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Items: 1 to 50 of 119

1.

The idiosyncratic drug-induced gene expression changes in HepG2 cells.

Jiang J, Mathijs K, Timmermans L, Claessen SM, Hecka A, Weusten J, Peters R, van Delft JH, Kleinjans JCS, Jennen DGJ, de Kok TM.

Data Brief. 2017 Jul 29;14:462-468. doi: 10.1016/j.dib.2017.07.074. eCollection 2017 Oct.

2.

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury.

Jiang J, Mathijs K, Timmermans L, Claessen SM, Hecka A, Weusten J, Peters R, van Delft JH, Kleinjans JCS, Jennen DGJ, de Kok TM.

Toxicol Appl Pharmacol. 2017 Oct 1;332:100-108. doi: 10.1016/j.taap.2017.07.014. Epub 2017 Jul 18.

PMID:
28733206
3.

Bayesian Network Inference Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans.

Jennen DG, van Leeuwen DM, Hendrickx DM, Gottschalk RW, van Delft JH, Kleinjans JC.

Chem Res Toxicol. 2015 Oct 19;28(10):1936-48. doi: 10.1021/acs.chemrestox.5b00145. Epub 2015 Sep 17.

PMID:
26360787
4.

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Jetten MJ, Ruiz-Aracama A, Coonen ML, Claessen SM, van Herwijnen MH, Lommen A, van Delft JH, Peijnenburg AA, Kleinjans JC.

Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.

5.

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.

Van den Hof WF, Ruiz-Aracama A, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC.

Toxicol In Vitro. 2015 Apr;29(3):489-501. doi: 10.1016/j.tiv.2014.12.016. Epub 2015 Jan 3.

PMID:
25562108
6.

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.

Jetten MJ, Claessen SM, Dejong CH, Lahoz A, Castell JV, van Delft JH, Kleinjans JC.

Toxicology. 2014 Sep 2;323:61-9. doi: 10.1016/j.tox.2014.06.007. Epub 2014 Jun 17.

PMID:
24949552
7.

Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity.

Hebels DG, Jetten MJ, Aerts HJ, Herwig R, Theunissen DH, Gaj S, van Delft JH, Kleinjans JC.

Biomark Med. 2014;8(2):185-200. doi: 10.2217/bmm.13.154. Review.

8.

Classification of hepatotoxicants using HepG2 cells: A proof of principle study.

Van den Hof WF, Coonen ML, van Herwijnen M, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC.

Chem Res Toxicol. 2014 Mar 17;27(3):433-42. doi: 10.1021/tx4004165. Epub 2014 Jan 28.

PMID:
24437676
9.

Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks.

Rieswijk L, Lizarraga D, Brauers KJ, Kleinjans JC, van Delft JH.

Mutagenesis. 2014 Jan;29(1):17-26. doi: 10.1093/mutage/get055. Epub 2013 Nov 26.

PMID:
24280081
10.

Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.

Fijten RR, Jennen DG, van Delft JH.

Curr Drug Metab. 2013 Dec;14(10):1022-8. Review.

PMID:
24261707
11.

Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.

Merlo DF, Agramunt S, Anna L, Besselink H, Botsivali M, Brady NJ, Ceppi M, Chatzi L, Chen B, Decordier I, Farmer PB, Fleming S, Fontana V, Försti A, Fthenou E, Gallo F, Georgiadis P, Gmuender H, Godschalk RW, Granum B, Hardie LJ, Hemminki K, Hochstenbach K, Knudsen LE, Kogevinas M, Kovács K, Kyrtopoulos SA, Løvik M, Nielsen JK, Nygaard UC, Pedersen M, Rydberg P, Schoket B, Segerbäck D, Singh R, Sunyer J, Törnqvist M, van Loveren H, van Schooten FJ, Vande Loock K, von Stedingk H, Wright J, Kleinjans JC, Kirsch-Volders M, van Delft JH; NewGeneris Consortium.

