Apr 6.

34.

β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.

Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB Jr, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S.

Cell Metab. 2017 Apr 4;25(4):898-910.e5. doi: 10.1016/j.cmet.2017.03.015.

35.

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.

Heim JB, Squirewell EJ, Neu A, Zocher G, Sominidi-Damodaran S, Wyles SP, Nikolova E, Behrendt N, Saunte DM, Lock-Andersen J, Gaonkar KS, Yan H, Sarkaria JN, Krendel M, van Deursen J, Sprangers R, Stehle T, Böttcher RT, Lee JH, Ordog T, Meves A.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3933-3938. doi: 10.1073/pnas.1614894114. Epub 2017 Mar 27.

36.

Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast.

Choi KM, Hong SJ, van Deursen JM, Kim S, Kim KH, Lee CK.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):29-38. doi: 10.1093/gerona/glx024.

PMID:
28329151
37.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.

Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ.

Nucleic Acids Res. 2017 May 5;45(8):4564-4576. doi: 10.1093/nar/gkx107.

38.

Singling Out Chromosome Gains in Tumor Evolution.

Naylor RM, van Deursen JM.

Cancer Cell. 2017 Feb 13;31(2):165-166. doi: 10.1016/j.ccell.2017.01.011.

39.

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.

de Boer JF, Schonewille M, Boesjes M, Wolters H, Bloks VW, Bos T, van Dijk TH, Jurdzinski A, Boverhof R, Wolters JC, Kuivenhoven JA, van Deursen JM, Oude Elferink RPJ, Moschetta A, Kremoser C, Verkade HJ, Kuipers F, Groen AK.

Gastroenterology. 2017 Apr;152(5):1126-1138.e6. doi: 10.1053/j.gastro.2016.12.037. Epub 2017 Jan 5.

PMID:
28065787
40.

Cellular senescence in renal ageing and disease.

Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM.

Nat Rev Nephrol. 2017 Feb;13(2):77-89. doi: 10.1038/nrneph.2016.183. Epub 2016 Dec 28. Review.

PMID:
28029153
41.

The progeroid gene BubR1 regulates axon myelination and motor function.

Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH.

Aging (Albany NY). 2016 Sep 12;8(11):2667-2688. doi: 10.18632/aging.101032.

42.

Aneuploidy in Cancer and Aging.

Naylor RM, van Deursen JM.

Annu Rev Genet. 2016 Nov 23;50:45-66. Review.

43.

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM.

Science. 2016 Oct 28;354(6311):472-477. Epub 2016 Oct 27.

44.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

45.

Deciphering the tumor suppressive mechanisms of Pten.

van Ree JH, van Deursen JM.

Cell Cycle. 2016 Dec 16;15(24):3329-3330. doi: 10.1080/15384101.2016.1229011. Epub 2016 Aug 30. No abstract available.

46.

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM.

Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620.

47.

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.

Booij HG, Yu H, De Boer RA, van de Kolk CW, van de Sluis B, Van Deursen JM, Van Gilst WH, Silljé HH, Westenbrink BD.

Cardiovasc Res. 2016 Aug 1;111(3):217-26. doi: 10.1093/cvr/cvw161. Epub 2016 Jun 14.

PMID:
27302402
48.

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.

Nat Cell Biol. 2016 Jul;18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30.

49.

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH.

Mol Cell. 2016 Apr 21;62(2):272-283. doi: 10.1016/j.molcel.2016.03.017. Epub 2016 Apr 14.

50.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

Supplemental Content

Loading ...
Support Center