Environ Health Perspect. 2014 Feb;122(2):193-200. doi: 10.1289/ehp.1206324. Epub 2013 Nov 19.

12.

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes.

Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, van Delft JH.

Toxicol In Vitro. 2013 Oct;27(7):2031-40. doi: 10.1016/j.tiv.2013.07.010. Epub 2013 Jul 31.

PMID:
23911569
13.

Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.

Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, Speksnijder EN, Roodbergen M, van Delft JH, Luijten M, van der Ven LT.

Toxicol Lett. 2013 Aug 29;221(3):225-36. doi: 10.1016/j.toxlet.2013.06.236. Epub 2013 Jul 3.

PMID:
23830897
14.

Gender-specific transcriptomic response to environmental exposure in Flemish adults.

De Coster S, van Leeuwen DM, Jennen DG, Koppen G, Den Hond E, Nelen V, Schoeters G, Baeyens W, van Delft JH, Kleinjans JC, van Larebeke N.

Environ Mol Mutagen. 2013 Aug;54(7):574-88. doi: 10.1002/em.21774. Epub 2013 May 8.

PMID:
23653218
15.

Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach.

Van Summeren A, Renes J, Lizarraga D, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC.

OMICS. 2013 Feb;17(2):71-83. doi: 10.1089/omi.2012.0079. Epub 2013 Jan 11.

16.

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity.

Tsamou M, Jennen DG, Claessen SM, Magkoufopoulou C, Kleinjans JC, van Delft JH.

Mutagenesis. 2012 Nov;27(6):645-52. doi: 10.1093/mutage/ges030. Epub 2012 Aug 21.

PMID:
22914676
17.

Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero.

Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Løvik M, Granum B, Nygaard U, Namork E, Kirsch-Volders M, Decordier I, Vande Loock K, Besselink H, Törnqvist M, von Stedingk H, Rydberg P, Kleinjans JC, van Loveren H, van Delft JH.

Cancer Epidemiol Biomarkers Prev. 2012 Oct;21(10):1756-67. doi: 10.1158/1055-9965.EPI-12-0304. Epub 2012 Aug 9.

18.

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells.

Limonciel A, Wilmes A, Aschauer L, Radford R, Bloch KM, McMorrow T, Pfaller W, van Delft JH, Slattery C, Ryan MP, Lock EA, Jennings P.

Arch Toxicol. 2012 Nov;86(11):1741-51. doi: 10.1007/s00204-012-0897-0. Epub 2012 Jul 4.

PMID:
22760423
19.

Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns.

Hochstenbach K, van Leeuwen DM, Gmuender H, Gottschalk RW, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, Meltzer HM, Kleinjans JC, van Delft JH, van Loveren H.

Toxicol Sci. 2012 Oct;129(2):315-24. doi: 10.1093/toxsci/kfs214. Epub 2012 Jun 27.

20.

A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo.

Magkoufopoulou C, Claessen SM, Tsamou M, Jennen DG, Kleinjans JC, van Delft JH.

Carcinogenesis. 2012 Jul;33(7):1421-9. doi: 10.1093/carcin/bgs182. Epub 2012 May 23.

PMID:
22623647
21.

Benzo[a]pyrene-induced changes in microRNA-mRNA networks.

Lizarraga D, Gaj S, Brauers KJ, Timmermans L, Kleinjans JC, van Delft JH.

Chem Res Toxicol. 2012 Apr 16;25(4):838-49. doi: 10.1021/tx2003799. Epub 2012 Feb 22.

PMID:
22316170
22.

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC.

Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20.

PMID:
22285215
23.

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity.

Van Summeren A, Renes J, van Delft JH, Kleinjans JC, Mariman EC.

Toxicol In Vitro. 2012 Apr;26(3):373-85. doi: 10.1016/j.tiv.2012.01.012. Epub 2012 Jan 17. Review.

PMID:
22274661
24.

Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure.

Hochstenbach K, van Leeuwen DM, Gottschalk RW, Gmuender H, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, van Loveren H, van Delft JH.

Mutat Res. 2012 Aug 15;746(2):124-34. doi: 10.1016/j.mrgentox.2012.01.002. Epub 2012 Jan 16.

PMID:
22269147
25.

Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.

Ketelslegers HB, Godschalk RW, Gottschalk RW, Knaapen AM, Koppen G, Schoeters G, Baeyens WF, Nelen V, Geraedts JP, van Delft JH, Kleinjans JC, van Larebeke NA.

Environ Health. 2011 Oct 5;10:85. doi: 10.1186/1476-069X-10-85.

26.

A lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber induces genetic and metabolic alterations in colon mucosa of female C57BL/6J mice.

Lizarraga D, Vinardell MP, Noé V, van Delft JH, Alcarraz-Vizán G, van Breda SG, Staal Y, Günther UL, Carrigan JB, Reed MA, Ciudad CJ, Torres JL, Cascante M.

J Nutr. 2011 Sep;141(9):1597-604. doi: 10.3945/jn.110.133199. Epub 2011 Jul 20. Erratum in: J Nutr. 2012 Feb 1;142(2):396. Carrigan, John B [added].

PMID:
21775529
27.

Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.

van Kesteren PC, Zwart PE, Pennings JL, Gottschalk WH, Kleinjans JC, van Delft JH, van Steeg H, Luijten M.

Toxicol Sci. 2011 Sep;123(1):123-32. doi: 10.1093/toxsci/kfr169. Epub 2011 Jun 29.

PMID:
21715664
28.

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.

Magkoufopoulou C, Claessen SM, Jennen DG, Kleinjans JC, van Delft JH.

Mutagenesis. 2011 Sep;26(5):593-604. doi: 10.1093/mutage/ger021. Epub 2011 Jun 1.

PMID:
21632981
29.

Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.

Stølevik SB, Nygaard UC, Namork E, Haugen M, Kvalem HE, Meltzer HM, Alexander J, van Delft JH, Loveren Hv, Løvik M, Granum B.

Food Chem Toxicol. 2011 Aug;49(8):1843-8. doi: 10.1016/j.fct.2011.05.002. Epub 2011 May 6.

PMID:
21571030
30.

Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes.

Bolleyn J, Fraczek J, Vinken M, Lizarraga D, Gaj S, van Delft JH, Rogiers V, Vanhaecke T.

Toxicol In Vitro. 2011 Sep;25(6):1173-82. doi: 10.1016/j.tiv.2011.04.013. Epub 2011 Apr 13.

PMID:
21513791
31.

Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures.

van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH.

Toxicol Appl Pharmacol. 2011 Mar 1;251(2):110-8. doi: 10.1016/j.taap.2010.12.008. Epub 2010 Dec 28.

PMID:
21192963
32.

Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

Van Summeren A, Renes J, Bouwman FG, Noben JP, van Delft JH, Kleinjans JC, Mariman EC.

Toxicol Sci. 2011 Mar;120(1):109-22. doi: 10.1093/toxsci/kfq380. Epub 2010 Dec 16.

PMID:
21163907
33.

In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals.

Stølevik SB, Nygaard UC, Namork E, Granum B, Pellerud A, van Leeuwen DM, Gmuender H, van Delft JH, van Loveren H, Løvik M.

Toxicol In Vitro. 2011 Mar;25(2):555-62. doi: 10.1016/j.tiv.2010.11.021. Epub 2010 Dec 7.

PMID:
21144890
34.

Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.

Kienhuis AS, Bessems JG, Pennings JL, Driessen M, Luijten M, van Delft JH, Peijnenburg AA, van der Ven LT.

Toxicol Appl Pharmacol. 2011 Jan 15;250(2):96-107. doi: 10.1016/j.taap.2010.10.013. Epub 2010 Oct 21. Review.

PMID:
20970440
35.

Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures.

van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH.

Toxicol Sci. 2011 Jan;119(1):126-34. doi: 10.1093/toxsci/kfq291. Epub 2010 Oct 8.

PMID:
20935163
36.

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes.

Jennen DG, Gaj S, Giesbertz PJ, van Delft JH, Evelo CT, Kleinjans JC.

Drug Discov Today. 2010 Oct;15(19-20):851-8. doi: 10.1016/j.drudis.2010.08.002. Epub 2010 Aug 11. Review.

PMID:
20708095
37.

Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in peripheral blood mononuclear cells.

Hochstenbach K, van Leeuwen DM, Gmuender H, Stølevik SB, Nygaard UC, Løvik M, Granum B, Namork E, van Delft JH, van Loveren H.

Toxicol Sci. 2010 Nov;118(1):19-30. doi: 10.1093/toxsci/kfq239. Epub 2010 Aug 11.

PMID:
20702593
38.

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds.

Mathijs K, Brauers KJ, Jennen DG, Lizarraga D, Kleinjans JC, van Delft JH.

Mutagenesis. 2010 Nov;25(6):561-8. doi: 10.1093/mutage/geq040. Epub 2010 Jul 21.

PMID:
20650930
39.

Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets.

van Delft JH, Mathijs K, Staal YC, van Herwijnen MH, Brauers KJ, Boorsma A, Kleinjans JC.

Toxicol Sci. 2010 Oct;117(2):381-92. doi: 10.1093/toxsci/kfq214. Epub 2010 Jul 12.

PMID:
20624995
40.

Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes.

van Dartel DA, Pennings JL, de la Fonteyne LJ, van Herwijnen MH, van Delft JH, van Schooten FJ, Piersma AH.

Toxicol Sci. 2010 Jul;116(1):130-9. doi: 10.1093/toxsci/kfq127. Epub 2010 Apr 26.

PMID:
20421339
41.

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH.

Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27.

PMID:
20106945
42.

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time.

Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH.

Toxicol Sci. 2009 Dec;112(2):374-84. doi: 10.1093/toxsci/kfp229. Epub 2009 Sep 21.

PMID:
19770486
43.

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH.

Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13.

PMID:
19527782
44.
45.

Potential role of cytochrome P450-1B1 in the metabolic activation of 4-aminobiphenyl in humans.

Ketelslegers HB, Godschalk RW, Eskens BJ, Dallinga JW, Gottschalk RW, van Schooten FJ, van Delft JH, Kleinjans JC.

Mol Carcinog. 2009 Aug;48(8):685-91. doi: 10.1002/mc.20530.

PMID:
19274671
46.

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH.

Drug Metab Dispos. 2009 Jun;37(6):1305-11. doi: 10.1124/dmd.108.025775. Epub 2009 Feb 27.

47.

Interlaboratory and interplatform comparison of microarray gene expression analysis of HepG2 cells exposed to benzo(a)pyrene.

Hockley SL, Mathijs K, Staal YC, Brewer D, Giddings I, van Delft JH, Phillips DH.

OMICS. 2009 Apr;13(2):115-25. doi: 10.1089/omi.2008.0060.

PMID:
19245359
48.

Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies.

van Leeuwen DM, Gottschalk RW, Schoeters G, van Larebeke NA, Nelen V, Baeyens WF, Kleinjans JC, van Delft JH.

Environ Health Perspect. 2008 Nov;116(11):1519-25. doi: 10.1289/ehp.11401. Epub 2008 Jun 23.

49.

Witch hazel (Hamamelis virginiana) fractions and the importance of gallate moieties--electron transfer capacities in their antitumoral properties.

Lizárraga D, Touriño S, Reyes-Zurita FJ, de Kok TM, van Delft JH, Maas LM, Briedé JJ, Centelles JJ, Torres JL, Cascante M.

J Agric Food Chem. 2008 Dec 24;56(24):11675-82. doi: 10.1021/jf802345x.

PMID:
19035659
50.

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH.

Toxicol Sci. 2009 Feb;107(2):544-52. doi: 10.1093/toxsci/kfn237. Epub 2008 Nov 12.

PMID:
19008212

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